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Sequence Analysis &alignment

Sequence analysis and alignment involves comparing sequences to find similar regions that may indicate functional, structural, or evolutionary relationships. Genome annotation is the process of identifying genes and other biological features in a DNA sequence. Comparative genomics studies the relationship of genome structure and function across species through gene finding and identifying noncoding functional elements. Systems biology uses computer simulations of cellular subsystems like metabolic networks and signaling pathways to analyze and visualize complex cellular processes.

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199 views2 pages

Sequence Analysis &alignment

Sequence analysis and alignment involves comparing sequences to find similar regions that may indicate functional, structural, or evolutionary relationships. Genome annotation is the process of identifying genes and other biological features in a DNA sequence. Comparative genomics studies the relationship of genome structure and function across species through gene finding and identifying noncoding functional elements. Systems biology uses computer simulations of cellular subsystems like metabolic networks and signaling pathways to analyze and visualize complex cellular processes.

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ohalsubash
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© Attribution Non-Commercial (BY-NC)
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Sequence analysis &alignment Comparison of sequence in order tofind the similar sequence.

. Way of arranging the sequences of DNA / RNA / Amino Acids to identifyregions of similarity that may be aconsequence of functional, structuralor evolutionary relationships. Identification of gene structures,reading frames, distributions of introns & exons & regulatoryelements. Genome annotation Process of marking the genes and otherbiological features in a DNA sequence First genome annotation softwaresystem was designed in 1995 by Dr.Owen White First genome of a free-living organismto be decoded, the bacteriumHaemophilus influenzae. Whites software system finds thegenes (places in the DNA sequence thatencode a protein), the transfer RNA,and other features.

Comparative genomics Comparative genomics is the studyof the relationship of genomestructure and function acrossdifferent biological species or strains. Gene finding is an importantapplication of comparative genomics,as is discovery of new, noncodingfunctional elements of the genome. Computational approaches togenome comparison have recentlybecome a common research topic in

Modeling biologicalsystems Systems biology involves the use of computer simulations of cellular subsystemssuch as the networks of metabolites andenzymes which comprise metabolism, signaltransduction pathways and gene regulatorynetworks) to both analyze and visualize thecomplex connections of these cellularprocesses.

Artificial life or virtual evolution attempts tounderstand evolutionary processes via thecomputer simulation of simple (artificial) lifeforms.

Protein-protein interaction& docking Protein-protein interactions involve theassociation of protein molecules. These associations are studied from theperspective of biochemistry, signaltransduction and networks. Wet Lab Techniques: Co-immunoprecipitation, FRET, BimolecularFluorescence Complementation Protein-protein docking: the prediction of protein-protein interaction based on thethreedimensional protein structures onlyis not satisfactory As of 2006. Biological SequenceDatabase Primary SequenceDatabases The International NucleotideSequence Database (INSD) consistsof the following databases. DDBJ (DNA Data Bank of Japan) EMBL Nucleotide DB (EuropeanMolecular Biology Laboratory) GenBank (National Center forBiotechnology Information) Theyinterchangethe storedinformation and are the source formany other databases NCBI National Center for BiotechnologyInformation is part of the United StatesNational Library of Medicine (NLM), abranch of the National Institutes of Health. Founded in 1988 sponsored by SenatorClaude Pepper. NCBI has had responsibility for makingavailable the GenBank DNA sequencedatabase since 1992 In addition to GenBank, NCBI providesOMIM, MMDB (3D protein structures),dbSNP, the Unique Human GeneSequence Collection, a Gene Map of the

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