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    Bioreactor Design Fundamentals

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    orion57854375
    The document discusses various types of bioreactors used in industrial applications including batch, continuous, continuous with recycle, and semi-continuous reactors. It defines limiting substrates as those that are first exhausted during batch growth and directly influence cell growth kinetics, while excess substrates do not affect growth. Rate equations for substrate utilization are presented, showing the relationship between rate, substrate concentration, and maximum transport rate.

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    Bioreactor Design Fundamentals

    Uploaded by

    orion57854375
    405 views42 pages
    The document discusses various types of bioreactors used in industrial applications including batch, continuous, continuous with recycle, and semi-continuous reactors. It defines limiting substrates as those that are first exhausted during batch growth and directly influence cell growth kinetics, while excess substrates do not affect growth. Rate equations for substrate utilization are presented, showing the relationship between rate, substrate concentration, and maximum transport rate.

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    Bioreactor Design Fundamentals

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    The document discusses various types of bioreactors used in industrial applications including batch, continuous, continuous with recycle, and semi-continuous reactors. It defines limiting substrates as those that are first exhausted during batch growth and directly influence cell growth kinetics, while excess substrates do not affect growth. Rate equations for substrate utilization are presented, showing the relationship between rate, substrate concentration, and maximum transport rate.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    405 views42 pages

    Bioreactor Design Fundamentals

    Uploaded by

    orion57854375
    The document discusses various types of bioreactors used in industrial applications including batch, continuous, continuous with recycle, and semi-continuous reactors. It defines limiting substrates as those that are first exhausted during batch growth and directly influence cell growth kinetics, while excess substrates do not affect growth. Rate equations for substrate utilization are presented, showing the relationship between rate, substrate concentration, and maximum transport rate.

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    Bioreactor Design Fundamentals

    The most widely used Industrial Bioreactors are: Batch Reactors Continuous Reactors Continuous Reactors With Recycle Semi Continuous Reactors (Fill/Draw Reactors including Sequencing Batch Reactors)

    Bioreactor Design Fundamentals (Contd)

    DEFINITIONS Limiting Substrate The substrate or substrate(s) (energy source, carbon source and/or nutrient source) which is/are first exhausted in batch growth. This substrate(s) has a direct influence on the kinetics of cell growth.

    Bioreactor Design Fundamentals (Contd)

    DEFINITIONS In Excess The substrate or substrate(s) (energy source, carbon source and/or nutrient source) which is/are NOT exhausted at the end of batch growth. This substrate(s) has NO EFFECT on the kinetics of cell growth.

    Bioreactor Design Fundamentals (Contd)

    Bioeactor Design Fundamentals (Contd) k1* and A are combined to form another constant k and the rate expression becomes: RATE = k (S / KS + S) Where k = maximum rate of transport of S ( mol / h) When S is much larger than KS : RATE k f (S) When S is similar to KS : RATE = f (S)

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    Bioreactor Design Fundamentals (Contd)

    THE LAG PHASE

    Bioreactor Design Fundamentals (Contd)

    THE LAG PHASE

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    Bioreactor Design Fundamentals (Contd)

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