Isoflurane Msds

Revision Date
01/03/11
Isoflurane, USP
1) PRODUCT AND COMPANY IDENTIFICATION
Product name: Synonyms: Isoflurane, USP Terrell Attane Isoflurane Escain Isofane Isofluran Isoflurano 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER 26675-46-7 CHF2OCClHCF3 Anesthetic, Halogenated Ether Piramal Critical Care 3950 Schelden Circle Bethlehem, PA 18017 CHEMTREC 1-703-527-3887 Weight % 100 Classification None
CAS Number: Formula: Chemical Family: Manufacturer:
24 Hour Emergency Number: Component Isoflurane
2) COMPOSITION/INFORMATION ON INGREDIENTS
3) HAZARDS IDENTIFICATION
Emergency Overview: CAUTION! Anesthetic Agent. Overexposure by inhalation to the vapors may cause temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination, or loss of conciousness, they should be moved to an area of fresh air. Concentrations of anesthetic in the air would have to reach approximately 2-3 % before personnel would be expected to experience significant dizziness. Gross overexposure (> 20%) may possibly alter the heart's electrical activity with irregular pulse, palpitations,or inadequate circulation. Inhalation. Skin contact. Eye contact. Ingestion. Practically non-toxic by inhalation. Cardiovascular effects may include fluctuations in heart rate, changes in blood pressure, chest pain. Respiratory effects may include shortness of breath, bronchospasms, laryngospasms, respiratory depression. Gastrointestinal effects may include nausea, upset stomach, loss of appetite. Nervous system effects may include ataxia, tremor, disturbance of speech, lethargy, headaches, dizziness, blurred vision. May cause skin irritation. May cause eye irritation. Practically non-toxic if swallowed. No specific hazards other than therapeutic effects. See inhalation.
Exposure Routes: Inhalation:
Skin Contact: Eye Contact: Ingestion:
4) FIRST AID MEASURES
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Inhalation:
If high concentrations are inhaled, immediately remove to fresh air. If not breathing, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible In case of contact, remove contaminated clothing, and wash contaminated skin with soap and water. Seek medical attention if irritation is present. In case of contact, immediately wash (irrigate) the eyes with large amounts of tepid potable water, occasionally lifting the lower and upper lids. Get medical attention immediately. DO NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities are swallowed, get medical attention immediately. Due to the possible disturbances of cardiac rhythm, catecholamine drugs, such as epinephrine, should be considered only as a last resort in lifethreatening emergencies.
Skin Contact: Eye Contact:
Ingestion:
Note to Physician:
5) FIRE FIGHTING MEASURES

Flash Point: Specific Methods: Flammable Limits in air-lower (%): Flammable Limits in air-upper (%): Autoignition: Extinguishing Media: Fire Fighting Instructions: Fire and Explosion Hazard: Not determined No information available Not available Not available Not available Use extinguishing media appropriate to surrounding fire conditions Fire fighters and others should wear NIOSH approved positive pressure selfcontained breathing apparatus (SCBA) and turnout gear. Use water spray to cool containers. Containers may rupture under fire conditions.
6) ACCIDENTAL RELEASE MEASURES

In Case of Spill or Leak: Small volumes of liquid anesthetic agents may readily evaporate at room temperatures and may dissipate before any clean up attempts are initiated. For large spills, provide adequate ventilation or evacuate area. Large quantities of anesthetic agents may cause sedative effects. Restrict personnel not donning protective equipment from areas of spills or leaks until clean up is complete. A sorbent designed for organic chemicals should be use for large spills. Spill pillows, vermiculite, and carbon-based sorbents are examples of suitable materials. Dike spill and prevent liquid from entering sewers, waterways or low areas. Sweep or scoop up and remove to a suitable container. Close container and dispose of container in accordance with federal, state, and local regulations.
7) HANDLING AND STORAGE

Handling: Storage: Wash thoroughly after handling. Keep container tightly sealed. Store in a dry, cool, and well ventilated place. Store between 15 - 30oC (59 - 86oF)
8) EXPOSURE CONTROLS/PERSONAL PROTECTION

Engineering Controls: Eye Protection: Investigate engineering techniques, process enclosures or local exhaust ventilation to keep airborne levels below recommended exposure limits. Safety glasses, chemical splash goggles, face shield, or other full faced protection should be available for use if potential exists for exposure to splashes. Chemical resistant, impervious gloves should be used to avoid prolonged or
Skin Protection:
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repeated exposure. Wear a work uniform or laboratory coat. Additional body garments should be used based upon the tasks being performed. Respiratory Protection: When working with small quantities in a well ventilated area, respiratory protection may not be required. If exposure levels exceed regulatory limits, implement a respiratory protection program that is in compliance with OSHA 29 CFR1910.134 or equivalent in other regions. Fire fighting requires the use of a self-contained breathing apparatus with full face piece and positive pressure mode. None None None None None None Ceiling 2 ppm (60 minutes) recommended exposure limit for halogenated waste anesthetic gas.
OSHA-Time Weighted Average: OSHA-Short Term Exposure Limit: OSHA-Ceiling Limits: ACGIH-Time Weighted Average: ACGIH-Short Term Exposure Limit: ACGIH-Ceiling Limit Value: NIOSH REL:
9) PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Appearance: Color: Odor: pH: Molecular Weight: Boiling Point: Vapor Pressure: Evaporation Rate: Water Solubility: % Volatile by Volume: Liquid Clear Colorless Slight ethereal Neutral 184.5 g/mole 48.5oC (119.3oF) at 760 mm Hg. 330 mm Hg at 25oC (77oF) Not available Slightly soluble 100 WT%
10) STABILITY AND REACTIVITY

Stability: Incompatibility: Polymerization: Hazardous Decomposition Products: Material is stable under recommended storage conditions. Peroxides Not applicable These products are halogenated compounds (e.g., hydrochloric and hydroflouric acids, phosgene).
11) TOXICOLOGICAL INFORMATION

LD50 LC50 LD50 LD50 LC50 LD50 Acute Toxicity: 4770 mg/Kg oral-rat 16300 ppm/3H inhalation-rat 4280 g/Kg intraperitoneal-rat 5080 g/Kg oral mouse 16800 ppm/3H inhalation-mouse 3030 mg/Kg intraperitoneal-mouse Cardiovascular effects - may include fluctuation in heart rate, change in blood pressure, chest pain. Respiratory effects- may include shortness of breath, bronchospasms, laryngospasms, respiratory depression. Gastrointestinal effects - may include nausea, upset stomach, loss of appetite. Nervous System effects - ataxia, tremor, disturbance of speech, lethargy, headache, dizziness, blurred vision. Target Organs- nervous system, heart, liver Not classified or listed by OSHA, IARC, NTP, EU, and ACGIH. No drug related carcinogenic/tumorigenic effects based on animal data.
Chronic Toxicity: Carcinogenic Effects:
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Mutagenic Effects: Reproductive Toxicity:
Not available No impairment to fertility based on animal data. May be fetotoxic at high doses based on animal data. Epidemiological studies suggest higher than normal incidences of problem pregnancies (particularly spontaneous abortions) among exposed personnel. C
FDA Pregnancy Category:
12) ECOLOGICAL INFORMATION

Ecotoxicity Effects: Bioaccumulation: No data available No data available
13) DISPOSAL CONSIDERATIONS

Waste Disposal: Comply with federal, state, and local regulations in the disposal of waste.
14) TRANSPORT INFORMATION

DOT: Not regulated for inner packagings not exceeding 5.0 L (1.3 gallons) net capacity each. Regulated for inner packagings exceeding 5.0 L (1.3 gallons) net capacity each. DOT shipping name: Aviation regulated liquid, N.O.S., (Isoflurane) UN number: UN3334 Packing Group: None DOT hazard class: 9 IATA proper shipping name: Aviation regulated liquid, N.O.S., (Isoflurane) IATA UN number: UN3334 IATA primary hazard class: 9 IATA packing group: None IATA packing instruction: 906 Not regulated Not regulated Not regulated
ICAO/IATA:
TDG (Canada): IMO/IMDG: ADR/RID:
15) REGULATORY INFORMATION

FDA: TSCA Inventory List: Regulated This product is excempt from TSCA.
16) OTHER INFORMATION

New MSDS format. The information above is believed to be accurate and is intended only as a guide. Piramal Critical Care assumes no responsibility for any damages resulting from handling or contact with the above material.
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Revision Date

CAS Number: Formula: Chemical Family: Manufacturer:

24 Hour Emergency Number: Component Isoflurane

Exposure Routes: Inhalation:

Skin Contact: Eye Contact: Ingestion:

4) FIRST AID MEASURES

Skin Contact: Eye Contact:

5) FIRE FIGHTING MEASURES

6) ACCIDENTAL RELEASE MEASURES

7) HANDLING AND STORAGE

8) EXPOSURE CONTROLS/PERSONAL PROTECTION

9) PHYSICAL AND CHEMICAL PROPERTIES

10) STABILITY AND REACTIVITY

11) TOXICOLOGICAL INFORMATION

Chronic Toxicity: Carcinogenic Effects:

Mutagenic Effects: Reproductive Toxicity:

FDA Pregnancy Category:

12) ECOLOGICAL INFORMATION

13) DISPOSAL CONSIDERATIONS

14) TRANSPORT INFORMATION

TDG (Canada): IMO/IMDG: ADR/RID:

15) REGULATORY INFORMATION

16) OTHER INFORMATION

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