STR FX Immune System
STR FX Immune System
STR FX Immune System
We already know
Structure & Function of the
Immune System
Lymphocytes
Lymphoid Organs
MHC
Dr Debasis Biswas
Nave: 6
Lymphoblast: 15
Plasma Cell: 15
B cells
T cells
Maturation: Thymus
Specific marker for ag recogn: T cell receptor
MHC-bound ag on APCs or on virus- infected
cells or cancer cells or grafts
Pan T cell marker: CD3
Helper T cell: CD4; Cytotoxic T cell: CD8
Normally TH: CTL= 2:1
TH cells
CTLs
Effector TH cells
T cells vs B cells
T cells
B cells
T cell Receptor, linked sIg
to CD3
Bind to Sheep RBCs coated
CD2 ag.. Bind to
with Ab & Complement
Sheep RBCs
(CR2 for C3)
Mitogens: PHA, ConA Mitogens: LPS, EB virus
No surface projections Filamentous surface with
microvilli
Cytokine profile
TH2: Supports
TH1: Supports
Inflammation; CMI Humoral immunity
11/26/2014
Lymphoid Organs
Primary Lymphoid Organs Secondary Lymphoid Organs
Maturn. of lymphocytes Interaction of lymphocytes
to achieve ag specificity
with antigen
Thymus (T cells)
Bone Marrow (B cells)
Lymph Nodes
Spleen
Mucosa- Associated
Lymphoid Tissue (MALT)
Thymus
Lymph node
Capsule
Cortex B cells, M, Follicular DCs: 1ry follicle
Ag stimuln
Paracortex T cells, Intdg DCs
2ry follicle with GC
Medulla
Cellular network
to trap antigens
in lymphatic fluid
Medulla:
Migration of
Plasma cells
from
2ry follicles
Afferent
Lymphatics
Cortex:
2ry follicles with GCs
Cortex:
Migration of B cells &
TH cells to 1ry follicles
Paracortex:
Ag presentn by IDCs
Paracortex
Diffn. into plasma cells
Foci of proliferating B cells
Primary
Lymphoid
Follicles
Germinal
Centers
Spleen
Primary
Lymphoid
Follicles
Germinal
Centers
11/26/2014
PALS:
Migration of IDCs
Stimulation of TH cells
Initial activn of B cells
Splenic
Artery
Submucosa:
Peyers patches with
Lymphoid Follicles
Human: HLA
Chromosome 6
Mouse: H-2
Chromosome 17
11/26/2014
Though infrequent,
Recombination leads to
diversity of alleles
within populations.
11/26/2014
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