Sysmex CS 5100

CS-5100
* Exceptional throughput of up to 400 tests per hour with gold standard results
* Efficient and productive, with remote access and LAS compatible
* Superior calibration and assay performance
* Pre analytical sample integrity check (HIL)
* Powerful multi-wavelength technology - clotting, chromogenic, immunological and platelet aggregation
methods
CS-5100 Simply, safely and speedily - outstanding coagulation

analysis
The CS-5100 is a superb coagulation analyser. With a throughput of up to 400 tests per hour, it delivers high quality
results in a very short timeframe. With its powerful multi-wavelength technology, it has 20 channels for clotting,
chromogenic and immunoassays and eight for platelet aggregation with automatic stirring. The device also checks
automatically for interfering substances (HIL) and can be run in random access with other assays.
We have also focused on making the device easy to use, flexible and productive for you. Pre-analytical sample checks
mean you no longer need to check manually, it offers remote access and it is easy include in larger laboratory solutions.
Advanced reagent management makes use of simplified software, and an auto QC on vial change significantly
diminishes the risk of errors. A great device, easy to use and as accurate as they come.
No compromise on quality
Using four different detection technologies, the CS-5100 delivers great quality analyses. With clotting, chromogenic,
immunoturbimetric and platelet aggregation assays it delivers accuracy and precision for all parameters.
Clotting method
The CS-5100 uses the Optical Detection Method to detect the change in turbidity of the sample-reaction mixture during
the coagulation process. This is reflected in the change in scattered light intensity when fibrinogen is converted into a
fibrin mesh. Light strikes the reaction mixture, after the scattered light intensity is received by a photodiode. This converts
the light intensity into electrical signals and is used to find the coagulation time. This method is used to measure
prothrombin time, APTT, fibrinogen, factors and many other clotting tests.
Chromogenic method
Light with a wavelength of 405 nm passes through the sample and reagent mixture and reaches a photodiode, where
the transmitted light is converted into electrical signals. The change in the intensity of this transmitted light is used to
determine the change in absorbance. This measurement is used for chromogenic assays like Antithrombin and Protein
C where a chromogenic substrate in presence of an activator causes the reagent mixture to change colour.
Immunoassay and platelet aggregation method
The sample-reagent mixture contains artificial particles that can aggregate when there is an antigen-antibody reaction
Design and specifications may be subject to change due to further product development.
Sysmex Europe GmbH, Bornbarch 1, 22848 Norderstedt, Germany, Phone: +49 (40) 527 26 0, Fax: +49 (40) 527 26 100
www.sysmex-europe.com
or particles that have a natural capability to aggregate like platelets. The mixture is exposed to light of a high wavelength,
and the change in light absorbance caused by the formation of aggregates is detected as the change in transmitted
light. This is used for D-dimer assays and platelet aggregation assays (Von Willebrand activity, ADP, Collagen, Arachidonic
Acid, Epinephrine).
Get it right before you start testing pre-analytical sample integrity helps
Pre-analytical issues can account for as much as 70% of a clinical laboratorys errors. Multi-wavelength scanning and
sample liquid-sensing technologies detect unsuitable specimens. A pre-analytical sample integrity check tests for
interfering substances in the sample haemolysis, icterus, lipaemia at three wavelengths: 405 nm, 575 nm and 660 nm.
A primary tube sample volume check provides assistance by identifying potential inaccuracies caused by improper
sample collection, which can result in an incorrect ratio of anticoagulant to patient plasma.
Under specific conditions, the CS-5100 will automatically use the optimal wavelengths to ensure result accuracy in the
presence of hemolysis, icterus or lipemia. This minimises the need for retesting and helps you deliver the highest quality
results on your first test run.
Multi-wave detection - reduce your repeat tests

Using a multi-wave detection system, the CS-5100 can simultaneously measure multiple parameters using four different
measurement methods: coagulation, chromogenic, immunoassay and aggregation. The systems photo-optical clot
detection means you have several advantages compared to mechanical detection.
* You can measure light transmittance over the entire course of clot formation, not just the end.
* You can identify atypical reaction patterns easily and so determine the correct coagulation reaction result for
your patients with unusual in vitro clot reactions such as sepsis and DIC.
* The clotting reactions display the complete clot signature, not just a single data point, so that you get far more
detailed test information and therefore better clinical utility.
Used on a single platform, the broad range of assays allows high test throughput up to 400 samples per hour.
Cooled reagent system flexible and cost-efficient

In the CS-5100, we have critically addressed the usability of our coagulation analysers based on extensive input from
users and our own knowhow. One of the results is our new, cooled reagent system with secure, in-situ barcode reading.
Reagent racks are now placed in a double-ring reagent table capable of handling a total of 40 reagent bottles maintained
at 10C. The bottles are slightly tilted to reduce dead volume and reagent waste and maximize the number of tests per
vial.
One position on each reagent rack can stir reagents so that you can use reagents that require continuous mixing.
A separate reagent rack system lets you group reagents for each rack and for high sample loads - up to three vials of
the same reagent. With a onboard capacity of 1000 cuvettes this delivers a long walk-away time . To reduce the risk of
errors, there is an optional automatic quality control when vials are changed.
Superior calibration and assay performance

* Convenient batch change with maximum security
* Accessibility for all users with standardized decision-making

* Excellent linearity negating multiple calibrations for different assay ranges
* Up to 12 dilution points for each calibration performed
* Up to 10 live calibration curves per assay
* Automatic recognition of the appropriate calibration curve.
Specifications
Detection principles
multi-wavelength detector for transmitted light at
340, 405, 575, 660 and 800 nm
Detection methods
20 channels for clotting, chromogenic and immunoassays
8 channels for platelet aggregation
Parameters
up to 60 parameters can be analysed simultaneously
Throughput
up to 400 tests/h
Sampling
rack type, auto sampler, cap piercing functionality, initial capacity for 10 racks with 10 sample
tubes each, continuous loading possibility, separate STAT positions
direct sampling (optional) to connect the CS-5100 via its left side to a lab automation transport
system
Reagent holder
40 positions cooled at 10 C
5 positions at room temperature
all positions with positive reagent identification
Reference curves
multi-lot management with max. 10 curves/reagent lot
and max. 10 reagent lots/parameter
Quality control
x-bar, Levey-Jennings and Westgard control
750 parameter files with max. 1,200 data points each
Data storage
up to 10,000 samples
Dimensions/weights
main unit*
IPU with cabinet

w x h x d [mm] / [kg]
approx. 1030 x 1280 x 1150 / 278
approx. 500 x 920 x 890 / 67
*excluding optional features, such as direct sampling, which will alter the dimensions.

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CS-5100

CS-5100 Simply, safely and speedily - outstanding coagulation

Multi-wave detection - reduce your repeat tests

Cooled reagent system flexible and cost-efficient

Superior calibration and assay performance

* Accessibility for all users with standardized decision-making

IPU with cabinet

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