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&$11$%,67+(5$3(87,&6,1+,9$,'6

APPENDIX
Purpose of the Project
To determine if there are physical, mood and perception changes resulting from use of the
test article.
To determine if the method of delivery affects measures of effectiveness.
To determine if different types of cannabis affect diagnoses and measures of effectiveness.
To assess the correlation between changes in mood and other measures of effectiveness.
Summary of Population
N = 77
43 males (56%)
22 females (29%)
12 missing gender distinction (15%)

TABLE 1. Description of Population by Primary Diagnosis

45
40

Primary Diagnosis

51%
39

35

25

18%
9%

5%

4%

1%

1%

1%

1%

Glaucoma

9%

Fibromyalgia

10

Arthritis

14

15

Lupus

20

Epilepsy

Orthopedic

Unknown

Cancer

Neurologic

HIV/AIDS

Cases

30

9DOHULH/HYHURQL&RUUDO



TABLE 2. Description of Patient Population by Secondary Diagnosis

35

33

30
25
20
15
11
7

5
6%

3%

3% 1 1% 1 1%

GI

Cancer

9%

Epilepsy

10%

Cardiac

10%

Unknown

14%

Orthopedic

HIV/AIDS

43%

Neurologic

Psychiatric

Arthritis

10

TABLE 3. Questionnaire Structure Measures of Effectiveness

Variable

None

Most

Desired Effect

Pain

10

Decrease

Energy

10

Increase

Mood

10

Increase

Nausea

10

Decrease

Appetite

10

Increase

Muscle Spasms

10

Decrease

Seizures

10

Decrease

Ocular

10

Decrease

Insomnia

10

Decrease

Awareness

10

Increase

Neuropathy

10

Decrease

Questionnaire Logistics
1892 Questionnaires Completed over 3 years
Range of 1 to 256 questionnaires
Average of 8 questionnaires/patient
Analysis completed based on the average number of questionnaires completed (to
normalize data for analysis)



&$11$%,67+(5$3(87,&6,1+,9$,'6
TABLE 4

Statistical Methods
432 questionnaires analyzed
Frequency analysis, Paired t-tests, Paired t-test correlations, One Way ANOVA, Post-Hoc
(Bonferroni), Pearson Correlation and Multivariate tests performed
One Way ANOVA conducted on variables using the following 3 groups
Group 1test article ingested
Muffins
Mothers milk
Group 2test article inhaled
African Queen
Purple Indica
Group 3Other
One Way ANOVA performed on the following test article groups:
Sativa (26161%)
Other (10524%)
Indica (655%)
Multivariate Tests performed for type of Cannabis, diagnosis, and change in variable
Pillais Trace
Wilks Lambda, and
Tests of Between-Subjects Effects
One Way ANOVA, Bonferroni, Post-Hoc tests performed for definition of diagnosis and
treatment effectiveness
All tests performed using SPSS (Statistical Program for Social Scientists) Version 9.0

TABLE 5
Question One
Are there physical, mood and perception changes resulting from use of the test article?
Paired Samples t test
Comparing means before and after
95% confidence interval (2-tailed)
Variable
Before
Pain
6.98
Energy
4.12
Mood
4.30
Nausea
7.06
Appetite
3.02
Awareness
5.73
All are significant

After
3.26
6.04
7.32
2.78
6.96
6.97

Difference
3.72 3
1.92 3
3.02 4
4.28 3
3.94 4
1.24 3

9DOHULH/HYHURQL&RUUDO



TABLE 6
Question Two
Does change in variable vary by method of treatment: ingested, inhaled or other?
Question TwoMeans of Variable Changes by Mode of Consumption
Pain
Energy
Mood
Nausea
Appetite
Spasm
Seizure
Ocular
Insomnia
Awareness

1
3.75
2.05
2.98
4.39
4.05
3.42
0.14
2.63
3.88
1.31

2
3.45
1.14
2.54
4.50
2.94
3.95
N/A
2.54
3.44
0.41

3
3.67
1.18
3.81
2.22
3.28
3.60
4.75
2.86
4.28
1.72

*Significant

ANOVA
Question Two
Examination of the mean change (One way Anova95% confidence interval)
Significance was found for the following variables
Spasm
p = 0.008
Insomnia
p = 0.036

TABLE 7
Interpretation of ANOVA Method of Test Article Delivery

Group 1 is different than group 3.

Average group 1 (ingested) = 4.39.
Average group 2 (inhaled) = 4.50.
Average group 3 (other) = 2.20.
There is greater improvement in nausea (0.36) with ingestables vs. other.
Ingestables and inhaled groups are not different.

p
0.274
0.630
0.840
0.934
0.418
0.008*
0.177
0.099
0.036*
0.259



&$11$%,67+(5$3(87,&6,1+,9$,'6
TABLE 8

Question Three
Are changes in variables related to the different types of cannabis and primary diagnoses?
Mean Change of Variables in Treatment Test Article Groups
Pain
Energy
Mood
Nausea
Appetite
Spasm
Seizure
Ocular
Insomnia
Awareness

Other
3.49
2.22
2.94
4.67
4.32
4.33
0.67
3.27
4.53
1.75

Sativa
3.99
1.53
2.89
4.19
3.41
3.53
2.12
2.34
3.82
0.96

Indica
2.93
3.06
3.76
4.01
5.22
2.23
0.50
3.00
3.18
1.24

p
0.078
0.012*
0.327
0.470
0.005*
0.071
0.316
0.646
0.221
0.173

One Way Anova95% CI

*Significant

TABLE 9
Interpretation of ANOVA Method of Test Article Treatment Group
The Indica Group is different than Sativa Group
Average Indica = 3.06
Average Sativa = 1.53
Average Other = 2.22
There is greater improvement in energy (0.012) with Indica vs. Sativa and Other.
Sativa and Other treatment groups are not different.
Interpretation of ANOVA Treatment Group
Indica was more effective to increase energy and appetite in any primary diagnosis group.
Use of any test article was effective in treating Nausea in the Orthopedic and HIV/AIDS diagnosis group.

9DOHULH/HYHURQL&RUUDO



TABLE 10
Mean Change in Variable by Primary Diagnosis
Mood
Pain
Energy
Mood
Nausea
Appetite
Spasm
Seizures
Ocular
Insomnia
Awareness

Ortho
4.36
4.93
3.54
4.36
1.58
4.57
4.17
NA
NA
4.68
2.21

Neuro
4.05
4.02
1.33
4.05
4.21
3.50
4.05
1.86
2.91
4.66
1.07

AIDS
2.87
3.31
2.31
2.86
4.54
4.44
1.83
0.89
2.00
3.49
1.15

Other
1.33
3.90
1.07
1.33
3.97
3.08
3.29
NA
4.00
2.93
0.65

Cancer
2.64
3.27
1.23
2.64
4.18
3.00
4.91
NA
NA
5.08
2.25

p
0.001*
0.011*
0.017*
0.094
0.015*
0.010*
0.401
0.001**
0.334
0.000*
0.000*

One Way Anova 95% CI

*Significant
**Small sample size unable to correlate

TABLE 11
Interpretation of ANOVA Method for Primary Diagnostic Group
The Orthopedic and Neurological group are different than the Other primary diagnostic
group.
There is greater improvement in Mood (p = 0.008) for the Orthopedic group vs. Other.
There is greater improvement in Mood (p = 0.001) for the Neurological group vs. Other.
Average Orthopedic
4.36
Average Neurological
4.04
Average HIV/AIDS
2.87
Average Other
1.33
Average Cancer
2.64
There is no difference between the AID/HIV and Cancer groups.

TABLE 12
Interpretation of ANOVA Method for Primary Diagnostic Group
The Orthopedic group is different than the Other primary diagnostic group.
There is greater improvement in Energy (p = 0.43) for the Orthopedic group than Other.
Average Orthopedic
3.54
Average Neurological
1.33
Average HIV/AIDS
2.31
Average Other
1.07
Average Cancer
1.23
There is no difference between the Neurological, AID/HIV, and Cancer groups.



&$11$%,67+(5$3(87,&6,1+,9$,'6
TABLE 13

Interpretation of ANOVA Method for Primary Diagnostic Group

The HIV/AIDS group is different than the Orthopedic primary diagnostic group.
There is greater improvement in Nausea (p = 0.04) for the HIV/AIDS group than Orthopedic
primary diagnostic group.
Average Orthopedic
1.58
Average Neurological
4.21
Average HIV/AIDS
4.54
Average Other
3.97
Average Cancer
4.18
There is no difference between the Neurological, Other, and Cancer groups.

TABLE 14
Interpretation of ANOVA Method for Primary Diagnostic Group
There is improvement in Appetite (0.010) for all diagnostic groups.
There is no difference in mean change for the Appetite variable for specific primary diagnostic groups.
Average Orthopedic
4.57
Average Neurological
3.50
Average HIV/AIDS
4.44
Average Other
3.08
Average Cancer
3.00

TABLE 15
Interpretation of ANOVA Method for Primary Diagnostic Group
There is improvement in Insomnia (p = 0.000) for all diagnostic groups.
There is no difference in mean change for the Insomnia variable for specific primary diagnostic groups.
Average Orthopedic
4.68
Average Neurological
4.66
Average HIV/AIDS
3.49
Average Other
2.93
Average Cancer
5.08

9DOHULH/HYHURQL&RUUDO



TABLE 16
Interpretation of ANOVA Method for Primary Diagnostic Group
There is improvement in Awareness (p = 0.000) for all diagnostic groups.
There is no difference in mean change for Awareness specific to primary diagnostic groups.
Average Orthopedic
2.21
Average Neurological
1.07
Average HIV/AIDS
1.15
Average Other
0.65
Average Cancer
2.25
Correlation Analysis Question Four
Is change in mood correlated to change in energy?
p = .035*
Is change in mood correlated to change in pain?
p = .817
Is change in mood correlated to change in nausea?
p = .434
Is change in mood correlated to change in insomnia?
p = .647
Is change in mood correlated to change in awareness?
p = .073
*Significant

Conclusions
There were observed changes in pain, energy, nausea, appetite, and awareness variables
from the use of the test article.



&$11$%,67+(5$3(87,&6,1+,9$,'6
TABLE 17

Please read the instructions on the other side of this page.

Name or ID: (Use your WAMM ID number if concerned about privacy.
You may place the label from your medicine here.)

Gender

Age

Race

Diagnosis

Years since
diagnosis

Weekly Medicine Allotment

Buds

DAY:

Muffins

WEDNESDAY

Milk

THURSDAY

Brownies

FRIDAY

SATURDAY

Other

SUNDAY

MONDAY

TUESDAY

DATE:
MEDICINE TYPE:
DOSAGE UNIT:
DOSAGE:
CONDITIO\N
Appeptite
Awareness
Consciousness
Enegy
Insomnia
Libido
Mood
Nausea
Neuropathy
Ocular pressure
Pain
Seizures
Spasms

Before

After

Before

After

Before

After

Before

After

Before

After

Before

After

Before

After

9DOHULH/HYHURQL&RUUDO



TABLE 18
Comments: (Use additional sheets of paper as needed. We are very interested in your comments.)

Instructions
Each day of the week, fill in the information BEFORE you take your medication for the first time in the day, and then again AFTER you
take your medication for the first time of the day. Using a scale of 1 to 10, with 1 meaning WORST and 10 meaning BEST, mark how
you are feeling in the spaces provided. If the condition (symptom) improves, the number goes up.
Notice that the week begins on Wednesday in order to synchronize with our weekly meetings on Tuesdays.
If a condition does not apply to you, simply leave it blank.
Make sure to fill in at least one date.
Terminology
Appetite

Desire for food or drink

Awareness
Best

Subjective experience of highest quality

Consciousness

Medicine type

The code that appears on your medicine container or

medicine name such as milk, muffins, brownies, buds.

Mood

State or quality of feeling at a particular time.

Prevailing emotional tone or general attitude

Nausea

Sickness at the stomach, especially when

accompanied by a loathing for food and an
involuntary impulse to vomit.

Neuropathy

Symptoms of a diseased nervous system like tingly

sensations.

Diagnosis

Name of disease such as cancer, HIV, glaucoma

Ocular pressure

Pressure within the eye

Dosage

Number of dosage units

Pain

Physical suffering or distress

Dosage unit

Name of dose, such as puffs, ounces, grams, bites,

drops, fraction of weekly allotment (for example 1/7
means 1/7 of the weekly allotment.

Seizures

A sudden attack, as of epilepsy or some other

disease

Energy

Capacity for vigorous activity

Spasms

Sudden, abnormal, involuntary muscular contraction

Gender

Male, female, transgendered

Worst

Subjective experience of lowest quality

Insomnia

Inability to sleep

Libido

Sexual instinct or drive

Developed by Rick Sinatra