Dr.

Jyoti Parkash, PhD

Assistant Professor
Centre for Animal Sciences
School of Basic and Applied Sciences
Central University Punjab, Bathinda, India 151001
E-mail: jtprksh.sharma@gmail.com
Phone: +91-8699212464
Education:
Degree

Institution

Year

Subject

Postdoctoral
Training

Development and Plasticity of Postnatal,

Brain, Jean-Pierre Aubert Research Center,
INSERM U837, place de Verdun 59045
Lille, Cedex France

2008-14

Hormone-dependent
development
and
plasticity
of
the
metabolic brain

Ph.D.

Guru Nanak Dev University (GNDU) Amritsar, 2002-07

Punjab, India 143005

Department of
Biotechnology

M.Sc.

Guru Nanak Dev University (GNDU) Amritsar, 2000Punjab, India 143005

2002

Zoology

B.Sc.

Himachal Pradesh University (HPU) Shimla, 1997Himachal Pradesh, India

2000

Zoology,
Chemistry
and Botany

Experiences:
Position Held

Place of Work

Assistant
Professor

Centre for Animal Sciences, School of Basic and 13-07-2015

Applied Sciences, Central University of Punjab,
Bathinda, (CUPB) Punjab India

Till date

Assistant
Professor

Department of Biotechnology, DAV University, 29-08-2014

Jalandhar, Punjab India

10-07- 2015 About 1 year

Postdoctoral
Development and Plasticity of Postnatal,
Fellow/Research Brain Jean-Pierre Aubert Research Center,
Scientist
INSERM U837, place de Verdun 59045
Lille, Cedex France

Start Date

08-01-2008

End Date

30-06-2014

Total
Experience

6 Yr. & 6
Months

Teaching Assignments:
1. Teaching Responsibilities: (Course Title)
1. Animal Biotechnology
2. Industrial Biotechnology
3. Cell Biology
4. Endocrinology
5. Animal Tissue Culture
6. Animal Physiology
7. Evolution and Development Biology
8. Basics in Neuroscience
Professional Recognition /Awards/Scholarship:
Awards
2005

Travel award for attending the Indian Academy of Neuroscience to attend the XXII annual meeting
in Jan 2005, Gwalior, India.

2006

Travel award to attend the Asian Pacific Society for Neurochemistry (APSN) for 7th Biennial
Meeting from July 2nd to 5th 2006, National University Singapore (NUS), Singapore.

2006

Travel award to attend the IBRO-Neuroscience Training School at National University Singapore,
Singapore in June 2006.

2006

Travel award to attend the Japan Neuroscience Society (JNS) for the 29th Annual Meeting from
July 19th to 21st 2006, Kyoto, Japan.

2008

Won Best Presentation Award in International symposium on Molecular Aspects of Brain Aging
and Neurological Disorders in November 2008 held at Department of Biotechnology, Guru Nanak
Dev University, Amritsar, India.

2001-2002 Qualified National Eligibility Test for Lectureship in Life Sciences (CSIR-NET Dec. 2001& June
2002, conducted by Council for Scientific and Industrial Research, New Delhi, India)
2002

Qualified Graduate Aptitude Test for Engineering (GATE 2001).

Peer Recognition:
2014 - Till date

Editorial Board Member for International Journal of Biology, Pharmaceutical and Allied
Sciences (IJBPAS)

2014 Till date

Editorial Board Member for Journal of Virology and Biotechnology.

Area specializations/Research Interest:

These past years we have provided compelling evidence that cell-to-cell communication processes involving non
neuronal cells, such as glial and endothelial cells, are important in regulating the secretory activity of those
hypothalamic neurons that secrete gonadotropin releasing hormone (GnRH). GnRH is a neuropeptide essential
for mammalian sexual development, acquisition of reproductive capacity at puberty, and adult reproductive
function. Our studies unveiled that glial-neuronal interactions in the median eminence, the projection field of
GnRH neurons, modulate the access of the GnRH nerve terminals to the pericapillary space during the estrous
cycle. Notwithstanding the importance of these plastic rearrangements, genetic approaches revealed that glia-toneuron signaling pathways involving neuregulins, transforming growth factors and their guidance cue (like
Semaphorins) play an essential role in the control of GnRH release, and that the disruption of this
communication system delays sexual maturation and impairs adult reproductive function. My research will focus
on the recognition of these new regulatory components, and the integrative use of cellular, molecular, and
genomic approaches, to unravel the basic cell-cell regulatory mechanisms controlling GnRH release within the
median eminence.
In the second part of my research I would also like to evaluate how pathologies (such as obesity) may affect
these neurobiological events and, conversely, how impairment of brain communication with the periphery
renders the organism prone to develop pathologies (obesity, diabetes, precocious and/or delayed puberty and
infertility). My research work is mainly focus to understand and elucidate the cellular and molecular mechanisms
of tripartite synapse, which is classically associated with different forms of plasticity in adult brain using animal
(rat and mice) as well as neuronal and glial cell lines as a model system.
Hormone-dependent development and plasticity of the metabolic brain
Role of semaphorins in brain development and neuro-glia plasticity
Publications:
S.
No.

Title, volume, page number

IF

1) Andrea Messina, Fanny Langlet, Konstantina Chachlaki, Juan Roa, S Rasika, Nathalie Jouy, Sarah 16.09
Gallet, Francisco Gaytan, Jyoti Parkash, Manuel Tena-Sempere, Paolo Giacobini, Vincent Prevot
2016 MicroRNAs regulate production of hypothalamic GnRH before puberty. Accepted in in Nature
Neuroscience.

2) Irene Cimino, Filippo Casoni, Andrea Messina, Jyoti Parkash, Soazik P Jamin, Sophie 11.77
Catteau-Jonard, Francis Collier, Marc Baroncini, Didier Dewailly, Pascal Pigny, Mel
Prescott, Rebecca Campbell, Allan Herbison, Vincent Prvot, and Paolo Giacobini 2015:
Novel Role for Anti-Mllerian Hormone in the Regulation of GnRH Neuron Excitability and
Hormone Secretion. Nature Comm. 12; 7: 10055.
3) Jyoti Parkash, Andrea Messina, Fanny Langlet, Irene Cimino, Anne Loyens, Sarah Gallet, 11.77
Eglantine Balland, Franois Pralong, Jeroen Pasterkamp, Vincent Prevot, Paolo Giacobini
2015: Semaphorin 7A regulates neuro-glial plasticity of the adult hypothalamic median
eminence Nature Comm. 6:6385.
4) Paolo Giacobini*, Jyoti Parkash*, Celine Campagne*, Naresh Kumar Hanchate, Daniel 13.45

5)

6)
7)

8)

9)

10)
11)

12)
13)
14)
15)

16)

Mazure, Vincent Prevot 2014: Brain Endothelial Cells Control Fertility through OvarianSetroid-Dependent Release of Semaphorin 3A. Plos Biology 12 (3), e1001808
Jyoti Parkash, Irene Cimino, Nicoletta Ferraris, Filippo Casoni, Susan Wray, Helene
Cappy, Vincent Prevot, Paolo Giacobini 2012: Suppression of 1- integrin in gonadotropinreleasing hormone cells distrupts migration and axonal extension resulting in severe
reproductive alterations. Journal of Neuroscience 32(47): 16992-17002
Gustav Collden, Eglantine Balland, Jyoti Parkash, Emilie Caron, Vincent Prevot, Sebastien
G. Bouret 2014: Neonatal Overnutrition Causes Early Alterations in the Central Response to
Peripheral Ghrelin Molecular Metabolism 24;4(1):15-24.
Hanchate NK*, Jyoti Parkash*, Nicole Bellefontaine, Danie`le Mazur, William H. Colledge,
Xavier dAnglemont de Tassigny, Vincent Prevot 2012: Kisspeptin-GPR54 signaling in
mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.
Journal of Neuroscience 32(3): 932-945
Nicole Bellefontaine, konstantina chachlaki, Jyoti Parkash, Charlotte Vanacker, William
Colledge, Xavier d'Anglemont de Tassigny, Sebastien Bouret and Vincent Prevot 2014:
Leptin facilitates reproduction through neuronal nitric oxide signaling in the hypothalamic
preoptic region in mice. Journal of Clinical investigation doi:10.1172/JCI65928
Naresh Kumar Hanchate, Paolo Giacobini, Pierre Lhuillier, Jyoti Parkash, Ccile Espy,
Corinne Fouveaut, Chrystel Leroy, Stphanie Baron, Cline Campagne, Francis Collier,
Alfons Garcia-Pineiro, Didier Dewailly, Christine Cortet-Rudelli, Ksenija Gersak, Michel
Pugeat, Jacques Young, Jean-Pierre Hardelin, Vincent Prevot and Catherine Dod 2012:
SEMA3A, a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann
Syndrome. PLoS Genetics 8(8):e1002896
Jyoti Parkash and Gurcharan Kaur 2007: Transcriptional Regulation of PSA-NCAM
Mediated Neuron-glial Plasticity in the Adult Hypothalamus. Neuron Glia Biology 3: 299307
Jyoti Parkash, , Xavier dAnglemont de Tassigny, Nicole Bellefontaine, Celine Campagne,
Danile Mazure, Valrie Bue-Scherrer, and Vincent Prevot 2010: Phosphorylation of Nmethyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on
estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle.
Endocrinology 151: 2723 2735
Sushil Kumar*, Jyoti Parkash*, Herdeep Kumar and Gurcharan Kaur 2009: Interactive
effect of excitotoxic injury and dietary restriction on neurogenesis and neurotrophic factors
in adult male rat brain. Neuroscience Research 65(4): 367-374
Jyoti Parkash and Gurcharan Kaur 2007: Potential of PSA-NCAM in neuron-glial plasticity
in the adult hypothalamus: Role of noradrenergic and GABAergic neurotransmitters. Brain
Research Bulletin 74(5): 317-328
Jyoti Parkash and Gurcharan Kaur 2005: Neuronal-Glial Plasticity in the GnRH Release in
Adult Female Rats: Role of Polysialylated Form of Neural Cell Adhesion Molecule. Journal
of Endocrinology 186: 397-409
Sushil Kumar, Jyoti Parkash, Herdeep Kumar and Gurcharan Kaur 2012: Enzymatic
removal of polysialic acid from neural cell adhesion molecule interrupts gonadotropin
releasing hormone (GnRH) neuron-glia remodeling.
Molecular and Cellular
Endocrinology 348(1): 95-103
Vctor Briz, Jyoti Parkash, Sara Snchez-Redondo, Vincent Prevot, Cristina Suol 2012:
Allopregnanolone Prevents Dieldrin-induced NMDA Receptor Internalization and

7.13

SNIP
1.16
7.13

13.21

9.13

6.64
4.75.

2.37
2.77
4.05
4.09

4.75

17)

18)

19)

20)

Neurotoxicity in Cortical Neurons by Preserving GABAa Receptor Functionality.

Endocrinology 153(2): 847-60
Jyoti Parkash and Gurcharan Kaur 2010: Steroid Hormones Regulate Post-Translational
Modification of Neural Cell Adhesion Molecule: Implication For The Neuroendocrine Control
of GnRH. Journal of Neurological Sciences 27(2): 197-213
Review Articles
Nicole Bellefontaine, Naresh Kumar Hanchate, Jyoti Parkash, Celine Campagne, Sandrine
de Seranno, Jrme Clasadonte, Xavier dAnglemont de Tassigny, Vincent Prevot 2011:
Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication
involved in the neuroendocrine control of reproduction. Neuroendocrinology 93: 74-89
Vincent Prevot, Bellefontaine N, Marc Beronni, Arian Shrif, Naresh Kumar Hanchate, Jyoti
Parkash, Celine Campagne, Sandrine de Seranno 2010: GnRH nerve terminals, tanycytes
and neurohaemal junction remodeling in the adult median eminence: functional
consequences for reproduction and dynamic role of vascular endothelial cells. Journal of
Neuroendocrinology 22 (7): 639-649
Vincent Prevot, Naresh Kumar Hanchate, Arian Shrif, Jyoti Parkash, Cecilia Estrella,
Ccile Allet, Celine Campagne, Sandrine de Seranno, Xavier dAnglemont de Tassigny,
Marc Beronni 2010: Function-related structural plasticity of the GnRH system A role for
neuronalglialendothelial interactions Structural plasticity in GnRH system. Frontier in
Neuroendocrinology 31 (3): 241-258.
Front cover of Journal Frontier of Neuroendocrinology: Schematic
representation of endothelialglial interactions involved in the control of GnRH
neurosecretion in the median eminence. Volume 31, 2010.

.13

3.27

4.67

12.06

* Contributed equally in above publications

Cumulative Impact Factor: 137.32 Total Citations 405
H index 12 and
i10 Index 13
http://www.ncbi.nlm.nih.gov.gate2.inist.fr/pubmed/?term=parkash+jyoti
https://www.researchgate.net/profile/Jyoti_Parkash/publications

Workshop/Conferences:
Workshops: Attended:
1. Attended National Workshop on the Art and Science of Scholarly Communication: Writing Better
Research Papers organized by DAV University on 14th March 2015.
2. Attended IBRO-Neuroscience Training School at National University Singapore, Singapore in June
2006.
3. Attended workshop on Tools for Bio-informatics Sub-center, Department of Biotechnology, Guru Nanak
Dev University, Amritsar from 3rd - 4th March, 2005.

Conference Organized:
1. Member of Organizing, Scientific and Cultural committees in National Organized conference by DAV
university Emerging Trends in Host Microbe Interactions held on April 17th-18th, 2015.
Conferences Attended:
Oral Presentations/Poster Presentations Awards:
1. Oral prsentation entitled Semaphorins regulate neuro-glia plasticity in the adult hypothlamic median
eminence conference organised by DAV university, Emerging trends of Host-Microbe interactions on
17-18th April 2015.
2. Invited source person in a workshop (organised by Doaba College, Jalandhar) under DBT Star College
Scheme Support (Ministry of Science & Technology) entitled Fundamentals of animal tissue culture
and its applications held on 18th March 2015.
3. Won Best Presentation Award in International symposium on Molecular Aspects of Brain Aging and
Neurological Disorders in November 2008 held at Department of Biotechnology, Guru Nanak Dev
University, Amritsar, India.

Poster Presentations:
1. J. Parkash, A. Loyens, S. Gallet, E. Balland, F. Pralong, J. Pastercamp, V. Prevot, P. Giacobini 2011
Semaphorin 7A expression in tanycytes is regulated by sex-steroid hormones and controls
gonadotropin-releasing hormone-1 (GnRH-1) cell plasticity. 41st Annual Meeting of Neuroscience (SFN),
November 2011, Washington DC, USA.
2. J. Parkash, A. Loyens, S. Gallet, E. Balland, F. Pralong, J. Pastercamp, V. Prevot, P. Giacobini
Sema7A is a Tanycytic-Secreted Guidance Molecule and Regulates GnRH Axon Outgrowth in the Adult
Brain. 14th LARC Neuroscience meeting, October 2010, Lille.
3. J. Parkash, D'Anglemont De Tassigny X, Bellefontaine N, Campagne C, Mazure D, Bue-Scherrer
V and Prvot V 2010 Phosphorylation of NMDAR associated nNOS modulates hypothalamic nitric oxide
production: The role of estrogen during ovarian cycle in female rats. 7th international congress of
Neuroendocrinology from 7th - 11th July, Rouen, France P2-182.
4. J. Parkash, D'Anglemont De Tassigny X, Bellefontaine N, Campagne C, Mazure D, Bue-Scherrer
V and Prvot V 2010 Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric
oxide synthase modulates hypothalamic nitric oxide production: The role of estrogen during ovarian
cycle in female rats; 36th Colloque De la societie de neuroendocrinologie international congress from
15th - 18th September, 2009, Nice, France.

5. J. Parkash and Kaur G Potential of PSA-NCAM to Mediate Neuronal-glial interaction in GnRH

Neurosecretion: Role of GABAergic and noradrenergic neurotransmitters; 29th Annual Japan
Neuroscience Society (JNS) Kyoto from 19th - 21st July (Neuroscience Research, 2006).
6. J. Parkash and Kaur G Activity dependent neuronal-glial remodeling in the ME of adult rat
hypothalamus: Role of GABAergic and noradrenergic neurotransmitters; 7 th Biennial Asian Pacific
Society for Neurochemistry (APSN 2006) Singapore from 2 nd - 5th July (Journal of Neurochemistry 98
(1): 71, 2006)
7. J. Parkash, A. Loyens, S. Gallet, E. Balland, F. Pralong, J. Pastercamp, V. Prevot, P. Giacobini
Sema7A is a tanycytic-Secreted Guidance Cue Regulates GnRH Axon plasticity in adult Brain. 30th
Annual meeting of Indian Academy of Neurosciences. 27th-30th Oct. 2012 Amritsar India.
8. P. Giacobini, J. Parkash, F. Langlet, A. Messina, A. Loyens, D. Leroy, S. Gallet, E. Balland, F. Pralong,
G. Cagnoni, L. Tamagnone, M. Mazzone, R. Pasterkamp, V. Prevot 2013 Semaphorin7a signaling in
periodical neuro-glial plasticity of the hypothalamic median eminence that underlies reproduction.
Annual Meeting of Neuroscience (SFN), November 2013, San-Diego California USA.
9. N. Bellefontaine, E. Caron, J. Parkash, C. Vanacker, S. G. Bouret, V. Prevot Neuronal nitric oxide
synthase activity is necessary for diet-induced obesity. Annual Meeting of Neuroscience (SFN),
November 2013, San-Diego California.
10. I. Cimino, F. Casoni, A. Messina, J. Parkash, A. Loyens, S. Jamin, N. Di Clemente, D. Dewailly, V.
Prevot, P. Giacobini Extra-ovarian effects of anti-mllerian hormone on the gonadotropin-releasing
hormone (gnrh) neurons. Annual Meeting of Neuroscience (SFN), November 2013, San-Diego
California.
11. Andrea Messina*, Langlet Fanny, Chlachaki Konstantina, Roa Juan, Gallet Sarah, Jyoti Parkash,
Manuel Tena-Sempere, Paolo Giacobini and Vincent Prevot 2015: MicroRNAs flip the switch for the
production of hypothalamic GnRH before puberty. 40th Colloque De la societie de neuroendocrinologie
international congress from 23rd - 25th September, 2015, Lille, France.
12. V. Briz M. Galofr, J. Parkash, V. Prevot, C. Suol 2010: Estradiol counteracts NMDAR internalization
induced by long-term exposure to dieldrin in cortical neurons. XII International Congress of Toxicology
19th -23th July 2010, Barcelona-Spain. Toxicology Letters. Volume 196, Supplement, Pages S1-S352
(17 July 2010).
13. Sushil Kumar, Jyoti Parkash, Dinesh Lakhanpal and Gurcharan Kaur : Interactive effect of excitotoxicity
injury and dietary restriction on neurogenesis and neurotrophic factors in adult male rat brain;
International symposium on Molecular Aspects of Brain Aging and Neurological Disorders at

Department of Biotechnology, Guru Nanak Dev University Amritsar from 28th - 29th November, 2008.
14. H. N. Kumar, J. Parkash, D Mazur, W.H Colleddge, X.DAngleomont De Tessigny, V, Prevot 2011 Nitric
oxide synthesizing neurons: important mediators of Kisspeptin- GnRH neuron interactions during the
estrous cycle. 41st Annual Meeting of Neuroscience (SFN), November 12th-16th 2011, Washington DC,
USA.
Grants:
Sr.
Sanction to
No.

Funding
Agency

Period
from..to

Amount
sanctioned

UGC

2015-2018

About
Lakhs

10

Neural-glial-endothelial
tripartite
interactions: Unravel the basic cell-cell
SERB, DST
regulatory
Dr.
Jyoti
Parkash
2016-2019
2.
India
Mechanisms involved in the central
control of reproduction.

About
Lakhs

50

1. Dr. Jyoti Parkash

Title
Role for Semaphorins
Receptors in the Control of

and

its

Sexual Brain Development and Adult

Brain Plasticity

3.
Leptin, puberty and obesity: a major CEFIPRA/IFC Submitted
Dr .Jyoti Parkash role for hypothalamic nitric-oxide- PAR
synthesizing neurons?

1 crore 16
lakhs

Student achievements:

1. Ankur Jairath my PhD student has been selected under French Eiffel Fellowship Program for
pursuing 10 months research in French Lab.

Collaborations:
1.

Prof. Gurcharan Kaur

Department of Biotechnology,
Guru Nanak Dev University,
Amritsar-143005, India.
Ph: 91-183-2258802-9 Ext. 3176
FAX: 91-183-2258272 and 2258820
E-mail: kgurcharan.neuro@yahoo.com

2. Dr. Vincent PREVOT (Director)

Development and Plasticity of the Neuroendocrine Brain
Neurobese Interantional Associated Laboratory
Jean-Pierre Aubert Research Center, Inserm U1172
University of Lille, Btiment Biserte, 1 place de Verdun
59045 Lille cedex, France
Tel: +33 3-20-62-20-64
Fax: +33 3-20-53-85-62
E-mail: vincent.prevot@inserm.fr
Last updated: 05-04-2016