Patofisiologi Dan Pencegahan BSK
Patofisiologi Dan Pencegahan BSK
Patofisiologi Dan Pencegahan BSK
Epidemiology
Life time prevalence : 1-15%1
1 to 5% in Asia, 5 to 9% in Europe, 13% in
North America, and 20% in Saudi Arabia. 2
Stone formation is affected by1
Gender
- Age
Race
- Ocupation
Body Mass Index
- Climate Geographic
location
Male : Female = 2-3:11
1.Pearle
MS
&
Lotan
Y;
Campbell
Walsh
Urology
2007
2.
Ramello
A
et
al;
J
Nephrol
2000
saturation.
n Concentration products exceeding
solubility product crystallization does
not necessarily occur ~ Presence of
inhibitors and other molecules
n High urine flow rates (more than 2 liters in
24 hours) will reduce supersaturation and
might prevent calculi formation
stones ( 75%)
n Struvite
n Uric
n Cystine
Calcium Stones
n Comprised
Infection stones
n Mainly
composed of MgNH4PO4.6H2O
(struvite)
n Related to the infection caused by bacteria
that splits urea (urease producing
bacteria)
Proteus mirabilis
Klebsiella Sp.
Pseudomonas Sp.
Staphylococcus Sp.
PREVENTION
Type of prevention
n General
prevention
prevention
General Prevention
Specific Prevention