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    Biosynthetic Pathway of Penicillins

    Uploaded by

    kuganatsuki
    Penicillins

    Copyright:

    © All Rights Reserved
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    Biosynthetic Pathway of Penicillins

    Uploaded by

    kuganatsuki
    96 views1 page
    Penicillins

    Copyright

    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    Penicillins

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    96 views1 page

    Biosynthetic Pathway of Penicillins

    Uploaded by

    kuganatsuki
    Penicillins

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    Biosynthetic pathway of penicillins

    NH2 O
    H2N H2N
    HO + SH +
    OH
    COOH COOH
    O
    L--aminoadipic acid L-cysteine L-valine
    3 ATP
    Mg2+ ACV-synthase
    3 AMP + 3 Pi

    H SH
    H2N N
    notice the epimierization of
    H L-valine to D-valine
    COOH O N
    (ACV) O
    COOH
    Ascorbate isopenicillin N synthase
    Fe2+, O2

    H H
    H2N N S
    COOH O N
    (isopenicillin N) O COOH

    isopenicillin N acyltransferase

    NH2 O
    HO
    OH
    O
    H
    H2N S
    OH
    N
    O O
    COOH
    phenylacetic acid (PAA)
    6-APA
    (+)-6-aminopenicillanic acid
    phenylacetyl-CoA ligase

    CoA

    O isopenicillin N acyltransferase

    H H
    N S
    O N
    O
    COOH
    Penicillin G
    (benzylpenicillin)

    Copyright 2011
    Doug E. Frantz, UTSA

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