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    ENZYMOLOGY

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    Carla Lagar Flores
    This document provides information on various enzymes including their major sources in the body, diagnostic significance of abnormal levels, common diagnostic methods, and reference values. It lists enzymes such as alkaline phosphatase, acid phosphatase, alanine aminotransferase, aspartate aminotransferase, amylase, lipase, lactate dehydrogenase, creatine kinase, aldolase, 5'-nucleotidase, gamma-glutamyl transferase, pseudocholinesterase, angiotensin-converting enzyme, ceruloplasmin, and glucose-6-phosphate dehydrogenase.

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    ENZYMOLOGY

    Uploaded by

    Carla Lagar Flores
    151 views2 pages
    This document provides information on various enzymes including their major sources in the body, diagnostic significance of abnormal levels, common diagnostic methods, and reference values. It lists enzymes such as alkaline phosphatase, acid phosphatase, alanine aminotransferase, aspartate aminotransferase, amylase, lipase, lactate dehydrogenase, creatine kinase, aldolase, 5'-nucleotidase, gamma-glutamyl transferase, pseudocholinesterase, angiotensin-converting enzyme, ceruloplasmin, and glucose-6-phosphate dehydrogenase.

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    ENZYMOLOGY (1).docx

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    This document provides information on various enzymes including their major sources in the body, diagnostic significance of abnormal levels, common diagnostic methods, and reference values. It lists enzymes such as alkaline phosphatase, acid phosphatase, alanine aminotransferase, aspartate aminotransferase, amylase, lipase, lactate dehydrogenase, creatine kinase, aldolase, 5'-nucleotidase, gamma-glutamyl transferase, pseudocholinesterase, angiotensin-converting enzyme, ceruloplasmin, and glucose-6-phosphate dehydrogenase.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    151 views2 pages

    ENZYMOLOGY

    Uploaded by

    Carla Lagar Flores
    This document provides information on various enzymes including their major sources in the body, diagnostic significance of abnormal levels, common diagnostic methods, and reference values. It lists enzymes such as alkaline phosphatase, acid phosphatase, alanine aminotransferase, aspartate aminotransferase, amylase, lipase, lactate dehydrogenase, creatine kinase, aldolase, 5'-nucleotidase, gamma-glutamyl transferase, pseudocholinesterase, angiotensin-converting enzyme, ceruloplasmin, and glucose-6-phosphate dehydrogenase.

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    © All Rights Reserved
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    of 2

    ENZYMOLOGY

    ENZYMES MAJOR SOURCES DIAGNOSTIC SIGNIFICANCE METHODS REFERENCE VALUE

    ALP Placenta & intestinal, liver, bone Hepatic biliary obstruction, Pagets’ Bowers & Mc Comb 30 – 90 u/L
    disease, rickets, osteomalacia, Bessy, Lowry, Brock
    fractures Electrophoresis
    Heat Fractionation
    Chemical inhibition

    ACP Prostate , RBC, platelets , Liver, bone Prostatic Adenocarcinoma, Urinary Gutman & Gutman Male :
    Tract Obstruction, Prostatic Shinowara 2.5 - 11. 7 U/ L (T ACP)
    Inflammation Babson, Read & Philips 0 - 3.5 ng/mL ( P ACP)
    Roy & Hillman

    AST Cardiac Tissue, Liver, Skeletal Myocardial infarction, hepatocellular Karmen method 5 - 37 U/L
    Muscle disorder, skeletal muscle
    involvement

    ALT Liver, Kidney, Pancreas, RBC, Heart, Hepatic disorder, hepatitis, screen Coupled enzymatic reaction 6 - 37 u/L
    Skeletal Muscle, Lungs blood donors, occupational toxic
    exposure

    AMS Acinar Cells ( pancreas), Salivary Acute pancreatitis , parotitis Amyloclastic, saccharogenic, 60 - 180 su/dL ( somogyi units),
    Glands, Adipose Tissue, Fallopian chromogenic, continuous monitoring 95 - 290 u/L
    tube, small intestine

    LPS Pancreas, stomach, small intestine Acute pancreatitis, peptic ulcers, Cheny crandal, Tietz & Flereck, 0 - 1 u/mL
    acute cholecystitis Reroxidase copling
    LD Heart, RBC, kidney, lungs, pancreas, Pernicious anemia, hemolytic Wacker method, Wrableuski Cabaud, 100 - 225 u/L (Fr)
    spleen, skeletal muscle, liver, disorder, hepatic carcinoma, viral Berger Broida 80 - 280 u/L (Rr)
    intestines hepatitis, cirrhosis

    CK Brain tissue, smooth skeletal muscle Acute myocardial infarction, Tanzer- Gilbarg Assay, Oliver - Male: 15 - 160 u/L
    & cardiac duchenne disorder, muscular Rosalki Female: 15 - 130 u/L
    dystrophy CK-MB: <6% of total CK
    ALDOLASE Skeletal muscle, liver, kidney, brain Skeletal muscle disorder, skeletal Akdose Test 1.0 - 25 u/L
    tissue muscle disease, leukemia, hepatic
    cancer, anemia
    5’NUCLEOTIDASE Liver Hepatobiliary disease, infiltrative Didon & Purdon, Campbell, Belfield 0 - 1.6 units
    lesion of liver & Goldberg
    GGT Kidney, prostate , pancreas, Warfarin, phenobarbital & Szass, Rosalki & Tarrow, Orlowski Female: 5 - 30 u/L
    canaliculi of hepatic epithelial cell phenytoin therapies, hepatic Male: 6 - 45 u/L
    disorder, normal in bone disease &
    pregnancy
    PSEUDOCHOLINESTERASE Liver, myocardlym & pancreas Acute nephritis, cirrhosis, carcinoma Ellman Technique, Potentiometric 0.5 - 1.3 pH units
    metastatic, malnutrition
    ACE Lungs, testes, macrophage, epithelial Sarcoidosis, multiple sclerosis, Angiotensin - Convering, Enzyme 8 - 53 u/L
    cells Addison’s disease, acute & chronic Test
    bronchitis, HIV infection
    CERULOPLASMIN Liver Wilson’s disease Copper oxidase Activity 18 - 45 mg/dL

    G6PD Adrenal cortex, spleen, RBC, Lymph Hemolytic anemia, myocardial G6PD red blood cell hemolysate 10 - 15 U/g hgB or 1200 - 2000
    nodes infarction, megaloblastic anemia mU/mL RBC

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