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    Preeclampsia SFlt-1-PlGF Ratio - Pocket Card

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    Rajeev Pareek
    preeclampsia test

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    Preeclampsia SFlt-1-PlGF Ratio - Pocket Card

    Uploaded by

    Rajeev Pareek
    222 views2 pages
    preeclampsia test

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    © © All Rights Reserved

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    preeclampsia test

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    222 views2 pages

    Preeclampsia SFlt-1-PlGF Ratio - Pocket Card

    Uploaded by

    Rajeev Pareek
    preeclampsia test

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    Preeclampsia sFlt-1/PlGF ratio

    A new biomarker to aid in the diagnosis of preeclampsia


    Determination of the sFlt-1/PlGF ratio from gestational week 20+0
    Suggested patient profile

    1 Investigation OR 2 Pathological OR 3 One of the following risk factors


    of suspected uterine artery • Preeclampsia in a previous pregnancy
    preeclampsia Doppler • Preexisting hypertension
    • Preexisting kidney disease
    • Diabetes

    Sample materials: Serum


    sFlt-1/PlGF ratio – Aid in diagnosis of preeclampsia

    Early-onset preeclampsia Late-onset preeclampsia Gestational


    20 34 weeks
    sFlt-1/PlGF Rule-in sFlt-1/PlGF
    Rule-in specificity: 95.5 %
    specificity: 99.5 % sensitivity: 58.2 %
    110
    sensitivity: 88.0 %
    85 *

    33 33
    Rule-out Rule-out
    specificity: 94.0 % specificity: 73.1 %
    sensitivity: 95.0 % sensitivity: 89.5 %

    * At a cut-off of 85 for the whole gestational period (from week 20+0 to delivery) the sensitivity was calculated at 82 % and the specificity at 95 %.

    References
    Verlohren, S., Galindo, A., Schlembach, D., Zeisler, H., Herraiz, I., Moertl, M. G., et al. (2010). An automated method for the determination
    of the sFlt-1/PIGF ratio in the assessment of preeclampsia. Am J Obstet Gynecol. 202(2):161.e1-161.e11.
    Study report: Diagnosis of Preeclampsia by means of the Elecsys® assays sFlt-1 and PlGF (2012); Data on file.

    COBAS, ELECSYS and LIFE NEEDS ANSWERS are trademarks of Roche.


    ©2013 Roche · Roche Diagnostics International Ltd · CH-6343 Rotkreuz · Switzerland · www.cobas.com

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