Fundamental Pharmacy's

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1. Flow rate of granules from the hopper can be improved by

A. Disintegrant

B. Glidant

C. Binder

D. Lubricant

2. Enteric coating can be achieved by

A. HPMC

B. CMC

C. Cellulose acetate phthalate

D. Povidone

3. What is the dose for 6 year old child if the adult dose is 250 mg.
A. 75 mg

B. 60 mg

C. 100 mg

D. 180 mg

4. In sugar coating tablets sub coating is done as

A. To prevent moisture absorption

B. To round the edges and build up the tablet size

C. To smoothen the surface

D. To cover and fill imperfection

5. Guiding the movement of punches are done by

A. Cams

B. Turrets

C. Wire meshes

D. Revolving belts

6. Bentonite gel shows

A. Plastic thixiotropy

B. Dilatant thixiotropy

C. Pseudoplastic thixiotropy

D. None of the above

7. Conductance cells for conductivity measurements can be made from two of the following
metals

P. Mercury. Q. sodium R. platinum S. stainless steel

Identify correct pair

A. P,R

B. Q,S

C. R,S

D. PQ

8. The relationship between concentration temperature and potential of a solution is given by

A. Ilkovic equation

B. Henderson equation

C. Nernst equation

D. Hassalbach equation

9. Concentrated ointment viscosity is determined by

A. Capillary viscometer

B. Cone & plate viscometer

C. Filling & rising viscometer

D. Ost ald s is o eter

10. Which one is the suitable method for particle volume determination

A. Optical microscopy
B. Coulter counter

C. Sedimentation

D. Air permeation

Correct answers with explanation

1. B ( glidant which reduces friction between granules & surface of hopper eg.corn starch,
colloidal silica, like arosil, cab o sil )

2. C (eg. Of enteric coating polymers CAP,CAT,PVAT,HPMCAS, Eudragit etc)

3. A (apply young formula)

4. B ( in order to round the edges and build up the tablet size)

5. A ( calm tract guide the movement of the punches)

6. B

7. C ( platinum & SS)

8. C

9. B ( because conc ointment non Newtonian type of flow shere rate not directly proportional
to shere stress)

10. B ( coulter counter method and Laser light scattering method are used for particle volume
determination)

1. Pick out the vector using in human Genome project

A. Phagemid vector

B. Yeast artificial chromosomes

C. Cosmid vectors

D. Yeast episomal plasmids

2. The Baterium that is most commonly used in genetic engineering is

A. Escherichia

B. Klebsiella

C. Proteius

D. Serratia

3. The light emitted by luminescent bacteria is mediated by the enzyme

A. Coenzyme Q

B. Luciferase

C. Lactose dehydrogenase

D. Carboxylase reductase

4. Fluroscent substance used in fluorescent microscopy are

A. Quinine sulphate

B. Auramine

C. All of these

D. None of these

5. The first antibody to contact invading microorganisms was

A. IgG

B. IgM

C. IgA

D. IgD
6. Rh factor of the blood was discovered by scientist

A. Louis Pasteur

B. Landsteiner and Weiner

C. Janskey

D. Moss

7. The ability of a pathogen to spread in the host tissues after establishing the infection is
known as

A. Adhesion

B. Invasiveness

C. Toxigenicity

D. None of these

8. On soybean which of the following forms symbiotism

A. Azatobactor paspali

B. Rhizobium

C. Nostoc

D. Bradyrhizobium

9. The most important virulence factors are

A. Adhesions

B. Invasiveness

C. Toxigenicity
D. Enzymes

E. All of the above

10. Spirulina belongs to class ...of bacteria

A. Xanthophyceae

B. Cyanophyceae

C. Rhodophyceae

D. Pheophyceae

Correct answers with explanation

1. B (East artificial vector and artificial bacterial vector that is BAC is mostly used in Human
Genome Project)

2. A ( E-Coli Bacteria is mostly used for genetic engineering)

3. B ( bacterial luciferase and fatty acid reductase enzyme are responsible for luminescence)

4. B( Auramine, acridine orange, fluorescence isothiocyanate etc are flurochromes)

5. B ( it is produced against primary antigenic response)

6. B ( 1937 karl landsteiner, Alexander Weiner conducted an experiment on rabbit using

rhesus monkey red blood Which produced antigen)

7. B (the ability of microorganism to enter in body and damage tissue)

8. D (nitrogen fixation is the function of that)

9. E (all of these options are virulence factors)

10. B (Kingdom bacteria, division cynophycota, class cynophycae, Family nostoceae it is anti
inflammatory immune booster has good source of nutrients)
1. The image obtained in a compound microscope is

A. Real

B. Virtual

C. Real inverted

D. Virtual inverted

2. Protein particles which can infect are called

A. Virons

B. Prions

C. Nucleoida

D. None of these

3. Direct microscopic count can be done with the aid of

A. Neuberg chamber

B. Anaerobic chamber

C. Mineral oil

D. Olive oil

4. The bacterial cells are at their metabolic peak during

A. Lag phase

B. Log phase

C. Stationary phase

D. Decline phase
5. Which one of the following fungi is the most serious threat in a bone marrow transplant
unit

A. Candida albicans

B. Aspergillus

C. Blastomyces

D. Cryptococus

6. Fixation of atmospheric nitrogen is by means of

A. Biological process

B. Lightining

C. Ultraviolet light

D. All of the above

7. In a fluorescent microscope the objective lens is made of

A. Glass

B. Quartz

C. Polythene

D. None of these

8. The etiologic agent of botulism is a

A. Neurotoxin

B. Endotoxin

C. Enterotoxin

D. All of the above

9. Salt and sugar preserve foods because they

A. Make them acid

B. Produce a hypotonic environment

C. Deplete nutrients

D. Produce a hypertonic environment

10. The functions of plasmid are

A. DNA replication

B. Protein synthesis

C. Cell wall synthesis

D. None of the above

Correct answers with explanation will be in evening

1. D (the final image formed in compound microscope is virtual inverted image)

2. B (already discussed yesterday Kuru disease)

3. A

4. B. (Lag- adaptation,Log- exponetial growth, Stationary- no growth, Decline- decrese in no

of growth or deth bcz finished nutrition & increased toxic metabolites)

5. B (most serious infection to treat during transplantation)

6. B ( lightening breaks down the atmospheric nitrogen which reacts with oxygen forrming
N2O which combines with water and forms nitrate NO2 comes on ground)

7. A

8. A ( exotoxin produced by botulinum is powerful neurotoxin 1 mg/kg dose is toxic)

9. D (sugar and salt together makes hypertonic environment which causes leakage of
bacterial water)

10. A (classmates are self replicating DNA fragments)

1. How would you distinguish pseudomonas species from E-coli?

A. Gram staining

B. Morphology

C. Glucose fermentation Vs Respiration

D. All of the above

2. The capacity of a given strain of microbial species to produce disease is known as

A. Pathogen

B. Virulence

C. Infection

D. None of these

3. An organism that is osmophilic and has a specific requirements for sodium chloride
resembles

A. Halophile

B. Basophile

C. Barophile

D. Xerophile

4. Kuru disease in Humans is caused by

A. Bacteria

B. Viroides

C. Prions

D. Mycoplasma

5. Which one of the following is about Herpes viruses?

A. Icosahedral, with envelope, ds DNA

B. Polyhedral with envelope, ds DNA

C. RNA, helical with envelope

D. ds DNA, brick shape

6. The main feature of prokaryotic organism is

A. Absence of locomotion

B. Absence of nuclear envelope

C. Absence of nuclear material

D. Absence of protein synthesis

7. Enzymes responsible for alcoholic fermentation

A. Ketolase

B. Zymase

C. Peroxidase

D. Oxidase

8. Limulus test is rapid in vitro test for parentral to detect

A. Particulate matter

B. Fungus

C. Pyrogen

D. Microorganism

9. Endotoxin produced by gram-negative bacteria is present in

A. Peptidoglycan

B. Lippolysacharide

C. Theichoic acid

D. Inner membrane

10. Small pox vaccine was first discovered by

A. Robert Koch

B. Louis Pasteur

C. Lister

D. Edward Jenner

Correct answers with explanation

1. C

2. B ( it is the degree of pathogenicity of organism, the term is often used to describe or

compair pathogenicity within the strain of microorganism)

3. A (osmophiles bacteria lives in high solute concentration, halophiles prefers to live in high
concentration of salt like NaCl )

4. C (prions are infectious protein formed from normal body protein after integration with
other prions protein)
5. A ( icosahedral capsid with double stranded DNA )

6. B

7. B ( Zymese enzyme obtained from east that is saccharomyces cervicesiae converts glucose
and Fructose to ethanol and Co2 )

8. C ( LAL test also called as limulus amebocyte test used to detect endotoxins that is
pyrogens from parenteral preparation)

9. B ( endotoxin is lipopolysaccharide and is also known as Lipid A it is a part of outer cell wall
of Gram Negative bacteria)

10. D ( 1796 Edward Jenner developed smallpox vaccine using cowpox bacteria, also known
as father of vaccination)

1. Hyoscine on hydrolysis with barium hydroxide gives

A. Tropanol and Tropic acid

B. Scopine and Tropic acid

C. Ecgonine and Benzoic acid

D. Benzyl ecgonine and methanol

2. Cryoscopic method is used for calculation of isotonicity. This method is based on:-

A. pH of drug

B. Molecular concentration of drug

C. Freezing point of drug

D. Displacement value of drug

3. The staining technique used to stain the metachromatic granules of Corynebacterium

A. Giemsa stain
B. Alberts stain

C. Acid fast staining

D. Both A and B

4. If the vectors transmit the infection mechanically they are called

A. Biological vectors

B. Mechanical vectors

C. Biological reservoir

D. Both A & C

5. Water resistance glass container tested by measuring

A. Amount of alkali release into water

B. Amount of acid release into water

C. Turbidity

D. Amount of silicate in water

6. During mitosis, synapsis occurs in the phase called

A. Telophase

B. Anaphase

C. Prophase

D. None of the above

7. Hybridoma technique was developed by

A. Kochler & Milston

B. Niel s Jer e

C. Both A & B

D. None of these

8. The tra sfer of ge eti aterial duri g tra sfor atio is pro ed asi g o Griffith s
experiment by

A. Avery Macleod & Mc.Carthy

B. Lederberg & Taulum

C. Zinder & Lederberg

D. Watson & Crick

9. The viruses that live as parasites on bacteria are

A. Fungi

B. Commensels

C. Bacteriophages

D. None of these

10. The ability of Microscope to distinguish two objects into two separate objects, is called.

A. Resolving power

B. Wave length

C. Not applicable

D. None of these

11. Sterilization temperature for aqueous solution in autoclave is

A. 121 C for 15 min.

B. 180 C for 15 min

C. 121 C for 30 min.

D. 180 C for 30 min

Correct answers with explanation

1. B( on hydrolysis hyoscine gives tropic acid and scopoline )

2. C (it is also known as freezing point depression method freezing point of sodium chloride is
-0.52)

3. A (Albert stain, staining with methylene blue will show bluish purple metachromatic
granules, Giemsa stain is used for blood and bone marrow specimen)

4. B

5. A (after autoclaving the container it is titrated against 0.01 molar HCL to check amount of
alkali released)

6. C (crossing over of two homologous so Gene MD combination is known as synapsis occurs

in prophase, this gives rise to Recombinant chromosomes)

7. C ( both of them jointly in 1975 ,awarded Nobel prize1984 for physiology)

8. A (1994 , Oswald Avery ,Colin macloid, Maccarty perform experiment and evidence on
bacterial transformation)

9. C ( virus attacks on bacteria it is known as bacteriophage)

10. A (the ability of microscope to distinguish between two close particle is , it is a reciprocal
of distance between two particle that can be resolved or can be seen in microscope is called
as resolving power)

11. A (121 degree Celsius for 15 minutes)

1. Ephedrine is dissolved in water and dilute HCl and then treated separately with copper
sulphate and NaOH. The solution gives violet color. if shaken with solvent ether, the organic
layers shows

A. Blue colour

B. Purple colour

C. Red colour

D. yellow colour

2. Meadow saffron seed, Ma-huang, Henbane, crow fig seed and Deadly night shade is
synonym for which group of alkaloid

A. Colchicum, ephedra, hyocyamus, belladonna and nux-vomica

B. Colchicum, ephedra, hyocyamus, nux-vomica. and belladonna

C. Nux-vomica, ephedra, hyocyamus, colchicum and belladonna

D. Ephedra, colchicum, hyocyamus, nux-vomica and belladonna

3. Atropine is the racemic mixture of

A. Hyoscine

B. l-Hyoscyamine

C. Scopoline

D. Both b & c

4. Opium contain papavarine which is

A. Monoacidic base & Optically inactive

B. Monoacidic base & Optically active

C. Dibasic acid & Optically inactive

D. Dibasic acid & Optically active

5. Endosperm of a drug is characterized by thick polyhedral unlignified cells with

plasmodesma, allurone grains & oil globules, identified the drug

A. lpecac

B. Nux-vomica

C. Curare

D. Ergot

6. Find the wrong combination from following drug, it's family,class& use

A. Nux vomica, Loganaceae. lndole, CNS stimulant

B. lpecac, Rubiaceae, Quinoline, Antiamoebic

C. Lobelia, Campanulaceae, Pyridine, Smoking detterent

D. Curare, Loganiaceae, lsoquinoline, Skeletal muscle relaxants

7. One of the following general characterstics in not true for alkaloids

A. Nitrogen in the heterocyclic nucleus

B. Good solubility in organic solvents

C. PKa less than 7

D. Exhibit Optical activity

8. Whi h of the follo i g is k o as Gi se g of l dia'

A. Panax ginseng

B. Withania somnifera
C. Ocimum sanctum

D. Azadirachta indica

9. Calcium, magnesium and potassium salts of arabic acid are formed in

A. Tragacanth

B. Karaya gum

C. Acacia gum

D. Guar gum

10. Cocaine on hydrolysis yields

A. Ecgonine + Ethyl alcohol+ Benzoic acid

B. Ecgonine + Methyl alcohol + Benzoic acid

C. Ecgonine + Methyl alcohol + Truxillic acid

D. Ecgonine + Ethyl alcohol + Cinnamic acid

Correct answers with explanation

1. B (Ephedrine is dissolved in water and dilute HCl and then treated separately with copper
sulphate and NaOH. The solution gives violet color. if shaken with solvent ether, the organic
layers shows purple color and aqueous layer will show blue colour this is known as Chen's
test

2. B (Colchicum, ephedra, hyocyamus, belladonna and nux-vomica has synonyms Meadow

saffron seed, Ma-huang, Henbane, crow fig seed and Deadly night shade respectively

3. B( atropine is racemic mixture of equal amount of dextro and levo l hyosciamine)

4. A (papaverine monoacidic base which is optically inactive)

5. B ( polyhedral unlignified cells with plasmodesma, allurone grains & oil globules, is
characteristic of endosperm of nux vomica)
6. B ( Ipeac contain isoquinoline alkaloids)

7. C

8. B ( synonym of withania)

9. C( arabin i.e K,Ca,Mg salt of arabic acid)

10. B ( Ecgonine + Methyl alcohol + ...., Benzoic acid (cocaine) cinamic acid
( cinamylcocai ) ,truxulic acid( truxilin)

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pin code 431001

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Sachin Jadhav

M.pharm in 2013

Manager

Fundamental Pharmacy

( Gpat,Niper qualified 3 times)

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