The Chemistry of Digestion
The Chemistry of Digestion
AP Chemistry Summative
The Chemistry of
Digestion
Harsh Patel
Mr.Jones
SCH4U9 Period 3
Table of Contents
Question …………………………………………………………………………………………………………………..……………………..…...2
Purpose……………………………………………………………………………………………………………………………………….………...2
Introduction………………………………………………………………………………………………………………...………………………...2
Ingestion………………………………………………………………………………………………………...……………………………………...3
Reaction
Rates………………………………………………………………………………………………..………………………...4
Propulsion……………………………………………………………………………………………………………………...……………………...6
Digestion…………………………………………………………………………………………………………………………..…………………...7
Mechanical Digestion……………………………………………………………………………………………..…..…………...7
Chemical Digestion……………………………………………………………………………………………………………….....8
Absorption………………………………………………………………………………………………………………………………….………...12
Organic and
Structures…………………………………………………………...……………………………………………...12
Rates of
Reactions………………………………………………………………………………………...………………………...14
Defecation………………………………………………………………………………………………………………………………….………...15
Conclusion……………………………………………………………………………………………………………………………….…………...1
5
1
Glossary………………………………………………………………………………………………………………………...……………………...1
6
Question
How does the digestive system relate to chemical structures and properties, organic
chemistry, chemical equilibrium, redox reactions, and heats and rates of chemical reactions?
Purpose
The purpose of this report is to explore the realm of chemical digestion, and how
chemical structures and properties, organic chemistry, chemical equilibrium, redox reactions, and
heats and rates of chemical reactions are found amongst the daily process of digestion.
Introduction
All living things need energy to survive. While plants obtain this via photosynthesis, and
their roots, animals including humans obtain nutrients by the consumption of other organisms. To
go more in depth, literally, the human biological molecules necessities are amino acids, lipids,
and sugars. However the food consumed contains carbohydrates, proteins, and fats. The humans
body therefore must convert such molecules to simpler ones that the human body can use for
cellular functions, and at the same time get rid of any waste. This is exactly what the digestive
system accomplishes during the processes of ingestion, propulsion, digestion, and absorption.
One of the main challenges that the human body naturally faces is maintaining a balance
between food intake, storage and energy expenditure. Taking in more energy than expended
builds up fat storage. The rise in obesity and the resulting diseases like type 2 diabetes makes
understanding the role of diet and nutrition in maintaining good health all the more important.
While there is quite a bit of biology amongst this report, there is equally as much of chemistry,
which talks about the natural beauty of how the human body naturally combines biology and
chemistry to display a sense of effectiveness. Hence, let's get started!
2
Ingestion
The first step to the digestive process is that of ingestion. Ingestion is a process where
food is taken in through the mouth and is mechanically and chemically broken down via the
assistance of teeth, and saliva respectively. The purpose of ingestion is that large clumps of food
bits cannot pass through the cell membrane and through the esophagus by peristalsis, and
therefore need to be broken down. The first step is ingestion: taking food through the mouth.
Once in the mouth, teeth, saliva, and tongue play important roles in mastication. Each type of
teeth have different roles amongst the ingestion process. The incisors are at the front of the
mouth and have sharp biting surface area of which are used for cutting or shearing foods into
small chewable bites. The canines are at the corners of the dental arcs, whose function is to grip
and tear food bits. Then there are the premolars, whose function is to tear and crush food. Lastly,
there are the molars themselves, who are responsible for “chewing”, crushing and grinding the
food.
Mastication is an extremely pivotal part of the digestive process, especially for fruits and
vegetables as these have indigestible cellulose coats which must physically be broken down.
Also, digestive enzymes only work on the surfaces of food particles, so the smaller the particles
of food, the more efficient the digestive process. While the food is mechanically being broken
down, the enzymes from saliva begin the chemically process the food as well.
3
incorporation of calcium and phosphate into enamel. Saliva also has antibacterial properties as
an enzyme to the name of amylases breaks
down food particles that stick to the teeth,
reducing the bacterial buildup that can lead to
enamel and teeth decay. Amylase has many
hydrogen bonds, along with the fact that it is
polar, and that it has london dispersion forces,
and dipole-dipole intermolecular forces.
Reaction Rates
There are several chemical
reactions that occur of which slightly
break down food. However the main
reaction is between that of amylase
and starches of which break down
into maltose, dextrin and glucose,
illustrated by figure 2.0. Amylase
coats and surrounds each starch
molecule in the mouth. Then the
enzyme deconstructs complex
starch molecules through hydrolysis,
or chemical breakdown, turning
them into smaller, more manageable
particles. Such reaction rates can
significantly be increased. The best
method that the human body
naturally does this is by increasing the surface
area of the starch by more mechanical
breakdown by the teeth, as a method to get
more contact with the enzyme. Additionally
such reaction does not have a high activation
energy because it readily occurs in the mouth,
with little to no input of heat. Lastly, due to the
presence of the other biological catalysts of
life - enzymes - amongst saliva the activation
4
energy for the reaction is lowered, as the presence of catalysts speed up reactions by providing
an alternative reaction mechanism without altering equilibrium. An example of such catalyse is
amylase itself. Traditionally a starch molecule would break down due the the acidic levels of aliva
to be 6.2, but the presence of amylase speeds up such decomposition. Lastly, most chemical
reactions proceed at a faster rate as temperature increases. Food digestion follows the same
principle. However there is an upper limit of 40 degrees celsius with saliva. As represented by
figure 2.1: at 40 degrees celcius there is the maximum rate of reaction for saliva.
The last and most effective form of buffer is that of carbonic acid and that of bicarbonate.
When food is placed in the mouth, the pH drops and an increase in the concentration of
bicarbonate occurs. The drop in pH is caused by increased concentrations of H+, due to lactic
acid being produced by bacteria. As a result more bicarbonate is produced as a byproduct of
cellular metabolism of which helps neutralise the increased amount of acid (H+). As represented
by figure 3.0, a rise in bicarbonate concentration increases the concentration of carbonic acid.
However, the concentration of carbonic acid remains at 1.3mMol/L. Therefore, this means that the
carbonic acid concentration causes the equilibrium to further shift to the left until CO2 is
produced. Such shift is also catalysed by carbonic anhydrase by lowering the activation energy
for the reaction by providing an alternative reaction mechanism. As the concentration of carbonic
acid falls, more bicarbonate ions bind to the hydrogen ions to form carbonic acid, establishing a
new equilibrium.
5
Propulsion
Propulsion is the movement of chime (food) along the digestive tract. The major method
of propulsion is that of peristalsis, which is a series of alternating contractions and relaxations of
smooth muscles that line the walls of the digestive organs and that force food the move forwards
amongst the digestive process. Specifically, it is the continuous segments of longitudinal smooth
muscle rhythmically contracting and relaxing in order to move food down through the esophagus,
gut and the small and large intestines. Peristaltic waves push the swallowed bolus down the
esophagus. In the stomach, peristalsis churns the food which ultimately mixes it with gastric
juices. It takes about a minute to chew a piece of food into a bolus and a few seconds swallow it,
but it takes a couple of hours to turn bolus into chyme. Propulsating the food down the
esophagus takes only 2-3 seconds, whereas propulsing it through the small and large intestines
takes a couple of hours.
The human esophagus has a mucous membrane, which allows for the food to easily go
through the esophagus, and also serves as a protective function against the abrasive effects of
food. Like other parts of the digestive tube, the esophagus has four tunics, which are unique and
important in their own ways. The proximal esophagus has striated muscle and the distal
esophagus has smooth muscles. Unfortunately, there is a significant lack of any real digestion
and absorption occurring throughout the stages of propulsion, and therefore lack the essence of
chemistry amongst such process.
6
Digestion
Chemical digestion really gets underway in the stomach. The top of the stomach is
connected to the end of the esophagus. The secretion of gastric juices are controlled by the
nerves and the homomes amongst the stomach. There are three phases of gastric secretion:
cephalic, gastric, and intestinal phases. The cephalic phase, also referred to as the reflect phase,
is when the smell, taste, sight, or thought of food triggers the preparation of gastric secretion. The
gastric phase lasts about three to four hours, of which is triggered by the entry of food into the
stomach. In this phase, parasympathetic neurons release acetylcholine, which provokes the
secretion of gastric juices. This creates an acidic environment amongst the internal of the
stomach. Additionally, the release of gastric juices also triggers stomach contractions, which help
into moving the food around the stomach, and also mechanically breaking it down. Lastly, the
intestinal phase of gastric secretion is when partially digested food fills the duodenum by
opening the pyloric sphincter.
Mechanical Digestion
Within a few
moments after food
bits enter the
stomach, mixing
waves begin. A mixing
wave is a unique type
of peristalsis that
mixed and softens the
food with gastric
juices to create
chyme. The initial
mixing waves are
generally soft initially
but they exponentially
get harder and
stronger the farther
down the chyme continues down the stomach. At the end the mixing waves get very significant,
significant enough that the waves themselves would break down the cyme, through mechanical
digestion, as represented in figure 4.0.
7
There is also the pylorus, which acts like a filter which only allows liquids and small food
particles pass through the end of the stomach. The remaining larger solids and then reenter the
stomach to be further processed by the gastric juices. Release of a greater amount of chyme at
one time would overwhelm the capacity of the small intestine to handle it.
Chemical Digestion
Fungus plays an important role, because it stores both undigested food and gases that
are released during the process of chemical digestion. Ultimately the mixing waves incorporate
the food with chyme, as the acidity of which inactivates salivary amylase and activate lingual
lipase. The lingual lipase begins breaking down triglycerides into free fatty acids, and mono and
diglycerides, as represented by figure 5.0 . On the other hand the breakdown of proteins starts in
the stomach through the actions of hydrochloric acid and the enzyme pepsin. What happens is
that hydrochloric acid activates pepsin, which then assists by breaking the bond links between
amino acids. Additionally there are many microorganisms that have their growth inhibited by an
acidic environment, which also assists in the prevention of infections.
8
Lastly, the enzyme pepsin has a molecular formulae of C34H63N5O9. With a significantly
greater molecular weight of 685.904 g/mol, it has 8 hydrogen bond donor counts, with 9
hydrogen bond acceptor counts. This organic molecule is polar, and therefore has the highest
amounts of intermolecular forces of which include: dipole - dipole forces, hydrogen bonds, and
london dispersion forces.
Overall due to the presence of such highly polar molecules they will mix together with
one another in order to help in chemical reactions.
9
10
Figure 9.0: The following figure illustrates the enthalpy, entropy and gibbs free energy of the
uncatalysed and catalysed reaction.
11
Absorption
The mechanical and digestive process have one goal, which is to convert food into
molecules small enough that they can be absorbed by cells amongst the intestinal villi (tiny hairs
throughout the small and large intestine that absorb nutrients and water) and then transferred to
the blood streams. Almost all ingested food, that is about 80% of electrolytes and 90% of water is
absorbed by villi throughout the long length of the small intestine. The muscles of the small
intestine mix food with digestive juices from the pancreas, liver and intestine, and propel the
mixture forward for further digestion. The pancreas makes a digestive juice that has enzymes that
break down carbohydrates, fats and proteins. The pancreas delivers the digestive juice to the
small intestine through small tubes called ducts. On the other hand, the liver makes a digestive
juice called bile that helps digest fats and some vitamins. Bilt ducts carry bible from the liver to
the gallbladder for storage, or to the small intestine for usage. Additionally, the small intestine
also makes digestive juices, which mixes with bile and pancreatic juices in amongst the
absorption process in the intestines to complete the breakdown of proteins, carbohydrates and
fats. Bacterias in the small intestine produce come of the enzymes needed for the digestion of
carbohydrates. Lastly, bacteria in the large intestine help break down remaining nutrients and
make Vitamin K. Waste products of digestion, including parts of food that are still too large
become a stool.
12
13
acids are actual groups of cholesterol that are synthesized in a hepatocyte. Cholesterol, which is
intaken as part of the diet is converted to bile acids cholic and chenodeoxycholic acids, which are
then conjugated to an amino acid. Bile acids as represented by figure 13.0, are actually
hydrophobic and hydrophilic, as one face is hydrophobic and the hydroxyl group is hydrophilic.
Such properties allows for emulsification of lipids. This causes fat blobs to break down into
minute, microscopic droplets. This allows the lipids to increase in surface area and therefore be
absorbed by the villi. Additionally, there is the presence of a lot of hydrogen bonds along with an
carboxylic acid group on the bile. There accounts for the presence of dipole-dipole
intermolecular forces and london dispersion forces.
. Rates of Reactions
There are three methods in which the reaction rates increase in favour towards the
products. Firstly, there is the presence of different types of enzymes, specifically the two
enzymes that assist in digesting carbohydrates, fats, and sugars are hydrolases and
phosphatases of which reduce the activation energy required to complete the reaction by
producing an alternative reaction mechanism, and at the same time not being consumed
amongst the reaction itself. Secondly, due to the ongoing form of peristalsis the chime is still
being broken down as it makes its way through the small intestine. Therefore as the surface area
of the chime continues to increase the reaction speed also continues to increase as there is an
14
increase in the surface area amongst which the two reactants can contact one another. Lastly,
due to the presence of villi amongst the linings of the intestines, the concentrations of the
products are being reduces, and therefore the reaction would shift in favour towards the
products. Additionally the concentration of the reactants is also increasing as more pancreatic
juices are being added to the chime. Therefore the cycle continues of the reactant concentration
increasing and the product concentration decreasing, ultimately shifting the equilibrium towards
the products.
Defecation
Defecation is the final act of digestion. It is a means by which solids, semisolids, or some
liquid waste materials are eliminated from the digestive tract via the anus. Waves of muscle
contractions called peristalsis amongst the wall of the colon move fecal matter through the
digestive tract towards the rectum. Undigested food may also be expelled this way, in a process
to the name of egestion. The physiology of defecation is quite simple. The rectum temporarily
stores fecal waste. As the walls of the rectum fill up there is an increase in pressure, of which
urges the human body to defecate.
Conclusion
Concludingly, there are a multitude of different chemical reaction that involve the
principles of grade 12 chemistry. There is the presence of rates of reactions which involves Le
Chatelier Principle, and how the human body naturally favours the products over the reactions.
Additionally, there is equilibrium and the presence of catalysts in the form of enzymes that
decrease the activation energy of reactions, ultimately increasing the rates of reactions.
Furthermore, there is the presence of acid base equilibriums amongst the human body. Due to
the presence of natural buffers of bicarbonate and carbonic acid amongst the stomach, this
allows acids to not cause complete internal acidification. Lastly, organic chemistry and structures
are present throughout the human body. From the organic properties of the natural enzymes
found in the stomach to the enzymes found in the mouth, there are hundreds of organic
structures present everywhere in the human body. Ultimately, the human body is a an array of
different chemical and biological inntercrasies. Despite the fact that we can not understand
everything about the human body, one can definitely, explore the chemical reactions and their
properties of the human body.
15
Glossary
Acetylcholine: a compound which occurs throughout the nervous system, in which it functions as
a neurotransmitter
Bilirubin: Bilirubin is formed by the breakdown of red blood cells in the body. The liver helps to
excrete it. High levels of bilirubin can lead to jaundice.
Bolus: a small rounded mass of a substance, especially of chewed food at the moment of
swallowing.
Buffer: a solution that resists changes in pH when acid or alkali is added to it. Buffers typically
involve a weak acid or alkali together with one of its salts.
Cellulose: an insoluble substance which is the main constituent of plant cell walls and of
vegetable fibers such as cotton. It is a polysaccharide consisting of chains of glucose monomers
Chime: the semifluid mass of partly digested food expelled by the stomach into the duodenum
Enzymes: a substance produced by a living organism which acts as a catalyst to bring about a
specific biochemical reaction
Hydrogen bond: a weak bond between two molecules resulting from an electrostatic attraction
between a proton in one molecule and an electronegative atom in the other.
Lipids: any of a class of organic compounds that are fatty acids or their derivatives and are
insoluble in water but soluble in organic solvents. They include many natural oils, waxes, and
steroids.
Mastication: Chewing
Metabolism: the chemical processes that occur within a living organism in order to maintain life.
16
Nucleophilic: (of a molecule or group) having a tendency to donate electrons or react at
electron-poor sites such as protons.
Parasympathetic neurons: The parasympathetic nervous system (PSNS) is one of the two
divisions of the autonomic nervous system (a division of the peripheral nervous system (PNS)), the
other being the sympathetic nervous system
Photosynthesis: the process by which green plants and some other organisms use sunlight to
synthesize foods from carbon dioxide and water. Photosynthesis in plants generally involves the
green pigment chlorophyll and generates oxygen as a byproduct.
Reaction Mechanism: In chemistry, a reaction mechanism is the step by step sequence of
elementary reactions by which overall chemical change occurs.
17