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Hepatitis B

Hepatitis B is caused by the hepatitis B virus (HBV) which belongs to the family Hepadnaviridae. HBV is the only DNA virus among the major hepatitis viruses (A, B, C, D, E, G) and contains reverse transcriptase. It is transmitted through contact with infectious blood or body fluids like semen and saliva. HBV infection can lead to acute or chronic hepatitis and in some cases develops into liver cirrhosis or liver cancer. Vaccination provides effective protection against HBV infection.

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62 views13 pages

Hepatitis B

Hepatitis B is caused by the hepatitis B virus (HBV) which belongs to the family Hepadnaviridae. HBV is the only DNA virus among the major hepatitis viruses (A, B, C, D, E, G) and contains reverse transcriptase. It is transmitted through contact with infectious blood or body fluids like semen and saliva. HBV infection can lead to acute or chronic hepatitis and in some cases develops into liver cirrhosis or liver cancer. Vaccination provides effective protection against HBV infection.

Uploaded by

Hakuna matata
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Hepatitis- B

1.All the following viruses are RNA


viruses except:
a.HBV b.HAV
c.HEV d.HGV

2.Transfusion hepatitis refers to


a.type A b.type B
c.type C d.type G

3.HBV belongs to the family


a.Picornavirus b.Hepadnavirus
c.Flaviviridiae c.Hepeviridiae
4.Which of the following nucleic acid is
present in HBV?
a.dsDNA b.ssRNA
c.ssDNA d.dsRNA

5.The schedule of Hepatitis B vaccine is


a.0,1,6 days b.0,1,6 weeks
c.0,1,6 months d.0,1,6 years

6.Which Hepatitis virus has reverse


transcriptase enzyme?
a.HAV b.HBV
c.HCV d.HGV
7.Which of the following viruses carries
highest risk of infection following
percutaneous injury?
a.HBV b.HCV
c.HIV d.HTLV1
8.A protective level of immune
response after HBV vaccination is
defined as a titre of anti-HBs
a.100 IU/L b.>10 IU/L
c.<10 U/L d.50 IU/L

9.HBsAg or Australian antigen includes


a.22 nm diameter spherical and
filamentous particles
b.envelope proteins expressed on the
surface of virions
c.virions
d.both a and b

10.HBcAg and HBeAg are coded by


a.S gene b.P gene
c.X gene d.C gene

11.P gene of HBV codes for


a.DNA polymerase b.HBxAg
c.HBeAg d.HBcAg

12.Hepatitis B virus is transmitted by


a.parenteral transfusion
b.perinatal transfusion
c.sexual transmission
d.all of the above

13.Which of the following is false?


a.carrier is a person with detectable
HBsAg in blood for more than 6 months
b.super carriers have high titre of
HBsAg
c.simple carriers have low titre of
HBsAg
d.simple carriers have high titre of
HBeAg

14.Indicator of viral replication and


infectivity
a.HBeAg and HBV DNA b.HBcAg
c.HBsAg d.anti-HBs
15.First viral marker to appear on
blood after HBV infection
a.HBsAg b.HBeAg
c.HBcAg d.anti-HBc
16.Earliest antibody marker to be seem
in blood after HBV infection
a.anti-HBs b.IgM anti-HBc
c.anti-HBe d.none of the above

17.Indicator of prior infection with HBV


a.HBsAg b.anti-HBs
c.IgG anti-Hbc d.anti-HBe

18.Which of the following contains HBV


in an infected person?
a.blood b.semen
c.saliva d.all of the above

19.Which of the following antigenic


types of HBV is present in the
envelope?
a.HBsAg b.HBeAg
c.HBcAg d.HBxAg

20.Hyperimmune hepatitis B immune


globulin (HBIG) is given in
a.passive immunisation
b.active immunisation
c.combined immunisation
d.both a and c
21.Dane particles refers to
a.HBsAg b.core of HBV
c.envelope of HBV d.complete HBV
22.Infection with which one of the
following will lead to a chronic carrier
state?
a.HBV b.HCV
c.HAV d.CMV

23.Infection period for hepatitis B


a.1-2 weeks b.2-4 weeks
c.4-8 weeks d.4-24 weeks

24.Hepatitis B seroconversion starts


with
a.IgM anti-HBc b.IgM anti-HBs
c.IgM anti-HBe d.IgG anti-HBc

25.Ground glass appearance of


hepatocytes is the diagnostic hallmark
of
a.chronic hepatitis B infection
b.chronic hepatitis C infection
c.acute hepatitis B infection
d.acute hepatitis A infection

26.Anti-HBsAg positivity indicates


a.acute infection
b.chronic infection
c.Hepatitis B carrier
d.Immunization
27.Hepatitis B vaccine contains
a.entire virus particle
b.HBsAg
c.HBeAg
d.HBsAg +HBeAg

28.True regarding super carriers


a.high HBsAg titre
b.HBV in circulation
c.DNA polymerase
d.all of the above

29.Which of the following drug is not


used in the treatment of chronic
hepatitis B infection?
a.pegylated interferon
b.lamivudine
c.adefovir
d.ribavirin

30.Which hepatitis virus has a unique


replicative strategy?
a.HAV b.HBV
c.HCV d.HGV

ANSWERS:
1.a 16.b
2.b 17.c
3.b 18.d
4.a 19.a
5.c 20.d
6.b 21.d
7.a 22.a
8.b 23.d
9.d 24.a
10.d 25.a
11.a 26.d
12.d 27.b
13.d 28.d
14.a 29.d
15.a 30.b
Mounika.B
Roll no: 76

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