SAFETY DATA SHEET

Creation Date 26-Oct-2010 Revision Date 18-Jan-2018 Revision Number 3

1. Identification
Product Name Fumaric acid

Cat No. : A120-500

CAS-No 110-17-8
Synonyms Lichenic acid; trans-Butenedioic acid; Boletic acid

Recommended Use Laboratory chemicals.

Uses advised against Not for food, drug, pesticide or biocidal product use

Details of the supplier of the safety data sheet

Company
Fisher Scientific
One Reagent Lane
Fair Lawn, NJ 07410
Tel: (201) 796-7100

Emergency Telephone Number

CHEMTRECÒ, Inside the USA: 800-424-9300
CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Serious Eye Damage/Eye Irritation Category 2

Combustible dust Yes

Label Elements

Signal Word
Warning

Hazard Statements
May form combustible dust concentrations in air
Causes serious eye irritation

Precautionary Statements
Prevention

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Wash face, hands and any exposed skin thoroughly after handling
Wear eye/face protection
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
If eye irritation persists: Get medical advice/attention
Storage
Store in a well-ventilated place. Keep container tightly closed
Hazards not otherwise classified (HNOC)
None identified

3. Composition/Information on Ingredients
Component CAS-No Weight %
Fumaric acid 110-17-8 >95

4. First-aid measures
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention.

Inhalation Remove from exposure, lie down. Move to fresh air. If not breathing, give artificial
respiration. Obtain medical attention.

Ingestion Do not induce vomiting. Clean mouth with water. Get medical attention.

Most important symptoms and No information available.

effects
Notes to Physician Treat symptomatically

5. Fire-fighting measures
Suitable Extinguishing Media Water spray. Carbon dioxide (CO 2). Dry chemical. Chemical foam.

Unsuitable Extinguishing Media No information available

Flash Point 230 °C / 446 °F

Method - No information available

Autoignition Temperature Not applicable 375 °C / 707 °F

Explosion Limits
Upper No data available
Lower No data available
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Fine dust dispersed in air may ignite.

Hazardous Combustion Products

Carbon monoxide (CO) Carbon dioxide (CO2)
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.

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NFPA
Health Flammability Instability Physical hazards
2 1 0 N/A

6. Accidental release measures

Personal Precautions Ensure adequate ventilation. Use personal protective equipment.
Environmental Precautions See Section 12 for additional ecological information. Do not flush into surface water or
sanitary sewer system.

Methods for Containment and Clean Sweep up or vacuum up spillage and collect in suitable container for disposal. Do not let
Up this chemical enter the environment. Avoid dust formation.

7. Handling and storage

Handling Avoid contact with skin and eyes. Avoid breathing dust. Do not ingest. Minimize dust
generation and accumulation. Wash hands before breaks and immediately after handling
the product.

Storage Keep in a dry, cool and well-ventilated place. Keep container tightly closed.

8. Exposure controls / personal protection

Exposure Guidelines This product does not contain any hazardous materials with occupational exposure
limitsestablished by the region specific regulatory bodies.

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations
and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection No protective equipment is needed under normal use conditions.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

9. Physical and chemical properties

Physical State Powder Solid
Appearance White
Odor Odorless
Odor Threshold No information available
pH No information available
Melting Point/Range 295 - 300 °C / 563 - 572 °F
Boiling Point/Range No information available
Flash Point 230 °C / 446 °F
Evaporation Rate Not applicable
Flammability (solid,gas) No information available
Flammability or explosive limits
Upper No data available
Lower No data available
Vapor Pressure No information available
Vapor Density Not applicable
Specific Gravity 1.620

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Solubility No information available

Partition coefficient; n-octanol/water No data available
Autoignition Temperature Not applicable 375 °C / 707 °F
Decomposition Temperature No information available
Viscosity Not applicable
Molecular Formula C4 H4 O4
Molecular Weight 116.07

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products.

Incompatible Materials Strong oxidizing agents

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization No information available.

Hazardous Reactions None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Fumaric acid LD50 = 9300 mg/kg ( Rat ) LD50 > 20000 mg/kg ( Rabbit ) Not listed

Toxicologically Synergistic No information available

Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico

Fumaric acid 110-17-8 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure None known

STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and No information available

delayed

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Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information

Ecotoxicity
Do not empty into drains. Contains a substance which is:. Harmful to aquatic organisms. The product contains following
substances which are hazardous for the environment.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Fumaric acid EC50: = 41 mg/L, 72h LC50: = 245 mg/L, 48h static Not listed EC50: = 73.6 mg/L, 24h
(Desmodesmus (Brachydanio rerio) (Daphnia magna)
subspicatus) EC50: 204 - 220 mg/L, 48h
(Daphnia magna)

Persistence and Degradability Persistence is unlikely

Bioaccumulation/ Accumulation No information available.

Mobility . Will likely be mobile in the environment due to its water solubility.

Component log Pow

Fumaric acid 0.33

13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

14. Transport information

DOT Not regulated
TDG Not regulated
IATA Not regulated
IMDG/IMO Not regulated
15. Regulatory information
International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL
Fumaric acid X X - 203-743-0 - X X X X X
Legend:
X - Listed
E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.
F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.
N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated
polymer made with any free-radical initiator regardless of the amount used.
P - Indicates a commenced PMN substance
R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.
S - Indicates a substance that is identified in a proposed or final Significant New Use Rule
T - Indicates a substance that is the subject of a Section 4 test rule under TSCA.
XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base
Production and Site Reports (40 CFR 710(B).
Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.
Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants
that comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

TSCA 12(b) Not applicable

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SARA 313 Not applicable

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act)

Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants
Substances Quantities
Fumaric acid X 5000 lb - -

Clean Air Act Not applicable

OSHA Occupational Safety and Health Administration

Not applicable

CERCLA This material, as supplied, contains one or more substances regulated as a hazardous
substance under the Comprehensive Environmental Response Compensation and Liability
Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs

Fumaric acid 5000 lb -
California Proposition 65 This product does not contain any Proposition 65 chemicals

U.S. State Right-to-Know

Regulations
Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island
Fumaric acid X X X - -

U.S. Department of Transportation

Reportable Quantity (RQ): Y

DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland Security

This product does not contain any DHS chemicals.

Other International Regulations

Mexico - Grade No information available

16. Other information

Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: EMSDS.RA@thermofisher.com

Creation Date 26-Oct-2010

Revision Date 18-Jan-2018
Print Date 18-Jan-2018
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

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End of SDS

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