Megavac 6

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Megavac-6 PRODUCT
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COMPOSITION
Megavac - 6 contains : Distemper*, Hepatitis (CAV2)*, Parvovirus*, Hepatitis (CAV1),
The potency of canine parvovirus is tested by injecting into seronegative pups and
Leptospira canicola, Leptospira icterohaemorrhagiae.
antibodies are checked by haemagglutination inhibition (HI) test and by virulent
challenge of the dogs after a single injection of vaccine. Vaccinated dogs showed no
* : Live Attenuated viruses clinical or haematological symptoms. No virus excretion was observed in the faeces.
: Inactivated antigens Megavac-P can be used to immunize puppies with low titres of maternal antibodies.
The above canine vaccine contain the following live attenuated viruses and / or AQUEOUS VACCINES - INACTIVATED
inactivated antigens. Canine contagious Hepatitis
Canine contagious hepatitis virus (canine adenovirus type-1) is grown on a continuous
FEEZE DRIED VACCINES - LIVE cell line and inactivated in such a manner that the virus loses its infectivity and retains
Canine Distemper its immunogenicity.
Live attenuated vaccine strain of canine distemper virus is grown on a continuous cell
line and presented in a freeze dried form. Each dose contains > 103 TCID50 live Leptospirosis
attenuated canine distemper virus. Continuous passage of the virus through tissue Leptospira canicola and Leptospira icterohaemorrhagiae are grown in a suitable
culture resulted in a highly attenuated virus vaccine of high purity, completely medium and inactivated in such a manner that the culture loses its infectivity and
homogeneous and without side effects on susceptible pups. The safety of the vaccine retains its immunogenicity. The inactivated antigen incorporated in the vaccine contains
is confirmed by intracerebral injection into susceptible pups and mice. > 2 x 108 bacteria each. The strains of leptospira used to produce this vaccine are free
from any pathogenic activity on any species. The somatic antigens are purified and
Canine Contagious Hepatitis concentrated by ultrafiltration. The antigens are inactivated by formaldehyde, and are
Live canine adenovirus type-2 (CAV-2) virus, causative organism of infectious purified at the end of inactivation and hence the final vaccine does not contain any
laryngotracheitis is grown on a continuous cell line and presented in a freeze dried residual toxic material. The final potency and safety of vaccine is tested on hamsters
form. Each dose contains > 103 TCID50 live attenuated CAV-2. The complete safety of and dogs, which have to be resistant to challenge, proving fatal to the controls.
CAV-2 strain and the total cross immunity properties with CAV-1, responsible agent
for canine contagious hepatitis, has led to this choice for hepatitis vaccine. The safety INDICATIONS
of vaccine is confirmed by intravenous injection into sensitive pups. For the active immunization against Canine Distemper, Canine Contagious Hepatitis,
Canine Parvovirus disease, Leptospirosis.
Canine Parvovirus
Live attenuated canine parvovirus is grown on a continuous cell line and presented in ADMINISTRATION AND DOSAGE
a freeze dried form. Each dose contains > 103 TCID50 live attenuated canine parvovirus. 1 ml intramuscularly or subcutaneously for the vaccine. Freeze dried vaccines may be
Parvovirus strain of canine origin is attenuated by continuous passages on cell cultures. reconstituted with either aqueous vaccines or sterile diluent just before use. Shake
The safety of this vaccine is determined by testing on susceptible pups and bitches at the reconstituted vaccines before use. Vaccine should be administered observing
different stages of pregnancy. aseptic precautions.
Continued
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PRODUCT
RANGE
VACCINATION REGIMEN
First vaccination : 8 - 9 weeks of age
Second vaccination : 12 weeks of age
Revaccination : Yearly (annual)
IMMUNITY
Adequate immunity is established approximately 10 to 15 days after vaccination in
case of seronegative dogs. In case of pups containing maternal antibodies second
vaccination is advocated for complete protection. Immunity lasts for 1 to 2 years and
annual revaccinations are recommended for fool proof protection. SHELF LIFE
24 months from the date of manufacture (when stored at recommended storage
ADVERSE REACTIONS / CONTRAINDICATIONS temperature).
Dogs already sick and / or heavily infested with parasites should not be vaccinated.
Utmost care should be taken while vaccinating pregnant bitches. Dogs under STORAGE AND TRANSPORT
corticosteroid therapy should not be vaccinated. In rare cases hypersensivity may Store and transport the vaccine between 2°C and 8°C till use. At no stage should the
occur, immediate treatment with antihistaminics is advocated. Use sterile material for vaccine be allowed to freeze.
injection purpose
PACKING INFORMATION
EFFECTS WITH OTHER VACCINES Megavac-6 is available in single dose packs. The vaccine is packed in glass vials. The
Megavac-6 is safe and can be used with other commonly used vaccines. glass vials are sealed with rubber bungs, aluminium flip off seals and labeled with
corresponding labels. 25 doses are packed in a plastic tray / container. These trays
OVERDOSE are packed in polystyrene boxes with two cool packs with an outer corrugated boxes
Twice the dose is also very safe in target species while transportation.
WITHDRAWAL PERIOD DISTRUCTION OF USED CONTAINERS

Not applicable The empty containers of the vaccine, used syringes and needles should be discarded
properly and carefully.
WARNINGS
The veterinarian who administer the vaccine should wash the hands before and after CAUTION
vaccination with soap followed by clean running water. For veterinary use only.
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