Registration no.

Total Number of pages:02 B.Pharma.

15PH501
257 257 5th Semester
257 257 Regular Examination
257 2017-18
257 257 257
Pharmaceutics-II(Pharmaceutical Technology - I)
BRANCH : B.Pharma.
Time : 3 Hours
Max Marks : 100
Q. Code: B112
Answer Question No.1 and 2 which are compulsory and any four from the rest.
257 257
The figures in257the right hand
257 257
margin indicate
257
marks. 257 257

Q1 Answer the following questions: multiple type or dash fill type (2x10)
a) Granule density is ____________ in‘high shear paddle mixer’,whereas granule
density is ____________ in ‘fluidized granulator’.
b) For acidic compounds,
pH = pKa + log (_______________drug) / [______________ drug]
For basic compounds,
257 257 pH = pKa257+ log (_____________drug)
257 / [______________
257 drug]
257 257 257

c) Surfactants are chemically classified as

___________, ____________, __________, ____________ .
d) The melting point of a drug can be measured using three techniques,
_____ ________, ________ _______ ________, ________ _______.
e) Emulsification is caused by (i) reduction of __________ ___________
,(ii)formation of rigid ___________ _____________, (iii)formation of
______________ ___________ _____________ .
257 257 257 257 257 257 257 257
f) Evaluation of tablets is carried out by several tests such as ________ test,
__________ test,_________ rate and ______ _____ tolerance,__________
uniformity and ________ of tablet.

g) Finished capsules from all filling equipments require some sort of dusting and
/or polishing operation such as _______ ________ and __________
,________ _______ and ______ __________.
h) Carr’s index (%) = [(____ ______ - Pored density)/_____ ______ ]*100
257 257 257 257 257 257 257 257
andHausner ratio = ______ density/________ density.
i) Barium sulfate in presence of sodium laurate (at pH 12) favors ________ type
emulsions, whereas barium sulfate coated with sodium dodecyl sulfate will
favor ________ type emulsions.
j) Weak acids with a pKa ______ 4.3 and weak bases with pKa ________ 8.5 are
generally readily absorbed in the system.

257
Q2
257
Answer 257
the following questions:Short
257
answer type
257 257 257 257
a) Classify liquid dosage forms according to vehicles. (2x10)
b) What is intrinsic solubility?
c) Write about chewable tablet with example.
d) Why pKa of drug is important parameter for drug selection?
e) Why flowability of powder is important and how is it characterized?
257 257 f) What is HLB
257 value and how
257 is it useful in 257
formulation? 257 257 257

g) Write about multiple emulsion with examples.

257 257 257 257 257 257 257 257

 h) Give two examples of polyhydric alcohols. Why polyhydric alcohols are
preferable than alcohols in the preparation of formulation?
i) What are the ingredients needed to manufacture soft gelatin shells and What
257 257 types of 257
different soft gel 257
fill matrices are used
257 ? 257 257 257
j) What are flocculated system and deflocculated system?

Q3 a) Describe with a flow sheet diagram, the method of tablet manufacturing by ‘dry (10)
granulation method’.

b) What is mottling of tablets and what is its preventive measure? (5)

257
Q4
257
a) What are257
the problems 257
associated with257the manufacturing
257
of liquid dosage
257
(10) 257

forms?
b) Discuss in brief on various types of monophasic liquid dosage forms. (5)

Q5 a) Discuss Glass and Plastic as packaging system for liquid formulations. (10)
b) Write on ideal properties of packaging materials. (5)

257 257 257 257 257 257 257 257

Q6 a) State different objectives of preformulation studies. How is a drug moiety with (10)
potential pharmacological activity screened out from synthetic compounds?
What are the significances of preformulation studies in designing of dosage
forms?
b) Discuss briefly on various preformulation parameters to be studied. (5)

Q7 a) Categorize various granulation techniques and write about characteristics of (10)

257 257 various granulating
257 agents.
257 257 257 257 257

b) Write on the mechanisms of granule formation. (5)

Q8 a) Write on the mechanisms of drug permeation of semi-solid dosage form (10)

through skin .What are the factors that influence skin permeation?
b) Discuss about ointments, creams, pastes and gels with examples and their (5)
packaging system.
257 257 257 257 257 257 257 257

Q9 a) Describe manufacturing method and quality control tests of soft gelatin (10)
capsules.
b) What are the advantages and disadvantages of hard and soft gelatin capsules? (5)

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

Registration No:

Total Number of Pages: 02 B.Pharma

15PH502
5th Semester Regular Examination 2017-18
257 257 257 257
Medicinal Chemistry-I
257 257 257 257
BRANCH: B.Pharma
Time: 3 Hours
Max Marks: 100
Q.CODE: B113
Answer Question No.1 and 2 which are compulsory and any four from the rest.
The figures in the right hand margin indicate marks.
257 Q1257 Answer 257the following questions:
257 multiple
257type or dash fill
257 up type 257 (2 x 10) 257

a) Thiazides diuretics is used in

a. Primary hyperaldosteronism.
b. Nephrogenic diabetes insipidus
c. Idiopathic hypercalciurea
d. Hypercalcaemia
b) Acetzolamide has following characteristics
a. acting on proximal tubules
257 257 b. Inhibits
257 carbonic anhydrase
257 257 257 257 257

c. Competitively antagonize aldosterone

d. Inhibits sodium secretion in the distal tubule
c) Acetylcholine and physostigmine are example of ------------ type drug
interaction.
a. Synergism
b. Addition
c. PotentiationAll of above.
257 257 d. Antagonism
257 257 257 257 257 257
d) Phentolamine is competitive antagonism of
a. Acetyl choline
b. Isoprenaline
c. Noradrenaline
d. Atropine
e) Calcium channel blocker with predominant peripheral action is
a. Nicardepine
257 257 b. Verapamil
257 257 257 257 257 257
c. Nifedipine
d. Diltiazem
f) Famotidine acts as
a. H1 histamine antagonist
b. H2 histamine antagonist
c. Proton pump inhibitor
d. H1 agonist
257 257
g) Crohn’s disease
257
affects ---------part
257 257 257 257 257
a. Gastrointestinal tract
b. Kidney
c. Lung
d. Heart
h) Clonidine is used in
a. Glucoma
b. Migraine
257 257
c. Opioid
257
withdrawal 257
syndrome 257 257 257 257
d. All

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

i) Which of the following is used in the diagnosis of myasthenia gravis?

a. Physostigmine
b. Neostigmine
c. Both
d. None
j) Clonidine, metronidazole and tinidazole have which of the group in common?
257 257
a. Quinidine
257 257 257 257 257 257

b. Benzimidazole
c. Imidazole
d. None of the above

Q2 Answer the following questions: Short answer type (2 x 10)

a) Define the term autocoids with example.
b) Define Bioisosterism.
257 257 c) Write down
257 the structure of
257Furosemide and
257Nifidipine. 257 257 257

d) What is the natural source of Chloramphenicol?

e) Write down the structure of Naproxan and their mode of action.
f) Define the term partition coefficient.
g) What are the causative organisms of tuberculosis and leprosy?
h) Mention the mechanism of action of Metronidazole and Thiabendazole.
i) What are diuretics?
j) Write down structure of any one antihistamine drug and one Eicosanoid drug.
257 257 257 257 257 257 257 257

Q3 a) Mention the physicochemical properties used in QSAR. (10)

b) Mention the relationship between logP and biological activity. (5)

Q4 a) Discuss the effect of electronic and steric parameter on lipophilicity. (10)

b) Write a note on Free Wilson model. (5)

Q5 a) Define and classify cholinergic and anticholinesterase drugs with examples. (10)
257 257 What are257muscarinic and nicotinic
257 effects? 257 257 257 257
b) Outline the synthesis and uses of Carbachol and Neostigmine. (5)

Q6 a) Discuss the SAR and mode of action of adrenergic and antiadrenergic drugs. (10)
b) -adrenergic blockers with their uses. (5)

Q7 a) What is the meaning of ‘autacoids’? Classify antihistaminic drugs with (10)

examples. Outline the mode of action and SAR of classic antihistaminics.
257 257
b) Outline the
257 synthesis and 257
chemical name of257Promethazine 257
and Ranitidine. 257 (5) 257

Q8 a) Define and classify diuretics with examples. Outline the mode of action and (10)
SAR of thiazide diuretics.
b) Mention the synthesis and chemical name of Ibuprofen and Diclofenac (5)
sodium.

Q9 a) Define and classify antihypertensive drugs with examples. Outline the (10)
257 257
synthesis257of Clonidine and257Methyldopa. 257 257 257 257
b) Write a note on anthelmintics. (5)

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

 Registration no:

Total Number of Pages: 02 B.Pharma

257 257 257 257 257 257 15PH503
257 257
5th Semester Regular Examination 2017-18
Pharm. Analysis-II
BRANCH : B.Pharma
Time: 3 Hours
Max Marks: 100
Q.CODE: B114
257
Answer
257
Question
257
No.1 and 2 which
257
are compulsory
257
and 257
any four from 257
the rest. 257
The figures in the right hand margin indicate marks.

Q1 Answer the following questions: (2x10)

a) Turbidity is carried out at wavelength
i) 450 nm ii) 680 nm
iii) 530 nm iv) 600 nm
257 257 b) The following
257 light is measured
257 in nephelometry
257 257 257 257

i) Scattered ii) Reflected

iii) Dispered iv) Transmitted
c) The following gas has got a higher thermal conductivity value:
i) Nitrogen ii) Helium
iii) Argon iii) Carbon
d) Diazotisation titration is 257
used for the assay of
257 257 257 257 257 257 257

i) NSAIDs ii) Sulpha drugs

iii) Steroids iv) All of the above
e) The end point of complexometric titrations is shown by
i) Acid-base indicators ii) pH indicators
iii) Colorimeter iv) pH meter
257 257
f) 257 257 257
Dropping mercury electrode is an important component of257 257 257

i) HPLC ii) Spectrophotometer

iii) Poalarograph iv) Potentiometer
g) In polarography, to eliminate migrationcurrent which of the following is used?
i) NaCl ii) KCl
257 257 257 257 257 257 257 257
iii) NaOH iv) KOH
h) In redox titration, indicator electrode is
i) Pt wire ii) Ag wire
iii) Glass electrode iv) Hg electrode

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

 i) Which of following is used as precipitating agent for Ca2+ ion in gravimetric ana
i) BaCl2 ii) HNO3
iii) NH4SCN iv) H2C2O4
257 257 j) Angle between
257
source and
257
detector in turbidimeter
257
is 257 257 257

i) 90º ii) 180º

iii) 45º iv) 60º

Q2 Answer the following questions: (2×10)

a) Discuss briefly about digestion.
257 257
b) Write down
257 the advantages
257 and application
257 of polarography.
257 257 257
c) What are the factors affecting amperometry.
d) Mention the factors that affect the Diazotization end point.
e) What are the radiation sources for nephelometr
f) Write down the application of radio-immunoassay.
g) Discuss different types of filters and monochromators related to turbidimetry.
h) What is the principle involved in conductometry?
i) Define and give examples of organic precipitations.
257 257 257 257 257 257 257 257
j) Write about the electrodes used in potentiometry.

Q3 a) Discuss the significance of solubility products and common ion effect on gravimetric (10)
assay. Define the following:- Co- precipitation, Post-precipitation, and peptization.
b) What are the characteristics of precipitating substance and washing solution. (5)

Q4 a) What are different methods of conductivity measurements? (10)

257 257 257 257 257 257 257 257
b) Explain the ion selective electrodes principle. (5)

Q5 a) What are the main application of nephelometry and turbidimetry? (10)

b) What is the main difference in the working principles of nephelometry ? (5)

Q6 a) What is the principle involved in the diazotization titrimetry? Mention the condition (10)
required for diazotization titrimetry.
257 257
b)
257 257 257
Write a note on Kjeldal method of nitrogen estimation.
257 257
(5)
257

Q7 a) Explain the principle involved in the Zone electrophoresis, gel lectrophoresis and (10)
capillary eletrophoresis. Discuss the instrumentation of electrophoresis.
b) What is the principle and procedure involved in Radioimmunoassay? (5)

Q8 a) Discuss the principle and procedure involved in KarlFischer titration. (10)

257 257
b) Write a 257
note on polarography
257 257 257 257
(5)
257

Q9 a) Write a note on Gasometry. (10)

b) Mention the advantages, disadvantages and application of Potentiometric titration. (5)

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

 Registration no:

Total Number of Pages: 02 B.Pharm

257 257 257 257 257 257 257 15PH504 257

5th Semester Regular Examination 2017-18

Pharmacology - I
BRANCH : B.Pharma
Time: 3 Hours
Max Marks: 100
257 257 257 257
Q.CODE: B115
257 257 257 257
Answer Question No.1 and 2 which are compulsory and any four from the rest.
The figures in the right hand margin indicate marks.

Q1 Answer the following questions: (2 x 10)

a) BCG vaccine is to be administered by ……………….. route. Most of the drugs are
transported across the membrane by ……………….
b) Aspirin causes …………….. damage by ……………. Mechanism.
257 c)
257 Myasthenia 257
gravis is an ………………….
257 Disorder
257 due to development
257 of 257 257

…………….. it occur.
d) ……………. Ion fluidizes the axonal membrane during neutrotransmitter release.
Phenylephrine is used as nasal decongestant acts by ……………….. agonism.
e) Lithium is used for ……………… and it is excreted in ……………..
f) Bromocriptine is effective in …………. . L-dopa stimulate …………….. type of
receptor.
g) ……………… appropriate antidote for the treatment of Pentazocine overdose.
257 257 Opoid mediated
257 flushing and257warming of the 257
skin is due to ……………..
257 257 257

h) Local anaesthetic acts by ………………….. local anaesthetic is given along with

adrenaline for ………………….
i) ……………….. is clinically used in treating grand mal seizures. Antiseizure drug
……………. Probably acts principally at Ca channels.
j) …………………. Is a neuromuscular blocker has histamine releasing property. All
neuromascular agents should administered through …………. route.

257 Q2 257 Answer the257 following question

257 : 257 257 257 (2×10)257
a) Write the definition of pharmacokinetics and pharmacodynamics.
b) Describe about the carrier mediated transport.
c) Briefly describe about partial agonist and inverse agonist with example.
d) Write the types of autonomic nervous system and write the names of principal
neurotransmitters of these types.
e) Explain about the parasympatholytic and sympathomimetic drugs with example.
f) Shortly explain about therapeutic index.
257 257 257 257 257 257 257 257
g) What is opoid analgesics. Write about the types of opoid receptor.
h) What is the difference between local anaesthetics and general anaesthetics. Write
some examples of these anaesthetics.
i) Describe the following terms :
Sedative
Hypnotics
j) Explain about microsomal and non-microsomal enzymes with their examples.
257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

 Q3 a) Write the definition of general anaesthesia. Explain the stages of general (2+5+3)
anaesthesia. Write about preanaesthetic medication of general anaesthesia.
b) Write about the classification of general anaesthesia and briefly explain about (2.5+2.5)
nitrous oxide.
257 257 257 257 257 257 257 257
Q4 a) Write the definition of affinity and efficacy. Discuss the different types of receptor. (5+5)
b) Write Briefly about the G-protein coupled receptor. (5)

Q5 a) What is apparent volume of distribution? Briefly discuss about neurohumoral (5+5)

transmission.
b) Write about first pass metabolism of drug. (5)
257 257 257 257 257 257 257 257
Q6 a) Define parkinsonism. Write the classification of antiparkinsonism drug. How (2+3+5)
levodopa is helpful for parkinsonism.
b) Why levodopa is used along with carbidopa. (5)

Q7 a) Write a note on : (10)

i) Tricyclic antidepressant
ii) Selective serotonin reuptake inhibitors
257 257 257 257 257 257 257 257
b) Explain briefly about passive diffusion and facilitated diffusion. (5)

Q8 a) Describe about the different types of administration along with their merits and (10)
demerits.
b) Explain about the different types of adrenergic receptors along with their location (5)
and function.

257 Q9 a)
257 What is epilepsy,
257 write about257the types. How257anticonvulsant 257
drugs act generally
257 on (2+3+5)257
different types of seizures? Give some examples?
b) What is endogenous opoid peptides. Write about the central pharmacological (2.5+2.5)
effects of Morphine.

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

 Registration no:
Total number of pages: 02 B. Pharma.
15PH505
5th Semester Regular Examination 2017-18
257 257 257 257 Pharmacognosy-III
257 257 257 257

BRANCH: B.Pharma
Time: 3 Hours
Max Marks: 100
Q.CODE: B116
Answer Question No.1 and 2 which are compulsory and any four from the rest.
The figures in the right hand margin indicate marks.
257 257 257 257 257 257 257 257
Q1 Multiple Choice Questions :
a) Rhein is a (2 x 10)
A) Sterol B) Anthraquinone C) Coumarin D) Phenol.
b) Keller-Kiliani test is performed for the detection of …………………………
c) Anthranilic acid is an intermediate in the biosynthesis of
A) Tryptophan B) Tyrosine C) Phenyl alanine D)
Ornithine
257 257
d) Under UV 257
radiation gentian
257
extract shows257
…………………….. 257
fluorescence.
257 257
e) Cassia obovata is commonly known as
A) PaltheSenna B) Mecca Senna C) Egyptian Senna D)
Dog Senna
f) Glycyrrhiza belongs to the family of
Liliaceae B) Leguminosae C) Solanaceae D)
Pinacee
g) Strophanthus glycosides + 80 % H2SO4
257 257 A) Violet 257 B) 257
Crimson red 257 C) Emerald
257 green D)
257 257
Cream
h) Bitter wood obtained from dried stem wood of ………………………….
i) BAP is a
Gibberalin B) Synthetic auxin C) Natural auxin D) Cytokinin
j) Panaxquinquefolium represents
American B) Chinese C) Korean D) Japanese
variety of ginseng.
257 257 257 257 257 257 257 257
Q2 Answer the following questions : (2 x 10)
a) Distinguish between Cardenoloides and Bufadienolides.
b) Give examples of two cytotoxic compounds obtained from marine source.
c) Write down the biological source of Senega.
d) Define the term ‘totipotency’.
e) Write down the biological sources of Trypsin and Pepsin.
f) How would you detect anthraquinone glycoside in a crude specimen?
257 257 g) Write down
257 the biological257
source, chemical
257constituents and
257 uses of Red Squill.
257 257
h) Give examples of two probiotics.
i) Write down the uses of Psoralea.
j) What down the name of the precursors involved in the biosynthesis of Tropane
alkaloids?

Q3 a) Define and classify plant tissue culture. (5)

b) Write an account on the nutritional requirements for the in vitro growth of plant (6)
257 257 tissue. 257 257 257 257 257 257

c) Write down the applications of plant tissue culture in the production of bioactive (4)
plant metabolites.

257 257 257 257 257 257 257 257

 Q4 a) Define and classify glycosides with suitable examples. (5)
b) Write down the biological source, microscopic features, chemical constituents (10)
and uses of Indian Senna.
257
Q5
257
a) Describe257
schematically the
257
‘Sta-Otto’ method
257
of isolation of257glycosides. 257
(5) 257

b) Write down the biological sources, chemical constituents and uses of Chirata (10)
and Rhubard.

Q6 a) Write down the microscopic features of aloe leaf. (5)

b) Describe the methods of cultivation and collection of Digitalis and Dioscorea. (10)

Q7 a) Describe the biosynthetic pathways for the bio-production of indole alkaloids (5 x2 =10)
257 257 257
and steroidal aglycones. 257 257 257 257 257

b) Describe schematically the biosynthesis of different amino acids via. shikimic (5)
acid pathway.

Q8 a) Write down the biological sources, method of preparation, physical properties (10)
and uses of papain and diastase.
b) Write note of poisonous plants of India. (5)
257 257 257 257 257 257 257 257
Q9 a) Give an account on marine drugs with special emphasis on antimicrobial (10)
agents and marine toxins.
b) Write short note on nutraceuticals. (5)

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

 Registration no:

Total number of Pages: 02 B. Pharma.

257 257 257 257 257 257 257
15PH506257
5th Semester Regular Examination 2017-18
Pharmaceutical Microbiology
BRANCH: B.Pharma.
Time: 3 Hours
Max Marks: 100
Q.CODE: B117
Answer Question No.1 and 2 which are compulsory and any four from the rest.
257 257 257 257 257 257 257 257
The figures in the right hand margin indicate marks.

Q1 Multiple Choice Questions :

a) Teichoic acid is present in ______ bacteria. It consists of ________ and (2 x 10)
_______.
b) Penicillin was isolated from the fungus ________. It acts on ________ of
bacteria.
257 257
c) Moist heat 257
sterilization involves
257
a temperature
257
of ____ and257a pressure of ____.
257 257
d) Gram staining involves _______ as the primary stain, _______ as the mordant
and ______ as the counterstain.
e) Autoclaving is which type of sterilization?
i. Physical
ii. Chemical
iii. Biological
iv. None of these
257 257
f) Which one 257
is a dimorphic257fungus? 257 257 257 257
i. Candida tropicalis
ii. Candida albicans
iii. Penicillium notatum
iv. Penicillium chrysogenum
g) LPS is present in which type of bacterial cell wall?
i. Gram positive
ii. Gram negative
257 257 iii.257 Both Gram positive
257 and Gram257negative 257 257 257
iv. None
h) Acid fast staining is used to stain which bacteria?
i. Micobacterium sp.
ii. Mycobacterium sp.
iii. Mycrobacterium sp.
iv. None
i) Which of the following is an antifungal agent?
257 257 i. 257 Penicillin 257 257 257 257 257
ii. Streptomycin
iii. Nystatin
iv. Rifampin
j) Salmonella has:
i. Monotrichous flagella
ii. Lophotrichous flagella
iii. Peritrichous flagella
257 257 iv.257 Amphitrichous 257flagella 257 257 257 257

257 257 257 257 257 257 257 257

 Q2 Answer the following questions : (2 x 10)
a) What do you mean by the term ‘Antibiotics’?
b) Define ‘Gram staining’.
c) What is the meaning of ‘Sterilization’?
257 257
d) Who discovered
257
‘Penicillin’?
257 257 257 257 257

e) Define the term ‘Fermentation’.

f) Which is the first phase of Bacterial growth curve? What is its significance?
g) Define ‘Mutation’.
h) Define and differentiate genomic and plasmid DNA.
i) What is the difference between ‘dry heat’ and ‘moist heat’ sterilization?
j) What is the importance of ‘Sex pili’?
257
Q3
257
a) Differentiate
257 257
between prokaryotes 257
and eukaryotes. 257 257
(10) 257

b) Write down the mechanism of moist heat sterilization. (5)

Q4 a) Describe the phases of bacterial growth curve. (10)

b) Differentiate between endotoxin and exotoxin. (5)

Q5 a) Briefly describe the different types of bacteriological culture media. (10)

b) Write down the mechanism of filtration sterilization. (5)
257 257 257 257 257 257 257 257

Q6 a) Write a note on Gram staining. (10)

b) Describe the different modes of bacterial nutrition. (5)

Q7 a) Differentiate between Gram positive and Gram negative bacteria with suitable (10)
examples.
b) Write down the different types of mutation. (5)
257 257 257 257 257 257 257 257
Q8 a) Write a note on Phenol Coefficient. What is its significance? (10)
b) Write down the different modes of action of important antibiotics. (5)

Q9 a) Write a note on the beneficial role of microbes. (10)

b) Write down the steps of conjugation with suitable diagram. (5)

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

Registration no.

Total Number of pages: 01 B.Pharma.

PH.5.1
5th Semester Back Examination 2017-18
Pharmaceutics –IV (Pharm. Tech. -I)
257 257 257
BRANCH: B.Pharma.
257 257 257 257 257

Time : 3 Hours
Max Marks :70
Q. Code: B118
Answer Question No. 1 which is compulsory and any five from the rest .
The figures in the right hand margin indicate marks.

257 Q1257 Answer the257 following questions

257 : 257 257 257 (2x10) 257

a) Classify liquid dosage form according to the route of administration.

b) Write on uses of Drops as liquid formulation.
c) Add a note on multiple emulsion.
d) What is phase inversion temperature and what is its significance?
e) Define suspension and mention the difference between flocculated and
deflocculated suspension.
257 257 f) What is the
257 need of granulation?
257 257 257 257 257

g) What type of problems may arise if lubricant is not added during tablet
preparation?
h) Differentiate between cream and paste.
i) Write advantage of lanolin as ointment base.
j) How suspending agents act in a suspension ?Give some examples of
suspending agents.
Q2 a) Write short notes on Mouth dissolving tablet and Chewable tablet with (5)
257 257 257 257 257 257 257 257
example of each.
b) Explain defects found in tablet dosage form during manufacturing ,and what (5)
are the reasons?
Q3 a) Write about the types and rationale of different coating processes. (5)
b) Explain equipments involved in coating. (5)

Q4 a) What are the problems associated with the manufacturing of liquid dosage (5)
257 257 forms? 257 257 257 257 257 257

b) Discuss in brief on various types of monophasic liquid dosage forms. (5)

Q5 a) Describe any one industrial scale filling machines for hard gelatin capsules. (5)
b) Write in brief on quality control and storage of capsule dosage form. (5)
Q6 a) What are the ingredients needed to manufacture soft gelatin shells and What (5)
types of different soft gel fill matrices are used ?
b) What are the rationale for the selection of soft gels dosage forms? (5)

257 Q7257 Write in detail

257 on pharmaceutical
257 Granulation
257 equipments. 257 257 (10) 257

Q8 Write short answer on any two of the following : (5x2)

a) Write on the mechanism of granule formation.
b) Write a short note on packaging system of liquid dosage forms.
c) Ideal properties of packaging materials.
d) Discuss about various types of creams.

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

Registration No:

Total Number of Pages: 01 B.Pharma.

PH.5.3

5th Semester Back Examination 2017-18

257 257 257 257
Applied Microbiology
257 257 257 257

BRANCH : B.Pharma.
Time: 3 Hours
Max Marks: 70
Q.CODE: B120
Answer Question No.1 which is compulsory and any five from the rest.
The figures in the right hand margin indicate marks.
257 257 257 257 257 257 257 257
Q1 Answer the following questions : (2 x 10)
a) What does generation time mean? What is incubation period ?
b) What is the difference between ‘stain’ and ‘strain’?
c) What is the meaning of mutation? Give one example of a mutagen.
d) Name one thermophilic and one mesophilic microorganism.
e) Why does the microbial growth curve plateau at the stationary phase?
f) Differentiate between transformation and transduction.
257 257 g) What is the
257 other name of257
vitamin B12 and257
which microorganism
257 can produce
257 257
it?
h) Penicillin and Streptomycin are produced by which fungi?
i) What is dimorphic fungus? Give an example.
j) What is exotoxin? Define pyrogen.

Q2 a) Write a note on membrane filtration technique. (5)

b) Differentiate between probiotics and prebiotics. (5)
257 257 257 257 257 257 257 257
Q3 a) Write down the different methods of microbial culture preservation. (5)
b) Describe the principle of radiation sterilization. (5)

Q4 a) Differentiate between flagella, cilia and fimbrae. (5)

b) Briefly describe the basic features of Gram negative bacterial cell wall. (5)

Q5 a) Differentiate between selective and differential media stating examples of (5)

257 257
each. 257 257 257 257 257 257
b) Briefly write about the different microbiological assays of antibiotics. (5)

Q6 a) Describe the principle of Zeihl Neelsen staining. Which organisms can be (5)
viewed using this staining technique?
b) Differentiate between plasmid and genomic DNA. (5)

Q7 Describe the working principle of an autoclave with mechanism of killing of (10)

microbes.
257 257 257 257 257 257 257 257

Q8 Write short answer on any TWO : (5 x 2)

a) Lyophilization.
b) Protoplast fusion.
c) SEM.
d) R.W. Coefficient.

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257 257 257 257 257 257 257 257

Registration No:

Total Number of Pages: 01 B.Pharma.

PH.5.5
5th Semester Back Examination 2017-18
PHARM.CHEMISTRY - V (MED. CHEM - I)
257 257 257 257BRANCH : B.Pharma.
257 257 257 257
Time: 3 Hours
Max Marks: 70
Q.CODE: B121
Answer Question No.1 which is compulsory and any five from the rest.
The figures in the right hand margin indicate marks.

Q1 Answer the following questions : (2 x 10)

257 257 a) What is geometric
257 isomerism?
257 Give example.
257 257 257 257

b) Classify adrenergic receptor mentioning atleast one agonist.

c) Mention the factors involved in drug-receptor interaction.
d) Mention the postulates of the Hansch analysis.
e) Define autacoids with example.
f) What are Eicosanoids?
g) Write down the structures of Chlorpheniramine and Ibuprofen.
h) Define the term Molecular connectivity Index?
257 257 i) Write down
257 the structures 257
of any two NSAIDs.
257 257 257 257

j) Define the term partition coefficient.

Q2 a) Classify sympathomimetics and discuss their therapeutic uses. (5)

b) Write down the synthetic scheme of Salbutamol and Phenylephrine. (5)

Q3 a) How do cholinergics interact with binding sites, discuss with an example. (5)
b) Discuss on SAR of cholinergic drugs. (5)
257 257 257 257 257 257 257 257
Q4 a) Define and classify antihistamine with examples. (5)
b) Outline the mode of action and SAR of classic antihistamines (5)

Q5 a) Discuss synthesis of Chlorpheniramine, Promethazine and Cimetidine. (5)

b) Write a note on Eicosanoids. (5)

Q6 a) What are the pathophysiology of inflammation, mention the cardinal (5)

257 257 symptoms 257of inflammation.
257 257 257 257 257
b) Outline the synthesis and mode of action of the following. (5)
Phenylbutazone, Diclofenac sodium.

Q7 Discuss in brief the antipyretic and analgesic drugs and mention their mode of (10)
action and SAR of Salicylic acid derivatives & heteroarylacetic acid
derivatives.

257
Q8257 Write short
257
answer on any
257
TWO : 257 257 257
(5 x 2) 257
a) Antiulcer drugs.
b) Neuromuscular blocking agents.
c) Physicochemical aspects of drug design.
d) Free wilson model and Hansch analysis.

257 257 257 257 257 257 257 257

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257 257 257 257 257 257 257 257

Registration No:

Total Number of Pages: 01 B.Pharma.

PH.5.7

5th Semester Back Examination 2017-18

257 257 257 257 Pharmacology
257 –I 257 257 257
BRANCH : B.Pharma.
Time: 3 Hours
Max Marks: 70
Q.CODE: B122
Answer Question No.1 which is compulsory and any five from the rest.
The figures in the right hand margin indicate marks.
257
Q1257 Answer 257 257
the following questions : 257 257 257
(2 x 10) 257

a) Drug metabolism
b) Blood brain barrier
c) Tolerance
d) Teratogenicity
e) Therapeutic index
f) Idiosyncrasy
g) Plasma t1/2
257 257
h) 257
Bioavailability 257 257 257 257 257

i) Prodrug
j) Apparent volume of distribution

Q2 a) Define and classify receptor. (5)

b) Briefly discuss about enzyme linked receptor. (5)

Q3 Write short notes on :

257 257 a) Synergism
257 257 257 257 257 (5) 257

b) Antagonism (5)

Q4 a) Discuss the different factors that responsible for parkinsonism. (5)

b) Briefly discuss about L-dopa as antiparkinsonism drug. (5)

Q5 a) Define analgesic. Classify analgesic drugs. (5)

b) Write down the mode of action, therapeutic application and side effect of (5)
257 257 Aspirin. 257 257 257 257 257 257

Q6 a) Define and classify sedative and hypnotics. (5)

b) Write shortly about Benzodiazepine. (5)

Q7 a) What are the different stages of general anaesthesia. (5)

b) Illustrate the term pre-anaesthetic medication. (5)
257 257 257 257 257 257 257 257
Q8 Write short answer on any TWO : (5 x 2)
a) Allopurinol
b) Narcotic analgesic
c) Tricyclic antidepressant

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

Registration No:

Total Number of Pages: 01 B.Pharma

PH.5.9
5th Semester Back Examination 2017-18
Pharm. Analysis - II
257 257 257 257 BRANCH : B.Pharma
257 257 257 257
Time: 3 Hours
Max Marks: 70
Q.CODE: B123
Answer Question No.1 which is compulsory and any five from the rest.
The figures in the right hand margin indicate marks.

Q1 Answer the following questions : (2 x 10)

257 257
a) What is the
257
self indicator?257 257 257 257 257

b) Define the term oxidizing and reducing agent.

c) Mention the factors that affect diazotization titrimetry.
d) What is the principle involved in coulometry?
e) What is the equivalent weight?
f) Mention the application of pH meter.
g) Mention the applications of potentiometry.
257 257 h) What is the
257 redox indicator?
257 257 257 257 257
i) What is the cell representation?
j) Define the term Iodimetry titration.

Q2 a) Explain in detail about the Instrumentation of coulometry (5)

b) Explain the theory involved in conductometry. (5)

Q3 a) Define the term nephlometry and turbidimetry. (5)

257 257 b) Write down
257
the working principle
257
of nephlometry
257
and turbidometry.
257 257 (5) 257

Q4 a) How will you measure the electrode potential? (5)

b) Explain the term oxidation-reduction curve with example. (5)

Q5 a) What are the differences between zone electrophoresis and gel (5)
electrophoresis?
b) Discuss the process involved in gel electrophoresis. (5)
257 257 257 257 257 257 257 257

Q6 a) Explain the theory involved in redox titration. (5)

b) What are the differences between Iodimetry and Iodometry titration? (5)

Q7 Explain the principle and procedure involved in Kjeldahl method for nitrogen (10)
estimation.

257 Q8257 Write short

257 answer on any
257 TWO : 257 257 257 (5 x 2) 257
a) Radio immuno assay
b) Karl Fischer titration
c) Polarography
d) Amperometry

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

257 257 257 257 257 257 257 257

Registration No:
Total Number of Pages: 01 B.Pharma.
PH.5.11
5th Semester Back Examination 2017-18
Community Pharmacy and Health Education
257 257 257 257
BRANCH : B.Pharma.
257 257 257 257

Time: 3 Hours
Max Marks: 70
Q.CODE: B119
Answer Question No.1 which is compulsory and any five from the rest.
The figures in the right hand margin indicate marks.

257
Q1257 Answer 257the following questions
257
: 257 257 257
(2x10) 257
a) What are the objectives of first aid?
b) What is Shock ?
c) Define physical health and mental health.
d) What is Epidemiology ?
e) What do you mean by balanced diet? Give example.
f) Write the two diseases occur due to malnutrition.
g) Write two live vaccines along with diseases in which they are used.
h) Which organ is affected in trachoma? What is causative organism of it?
257 257 257 257 257 257 257 257
i) Differentiate between tuberculoid and lepromatous leprosy.
j) What is trace elements? Give examples.

Q2 Give the causative organisms, mode of transmission and prevention of the

following communicable diseases :
a) Chicken pox (5)
b) Malaria. (5)
257
Q3257 a) 257
Explain demography cycle257with its different257
stages. 257 257
(5) 257

b) Describe behavioural and mechanical methods of contraception. (5)

Q4 a) Discuss descriptive epidemiology in detail. (5)

b) Write about the role of pharmacist in community health care. (5)

Q5 a) Write on emergency treatment of snake bite or burns. (5)

b) Write short notes on cardio-pulmonary-resuscitation (CPR). (5)
257 257 257 257 257 257 257 257

Q6 a) Write about oral contraceptive pills. (5)

b) Write on immunization schedule. (5)

Q7 Write short notes on :

a) OTC Drugs (5)
b) HIV - AIDS (5)

257 Q8257 Write short

257 answer on any 257 TWO : 257 257 257 (5 x 2) 257

a) Legal requirements for establishment of Retail Drug Store.

b) MDR - TB.
c) Classification of different foods.
d) Sabin vaccine.

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