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    Anti Tetanus Serum I

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    Robby Effendy
    ATS is a solution of purified antibodies prepared from equine blood that is used to both prevent and treat tetanus. It is available in ampoules of various sizes containing different amounts of international units (IU). ATS works by neutralizing toxins produced by Clostridium tetani, the bacteria that causes tetanus. For prophylaxis, a dose of at least 1500 IU is injected after an injury to provide protection for 1-3 weeks. Active immunization with tetanus vaccine is also recommended to provide long-term immunity. For treatment of tetanus, 10000 to 20000 IU is injected along with other supportive medications.

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    Anti Tetanus Serum I

    Uploaded by

    Robby Effendy
    265 views2 pages
    ATS is a solution of purified antibodies prepared from equine blood that is used to both prevent and treat tetanus. It is available in ampoules of various sizes containing different amounts of international units (IU). ATS works by neutralizing toxins produced by Clostridium tetani, the bacteria that causes tetanus. For prophylaxis, a dose of at least 1500 IU is injected after an injury to provide protection for 1-3 weeks. Active immunization with tetanus vaccine is also recommended to provide long-term immunity. For treatment of tetanus, 10000 to 20000 IU is injected along with other supportive medications.

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    ATS is a solution of purified antibodies prepared from equine blood that is used to both prevent and treat tetanus. It is available in ampoules of various sizes containing different amounts of international units (IU). ATS works by neutralizing toxins produced by Clostridium tetani, the bacteria that causes tetanus. For prophylaxis, a dose of at least 1500 IU is injected after an injury to provide protection for 1-3 weeks. Active immunization with tetanus vaccine is also recommended to provide long-term immunity. For treatment of tetanus, 10000 to 20000 IU is injected along with other supportive medications.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    265 views2 pages

    Anti Tetanus Serum I

    Uploaded by

    Robby Effendy
    ATS is a solution of purified antibodies prepared from equine blood that is used to both prevent and treat tetanus. It is available in ampoules of various sizes containing different amounts of international units (IU). ATS works by neutralizing toxins produced by Clostridium tetani, the bacteria that causes tetanus. For prophylaxis, a dose of at least 1500 IU is injected after an injury to provide protection for 1-3 weeks. Active immunization with tetanus vaccine is also recommended to provide long-term immunity. For treatment of tetanus, 10000 to 20000 IU is injected along with other supportive medications.

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    Anti Tetanus Serum I.P.

    (A T S)
    It is used for both preventing and curing Tetanus.
    ATS is a solution of purified antibodies prepared  
    from Equine Blood. It is available in Ampoules of
    1 ml., 3-4 ml and 5 ml.
     
    Enzyme refined equine globulin solution
    1500 IU/1ml ampoule
    Active Ingredients :
    10,000 IU/3.4ml vial
    20,000 IU/5ml vial
    1ml ampoule X 10,
    1ml ampoule X 100 
    Packing :  
    3.4ml vial X 10 
    5ml vial X 10
    Category : Passive immunising agent.
    By subcutaneous or intramuscular injection Prophylactic not less than
    Dosage    :  
    1500 units preferably under the cover of antihistamines
    Adverse Drug Occasional sensitivity reactions accute anaphylactic shock which needs
    Reaction : immediate treatment.
    Sensitivity tests should be done whenever possible before
    administration.
    Precautions :
    Antihistamines and treatment for anaphylactic shock should be
    kept ready.
    TETANUS ANTITOXIN
    Tetanus antitoxin is prepared by hyperimmunising horses with tetanus toxin. Blood plasma obtained
    from the hyperimmunised horses which is rich in antibodies to tetanus toxin, is enzyme refined
    purified and concentrated. The antitoxin has the specific power of neutralising the toxin secreted
    by Clostridium tetani, the causative organism of tetanus.
    Use in prophylaxis :
    A dose of 1500 international units of tetanus antitoxin should be injected subcutaneously or
    intramuscularly, after testing for serum sensitivity (see below for reactions to horse serum). It should
    be injected as soon as possible after tetanus prone injury, such as wounds contaminated with soil,
    dirt etc. Adequate surgical treatment of wounds with the use of suitable antibiotics should be carried
    out in addition to the prophylactic injection of antitoxin, if the patient is sensitive to serum or has
    been actively immunised previously with tetanus vaccine (adsorbed) the patient should receive the
    dose of tetanus vaccine(adsorbed) only and not tetanus antitoxin. The use of antitoxin gives
    protection for 1 to 3 weeks only. While tetanus vaccine gives long time immunity and is cheaper and
    practically free from reactions. It is also adviced that simultanously with the administration of the
    prophylactic dose of tetanus antitoxin active immunization should be started. This is done by
    injecting at the same time in another arm, 0.5ml of adsorbed tetanus vaccine (Tet./Vac./P.T.A.P.)
    since adsorbed tetanus vaccine is able to actively immunize against tetanus even in the presence of
    tetanus antitoxin (B.J.Vakil et al Ind. J.Med. Research, 1968 Vol.56 pp 1188-1201). A second dose
    of 0.5ml adsorbed tetanus vaccine only is to be injected between 1 to 2 months after the first dose of
    vaccine and a third dose 6 to 12 months after the second dose to produce adequate long term
    protection.
    Use in treatment of tetanus:
    It is recommended that a dose of 10000 to 20000 I.U. of tetanus antitoxin should be injected
    intramuscularly soon after admission of patient with symptoms of tetanus such as lockjaw, muscular
    spasms, etc. after taking precautions against possible serum reaction. The dose of 10000 to 20000
    I.U. is now considered adequate (J.C.Patel et al. proceeding of the first international conference of
    tetanus p 346, B.J.Vakil et al ibid, p.337 the study group of tetanus, Bombay 1965). In addition,
    symptomatic treatment consisting of antibiotics, sedatives, anticonvulsants and muscle relaxants
    may be given. The patient should be actively immunized with adsorbed tetanus vaccine
    (Tel/Vac/PTap), at the time of discharge and advised to return after 1 or 2 months for a second dose
    of the adsorbed tetanus and 6 to 12 months later for the third dose.

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