This document summarizes preliminary data from case reports on COVID-19. It discusses diagnosis of COVID-19 using RT-PCR tests and how CT chest scans can help assess patient status. Severe cases are often associated with ARDS. Several potential treatments are mentioned including Remdesivir, Lopinavir/Ritonavir, and chloroquine, but large trials are still needed to establish efficacy and safety. Oxygen therapy and non-invasive ventilation like CPAP are beneficial. Steroids may help severe cases with cytokine storm, while generally steroids are not recommended due to possible increased viral shedding.
This document summarizes preliminary data from case reports on COVID-19. It discusses diagnosis of COVID-19 using RT-PCR tests and how CT chest scans can help assess patient status. Severe cases are often associated with ARDS. Several potential treatments are mentioned including Remdesivir, Lopinavir/Ritonavir, and chloroquine, but large trials are still needed to establish efficacy and safety. Oxygen therapy and non-invasive ventilation like CPAP are beneficial. Steroids may help severe cases with cytokine storm, while generally steroids are not recommended due to possible increased viral shedding.
This document summarizes preliminary data from case reports on COVID-19. It discusses diagnosis of COVID-19 using RT-PCR tests and how CT chest scans can help assess patient status. Severe cases are often associated with ARDS. Several potential treatments are mentioned including Remdesivir, Lopinavir/Ritonavir, and chloroquine, but large trials are still needed to establish efficacy and safety. Oxygen therapy and non-invasive ventilation like CPAP are beneficial. Steroids may help severe cases with cytokine storm, while generally steroids are not recommended due to possible increased viral shedding.
This document summarizes preliminary data from case reports on COVID-19. It discusses diagnosis of COVID-19 using RT-PCR tests and how CT chest scans can help assess patient status. Severe cases are often associated with ARDS. Several potential treatments are mentioned including Remdesivir, Lopinavir/Ritonavir, and chloroquine, but large trials are still needed to establish efficacy and safety. Oxygen therapy and non-invasive ventilation like CPAP are beneficial. Steroids may help severe cases with cytokine storm, while generally steroids are not recommended due to possible increased viral shedding.
Prelim data from case reports and case studies from different resources – Lancet/BMJ, NEMJ, Infection disease journal Mukhmohit singh Sensitive test -RTPCR – Diagnosis by RT-PCR (FDA approved kits) CT chest is very good indicator for clinical status of patient
severe cases - often associated with NAGMA, ARDS
Treatment – multiple RCTs are on..
• Remdesivir – new drug, promising result, toxicity and safety not established • Lpv/R – established drug profile, shows good results, but larger cohort is required to draw conclusive evidence • Lpv/R/Ribavarin – triple drug – o reasonable anti corona virus effects o positive outcomes in animal models for MERS/CoV o small human cohorts (< 40-50 patients) have been tested, results awaited o dosing, toxicity not yet established • chloroquine and hydroxychloroquine o shown to have innate antiviral action – to what extent – unknown? o small cohort, quasi trials are done..(I am working on data, non-conclusive results as of now) o maybe associated cardiac effects, porphyria, haematological disorders maybe of concern • Oseltamivir – our life savour drug in Swine Flu pandemic – is against the H and N (anti – influenza) .. still to be researched – but I personally do not have any positive results from the data compiled and pre-liminary analysis)
what proves best:
- Oxygen therapy (helmet > nasal) - Non-invasive ventilation (CPAP better results than BiPAP – positive results from larger cohort) - empiric anti-bacterial to avoid secondary infections
in severe cases of cytokine storm:
- steroids and immunosuppressive - Tocilizumab – mAb – maybe of some benefit in case of known and established cytokine storm in severe COVID19 infection cases. case series have been reported with low evidence - Note: Steroid is usually ‘not’ indicated. they may promote viral shedding in early course of the disease.
