Development of an aptamer-based platform to detect novel

Tuberculosis markers in human serum

Achira Labs Pvt. Ltd.

Dhananjaya Dendukuri (Call 1)

The Journey
A simple, yet accurate serological test for TB is an urgent unmet need. Through its BIG grant, Achira has developed a multiplexed,
antigen detection test for TB using novel aptamer reagents. These nucleic acid based reagents are specific enough to pick up two
different TB antigens that are secreted by the bacillus. The aptamer reagents have been ported onto Achira’s proprietary microfluidics
platform where they are currently undergoing clinical performance evaluation. Achira has benefitted from the BIG grant through funding
for a high-impact, high-risk project and also through access to the larger biotech community in India and timely advice from the review
committees at BIRAC and CCAMP. Once validated, we believe that this test will be an important addition to the battle against TB

Development of trypsin resistant PAN reactive trypsin

antibodies for industrial application

Affigenix Biosolutions Private Limited

Arumugam Muruganandam (Call 3)

The Journey
Affigenix Biosolutions Private Limited is on its way in meeting the milestones of DBT-BIRAC BIG 3 grant project titled “Development
of pan reactive Trypsin resistant antibodies for industrial applications” in association with C-CAMP , BIG partner. We currently have
clients from Biopharma industries who are using our anti-Trypsin antibodies developed from the proof-of-concept studies and have
been successful in generating revenues. In case of Affigenix, BIRAC seed to budding entrepreneurs have indeed started to bloom early
and bear fruits and we are confident of anchoring our roots in India and branch into the world market soon.

BIG Report 2015 | 41 |

To demonstrate Proof of Concept for a novel, non-invasive exosome - based
screening (for early detection) cum diagnostic kit for multiple cancers
(using one test) utilizing patient derived biofluids

Exocan Healthcare Technologies Pvt. Ltd.

Aman Sharma (Call 4)

The Journey
The BIG project “To demonstrate Proof of Concept for a novel, non-invasive exosome-based screening cum diagnostic kit for multiple
cancers utilizing patient derived biofluids” is related to development of a liquid biopsy test to detect and diagnose cancer(s) at molecular
level. For this, we aim to assemble the technology into a kit for non-subjective, non-expensive and single test based cancer(s)diagnosis.
The technology should reduce patient’s travel time, omits the need of highly skilled medical professionals, and enhances accessibility
of oncodiagnostics to the larger population. Our goal is to implement it for early cancer screening purposes once the proof-of-concept
is ready. BIG funding has been instrumental in creating further grant opportunities for me and I formed a company, established multiple
National, International collaborations.

Production of collagen and by production from

fresh water fish origin for biomedical applications

Amnivor Medicare Pvt. Ltd

Santanu Dhara (Call 2)

The Journey
We (Amnivor Medicare Pvt. Ltd.) have developed a procedure for isolation of collagen with higher thermal stability from fish scales of
fresh water origin and prepared collagen based downstream products for wound healing and tissue engineering applications in a cost
effective way. This source is safer i.e. less chance of disease transmission and economical as compared with bovine sources. In our
country most of these products are imported and costly, and therefore not affordable to even middle class people. Our indigenously
developed technology can improve health care delivery in a cost-effective way and hence serve mass population specifically poor
sectionof the society. The proposed collagen source will also facilitate to overcome the religious barrier. The BIRAC has supported us to
set up pilot scale plantand arranged training on entrepreneurship skill development.

| 42 | BIG Report 2015

Process Crystallization as a Purification Tool
to Therapeutic Antibody

Bhami’s Research Laboratory

Bhami Shenoy (Call 4)

The Journey
Monoclonal antibodies (MAbs) have been widely used as treatments for a range of indications, including oncology, and infectious
diseases. Manufacturing costs now represent 20 –25 % of annual sales. The downstream processing costs are 50 – 80 % of the total costs.
There is an urgent need for alternative strategies to purify MAbs to reduce the costs. We purified trastuzumab, directly from cell culture
media using crystalline technology and compared it with soluble with regard to its purity, biosimilarity and efficacy. The current strategy
can be used to eliminate costly Protein A column to reduce the cost of manufacturing.

Pharmacological Evaluation of N-oxide Metabolite of

Antipsychotic Drug for Type 2 Diabetes

Crystalin Research Pvt. Ltd.

Ashwini Nangia (Call 1)

The Journey
Diabetes drugs are insulin sensitizers and/or insulin releasers, e.g. metformin, glitazones, and glipizide, tolbutamide, followed by the
incretin activators or DPP-IV inhibitor gliptin drugs. The BIG project explores a new class of N-oxide drugs which are postulated to
interact with the -cell signaling pathway to activate insulin release and also increase the islet density and pancreatic cells mass. A proof
of concept study of BLNO was carried out in insulinogenic cell lines and Wistar rats. BIG funding was helpful to carry out the early
explorations. Now we have POC results in hand on a novel first in class lead drug for type 2 diabetes.

BIG Report 2015 | 43 |

Green Manufacturing of Cephalosporin Antibiotics
Using Recombinant Deacetylase

Cellzyme Biotech
Rajkumar Rajagopal(Call 4)

The Journey
CELLZYME BIOTECH, a Coimbatore based start-up was founded by Dr. Rajkumar Rajagopal in 2013. Antibiotics are manufactured at -50°C
and require harmful organic solvents and high amounts of alkali leading to the regulatory hurdles due to the formation of undesired
impurities. Our BIG idea stems on addressing the unmet need of USFDA regulated pharmaceutical industries. Our proposed enzymatic
process is cost-effective, greener and safer. Our central focus in BIRAC-SPARSH project is to develop an iron rich protein hydrolysate from
rice bran to address the nutritional requirements of infants and young mothers. In addition to the financial support, BIRAC supported us
with mentoring as BIRAC-IGNITE fellowship to attend IGNITE 2015 at Judge Business School, University of Cambridge.

Hand-held Imaging Flow Cytometer for

Quantitative Diagnosis of Malaria

Sai Siva Gorthi (Call 3)

The Journey
Biotechnology Ignition Grant of BIRAC has enabled us in realizing a handheld “imaging” based malaria diagnostic device which fully
automates the conventional microscopy based analysis- the gold standard method of malaria detection. The product consists of a
custom designed portable digital microscope augmented with dedicated microfluidic lab-on-chips to enable process automation, as
well as, cost-effective implementation. This self-operable in-vitro point-of-care quantitative diagnostic device requires only a drop-of-
blood, and examines lakhs of cells on a single-cell level within a span of five minutes at such an affordable cost-per-test that it could be
used by people living in rural areas as well.

| 44 | BIG Report 2015

Establishing and Validating a novel drug target in
mycobacterium tuberculosis

GeNext Genomics
Supriya Kashikar (Call 2)

The Journey
GeNext Genomics (GNG) Pvt. Ltd. team is validating a unique target and developing a novel therapeutic in the form of a new biological
entity for the cure of tuberculosis. “Dying of tuberculosis: The earth is suffocating- Swear to make them cut me open, so that I won’t be
buried alive- Fredrich Chopin”. TB kills two million individuals every year, infecting one third of world’s population. A novel and effective
molecule will not only cure the disease but also have huge social impact. BIRAC-BIG has provided a niche for us to take up high risk
project and deliver. The mentorship program provided by C-CAMP helped us nurture our entrepreneur journey.

mCAPD Mobile Continuous Ambulatory Peritioneal Dialysis

Gowrishankar W (Call 3)

The Journey
BIRAC is the main facilitator to bring my dream of a wearable dialysis device to reality through its BIG grant, bringing my simple idea
into a proof of concept in a BIG way. BIRAC has been the magical “open sesame” in getting BIG incubation support, angel investments,
network with doctors and patients. It has provided me with a bigger launchpad, lifting my project to higher levels with all stake holders.
BIRAC shall surely usher in a biggest relief for renal patients throughout the world to lead a normal.

BIG Report 2015 | 45 |

Novel, Percutaneous Soft Tissue Biopsy System
with assisted Hemostasis

Indio Labs Pvt. Ltd.

Siraj Bagwan (Call 3)

The Journey
IndioLabs has developed a novel semi-automated biopsy device, integrating two unique technologies. BioScoop™ is a novel needle
designed to pierce through and sample soft tissue with a single needle. Simultaneously, the BxSeal™ technology injects a controlled
volume of hemostatic agent into the tissue cavity, thereby immediately stabilizing any internal hemorrhaging from the tissue. Together,
they offer a novel, simple, safe and cost-effective solution for liver biopsy.
The need of a device solution was identified during clinical immersion at the Stanford India Biodesign Programme at AIIMS. Indio Labs
was funded under the BIG scheme to further develop the tissue resection technology and needle characterization/calibration. The
mentors at C-CAMP helped from all aspects in developing the relevant connections and made our entrepreneurial journey a smooth one.

Intraosseous Device

Jayant Karve (call 1)

The Journey
‘Ozyn-D’ a novel intraosseous device allows immediate vascular access through long bones in patients having difficult intravenous access
in clinical emergencies. Also, a huge requirement exists in defence segment. It is acompact, lightweight, affordable and easy-to-use even
by paramedics in resource constrained settings. Available as a pre-packaged, ready-to-insert, sterile disposable device, it becomes non-
reusable after single insertion. Protected by the PCT application (patent filed) it has undergone third party biocompatibility testing.
With ‘Make in India’ approach the development has been supported by BIRAC through the BIG. Having completed the in-human cadaver
study at AIIMS, New Delhi it is now ready for First-in-Human (FIH) clinical trial.

| 46 | BIG Report 2015

World’s Most Affordable, long life Defibrillator that is Battery less,
Hand Cranked, Rugged with reusable paddles.

Jeevtronics Pvt. Ltd.

Aniruddha Atre &
Ashish Gawade (Call 2)

The Journey
Using BIRAC-BIG support, Jeevtronics has developed a proof-of-concept for a life saving defibrillator with built-in generator, audio-
ECG (easier to interpret vs. Display ECG) and 4 times more affordable. Two new patents were filed during the BIG phase. Novel power
electronics thus developed has enabled achievement of 4 times lower price. This will work even in rural India, where electricity is not
available for 24 hours/ day. Audio ECG will enable relatively lower skilled personnel to operate this device. This will help improve the
defibrillator to bed ratio in an ICU (presently at 1:50 vs. 1:3 in UK).

Biomimetic Bone Substitutes

Sitalogics Pvt. Ltd.

K Srinivas Rao (Call 2)

The Journey
In SITALOGICS we have a mission to develop innovative biomaterial and regenerative technologies that are cost effective in India. We
are an integrated developer and manufacturer of regenerative bio-materials. We aim to become a world player in five year through our
proprietary cell-interactive biomaterial technologies capable of multiple applications in life science including medical research tools,
drug development and therapeutics Company is focused on translational process towards commercialization of biomedical devices for
wound care, orthobiologic bone graft substitute, biologic haemostat devices apart from research and development efforts for advanced
devices for cellular therapy and tissue engineering We will soon manufacture, formulate, research, develop, process, refine, import,
export, wholesale and/or retail trade in medical devices, Bio Implants, Health Care Products and Tissue Engineering.

BIG Report 2015 | 47 |

3-D Printer Filaments that are Biomaterial-Based
and Eco-Friendly

Karthik Chethan Venkateshan (Call 3)

The Journey
Currently there is great demand for low cost environment friendly raw material for 3D printing industry in India. Our technology focuses
on developing 3D printable bio-based filaments wherein the formulation and processing characteristics have been optimized. Further,
the developed printable filament will meet requirements such as, biocompatibility and reduced material and process cost. Currently, we
are fine-tuning the various biomaterial formulations and their extrusion parameters. Progress has been made in developing printable
filaments. The BIG award from BIRAC has enabled us immensely to conduct innovative research on this particular technology and we are
indebted for this invaluable financial assistance.

Clonal propagation of elite genotype of orchid hybrids

synthesised in Manipur for commercial cultivation

Kwaklei & Khonggunmelei Orchids Pvt. Ltd.

Rajkumar Kishor (Call 2)

The Journey
Certain important orchid hybrids, viz., Aeridovanda Shiv Sidhu, Holcanthera MS Swaminathan, Renantanda Prof. G.J. Sharma, Renantanda
Kebisana Shija, Renantanda Momon Shija, etc. have been synthesised and registered with the Royal Horticultural Society, London by
Dr. Rajkumar Kishor. The ongoing project, under Biotechnology Ignition Grant (BIG) of BIRAC, focuses on selection of elite clones of the hybrids
and micropropagation for commercial cultivation. It also involves production of secondary hybrids using the above mentioned hybrids as
potential parents. This shall ensure a new range of breeds for future. Orchid hybrids of purely Indian origin shall definitely be novel and there is
high chance of establishing and controlling their market both nationally and internationally. This may help the local growers and entrepreneurs
avail new and surplus planting materials continuously.

| 48 | BIG Report 2015

Exploring Muga silk fibre as a promising suture material

Mugagen Laboratories Pvt. Ltd.

Utpal Bora (Call 2)

The Journey
The project is focussed on developing a standardized reeling and degumming protocol for Muga silk for eventually braiding and swaging
them into needles of appropriate size to make a complete surgical suture. The technological gap in degumming and braiding of wild
varieties of silk fibers are the major issues that the present innovation addresses. Besides the financial support to materialize our
idea, BIRAC has helped us in overcoming the communication and knowledge gap between industry, academia, regulatory bodies and
the market through several workshops and training programs. These programs have helped us in planning the course correction of
the current project and encouraged us to transcend the myopic vision of academic research and focus on developing actual bench
side products.

Rapid Detection of Acute Myocardial Infarction by sensing

Cardiac Markers using Micro Cantilever Technology

Nanosniff Technologies Pvt. Ltd.

Nitin Kale (Call 1)

The Journey
We have demonstrated aPoC for detection of Cardiac Markers (eg hFAbP), using MEMS Microcantilevers, that are released in the blood
after a person has a heart attack. We are now on-track to build a Point-of-Care instrument that can help a Doctor in determining whether
the patient with chest-pain is actually undergoing a heart attack or not. The instrument can be deployed at even Rural Hospitals &
it can be used by a nurse with results in 10 mins. Impact of myocardial infarction on our society is huge, in terms of loss of life and
incapacitation. Our innovation will have a game changing and positive impact on the society, and also on the economic life of our
populace. With BIRAC support we could demonstrate the proof of concept of our innovative idea.

BIG Report 2015 | 49 |

Synthetic biology for overproduction of 2,3-butanediol

Butacell Research Pvt. Ltd.

Nidhi Adlaka & Neha Munjal(Call 2)

The Journey
We have developed a technology for overproduction of 2,3-butanediol (BDO) using synthetic biology approach. BDO is a platform
chemical with wide application ranging from pharmaceuticals, fuels to rubber industry. Even though it has huge market potential,
India does not have indigenous technology for BDO production. Therefore, we aimed at developing cost effective technology for BDO
production using synthetic biology route for Indian market. It was not very easy to scale up and standardize the whole process but help
by BIRAC in both mentoring and providing monetary help has boosted us to reach our goal on time.

Development of a novel fungal bio control agent using protoplast fusion

technology to target drug resistant gastrointestinal cattle worms responsible for
reducing productivity, by an eco-friendly approach.

Wobble Base Bioresearch Pvt. Ltd.

Pratap Mukhopadhyaya (Call 2)

The Journey
The innovation pursued in this project was aimed at addressing the ever increasing menace of drug resistance in gastrointestinal
nematodes of dairy by way of developing a fungal spore formulation guided by an innovative gene expression profile and a unique
delivery device in the form of jaggery tablets. Due to drug resistance, farmers are tempted to use excess drugs that secrete in the milk
which can be controlled with this innovation. BIRAC has been of exceptional assistance in helping me give shape to my thoughts by more
than one ways including fund, guidance, networking and encouragement.

| 50 | BIG Report 2015

Novel Oncotherapeutic Measles Virus using eSAME system

Seagull Biosolutions Pvt. Ltd

Vishwas Joshi (Call 1)

The Journey
SBPL deployed the grant to develop & synthesize “Custom designed Measles viruses” which in-turn helped us to produce SBPL-0100
which kills a wide range of cancer cells without causing toxicity to non-cancerous cells. If successfully launched, SBPL-0100 would be
India’s first “Targeted Cancer therapy” and available at costs lesser than mABs therapies.
We have developed “Active Virosome Technology” platform useful for producing vaccines against viral diseases& used it to produce a
novel vaccine agent (SBPL-0200) for Dengue. SBPL has also produced world’s first VLP vaccine (SBPL-0500) for Measles and shown that
it can induce anti-measles immunity. SBPL-0500 has potential to be useful to vaccinate infants (age 4 to 9 months) which cannot be
vaccinated using current Measles vaccine. We thank DSIR & DBT GOI, The BMGF, USA and ICICI Bank.

Keyhole surgery replaceable artificial heart

SG ArtHeart Pvt. Ltd.

Sujoy K Guha (Call 3)

The Journey
In India particularly, terminal heart disease is a huge issue even affecting younger population. Hence the need for Artificial Heart over a
long life span is there especially that can withstand wear and tear.
BIRAC support under BIG has enabled giving practical form to the “In use repairable artificial heart” and the patent filing for it. Animal
study being worked out with the BIG support. Physical experiment and Animal experiment facilities at IIT Kharagpur; STEP IIT Kharagpur
gives the infrastructure for the development.

BIG Report 2015 | 51 |

Atomic Force Probing of cells for for clinical and
pharmaceutical applications

Shilps Sciences Pvt. Ltd.

Ashwin Lal (Call 4)

The Journey
Shilps Sciences is a life science and nano-tech company founded in December 2013 with the goal of bringing advancements in
nanotechnology to healthcare. We are developing an Atomic Force Microscope to detect mechanical parameters of cells at the nanometer
scale and use this as a biomarker for metastatic potential in cancer. We have also developed novel microfluidics for single cell analysis.
The goal is to use this for investigating cell heterogeneity, with implications in drug screening, cell based therapies and companion
diagnostics. The company has benefitted from BIRAC’s BIG program and sponsorship for Ignite, a Cambridge entrepreneurship workshop.

Multispectral Optical Imaging and Computing Technologies for Realtime

in situ Functional Characterization and Monitoring of
Cutaneous Wound Healing Progression

SkinCurate Research Pvt Ltd.

Debdoot Sheet /
Sri Phani Krishna Karri (Call 4)

The Journey
The innovation is a hardware software co-designed mobile app for real time noninvasive diagnostic imaging of dermatoses. At an initial
phase, the theoretical concepts to model the multispectal optical interactions with various wounds have been conceived. Construction
of multispectral image database for various wounds is under process. The outcome of the product enables real time in situ functional
characterization of dermatoses, avoiding biopsy procedure. The product helps paramedics reach out to resource constrained areas,
facilitating patient comfort centric point-of-care diagnosis. We are based in Kharagpur, incubated at STEP-IIT Kharagpur, and financially
supported by the BIRAC-BIG grant locally through the KIIT-TBI, Bhubaneswar.

| 52 | BIG Report 2015

A novel device to screen newborns for hearing loss
in resource poor settings

Sohum Innovation Lab

Nitin Sisodia(Call 2)

The Journey
Sohum is a unique device & system solution to do mass screening of newborns for hearing loss in resource-poor settings to prevent
speech loss. In India, hearing impairment goes undiagnosed till the child is about 4 years. By then, it is too late for the care cycle to be
effective. This leads to speech loss, impaired communication skills, possible mental illness and unemployment. Sohum is a noninvasive,
safe technology to screen neonates for hearing impairment with high sensitivity and specificity in resource-limited settings. It uses
brainstem auditory evoked response (BAER) technology which is gold standard, in an innovative way with an easy-to-use interface
designed specifically for use in developing countries scenario. BIRAC supported Sohum through BIG scheme which helped us refine key
features of Sohum and design refined specification.

Economical process for conversion of waste

to green chemicals

String Bio
Ezhil Subbian (Call 3)

The Journey
Imagine a clean world that we would be proud to leave behind for our kids. String’s solution brings us closer to this reality. We are
developing processes to capture methane, largely from waste, into everyday products. Everyday products from plastic cups to
high performance polymers like stents and sutures. Our goal is to enable sustainable cycles for managing waste by using it to make
biodegradable polymers.
Funded by the BIG project from BIRAC, over the course of the last year, we have developed IP protected biocatalysts, fermentation
processes and downstream purification technologies to enable this solution.

BIG Report 2015 | 53 |

Novel Chitosan derivative for building SAR in plants: specifically leaf blight
of Pomegranate caused by Xanthomonas sp.

Swasti Agro & Bioproducts Pvt. Ltd.

Abhay Shendye (Call 4)

The Journey
Swasti Agro and Bioproducts Pvt. Ltd. builds disease resistance in pomegranate against bacterial blight. This has huge positive
environmental impact since toxic chemicals are eliminated. Farmers get predicted, higher yields and more profits. Preliminary results
on sixteen crops grown in India suggest a potential for yield increase of Rs. 15000 cr. per annum.
Initial work on this innovative idea was possibly based only on alchemy of ignorance and amnesia. With BIRAC support we developed
scientific basis, and proof of concept. Development of strong data on mechanism of action was instrumental in attracting serious
investors. Networking opportunities provided much needed connections.

To develop a novel, cost effective, non - allergic herbal formulation for

management of spontaneous bleeding and allied complications
in multiple coagulation disorders.

Tania Paul (Call 4)

The Journey
The idea is to develop a novel herbal formulation which when administered orally and/or applied topically at the site of injury will
solve coagulation disorders in thousands of people who are suffering from Hemophilia, Thrombocytopenia and different types of
Hemorrhages. It is predicted that the world drugs market for preventing haemorrhages will generate $13.5bn in the year 2017. The
grant has provided the platform from where we can provide the society with a drug that will facilitate in reducing the bleeding diathesis
in people suffering from blood loss. This journey wouldn’t have initiated without the grant provided by BIG BIRAC as this was like a
backbone to an idea that will rise to entrepreneurship.

| 54 | BIG Report 2015

Development of Fucose Knock out technology platform in CHO S
cell line for improved Biotherapeutics

Theramyt Biologics Pvt. Ltd.

Maloy Ghosh &
Kavitha Iyer Rodrigues (Call 2)

The Journey
Theramyt’s technology platforms are focused on development of series of novel biomolecules and improved biologics that constitutes
a long term product pipeline. Our target is to alter fucosylation of antibody Fc region to create Biobetter molecules with enhanced
Antibody dependent cellular cytotoxicity (ADCC). The product is expected to provide new treatment options with reduced drug dosage.
The BIG project through BIRAC has helped us to start our R&D program as well as allowed us to incubate at CCAMP, Bangalore. The
support system at CCAMP and through BIRAC has helped us in technical evaluation of our research ideas and refinement of strategy to
achieve specific goals in fairly short period of time. We have already filed multiple provisional patents related to our product and platform
development technologies. We aim to take these novel biologics from bench to manufacturing scale and finally to global market.

Modular Resilin-mimetic Elastomeric Platform

Pandorum Technologies Pvt. Ltd.

Tuhin Bhowmick (Call 1)

The Journey
Innovative materials and methods to create environments that can promote functional cell/ tissue growth in vivo and in vitro has a range
of medical applications including regenerative medicine, drug screening and implantable devices. Our BIG project was to develop of a
novel biomaterial class through assembly of molecular building block- ‘legos’ with tunable material property and functions that can
form the base of the ‘technology pyramid’ of tissue engineering. With BIG, it was possible for us to take the first step into the path of
translational research. Besides funding, BIRAC’s guidance taught us the importance of collaboration with end-users and an awareness of
aspects such as toxicology, ethical and regulatory issues, health economics and clinical trial design that builds the path from the bench
to the bed-side.

BIG Report 2015 | 55 |

Fibre lasers for photoselective tissue ablation

Unilumen Photonics Pvt. Ltd.

Anil Prabhakar(Call 2)

The Journey
Fibre lasers are the next generation of high power lasers useful for material modification and surface micro-machining. Unilumen
Photonics has modified this technology for use in surgical applications, such as tissue photo-ablation for prostrate surgery and retinal
photo-coagulation. The lasers are available in both infra-red and visible wavelengths. In addition, pulsed fibre lasers can be synchronized
through a method of injection locking to an external trigger signal. Synchronized pulsed lasers find applications in fields as diverse as
optofluidics lab-on-chip diagnostics and in super-resolution microscopy.

Laser Desorption / Ionization Mass Spectrometric (LDI MS) solutions for

High throughput detection and analysis of residual compounds, contaminants
and small molecules in milk and dairy products.

Barefeet Analytics Pvt. Ltd.

Venkateswarlu Panchagnula (Call 3)

The Journey
There are numerous challenges in the quality, logistics and economics of food analysiswith significant rejection rates and losses in the
export market. Barefeet Analytics aims to address this by providing innovative, reliable and cost efficient solutions for pesticide residue
and contaminant analysis from food. Using laser desorption ionization mass spectrometry methods developed for pesticide analysis,
large numbers of samples can be analyzed rapidly – about 20 times the throughput at about one fifth of the cost of existing methods.
Support from the BIRAC BIG scheme is enabling the development of POC and field trials for analysis from milk.

| 56 | BIG Report 2015

Direct Beta Thalassemia Carrier Detection Kit

Yogesh Badhe (Call 4)

The Journey
Simple cost effective, efficient, reliable, beta thalassemia carrier detection kit has been developed, requiring no equipment and electricity,
suitable for field application. Validation of the kit in field application is being established with the help of BIRAC BIG grant. Every year
about one lakh thalassemia major children are born all over the world and ten thousand in India alone. The thalassemia children need
blood transfusion every three weeks and their life span is no more than 30 years. The family suffers in distress and helplessness and
country has huge financial burden. The kit aims at thalassemia free society.

Novel inhibitors of DNA Gyrase for the treatment of

multidrug resistant infections

Vitas Pharma Research Pvt. Ltd.

Radha Rangarajan (Call 1)

The Journey
With BIG support, Vitas Pharma undertook research on a novel class of compounds that target DNA replication in bacteria. The team has
identified a lead series of compounds with in vitro activity against highly resistant Gram negative clinical strains and has established
proof of- concept in the animal model. Further studies to establish the safety of the series are underway. The company has been approved
for a follow-on BIPP Grant. A successful drug emerging from this research will significantly reduce the burden of multidrug resistance and
provide physicians with a novel therapy to treat infections. BIG Grant has allowed us to accelerate our research and was a key factor in
our accessing external funding.

BIG Report 2015 | 57 |

Mechanical Heart Valve Fixation System: A Improve Design
for Superior cardiac performance

Innovator Lab Consultants India Pvt. Ltd.

Sujay Shad (Call 1)

The Journey
We are designing an improved mechanical heart valves that are meant to replace heart valves damaged by infections and ageing and
have more space, reduce possibility of infective complications & paraprosthetic leaks. We estimate a 35% to 115% increase in effective
orifice area. The innovation will have immense societal impact as over 600K patients globally and 40K Indian suffer heart valve disease.
Importantly, 25% patients are small adults or young children who remain the dominant focus of our development. I had considered this
concept design over 10 yrs ago, and along the way I tried to get research organisations to undertake development. That did not work
out. I tried rope in the only Indian heart valve manufacturer to undertake this development, that too did not succeed. With the BIG grant
the much delayed journey started.

Fetal Electrocardiogram and Uterine Activity signal extraction from Maternal

Electrocardiogram eliminating the need for the use of conventional transducers

Pradin Technologies Pvt. Ltd.

Dinesh Bindiganavale (Call 1)

The Journey
Transducer-less fetal monitors unlike conventional cardiotocographs is a novel approach to promotecontinuous monitoring of high
& medium risk pregnancies. The alarming rate of stillbirths in India isgreater than the sum of malaria & AIDS related deaths together.
Motivation for the project is anaffordable, portable, non-invasive & easy to use solution for the primary & home care segment. The
first BIG grant from BIRAC has catalysed our idea into a proof-of-concept development. This is nowbeing engineered for pilot market
introduction. This also started us on an entrepreneurial journey by registering “Pradin Technologies Pvt Ltd”.

| 58 | BIG Report 2015

Value added products such as nutraceuticals, poultry feed, aqua feed
from the wastes/byproducts of palm oil mills and silk reeling industries

Srinivas Bandlamori (Call 2)

The Journey
Through this project we identified two industries viz., Oil Palm and Silk reeling industry. Of the total raw silk produced in India (26,480
MT), only 25% is used for silk production, while remaining 75% is discarded as waste. India produces 50,000 M, for every Kg of oil, 3.45 Kg
of waste is generated. Wastes from both these industries have been used to develop High Value Low Volume products such as Omega-3
fatty acids, & Low Value High Volume products like poultry feed, aqua feed, etc. The collaboration with BIRAC and their BIG Partner has
helped us to scale up the innovation and convert it into a commercially viable products. The handholding and the mentorship provided
was a key behind the success of this project.

Pupil Expansion Ring & Delivery Systems

Nayan Eye Centre Pvt. Ltd.

Suven Bhattacharjee (Call 4)

The Journey
The simple single plane design of the ‘Bhattacharjee ring’ redefines the way pupil is expanded during cataract surgery in eyes which
do not dilate with medications. It paves the way for machine manufacture of the device, translating into reduced costs to the patient
and health care system. The rings are made of 5-0 (0.1 mm) nylon andcan be inserted and removed through a 0.9 mm incision which no
device has been able to achieve. BIRAC through the BIG funding is assisting validation of the concept through multicenter global trials
and development of the ‘Truly Continuous Ring’, ‘Delivery Systems’ & ‘Expandable Ring’.

BIG Report 2015 | 59 |

Development of Diagnostic Reagents for
Acute Myocardial Infarction

G.M. Biotech
Susmita Ghosh (Call 1)

The Journey
G.M. Biotech have innovated an animal free, antibody free reagent development platform technology that can be used for detection of
protein markers. Our first product in pipeline is an acute myocardial infarction detection kit based upon earliest cardiac marker H-FABP.
The novel platform technology also enabled us to develop a new instrument-free format of diagnostics that can be practiced in any
healthcare set-up, rural or urban. Since our kit will detect heart attack within 1-2 hrs after the onset, it will aid in much earlier medical
intervention and save more lives. Grant from BIRAC aided us launching this high risk project in a systematic manner and also helped us
building a self-sufficient R&D laboratory.

| 60 | BIG Report 2015

 List of Innovators / Entrepreneurs

Biotechnology Ignition Grant (BIG)

CALL 1-6

S. Call Title of the project Name of Project BIG Partner

No Grantee Coordinator
1 1 Rapid Detection of Acute Myocardial Nanosniff Dr. Nitin Kale Foundation for Innovation and
Infarction by sensing Cardiac Markers using Technologies Technology Transfer (FITT), New Delhi
Micro Cantilever Technology- Nitin Kale Pvt Ltd
2 1 Study, Design and Development of Hit Novo Informatics Mr. Avinash Foundation for Innovation and
Molecules for Type II Diabetes -Avinash Pvt Ltd Mishra Technology Transfer (FITT), New Delhi
Mishra
3 1 Development of Diagnostic Reagents for G.M. Biotech Dr. Susmita Ghosh Foundation for Innovation and
Acute Myocardial Infarction-S. Ghosh Technology Transfer (FITT), New Delhi
4 1 Intraosseous Device Dr. Jayant Karve Dr. Sandeep Singh Foundation for Innovation and
Technology Transfer (FITT), New Delhi
5 1 Mechanical Heart Valve Fixation System: Innovator Lab Dr. Sujay Shad Foundation for Innovation and
A Improve Design for Superior cardiac Consultants Technology Transfer (FITT), New Delhi
performance: -
Dr.Sujay Shad
6 1 Personal Ophthalmic Diagnostic I4Vision Dr. Dinesh Verma Foundation for Innovation and
System (PODS) Diagnostics Technology Transfer (FITT), New Delhi
Private Limited
7 2 production of collagen and by production Amnivor Medical Dr. Santanu Dhara Foundation for Innovation and
from fresh water fish origin for biomedical Private Limited Technology Transfer (FITT), New Delhi
applications:
8 2 Design and Development of a Rapid Point- Dr. Shalini Gupta - Foundation for Innovation and
of-Care Device for Endotoxin Detection in Technology Transfer (FITT), New Delhi
Critically Ill/Septicemia Patients- Shalini
Gupta
9 2 Detection of Circulating Tumor Cells Actorius Dr. Muralidhara Foundation for Innovation and
by Multifunctional Highly Dispersible Innovations and Padigaru Technology Transfer (FITT),
Polymeric-Magneto-Antibody Nanosystem - Research New Delhi
10 2 Use of Novel Superoxide dismutase with Mahesh Sankar - Foundation for Innovation and
anti-ageing properties as oral supplement Dhar Technology Transfer (FITT), New Delhi
and cosmetics.

BIG Report 2015 | 63 |

 S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
11 2 Biomimetic Bone Substitutes: - Sitalogics Dr. K Srinivas Rao Foundation for Innovation and
Pvt. Ltd. Technology Transfer (FITT), New Delhi
12 2 Deglycosylated ethnic banana as a mucosal A Pallavi - Foundation for Innovation and
health protectant- Technology Transfer (FITT), New Delhi
13 3 Keyhole surgery replaceable artificial heart SG ArtHeart Dr. Sujoy K Guha Foundation for Innovation and
Private Limited Technology Transfer (FITT), New Delhi
14 3 Production of Phytate free food Dr. M.K. Reddy - Foundation for Innovation and
grains: Effective Strategy to deal with Technology Transfer (FITT), New Delhi
micronutrient deficiency
15 3 Development of a commercial grade low Mr. Sushant - Foundation for Innovation and
cost Arterial pulse analyzer Poojary Technology Transfer (FITT), New Delhi
16 3 Transdermal Iron Replenishment Therapy Dr. H.N. - Foundation for Innovation and
Shivakumar Technology Transfer (FITT), New Delhi
17 3 Interaction of Nano-embedded Dr. Ajit Varma - Foundation for Innovation and
Piriformospora indica with the plant of Technology Transfer (FITT), New Delhi
medicinal importance, Brassica oleracea
var. Botrytis (Broccoli)
18 3 mCAPD Mobile Continuous Ambulatory Gowrishankar W Mr. S Foundation for Innovation and
Peritioneal Dialysis Pattabiraman Technology Transfer (FITT), New Delhi
19 4 Pupil Expansion Devices and Delivery Dr. Suven - Foundation for Innovation and
System Bhattacharjee Technology Transfer (FITT), New Delhi
20 4 Process Crystallization as a Purification Bhami's Dr. Bhami Shenoy Foundation for Innovation and
Tool to Therapeutic Antibody Research Technology Transfer (FITT), New Delhi
Laboratory
21 4 Developing a rapid multiplex test to Yaathm Biotech Ms. Anitha Foundation for Innovation and
dianose extensively drug resistant (XDR) TB Pvt Ltd Rajagopal Technology Transfer (FITT), New Delhi
and Multidrug resistant (MOR) TB
22 4 Development of an indigenous rapid card Sakosh Biotech Dr. Kavita Singh Foundation for Innovation and
test to detect IgM against TORCH infections Private Limited Technology Transfer (FITT), New Delhi
in prenatal and perinatal causes using
recombinant proteins as capture antigens
23 4 An innovative, hand-held (pen-styled) Abhijith Bailur Dr. Rajnish Juneja Foundation for Innovation and
sensor system for early identification of Technology Transfer (FITT), New Delhi
coarctation of aorta in neonates
24 4 Introduction and development of a new Nextec Dr. Ranjana Foundation for Innovation and
DNA based kit for Early and accurate Lifesciences Srivastava Technology Transfer (FITT), New Delhi
diagnosis of Tuberculosis Pvt. Ltd
25 4 Development and Validation of novel Plasmatech Mr. Vignesh N Foundation for Innovation and
pseudobioaffinity based purification Solutions Janakiraman Technology Transfer (FITT), New Delhi
method for efficient recovery of coagulation Pvt. Ltd.
factor VIII

| 64 | BIG Report 2015

S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
26 4 Renewable chemicals for high performance Aseem Gupta - Foundation for Innovation and
materials Technology Transfer (FITT), New Delhi
27 5 Development of early Breast and Cervical Dr. Sarita - Foundation for Innovation and
cancer detection method using novel, high Ahlawat Technology Transfer (FITT), New Delhi
resolution digital holographic microscope
28 5 Scintilla - a portable urine protein analyser Cutting Edge Dr. Pankaj Foundation for Innovation and
device for Mass Healthcare Medical Devices Parashar Technology Transfer (FITT), New Delhi
Pvt Ltd
29 5 A safe and effective technology for treating Dr. Vanaja K - Foundation for Innovation and
musculoskeletal dirorders in elder patients Gowda Technology Transfer (FITT), New Delhi
30 5 Rapid diagnosis of bacterial gastroenteritis Dr. - Foundation for Innovation and
in resource poor settings Vivekanandan Technology Transfer (FITT), New Delhi
Perumal
31 5 Innovative approached for upscalling Dr. Neera - Foundation for Innovation and
natural tocopherol production from Bhalla Sarin Technology Transfer (FITT), New Delhi
engineered brassica juncea (Indian
mustard) for therapeutics
32 5 Development of affordable breast Dr. Pawan - Foundation for Innovation and
prosthesis and mastectomy bras for breast Mehrotra Technology Transfer (FITT), New Delhi
cancer patients
33 6 Design and development of a low cost, Dr. Anupan Bam - Foundation for Innovation and
easy-to-use stretcher, for complete Technology Transfer (FITT), New Delhi
immobilization of spine and limbs, and
shock absorption during transport of
physical trauma patients
34 6 Manufacturing of a new universally Dr. Alka Banker - Foundation for Innovation and
adjustable orthodontic bracket Technology Transfer (FITT), New Delhi
35 1 Development of an aptamer-based Achira Labs Dr. Dhananjaya Centre for Cellular and Molecular
platform to detect novel Tuberculosis Pvt. Ltd. Dendukuri Platforms (C-CAMP), Bangalore
markers in human serum
36 1 Modular Resilin-mimetic Elastomeric Pandorum Dr. Tuhin Centre for Cellular and Molecular
Platform Technologies Bhowmick Platforms (C-CAMP), Bangalore
Pvt. Ltd.
37 1 Metabolic Engineering of marine bacteria Sea6 Energy Ms. Sri Sailaja Centre for Cellular and Molecular
for the production of isobutanol in salt Pvt. Ltd. Nori Platforms (C-CAMP), Bangalore
water
38 1 Dr. Vikas Mehra - Expression of therapeutic Dr. Vikas Mehra Dr. Bharat Centre for Cellular and Molecular
diabody against Chattoo Platforms (C-CAMP), Bangalore
TNF-alpha and IL17R

BIG Report 2015 | 65 |

 S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
39 1 Cancer treatment through autologous Western Range Dr. Vinod Centre for Cellular and Molecular
activated dendritic cells Biopharma- Kuberkar Platforms (C-CAMP), Bangalore
ceuticals

40 1 Enzymatic maceration of mango pulp to Codon Dr. Archana Centre for Cellular and Molecular
produce quality wine Biosciences Thakur Platforms (C-CAMP), Bangalore
Pvt. Ltd.
41 2 Fibre lasers for photoselective tissue Unilumen Mr. Anil Prabhakar Centre for Cellular and Molecular
ablation Photonics Platforms (C-CAMP), Bangalore
Pvt Ltd
42 2 Testing the feasibility of Nano magnetic Nurture Earth Dr. Seshgiri Centre for Cellular and Molecular
disc based ablation of Cancer cells in vitro R&D Pvt. Ltd. Raghukumar Platforms (C-CAMP), Bangalore
43 2 Establishing and Validating a novel drug GeNext Mrs. Supriya Centre for Cellular and Molecular
target in mycobacterium tuberculosis Genomics Kashikar Platforms (C-CAMP), Bangalore
Pvt Ltd
44 2 Industrial application of a novel cancer InvivoD Dr. Pradip Sinha Centre for Cellular and Molecular
drug screening method Solutions Private Platforms (C-CAMP), Bangalore
Limited
45 2 Development of Fucose Knock out Theramyt Dr. Maloy Ghosh/ Centre for Cellular and Molecular
technology platform in CHO S cell line for Biologics Pvt Ltd Ms. Kavitha Iyer Platforms (C-CAMP), Bangalore
improved Biotherapeutics Rodrigues
46 2 Development and Validation of Gene Dr. Yashoda - Centre for Cellular and Molecular
Delivery System for Novel Model Organisms Ghanekar Platforms (C-CAMP), Bangalore
47 2 A Yeast based system for protein expression Dr. Vinod Nayak - Centre for Cellular and Molecular
and metabolic engineering Platforms (C-CAMP), Bangalore
48 2 Synthetic biology for overproduction of Butacell Research Dr. Nidhi Adlaka Centre for Cellular and Molecular
2,3-butanediol Pvt. Ltd. Platforms (C-CAMP), Bangalore
49 2 Value added products such as Mr. Srinivas - Centre for Cellular and Molecular
nutraceuticals,poultry feed, aqua feed from Bandlamori Platforms (C-CAMP), Bangalore
the wastes/byproducts of palm oil mills and
silk reeling industries
50 2 Developing Novel Lactic Acid Bacteria Dr. Swetha - Centre for Cellular and Molecular
Antimicrobial Interventions to Improve Morey Platforms (C-CAMP), Bangalore
Food Safety and Shelf-Life
51 2 Development Of Low Cost High Shirdi Sai Dr. Munishwar N Centre for Cellular and Molecular
Performance Immobilized Lipases For Nutraceuticals Gupta Platforms (C-CAMP), Bangalore
Intersterification Of Oils Andfats To Produce Pvt. Ltd
Healthy Fats
52 3 Novel, Percutaneous Soft Tissue Biopsy Indio Labs Dr. Siraj Bagwan Centre for Cellular and Molecular
System with assisted Hemostasis Pvt. Ltd. Platforms (C-CAMP), Bangalore
53 3 Hand-held Imaging Flow Cytometer for Dr. Sai Siva - Centre for Cellular and Molecular
Quantitative Diagnosis of Malaria Gorthi Platforms (C-CAMP), Bangalore

| 66 | BIG Report 2015

S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
54 3 A simple platform based novel,rapid and Module Mr. Sachin Dubey Centre for Cellular and Molecular
color changing one-time and reusable Innovations Pvt. Platforms (C-CAMP), Bangalore
nanofiber strips for selective detection Ltd.
of Enterohaemorrhagic Escherichia coli
(EHEC)O157:H7
55 3 Development of Long Circulating Robust herbals Dr. Ravikumar K Centre for Cellular and Molecular
Biodegradable Nanoparticle MRI Contrast Pvt. Ltd. Platforms (C-CAMP), Bangalore
Agents Based on Hydroxypropyl-beta-
Cyclodextrin
56 3 An implantable drug-delivery device Dr. Jonathan - Centre for Cellular and Molecular
for improving Tuberculosis treatment Pillai Platforms (C-CAMP), Bangalore
adherence and compliance
57 3 Low-Cost Prophylactic Topical Dermal Dr. Praveen - Centre for Cellular and Molecular
Cream to Prevent Chronic Exposure of Toxic Vemula Platforms (C-CAMP), Bangalore
Pesticides
58 3 Development of trypsin resistant PAN Affigenix Dr. Arumugam Centre for Cellular and Molecular
reactive trypsin antibodies for industrial Biosolutions Muruganandam Platforms (C-CAMP), Bangalore
application Pvt Ltd
59 3 Bicistronic self replicating DNA vaccine for Geniron Biolabs Dr. Prashant T Centre for Cellular and Molecular
rabies and immunocontraception in stray Pvt. Ltd. Platforms (C-CAMP), Bangalore
dogs
60 3 3D printer filaments that are biomaterial- Dr. Karthik - Centre for Cellular and Molecular
based and eco-friendly Chetan Platforms (C-CAMP), Bangalore
61 3 Economical process for conversion of waste String Bio Dr. Ezhil Subbian Centre for Cellular and Molecular
to green chemicals Platforms (C-CAMP), Bangalore
62 3 Upscaling Banana propagation using Dr. Sukhada - Centre for Cellular and Molecular
bioreactors Mohandas Platforms (C-CAMP), Bangalore
63 3 Development of economically viable Dr. Mousumi - Centre for Cellular and Molecular
synergistic nutraceutical formulations with Mondal Platforms (C-CAMP), Bangalore
Cordyceps and male silkworm larvae for
disorders related to pancreas, kidney, liver,
impotency etc. by culturing Cordyceps on
silkworm in an artificial environment
64 3 ‘A novel therapeutic modality using Total Potential Dr. Bhaskar Vyas Centre for Cellular and Molecular
Adipose derived Mesenchymal Stem Cells (P) Ltd. Platforms (C-CAMP), Bangalore
cells (ADMSCs) for treating Osteoarthritis
patients & establishing clinical based
evidence’.
65 3 Establishment of a Mesenchymal Stem Cell OCT Therapies Dr. Caroline Centre for Cellular and Molecular
Bank as an Alternative and Research Mathen Platforms (C-CAMP), Bangalore
Skin Bank Private Limited
66 4 Novel Therapeutic interventions against Dr. B. Mohana - Centre for Cellular and Molecular
fatal canine viral pathogenisis Subramanian Platforms (C-CAMP), Bangalore

BIG Report 2015 | 67 |

 S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
67 4 A Safer and easier Nasal foreign body Inaccel Dr. Jagdish Centre for Cellular and Molecular
extractor for clinicians in under-served Consulting Chaturvedi Platforms (C-CAMP), Bangalore
areas
68 4 Mapping of Prochiral Chemical Space Biomoneta Dr. Srividya Centre for Cellular and Molecular
covered by Ketoreductases Research Janani Platforms (C-CAMP), Bangalore
Venkatraman
69 4 Evaluation of Clovamide analogs as Kinome Pharma Dr. Vellareddy Centre for Cellular and Molecular
Neuroprotective Agents for treatment of Anantharam Platforms (C-CAMP), Bangalore
Parkinson’s disease
70 4 Unraveling mechanism of action for Bugworks Mr. Ramanujan Centre for Cellular and Molecular
anti-bacterial compounds emerging from Research Kadambi Platforms (C-CAMP), Bangalore
phenotypic screens
71 4 Atomic Force Probing of cells for for clinical Shilps Sciences Dr. Ashwin Lal Centre for Cellular and Molecular
and pharmaceutical applications Private Limited Platforms (C-CAMP), Bangalore
72 4 Microarray based technology for Dr. Sampath - Centre for Cellular and Molecular
simultaneous detection of food and water Srisailam Platforms (C-CAMP), Bangalore
borne pathogens
73 5 Novel and effective way to reduce the risk Coeo Labs Mr. Nachiket Centre for Cellular and Molecular
of ventilator associated pneumonia Deval Platforms (C-CAMP), Bangalore
74 5 Bile acid lipoids as potential therapeutics Dr. Srujan Kumar - Centre for Cellular and Molecular
for psoriasis Marepally Platforms (C-CAMP), Bangalore
75 5 Development of highly sensitive and Dr. Satya Tapas - Centre for Cellular and Molecular
portable optical microscope for malaria Platforms (C-CAMP), Bangalore
parasite detection.
76 5 First-in-Class Therapeutics for Lysosomal Aten Dr. Aditya Centre for Cellular and Molecular
Storage Disorders Biotherapeutics Kulkarni Platforms (C-CAMP), Bangalore
Pvt. Ltd.
77 5 PentaFluVac – An indigenous replication- Pentavalent Bio Ms. Bhavani PV Centre for Cellular and Molecular
incompetent viral vaccine for avian, swine Sciences Pvt.Ltd. Platforms (C-CAMP), Bangalore
and
human influenza
78 5 Conversion of CT/MR data to 3d printed DF3D Creations Mr. Deepak Raj K Centre for Cellular and Molecular
models help the surgeons plan surgery Pvt. Ltd. Platforms (C-CAMP), Bangalore
more accurately by means of better
implants thereby increasing accuracy &
reducing time taken for actual procedure.
This brings down costs, increases
throughput & accuracy.
79 5 Automated detection of abnormal copy Dr. Naga Mohan - Centre for Cellular and Molecular
number variants in human diseases Kommu Platforms (C-CAMP), Bangalore
80 5 Development of a novel monolayer based Vital Bioscientific Mrs. Padma Priya Centre for Cellular and Molecular
parallel artificial membrane permeability Solutions Pvt Ltd Paragi Vedanthi Platforms (C-CAMP), Bangalore
assay to determine permeability of new
chemical entities and drugs

| 68 | BIG Report 2015

S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
81 5 The PubMed Graph: System to query and RelAgent Dr. S Ramanan Centre for Cellular and Molecular
rank search results spanning multiple Technologies Platforms (C-CAMP), Bangalore
biomedical documents Pvt. Ltd
82 5 Harnessing cheater cells for probiotics: Dr. Soumen Roy - Centre for Cellular and Molecular
applying game theory for nutrition and Platforms (C-CAMP), Bangalore
health
83 1 A Platform for Rapid Antibiotic Sabio Innovative Mr. Udit Parekh IKP Knowledge Park, Hyderabad
Susceptibility Testing (AST) and Assessment Solutions
Of Bacterial Load Pvt. Ltd.
84 1 Novel inhibitors of DNA Gyrase for the Vitas Pharma Dr. Radha IKP Knowledge Park, Hyderabad
treatment of multidrug resistant infections Research Pvt. Rangarajan
Ltd.
85 1 Pharmacological Evaluation of N-oxide Crystalin Dr. Ashwini IKP Knowledge Park, Hyderabad
Metabolite of Antipsychotic Drug for Type 2 Research Pvt. Nangia
Diabetes Ltd.
86 1 Novel Oncotherapeutic Measles Virus using Seagull Dr. Vishwas Joshi IKP Knowledge Park, Hyderabad
eSAME system Biosolutions
Pvt. Ltd
87 1 Fetal Electrocardiogram and Uterine Pradin Mr. Dinesh IKP Knowledge Park, Hyderabad
Activity signal extraction from Maternal Technologies Bindiganavale
Electrocardiogram eliminating the need for
the use of conventional transducers
88 1 Creation of transgenic zebrafish as cancer Zephase Dr. Kiranam Chatti IKP Knowledge Park, Hyderabad
models Therapeutics
Pvt. Ltd.
89 1 Biochemical Research & Development to GPS Renewables Dr. Mainak IKP Knowledge Park, Hyderabad
Improve the Efficacy of a Dry, Thermophilic, Pvt. Ltd. Chakravarty/Mr.
Anaerobic Reactor Sajal Chakravarty
90 1 Engineered stable, nano-sized bubble Dr. Praveer - IKP Knowledge Park, Hyderabad
liposomes - a commercially viable drug Gupta
delivery platform
91 2 Bioremediations for Agro Industrial Solid Swayambhu Mr. Balaji R IKP Knowledge Park, Hyderabad
Wastes by ARBIT for Efficient Management Biologics
Through Energy and Biomanure Pvt. Ltd.
Conversions.
92 2 Novel Integrated Newborn Resuscitation Windmill Health Dr. Ayesha IKP Knowledge Park, Hyderabad
Solution to Empower Front-line Health Tech. Pvt. Ltd. Chaudhary/
Workers to Resuscitate Newborns Dr. Avijit Bansal
Effectively
93 2 A novel device to screen newborns for Sohum Mr. Nitin Sisodia IKP Knowledge Park, Hyderabad
hearing loss in resource poor settings Innovations
Pvt. Ltd.

BIG Report 2015 | 69 |

 S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
94 2 Clonal propagation of elite genotype of Kwaklei & Dr. Kishor IKP Knowledge Park, Hyderabad
orchid hybrids synthesised in Manipur for Khonggunmelei Rajkumar
commercial cultivation Orchids Pvt. Ltd.
95 2 Exploring Muga silk fibre as a promising Mugagen Dr. Utpal Bora IKP Knowledge Park, Hyderabad
suture material Laboratories
Pvt. Ltd.
96 2 Delivery and retention of Irinotecan loaded Vegrandis Dr. Uday Saxena IKP Knowledge Park, Hyderabad
magnetic nanoparticles for treatment of Therapeutics
brain tumors Pvt. Ltd.
97 2 Development of a novel fungal bio control Wobble Base Dr. Pratap IKP Knowledge Park, Hyderabad
agent using protoplast fusion technology Bioresearch Mukhopadhyaya
to target drug resistant gastrointestinal Pvt. Ltd.
cattle worms responsible for reducing
productivity, by an eco friendly approach.
98 2 World's Most Affordable, long life Jeevtronics Mr. Aniruddha IKP Knowledge Park, Hyderabad
Defibrillator that is Battery less, Hand Pvt. Ltd. Atre
Cranked, Rugged with reusable paddles.
99 2 Hollow Fibre Membrane Based Low- Genrich Mr. Amin Almel IKP Knowledge Park, Hyderabad
Cost Oxygen Concentrator for Medical Membranes
Applications Pvt. Ltd.
100 3 Metabolic engineering of Pseudomonas Mr. - IKP Knowledge Park, Hyderabad
putida for 3-Hydroxypropionic acid P.Sathyavrathan
production /
101 3 Glycolytic Inhibhitor M/s. AtharvWin Mr. Anil Roy IKP Knowledge Park, Hyderabad
Healthcare
Pvt Ltd
102 3 3-D Bone Graft and GBR Membrane for Regensol Mr. Kunal Khanna IKP Knowledge Park, Hyderabad
Maxillofacial and periodontal repair:
Towards a clinical study
103 3 A Novel method of converting Agri Waste Sky Solar & Mr. Mike IKP Knowledge Park, Hyderabad
to Energy with direct benefit to farmers: Power India Ragahvan
Use Rice Husks to produce Carbon-coated Limited
Nanoporous Si/SiO2 for Li-ion batteries &
create THRIFT fund for farmer contribution
for solar water pump under subsidy scheme
104 3 Non-invasive prenatal diagnosis kit for Pregene Dr. Shivkumar D. IKP Knowledge Park, Hyderabad
sickle cell anemia Research Pvt. Chauhan
Ltd.
105 3 Bioabsorbable implants based on polylactic Orthocrafts Ashish K Lele IKP Knowledge Park, Hyderabad
acid (PLLA) Innovations
Pvt. Ltd.

| 70 | BIG Report 2015

S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
106 3 A novel formulation for Probiotic food Abhiruchi Dr. Archana IKP Knowledge Park, Hyderabad
additive. Probiotics Pundle/Mr.
Pvt. Ltd Hrishikesh Mungi
107 3 Development of a Biosensor based Point- M/s. Purius Mr. IKP Knowledge Park, Hyderabad
of-care Nucleic Acid Testing System Nanosystems Purushothaman
Pvt. Ltd. Gempuraj
108 3 Laser Desorption / Ionization Mass Barefeet Dr. Venkateswarlu IKP Knowledge Park, Hyderabad
Spectrometric (LDI MS) solutions for HIGH Analytics Pvt. Ltd Panchagnula
throughput detection and analysis of
residual compounds, contaminants and
small molecules in milk and dairy products.
109 4 Osteoconductive Bone Graft Susbtitutes BiolMed Mrs. Anuya Nisal IKP Knowledge Park, Hyderabad
Innovations
Pvt. Ltd.
110 4 Production of non-alcoholic drink enriched Naturlich Global Mr. Arjun Radha IKP Knowledge Park, Hyderabad
with essential vitamins and minerals by Beverages Krishna
microbial fermentation of natural raw Pvt. Ltd.
materials
111 4 Application of pentose utilizing yeast Dr. Sushma - IKP Knowledge Park, Hyderabad
strain(s) for higher ethanol production from Meshram
hemicelluloses
112 4 Brun – A Perinatal Monitoring Device Brun Health Mr. Anirudh IKP Knowledge Park, Hyderabad
Pvt. Ltd. Chaturvedi
113 4 VodCa for Distillery Industry [VodCa: Vortex Vivira Process Dr. Vivek Ranade IKP Knowledge Park, Hyderabad
Diode based Cavitation Devices] Technologies
Pvt. Ltd.
114 4 Development of a novel diagnostic kit for Annweshan Dr. Dhiman Sarkar IKP Knowledge Park, Hyderabad
Tuberculosis SciTech. Pvt. Ltd.
115 5 Develop and Test Certain 3D Printing Dr. Srinivasa - IKP Knowledge Park, Hyderabad
Technologies to Produce Innovative limbs Prakash Regalla
at Affordable Costs for the Disabled in India
116 5 Remote Cardiac Monitoring and Real-Time Monitra Mr. Ravi Bhogu IKP Knowledge Park, Hyderabad
Outpatient Cardiac Telemetry Healthcare
Pvt. Ltd.
117 5 Bio-Synthesis, Production and Formulation Mr. Mihir Mehta - IKP Knowledge Park, Hyderabad
of Sophorolipids for the purpose of
Sanitizing/Sterilizing Fruits and Vegetables
thus enhancing their shelf-life.
118 5 ISITE Intra-Ocular Lens for Spectacle Free Nayam Mr. Tanuj Gigras IKP Knowledge Park, Hyderabad
Vision Innovations
Pvt. Ltd.

BIG Report 2015 | 71 |

 S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
119 5 Establishment and Validation of AlgalR Dr. Mohanraj IKP Knowledge Park, Hyderabad
Commercially Viable Technologies for the NutraPharms Subramanian
Production of Omega-3 Fatty Acids from Pvt. Ltd.
Marine Microalgae
120 6 An Affordable, 'Point-of-sample collection' Aindra Systems Mr. Adarsh IKP Knowledge Park, Hyderabad
Cervical Cancer screening tool Pvt. Ltd. Natarajan
121 6 Development of Oral Cancer Screening Sascan Meditech Dr. Subhash IKP Knowledge Park, Hyderabad
Camera Pvt. Ltd. Narayanan
122 6 Development of Handheld Device for Pathshodh Dr. Navakanta IKP Knowledge Park, Hyderabad
Glycated Hemoglobin and Albumin Sensing Healthcare Bhat
Pvt. Ltd.
123 4 Recombinant Enabling MDR Platform Dr. Shrikant - KIIT Technology Business Incubator
Mishra (KIIT-TBI), Bhubaneswar
124 4 Multispectral Optical Imaging and SkinCurate Mr. Debdoot KIIT Technology Business Incubator
Computing Technologies for Realtime Research Pvt Ltd Sheet (KIIT-TBI), Bhubaneswar
In situ Functional Characterization and
Monitoring of Cutaneous Wound Healing
Progression
125 4 Development of a novel technology for Viravecs Labs Dr. Rohan H KIIT Technology Business Incubator
generation of stable transgenic systems Kamat (KIIT-TBI), Bhubaneswar
with no off-targets
126 5 Multiplexed bead based suspension array Dr. Biswadeep - KIIT Technology Business Incubator
for dengue serotyping Das (KIIT-TBI), Bhubaneswar
127 5 Design And Evaluation Of Novel Ms. Chaitali - KIIT Technology Business Incubator
Formulations Of Some Anti- Cancer Drugs Vibhakar Surve (KIIT-TBI), Bhubaneswar
For Metronomic Chemotherapy
128 5 Development of De-metalizer Kit from Dr. Luna - KIIT Technology Business Incubator
Biopolymers for Efficient Removal of Heavy Goswami (KIIT-TBI), Bhubaneswar
Metal Ions from Contaminated Water
Especially of the Mining Areas
129 5 Optically tunable nanobio-sensor for Dr. Raghabendra - KIIT Technology Business Incubator
detecting the efficacy of mosquitocidal Samantaray (KIIT-TBI), Bhubaneswar
repellants
130 5 Development of food colourants and textile Dr. Sureshkumar - KIIT Technology Business Incubator
dyes from natural pigments of microbial Singh (KIIT-TBI), Bhubaneswar
origin
131 6 Tear Dipstick immunoassay for diagnosis of Dr. Aparna Rao - KIIT Technology Business Incubator
adult primary glaucoma (KIIT-TBI), Bhubaneswar
132 6 Development of a molecular needle as a Dr. Nusrat J M - KIIT Technology Business Incubator
novel platform for delivery of anticancer Sanghamitra (KIIT-TBI), Bhubaneswar
drugs
133 6 Networked Critical Care Monitoring in Low Lattice Mr. Chayan KIIT Technology Business Incubator
Resource Settings Innovations Chatterjee (KIIT-TBI), Bhubaneswar
Pvt Ltd

| 72 | BIG Report 2015

S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
134 6 Point-of-Care Diagnostic Kit for Diarrheal Priti Sundar - KIIT Technology Business Incubator
Bacterial Pathogens Mohanty (KIIT-TBI), Bhubaneswar
135 6 Detection and diagnosis of Urinary Tract Dr. Surajit - KIIT Technology Business Incubator
Infection through development of a rapid Bhattacharjee (KIIT-TBI), Bhubaneswar
and sensitive non-invasive agglutination
method
136 4 Green Manufacturing of Cephalosporin Cellzyme Biotech Dr. Rajkumar Venture Center, Pune
Antibiotics Using Recombinant Deacetylase India Pvt. Ltd. Rajagopal
137 4 Novel Chitosan derivative for building Swasti Agro & Dr. Abhay Venture Center, Pune
SAR in plants: specifically leaf blight of Bioproducts Shendye
Pomegranate caused by Xanthomonas sp. Pvt. Ltd.
138 4 To demonstrate Proof of Concept for Mr. Aman - Venture Center, Pune
a novel, non-invasive exosome -based Sharma
screening (for early detection) cum
diagnostic kit for multiple cancers (using
one test) utilizing patient derived biofluids
139 4 To demonstrate proof-of-concept for an InDNA Research Mr. Aditya Phatak Venture Center, Pune
automated clinical analysis and annotation Labs Pvt. Ltd.
pipeline for NGS based somatic cancer
genomic test for diagnosis, prognosis and
personalized therapy. This will enable low
cost and actionable genomic testing in
India.
140 4 To develop a novel, cost effective, Miss. Tania Paul - Venture Center, Pune
non- allergic herbal formulation for
management of spontaneous bleeding
and allied complications in multiple
coagulation disorders.
141 4 Use of Portable Raman Spectrometer for Molqbits Sensors Dr. Girish Arabale Venture Center, Pune
Soil & Minerals Analysis and Data Pvt. Ltd
142 4 Direct beta thalassemia carrier detection kit Mr. Yogesh - Venture Center, Pune
Badhe
143 5 Design second stage of prototype for Low Mother Mr. Karthik Venture Center, Pune
cost, low dosage Digital X-Ray using TDI Diagnostic Somsundaram
sensor Systems Pvt Ltd
144 5 Development of smartphone based eye Visint Healthcare Dr. Ramesh S Ve Venture Center, Pune
imaging system
145 5 Production of Dr. Sanjay Nene - Venture Center, Pune
Ccclodextringlycosyltransferase / CGTase
enzyme using a Membrane Cell Recycle
Bioreactor (MCRB)
146 5 A novel organic and inorganic nano- Mr Milind - Venture Center, Pune
formulation for rapid wound healing and K. Choudhari
control of infection

BIG Report 2015 | 73 |

 S. Call Title of the project Name of Project BIG Partner
No Grantee Coordinator
147 5 Innovative scar-free organ retractor for Croleon Mr. Chinmay Venture Center, Pune
reduced port laparoscopic surgery Innovation Labs Deodhar
Pvt. Ltd.
148 5 Process to produce double haploid Dr. Renuka - Venture Center, Pune
parental lines with new, unique, rare Diwan
genetic combinations using DH technology
coupled with a strategy to increase or alter
meiotic recombination in the technology
demonstration system of mustard
149 5 Novel process for manufacturing of Shweta Shree Dr. Guruprasad Venture Center, Pune
D-Penicillamine Life Sciences Kulkarni
Pvt. Ltd.
150 5 Development of a point-of-care device for Dr. Rishi - Venture Center, Pune
prenatal diagnosis of congenital anomalies Adhikary
151 6 SphinX - Ostomy management device Pranav Chopra - Venture Center, Pune
152 6 DNA Testing on Disposable Plastic Biochips: OmiX Research Dr. Sudeshna Venture Center, Pune
A High Sensitivity Platform for Malaria and Diagnostics Adak
Detection Laboratories
Pvt. Ltd.
153 6 Affordable and Safe therapy for Neonates Sensivision Mr. Jayadeep K. Venture Center, Pune
with Hypoxic Ischemic Encephalopathy Health Unni
Technologies
Pvt Ltd
154 6 A cost effective process of making Dr. Vanita Prasad - Venture Center, Pune
Anaerobic Granulated Sludge optimized for
quick start-up and easy operation of UASB
in WWTP while making the process energy
efficient, achieving higher COD removal
rate, high yield of CH4 at higher loading
rates
155 6 A gonio camera without a slit lamp Dr. H V Srinivas - Venture Center, Pune

References:
https://www.sbir.gov/about/about-sbir
http://www.israelbusiness.org.il/financialassistance/rdfound
http://erawatch.jrc.ec.europa.eu/erawatch/opencms/information/country_pages/il/
supportmeasure/support_0021http://erawatch.jrc.ec.europa.eu/erawatch/opencms/information/country_pages/il/supportmeasure/support_0021
http://www.spring.gov.sg/Nurturing-Startups/Pages/technology-enterprise-commercialisation-scheme.aspx
http://deshpande.mit.edu/grants-resources
http://www.research-in-germany.org/en/research-areas-a-z/biotechnology/programmes-and-initiatives/go-bio.html
http://www.bio-economy.net/bioeconomy/member_states/germany/index_germany.html
http://www.ft.com/cms/s/0/f4109fae-40df-11e5-b98b-87c7270955cf.html
http://www.economist.com/news/business/21584307-new-book-points-out-big-role-governments-play-creating-innovative-businesses

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