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    2022C Biochemistry Le 3 Objectives List

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    Manila Med
    This document outlines the objectives for a biochemistry course, covering topics such as glycogenolysis, gluconeogenesis, lipid chemistry, cholesterol metabolism, β-oxidation, and ketogenesis. Some key objectives include distinguishing the roles of various proteins in cholesterol transport, evaluating the relationship between lipid metabolism and heart disease, reviewing membrane composition and phospholipid synthesis, and describing the pathways of fatty acid breakdown and ketone body formation. The objectives provide an overview of the major metabolic pathways that will be covered in the course.

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    2022C Biochemistry Le 3 Objectives List

    Uploaded by

    Manila Med
    41 views1 page
    This document outlines the objectives for a biochemistry course, covering topics such as glycogenolysis, gluconeogenesis, lipid chemistry, cholesterol metabolism, β-oxidation, and ketogenesis. Some key objectives include distinguishing the roles of various proteins in cholesterol transport, evaluating the relationship between lipid metabolism and heart disease, reviewing membrane composition and phospholipid synthesis, and describing the pathways of fatty acid breakdown and ketone body formation. The objectives provide an overview of the major metabolic pathways that will be covered in the course.

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    This document outlines the objectives for a biochemistry course, covering topics such as glycogenolysis, gluconeogenesis, lipid chemistry, cholesterol metabolism, β-oxidation, and ketogenesis. Some key objectives include distinguishing the roles of various proteins in cholesterol transport, evaluating the relationship between lipid metabolism and heart disease, reviewing membrane composition and phospholipid synthesis, and describing the pathways of fatty acid breakdown and ketone body formation. The objectives provide an overview of the major metabolic pathways that will be covered in the course.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    41 views1 page

    2022C Biochemistry Le 3 Objectives List

    Uploaded by

    Manila Med
    This document outlines the objectives for a biochemistry course, covering topics such as glycogenolysis, gluconeogenesis, lipid chemistry, cholesterol metabolism, β-oxidation, and ketogenesis. Some key objectives include distinguishing the roles of various proteins in cholesterol transport, evaluating the relationship between lipid metabolism and heart disease, reviewing membrane composition and phospholipid synthesis, and describing the pathways of fatty acid breakdown and ketone body formation. The objectives provide an overview of the major metabolic pathways that will be covered in the course.

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    2022C BIOCHEMISTRY LE 3 OBJECTIVES LIST • Distinguish the roles of ABCG-1, ABCA-1, LCAT, CETP,

    LDL–R, and SR-B1 in the centripetal transport of


    3.01 Glycogenolysis cholesterol.
    • Discuss glycogenolysis • Evaluate the relationship between lipid metabolism,
    • Explain the regulation of glycogenolysis myocardial infarct and hypercholesterolemia.
    • Discuss the different glycogen storage diseases
    3.07 Biological Membrane Phospholipids
    3.02 Gluconeogenesis • Review of the basic composition and the fluid mosaic
    • Review Glycolysis and Tricarboxylic Acid Cycle model of biologic membranes
    • Describe the physiological significance of • Chemistry – general structure, types and characteristics
    gluconeogenesis • Synthesis
    • Compare and contrast the steps of glycolysis and • Phospholipids, sphingolipids and glycosphingolipids
    gluconeogenesis o Intracellular sites, precursors, mechanisms,
    • Discuss the key features of gluconeogenesis enzymes
    • Describe the pathway in terms of its substrates: lactate, o Interconversions – base-exchange, methylation,
    glucogenic amino acids, glycerol, propionyl-CoA decarboxylation
    • Differentiate between Cori cycle and Glucose-Alanine • Ether phospholipids – precursors, enzymes
    cycle • Deficiency syndromes
    • Discuss the regulation of the pathway during fasting • Degradation
    • Functions
    3.03 BGD: Carbohydrates in Everyday Life
    • Review the major carbohydrate and common metabolic 3.08 Eicosanoid Metabolism
    pathways in the well fed and fasting state Discuss Eicosanoids in terms of:
    • Compare these pathways based on several criteria • Characteristics
    • Enumerate the different inborn errors of carbohydrate • Biosynthesis
    metabolism o Precursor
    o Major pathways, enzymes and products
    • Elucidate the mechanism by which useful energy is
    o Minor pathways
    extracted from carbohydrates • Functions
    • Review the hormones in terms of chemical composition
    and signaling mechanism 3.09 Sphingolipids and Glycosphingolipids
    Discuss sphingolipids and glycosphingolipids in terms of:
    3.04 Lipid Chemistry • Chemistry – general structure, types
    • Classify the lipids • Synthesis – precursors, enzymes
    • Summarize their major functions • Degradation – enzymes, products and
    • Compare their unique structures • mechanism of lipid storage diseases
    • Describe the main stages of lipid digestion
    • Discuss the role of digestive enzymes 3.10 BGD: Lipid Metabolism with Clinical Correlates
    • Identify compounds arising from the digestion of lipids
    that become substrates for further metabolism
    3.11 B-Oxidation and Ketogenesis
    • Describe the process by which FA are transported in
    3.05 Lipogenesis blood, activated and transported in the mitochondria for
    • Summarize the digestion & transport of dietary TAGs. breakdown to produce energy thru β-oxidation of fatty
    • Recognize the route (pathways and transporters) by acids.
    which dietary glucose is converted to fatty acids. o Site
    • Compare and contrast the chemical reactions, o Steps involved
    precursor/s, enzymes, and co-enzymes for triacylglycerol o Enzymes/Co-enzyme
    metabolism in the FED and FAST states as to: o Substrate and Products
    o Liver and adipose tissues • Differentiate the β-oxidation and odd-numbered fatty
    o Synthesis/regulation acids and unsaturated fatty acids.
    o Transport • Compute for the energy yield of the β-oxidation of fatty
    • Describe: Insulin resistance – role of muscle and acids
    pancreas. • Differentiate β-oxidation from α-oxidation and ω-oxidation
    • Summarize the role of the liver in ethanol metabolism, as of fatty acids
    to: • Discuss the regulation of β-oxidation of fatty acids
    o Occasional/mild alcohol ingestion • Discuss the process of ketogenesis
    o Chronic/increased alcohol ingestion o Site
    o Substrate
    3.06 Cholesterol Metabolism o Enzymes/Coenzymes
    • Explain cholesterol metabolism as to: o Products
    o Regulation of intracellular cholesterol content: • Describe the regulation of ketogenesis
    diet and de novo synthesis • Discuss the different abnormalities associated with
    o synthesis/regulation - chemical reactions, oxidation of fatty acids
    precursors, enzymes, and co-enzymes;
    o transport;
    o degradation and excretion
    • Explain lipoprotein metabolism as to:
    o Contents
    o Biosynthesis
    o Regulation
    o Breakdown

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