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    Virology: Herpesviruses II: Herpes Simplex

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    Jaz C
    1. Several viruses were discussed including herpesviruses, DNA viruses like adenovirus and papillomavirus, RNA viruses like influenza, and hepatitis viruses. 2. Many of the viruses cause common infections like the common cold, influenza, and various childhood illnesses. Some can also cause more serious diseases like hepatitis, meningitis, encephalitis, and cancers in immunocompromised individuals. 3. Treatment depends on the specific virus but often involves symptomatic relief, antiviral medications, replenishing fluids, and vaccination when available.

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    Virology: Herpesviruses II: Herpes Simplex

    Uploaded by

    Jaz C
    88 views4 pages
    1. Several viruses were discussed including herpesviruses, DNA viruses like adenovirus and papillomavirus, RNA viruses like influenza, and hepatitis viruses. 2. Many of the viruses cause common infections like the common cold, influenza, and various childhood illnesses. Some can also cause more serious diseases like hepatitis, meningitis, encephalitis, and cancers in immunocompromised individuals. 3. Treatment depends on the specific virus but often involves symptomatic relief, antiviral medications, replenishing fluids, and vaccination when available.

    Original Description:

    Notes on Virology

    Original Title

    Virology Notes

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    1. Several viruses were discussed including herpesviruses, DNA viruses like adenovirus and papillomavirus, RNA viruses like influenza, and hepatitis viruses. 2. Many of the viruses cause common infections like the common cold, influenza, and various childhood illnesses. Some can also cause more serious diseases like hepatitis, meningitis, encephalitis, and cancers in immunocompromised individuals. 3. Treatment depends on the specific virus but often involves symptomatic relief, antiviral medications, replenishing fluids, and vaccination when available.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    88 views4 pages

    Virology: Herpesviruses II: Herpes Simplex

    Uploaded by

    Jaz C
    1. Several viruses were discussed including herpesviruses, DNA viruses like adenovirus and papillomavirus, RNA viruses like influenza, and hepatitis viruses. 2. Many of the viruses cause common infections like the common cold, influenza, and various childhood illnesses. Some can also cause more serious diseases like hepatitis, meningitis, encephalitis, and cancers in immunocompromised individuals. 3. Treatment depends on the specific virus but often involves symptomatic relief, antiviral medications, replenishing fluids, and vaccination when available.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 4

    No catara symptom; prioritize the fever- give paracetimol as

    VIROLOGY antipyretic
    Syphilis- can cross the placenta  and cause anomalies; can be Turn patient to the side, side rails of bed up when seizure
    treated before 18 months of gestation ensures
    Primary- chunker painless ulcer with rubbery edge 7: ask in which body part the rashes started
     
    Part of the cell that is affected: nucleus-> viral DNA HHV 8
    RNA viruses single stran; DNA- double strand May tubig yung rashes 
    RNA viruses Usually present in people with full-blown AIDS
    1.       RNA sense- served as mRNA
    2.        RNA antisense Herpesviruses II: herpes simplex
    3.       Capsid Similar to bulutong tubig
    Envelope- must be destroyed by meds HSV-1 (common in children): very red eyes
    The virus cannot be fully eradicated; the immune system must (keratoconjunctivitis-> may lead to blindness)
    always be up else the virus will resurface HSV-2: May cause genital ulceration (increases the risk of HIV
    Herpersviruses I: Cytomegalovirus transmission)
    Close contact- through direct contact; mother must wear mask  
    to prevent her child from contracting the disease Varicella Zoster virus
    May cause genetical anomaly to the fetus Transmission is through direct contact duh
    Immuno-compromised patients and infants are more Superficial scars which may take years to fade
    susceptible
    These antiviral drugs are more toxic to infants so diagnose DNA viruses: Adenovirus
    carefully
    DNA viruses: Parvovirus
    Herpesviruses I: Epstein-Barr virus May cause erythema infectiosum or fifth disease (Not
    Nasophrayngeal carcinoma caused by cigarette smoking is contagious)
    more usual here in the Philippines through tissue biopsy (Do Usually occurs in the colder months
    not touch because it has affected the squamous cells) There is malar blush or slap cheeks; no discomfort
    Versus Burkitt’s lymphoma Next: Trunk and extremities
    Jackie O had lymphoma of the nodes On the 5th day: Reticular or lacy-pattern rash with central
    clearing
    Herpesviruses I: HHV-6 & 7 Fever is also low so need to worry
    6: Subtypes: A & B No vaccine present
    Roseola infantum Different from parvovirus in dogs
    Face and trunk fine rashes
    No peeling off versus  DNA viruses: Papillomavirus
    Responsible for genital warts Symptomatic treatment: analgesic, anti pyretic, alternating cold
    Cryosurgery to remove the warts (repeated) and hot compress, soft diet, complete bedrest
    Cannot fully eradicate it In males: wear properly fitted suspensory- supporter; not
    Puts females at risk for HPV cancer so there is a vaccine advised to walk around- may increase inflammation

    DNA viruses: Poxvirus Rubivirus/German measles


    Causes smallpox, monkeypox (zoonotic- infects patches of Through direct contact: aerial droplets, through linens and
    skin only), orf (may cause pustular dermatitis- comes from articles infected by droplets and urine
    goats) Low grade fever, mild cataral symptoms
    Moluscum contagiosum: Pearl-like skin lesions Can cause (?) Rothel disease
    Tanapox: Single nodular skin lesion (may be contracted from Incubation period: 10-21 days
    furry animals) Transplacental and may reach the infant and cause anomalies
    Face, chest and will spread to extremities
    RNA Viruses Rashes for three days, no discoloratiom after
    1. Morbilivirus:  Pinkish not reddish
    1. affects the epithelial cells, results in viraemia; Kulani sa likod ng tenga (suboccipital area)
    contagious through droplets; coplic spots in the Forschermer spots (soft lesions in the soft palate) also seen in
    cheek opposite the second molar (use a tongue strep fever
    depressor), hairline Complication: otitis media, encephalitis
    2. Leaves discoloration after seven days (do not Mother in the first/second/third trimester- may also lead to
    peel off) premature labor, abortion, congenital anomalies
    3. Fever peaks at the height of the rashes First trimester: teratogenic
    4. Remitent IgM, IgG antibodies/NAAT
    5. Morbilivirus: may lead to pneumonia (cause of
    death in children) Influenza
    6. Dx through EIA Antigenic shift versus drift
    7. Give mucolitoc expectorants and pausok Myalgia, cough
    b. Mumps virusMumps virus: aerial route/ droplets  Avian flu: complication-> pneumonia
    May cause sterility (if two balls/ovaries are affected) NAAT, direct immunofluorescent
    Parotid gland enlargement and tenderness Case hx: intake of chicken?
    Pain when chewing (odynophagia) Vaccination: 70% of protection
    May cause neurologic complications: meningitis, encephalitis, No vaccine for avian flu yet
    permanent deafness, olineorhitis?, optic neuritis
    Orchitis: Unilateral testes affectation but may also be bilateral Parainfluenza
    after five to ten days of illness (after mawala ang enlargement) Treatment: medication and humidification (humidified oxygen)
    Myocarditis
    RS virus Also if it continues for more than 24hrs
    Coryza in newborns- difficulty in breathing Tx: nuprintrivir
    Symptomatic treatment
    Stiminilation (?) Rotavirus
    X vaccine Main cause of viral diarrhea
    No specific antibiotic; replenish lost fluids
    Coronavirus and electrolytes
    Causes coryza-like sickness similar to rhinovirus
    SARS: Through droplets Norovirus and Astrovirus
    Must have continuous fever Noro: fecal-oral/aerosol
    Mild respiratory symptoms at the onset I.e. Yemen- contaminated water by Kingdom of Saudi Arabia
    But may lead to dry, unproductive cough Astro: mqy cause accute diarrhea
    Hypoxemia Important to request for stool exam (3x)
    High risk: housemates *wards are ordered to be closed
    Antiviral drug: remdicivir, ribavirin in combo with steroid (to
    reduce inflammation) Hepatitis A
    20 strains of COVID Affects the liver lobules/hepatocytes/kaufer? cells
    Changes liver cells structure and fxn: swelling and
    Enterovirus degeneration-> repair
    Heinmeilen (?) disease High mortality
    Polymelitis virus Chief cause of hepatic cancer and cirrhosis
    1 Brunhilde Accure stage-very contagious
    2 lansing Three doses of vaccine
    3?
    Treatment: artificial ventilation Hepatitis B
    Vaccine: parenteral; oral luve attenuated sabin; oral polio One dose of vaccine
    vaccine 2-3 drops orally  Hepa B immunoglubbulin
    Under the tongue? Hippie hepatitis-common in drug users
    X eating after the child has been given the vaccine to maintain Pegylated alpha-interferon
    the right dissolutiob for best absorption Sex partners are particularly susceptible

    Rhinovirus Hepatitis C
    Common cold
    Infects the mucosa and submucosa of the URT Rabies
    see if nasal discharge changes its color the you may give an Infects warm blooded animals
    antibiotic Found in the saliva
    *negribodies Grade 2 
    Incubation: average 20-60 Grade 3 circulatory failure, rapid and weak pulse
    Variable incubation period d/t viral dose, location of bite, host Grade 4: shock, palpatory blood pressure
    response (low immune-faster time, area where you got beaten, DEATH
    animal who bit you (10-14 days) Tx: symptomatic and supportive treatment; side drip; vit c for
    Tx: copious washing with soap and water capillary permeability (skin test!!!); IV fluid; antipyretic
    Stage 2: increased excitement Xaspirin!!!! (Will lead to bleeding)
    Prodromal (?) 3. Japanese B encephalitis
    Terminal: tachycardia, prog paralysis 3. Lassa Fever
    Cause of death: resp failure 3. Ebola and Marburg virus
    No cure for rabies 3. Hantavirus
    Clinical and epidemiological features 3. Nipah and Hendra virus
    Bring the dog’s head sa clinic kung papatayin mo man
    Two booster doses if bitten again after 3-6 mos of the first bite
    Six months after: seven daily injection and antiserum
    Coprosky (?) high cure rate
    Semple vaccine- cheaper, more widely used
    Decapitation of the dog, then send dog to the clinic

    Yellow fever virus


    May not be present here in Ph
    X hanging underwear and pants
    Attenuated vaccine

    Dengue
    July-October
    Capillaries- Herman’s sign
    The virus will destroy the new platelets thus it will lower in
    number
    Decrease blood coagulation factor 7, 5 and 9
    Classification of dengue according to severity
    Grade 1: torniquet test (10-15 secs) then marks will be seen
    Rample test (Bp apparatus: bp up) 110/70 add 110+70/90 (bp:
    90, stop for several seconds- marks will be seen); platelet
    count has decreased; do not wait for patient to bleed because
    it will not clot; PTK, severe nosebleeding

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