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Unit 3 - Two Dimensional NMR: Week - 2 - Assignment

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359 views4 pages

Unit 3 - Two Dimensional NMR: Week - 2 - Assignment

Uploaded by

Saurav Paul
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Unit 3 - Two
dimensional NMR
Register for
Certification exam week_2_assignment
The due date for submitting this assignment has passed.
Course As per our records you have not submitted this Due on 2019-02-13, 23:59 IST.
outline
assignment.

How to access 1) Which of the following is not an advantage of 2D NMR as compared to 1D 1 point
the portal NMR?

Introduction to It is possible to correlate two different chemical shifts by 2D NMR


Basics of NMR
It is possible to observe multiple quantum coherences directly in a 2D spectrum
Two dimensional The sensitivity of 2D NMR spectrum is better than 1D NMR so it takes comparatively less
NMR
time to acquire 2D NMR spectrum
Basic concepts 2D NMR spectra have better resolution than 1D NMR spectrum
in 2D NMR
spectroscopy No, the answer is incorrect.
Score: 0
Principles of 2D
correlation Accepted Answers:
spectroscopy The sensitivity of 2D NMR spectrum is better than 1D NMR so it takes comparatively less time to acquire
COSY
2D NMR spectrum
Principles of 2D
2) Which of the following is a homonuclear NMR experiment? 1 point
Total correlation
spectroscopy
(TOCSY) HSQC
2D Nuclear HMQC
Overhauser
COSY
Effect
Spectroscopy HMBC
2D NOESY and No, the answer is incorrect.
2D ROESY
Score: 0
Quiz : Accepted Answers:
week_2_assignment
COSY
week_2
assignment 3) What is the total number of peaks in the COSY spectra of CH3-CH2-CH2-Cl 1 point
solution page 1 (Ignore the J-multiplet pattern)?
week_2
assignment © 20147NPTEL - Privacy & Terms - Honor Code - FAQs -
solution
A project of page 2 6 In association with
week_2 8
assignment
solution page 3 5
Funded by
week_2 No, the answer is incorrect.

1 of 4 Thursday 02 May 2019 05:23 PM


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assignment Score: 0 Powered by


solution page 4
Accepted Answers:
Important 2D 7
NMR
4) What is the total number of peaks in the TOCSY spectra of CH3-CH2-CH2-Cl 1 point
experiments for
Biomolecules (Ignore the J-multiplet pattern)?

3D NMR 11
Spectroscopy
8

Basics of 9
Protein
Structure 7

No, the answer is incorrect.


Isotope
Score: 0
Labelling
Accepted Answers:
Resonance 9
assignment of
Proteins with 5) In which of the following NMR experiments, the magnetization is transferred 1 point
NMR and among all spins in a spin system having J-couplings to each other?
Structure
Determination COSY

NMR NOESY
Experiments for
Studying
Protein-Ligand TOCSY
Interactions
ROESY
DOWNLOAD
No, the answer is incorrect.
VIDEO
Score: 0

Interaction Accepted Answers:


session TOCSY

6) There are two pairs of protons: A-B and C-D. In a 2D NOESY spectrum, the 1 point
intensity of cross peak between A-B was 10 times more than the intensity of cross peaks
between C-D. Which of the following is true about the distances: r(A-B) and r(C-D)?

r(A-B) is approximately 3 times greater than r(C-D)


r(A-B) is approximately 1.5 times greater than r(C-D)
r(A-B) is approximately 3 times smaller than r(C-D)
r(A-B) is approximately 1.5 times smaller than r(C-D)

No, the answer is incorrect.


Score: 0
Accepted Answers:
r(A-B) is approximately 1.5 times smaller than r(C-D)

7) Which of the following is true about the difference between 2D ROESY and 1 point
2D NOESY?

In 2D ROESY, magnetization is transferred through J-coupling, but not in 2D


NOESY
In 2D NOESY, magnetization is transferred through J-coupling, but not in 2D
ROESY
There is a mixing time in 2D NOESY and not in 2D ROESY
The cross peaks and diagonal peaks in 2D ROESY are opposite in sign but same sign in 2D
NOESY

No, the answer is incorrect.

2 of 4 Thursday 02 May 2019 05:23 PM


Multidimensional NMR Spectroscopy for Struct... https://onlinecourses.nptel.ac.in/noc19_cy12/uni...

Score: 0
Accepted Answers:
The cross peaks and diagonal peaks in 2D ROESY are opposite in sign but same sign in 2D NOESY

8) Which of the following is true about 2D NOESY? 1 point

The distance between two protons is directly proportional to the intensity of the
cross peaks in 2D NOESY
The intensity of cross peaks in 2D NOESY does not keep increasing with increase in mixing
time

A mixing time of 200-300 ms is used in 2D NOESY for proteins


A 2D NOESY spectrum can never contain more number of peaks than 2D
TOCSY
No, the answer is incorrect.
Score: 0
Accepted Answers:
The intensity of cross peaks in 2D NOESY does not keep increasing with increase in mixing time

9) Which of the following mixing times is most likely used in a 2D homonuclear 1 point
TOCSY?

30 ms
5 ms
40 ms
80 ms

No, the answer is incorrect.


Score: 0
Accepted Answers:
80 ms

10)In a 2D experiment, what is sandwiched between two evolution times? 1 point

Preparation period
Mixing period

Decoupling period
Detection period
No, the answer is incorrect.
Score: 0
Accepted Answers:
Mixing period

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