Abstract said substances are the nature of the solute

and solvent, wherein water serves as the

Solubility happens as stated by the solvent and medicinal tablet as the solute.
International Union of Pure and Applied
Chemistry (IUPAC) when the analytical Keywords: Medicine; Pulverize Medicine;
composition of a saturated solution Solubility; Mixture
expressed as a proportion of a designated
solute in a designated solvent. Loftsson et al. Introduction
(2010), it was found out that 40% of Nowadays, as stated by Loftsson et
approved drugs and nearly 90% of the al. (2010), it was found out that 40% of
developmental pipeline drugs consist of approved drugs and nearly 90% of the
poorly soluble molecules. According to developmental pipeline drugs consist of
Seltzer (2013), tablets places within the poorly soluble molecules. Moreover, the
water dissolved much faster, due to the Biopharmaceutics Classification System
presence of the sodium bicarbonate splits (BCS), conducted a classification between
apart to form sodium and bicarbonate ions. different drugs based on their solubility and
The researcher aims to be compared the its capacities.
solubility of substances in various solvent
and demonstrate the factors affecting Solubility happens as stated by the
solubility. International Union of Pure and Applied
Chemistry (IUPAC) when the analytical
In performing the experiment, first is composition of a saturated solution
too gathered and prepared the following expressed as a proportion of a designated
materials such as the alternative mortar and solute in a designated solvent. Solubility
pestle, soluble medicine tablets, 2 glass and may be stated in units of concentration,
containers and especially the water. Second, molality, mole fraction, mole ratio, and other
cut the soluble medicine tablet into two, one units. Aulton (2002) defined drug solubility
should be pulverize or crushed while the as the amount of drug that passes into
second one should be remains to its half solution when equilibrium is established
state. After, separating insert small amount between the drug solute in solution and any
of water to the container or glass and insert excess.
the two separated medicinal tablets into the
two separated glasses. Lastly, kindly Based on the experiment conducted
observed and examined what will happen to by Seltzer (2013), it was stated that when the
the tablets placed separately. tablets places on the water it dissolves the
substances faster, due to the sodium
The researchers found out that the bicarbonate splits apart to form sodium and
crushed or pulverized tablet is very soluble bicarbonate ions. Moreover, it also
compared with tablet that uncrushed which elaborates that the bicarbonate ions react
considered classify as moderately soluble. with hydrogen ions from the citric acid to
Moreover, the researchers also discovered form carbon dioxide gas (and water).
that the factors affecting the solubility of the
 The objectives of the study, was to Figure 1: It shows the process occurs
be able to be compared the solubility of during the said experiment
substances in various solvent and
demonstrate the factors affecting solubility. Experiment Level of Factors
Solubility Affecting the
Methodology Solubility
Pulverize Very Soluble Nature of
Materials Medicine Solute and
into the Solvent
 Alternative Mortar and Pestle Water
 Soluble Medicine Tablet Non- Moderate Nature of
pulverized Soluble Solute and
 Water
medicine Solvent
 2 Glass/Containers tablet in
Water
Procedure

1. First, prepare the following materials such

Table 1: It shows the level of solubility as
as the alternative mortar and pestle, soluble
well as the factors affecting the solubility
medicine tablet, 2 glass/containers and
water. Based on the result of the
experiment, the researchers found out that
2. Second, cut the tablet medicine into two
pulverize or crushed tablet is very soluble in
and pulverize the half and remains the other
water compared with the uncrushed tablet.
half.
The researchers, also figured out that the
3. Third, put the pulverize tablet in the first solubility of the crushed tablet happens due
container while the second one on the to the sodium bicarbonate splits apart that
second container. forms the sodium and bicarbonate ions, as
stated with Seltzer (2013). Moreover, the
4. Lastly, do not stir the mixtures and take researchers identified that the tablet used in
note and observes what will happen. the experiments serves as the solute and
water is serves as the solvent. The factors
Results and Discussion
affecting the solubility are the nature of
solute and solvent, wherein the medicine
tablet (solute material) easily dissolve on the
water (solvent material).

Conclusion

The researchers concludes that the

crushed or pulverize tablet is very soluble
compared with uncrushed tablet, which
identified as moderately soluble. Moreover,
the researchers also identified that the factor
affecting the solubility in the experiment, Savjani, Gajjar, and Savjani, (2012,
and it is due to the nature of the solute and May 8). Drug Solubility: Importance and
solvent, wherein the water serves as the Enhancement Techniques. Retrieved from
solvent and the medicinal tablets serves as https://www.Researchgate.Net/Publication/2
the solute. 64208352_ChemInform_Abstract_Drug_Sol
ubility_Importance_and_Enhancement_Tec
References hniques.
Ahuja, N., Katare, O. P., & Singh, B. Seltzer, A. (2013, August 29).
(2007). Studies on dissolution enhancement Carbonation Countdown: The Effect of
and mathematical modeling of drug release Temperature of Reaction Time. Retrieved
of a poorly water-soluble drug using water- from
soluble carriers. European Journal of https://www.scientificamerican.com/article/
Pharmaceutics and Biopharmaceutics, 65(1), bring-science-home-carbonation-time/
26–38. Retrieved from https://sci-
hub.do/https://www.sciencedirect.com/scien
ce/article/abs/pii/S0939641106001901
Singh, Kaur, Gupta and Sharma, G.
Loftsson T, Brewster ME. G. D. S. (2016, August 21). Enhancement of
Pharmaceutical applications of the Solubility of Poorly Water Soluble
cyclodextrins: basic science and product Drugs through Solid Dispersion: A
development. J Pharm Pharmacol. Comprehensive Review. Retrieved from
2010;62:1607–1621.Retrieved from https://www.ijpsonline.com/articles/enhance
https://www.ncbi.nlm.nih.gov/pmc/articles/P ment-of-the-solubility-of-poorly-water-
MC4629443/ soluble-drugs-through-solid-dispersion-a-
comprehensive-review-3377.html
Loh, Z. H., Samanta, A. K., & Sia
Heng, P. W. (2015). Overview of milling
techniques for improving the solubility of
poorly water-soluble drugs. Asian Journal of
Pharmaceutical Sciences, 10(4), 255–
274.Retrieved from https://sci-
hub.do/https://www.sciencedirect.com/scien
ce/article/pii/S1818087615000100

M.E. Aulton (Ed.), Pharmaceutics:

the science of dosage form design (2nd ed),
Churchill Livingstone, London (2002), pp.
15-32. Retrieved from
https://www.sciencedirect.com/science/articl
e/pii/S1818087615000100#bib2