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    Acute Kidney Injury. Clinical - 2: Ckd-Epi

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    Acute Kidney Injury. Clinical - 2: Ckd-Epi

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    jagodzinska2016.pdf

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    Acute Kidney Injury. Clinical - 2: Ckd-Epi

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    Nephrology Dialysis Transplantation 31 (Supplement 1): i406–i421, 2016

    doi:10.1093/ndt/gfw187.33

    ACUTE KIDNEY INJURY. CLINICAL - 2 patients undergoing planned radiological investigations that required intravenous CM
    administration.
    Methods: A randomized double-blind placebo-controlled study included 43
    hospitalized patients (n=43, 19 M and 24 F, mean age 80±7 years, BMI 31.3±6.9 kg/
    MP227 EFFECT OF PRE-TREATMENT WITH ORAL SUPEROXIDE m2) with eGFRCKD-EPI <60 ml/min. All patients underwent a scheduled radiological
    DISMUTASE ON SERUM MARKERS OF KIDNEY AND investigation with i.v. infusion of 79±16 ml of ioxehol. The patients were randomly
    ENDOTHELIAL INJURY IN PATIENTS UNDERGOING assigned to a 7-day oral administration of SOD (n=23, 10 M and 13 F) or placebo
    PLANNED RADIOLOGICAL INVESTIGATIONS WITH administration (n=20, 9 M and 11 F). Four days before and 3 days after CM infusion
    INTRAVENOUS CONTRAST MEDIUM ADMINISTRATION the patients received 500 mg orally bioavailable vegetable SOD (Glisodin) per day or

    Downloaded from https://academic.oup.com/ndt/article-abstract/31/suppl_1/i415/2225065 by guest on 07 January 2019


    placebo respectively. All patients received oral fluids for routine CIN prophylaxis. The
    Marta Jagodzinska1, Szymon Jagodzinski2 and Michał Nowicki3 blood for the measurement of serum creatinine, cystatin C, lipids, CRP, NGAL,
    1
    Medical University of Lodz, Nephrology, Hypertension and Kidney ICAM-1, and vWF-1 was taken at baseline and 24 and 48 hours after iohexol
    Transplantation, Łódź, POLAND, 2Medical University of Łódź, Nephrology, administration.
    Hypertension and Kidney Transplantation, Łódź, POLAND, 3Medical University of Results: Mean estimated GFR (serum cystatin and creatinine-based) decreased by 4
    Łódź, Dept. Nephrology, Hypertension and Kidney Transplantation, Łódź, ml/min 48 hours after CM in placebo group but was virtually unchanged in patients
    POLAND treated with SOD. The changes in serum vWF, ICAM-1 and NGAL after CM
    administration were not different between groups. High-sensitivity CRP increased from
    0.07±0.03 to 0.09±0.03 mg/l ( p=0.02) after 48 hours following the CM administration.
    Introduction and Aims: Contrast-induced nephropathy (CIN) is a complication of There was a significant difference in hsCRP between treatment groups (0.06±0.04 mg/l
    radiologic tests resulting from the administration of contrast media (CM). The in SOD group vs. 0.09±0.03 mg/l in placebo group, p=0.01) 48 hours after CM.
    infusion of CM can lead to an acute kidney injury (AKI) and endothelial injury Conclusions: The results of the study did not confirm the beneficial effect of
    mediated by increased oxidative stress. Superoxide dismutase (SOD) is the crucial pre-treatment with oral superoxide dysmutase on the biomarkers of endothelial and
    component of antioxidant defense. We hypothesized that the administration of SOD renal injury in patients receiving intravenous iodine contrast media
    can prevent the occurrence of AKI. The aim of the study was to evaluate the influence
    of oral SOD administration on serum markers of kidney and endothelial injury in

    © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

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