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Tablet Coating Experiment

The document describes the procedure for film coating of tablets. It involves preparing a film coating suspension with HPMC as the film former, talc as the anti-tacking agent, and other ingredients like dyes. Tablets are then coated in a coating pan under specified parameters. The coated tablets are evaluated for percentage weight gain, hardness, thickness, weight variation, friability, and disintegration time to ensure the coating process produced tablets meeting standards.

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Shivraj Jadhav
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698 views

Tablet Coating Experiment

The document describes the procedure for film coating of tablets. It involves preparing a film coating suspension with HPMC as the film former, talc as the anti-tacking agent, and other ingredients like dyes. Tablets are then coated in a coating pan under specified parameters. The coated tablets are evaluated for percentage weight gain, hardness, thickness, weight variation, friability, and disintegration time to ensure the coating process produced tablets meeting standards.

Uploaded by

Shivraj Jadhav
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Aim: Coating of tablets- film coating of tables/granules

Requirements:
Chemicals:
HPMC, Talc, Ethanol, acetone, polyethylene glycol, any colour dye
Glassware and apparatus: Beaker, measuring cylinder, pipette, coating pan, spraying gun
Theory:
Write down theory of related to table coating
Procedure:
Preparation of film coating suspension:
Sr. Ingredient Function Quantity
No.
1 HPMC Film former 10 mg
2 Talc Anti-tacking agent 5 mg
3 Titanium dioxide Opacifying agent 5 mg
4 Dye Colour 1 mg
5 polyethylene glycol Plasticizer 2 mg
6 Water Vehicle Qs
7 Isopropyl alcohol Vehicle Qs
Film coating suspension was prepared by dispersing HPMC in isopropyl alcohol and then
water is added slowly to obtain clear lump free solution. PEG is dissolved in purified water to
get clear solution. To above mixture add remaining ingredients and make uniform
suspension. Coating solution is ready.
Keep the coating pan specifications as follows:

Carry out film coating of 100 uncoated tablets (previously prepared) until uniform coating is
obtained.
Evaluation parameters after coating:
Percentage of weight gain:
Initial weight of 100 tablets: 49.10 gm
Final weigh after coating of 100 tablets: 58. 55 gm
Hence calculate percentage of weight gain.

Hardness:
Tablet number Observed Hardness
1 5 kg
2 5.4 kg
3 3 kg
4 4.5 kg
5 3.8 kg
Average …………………… kg
Thickness:
Tablet number Observed Thickness
1 3 mm
2 3 mm
3 3.2 mm
4 3.2 mm
5 3.4 mm
Average …………………… kg
Weight variation test:
Tablet number Weight mg
1 520
2 530
3 530
4 535
5 520
6 530
7 525
8 525
9 530
10 525
11 520
12 520
13 520
14 520
15 525
16 530
17 525
18 530
19 535
20 540
Average ………………….. mg
Calculation:
Friability:
Weigh of coated 20 tablets before friability: 10.60 gm
Weight of coated 20 tablets after friability:10.55 gm
Calculate percentage of friability?

Disintegration test:
Tablets used for disintegration: 6
Time required for disintegration: 45 to 50 minutes
Media used: 900 ml distilled water
Temperature:………………………..

Result:
Sr. No. Test Result
1 Thickness test
2 Hardness test
3 Weight variation test
4 % of friability test
5 Disintegration test

Tablet coating was carried out and evaluation of coated tablet was performed.

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