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    Folic Acid Presentation PDF

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    Angela Ilustrisimo
    Folic acid is a water soluble B vitamin that is converted in the body to tetrahydrofolic acid and methyltetrahydrofolate which are involved in nucleoprotein synthesis, red blood cell production, and regulation of homocysteine metabolism. It is used to prevent and treat megaloblastic anemias, folic acid deficiency, and promote normal fetal development during pregnancy. Common side effects include rash, fever, irritability, and difficulty sleeping. It should be used cautiously in patients with pernicious, aplastic, or normocytic anemias.

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    Folic Acid Presentation PDF

    Uploaded by

    Angela Ilustrisimo
    87 views13 pages
    Folic acid is a water soluble B vitamin that is converted in the body to tetrahydrofolic acid and methyltetrahydrofolate which are involved in nucleoprotein synthesis, red blood cell production, and regulation of homocysteine metabolism. It is used to prevent and treat megaloblastic anemias, folic acid deficiency, and promote normal fetal development during pregnancy. Common side effects include rash, fever, irritability, and difficulty sleeping. It should be used cautiously in patients with pernicious, aplastic, or normocytic anemias.

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    Folic acid is a water soluble B vitamin that is converted in the body to tetrahydrofolic acid and methyltetrahydrofolate which are involved in nucleoprotein synthesis, red blood cell production, and regulation of homocysteine metabolism. It is used to prevent and treat megaloblastic anemias, folic acid deficiency, and promote normal fetal development during pregnancy. Common side effects include rash, fever, irritability, and difficulty sleeping. It should be used cautiously in patients with pernicious, aplastic, or normocytic anemias.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    87 views13 pages

    Folic Acid Presentation PDF

    Uploaded by

    Angela Ilustrisimo
    Folic acid is a water soluble B vitamin that is converted in the body to tetrahydrofolic acid and methyltetrahydrofolate which are involved in nucleoprotein synthesis, red blood cell production, and regulation of homocysteine metabolism. It is used to prevent and treat megaloblastic anemias, folic acid deficiency, and promote normal fetal development during pregnancy. Common side effects include rash, fever, irritability, and difficulty sleeping. It should be used cautiously in patients with pernicious, aplastic, or normocytic anemias.

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    of 13

    DRUG STUDY

    FOLIC ACID
    Ilustrisimo, Angela Renee B. | September 22, 2020
    DRUG:
    Brand Name
    Folart
    Generic Name
    Folic Acid
    Classification
    Pregnancy Category A
    Therapeutic: antianemics, vitamins
    Pharmacologic: water soluble vitamins
    Route
    PO, IM, SC, IV
    DRUG:
    Dosage
    (Adults and Children > 11 yr) : 1 mg/day initial dose
    then 0.5 mg/day maintenance dose.
    Pregnancy and lactation : 0.8 mg/day.
    (Children > 1 yr) : 1 mg/day initial dose then 0.1– 0.4
    mg/day maintenance dose.
    (Infants) : 0.1 mg/day.
    < 4 yr: Up to 0.3 mg/day.
    > 4 yr: 0.4 mg/day.
    Frequency
    as per doctor’s order
    Vitamin supplement : one dose per day
    MECHANISM OF ACTION
    Folic acid is first converted to tetrahydrofolic acid
    and methyltetrahydrofolate, which are then
    transported across cells by receptor-mediated
    endocytosis where they are needed for:
    nucleoprotein synthesis; maintenance and
    production of red blood cells, white blood cells,
    and platelets; restores and maintains normal
    ematopoiesis; regulation of homocysteine
    metabolism which prevents structural anomalies in
    the fetus.
    Side Effects

    1 DERM 3 MISC
    rash fever

    2 CNS
    irritability,

    difficulty sleeping,

    malaise, confusion
    INDICATION CONTRAINDICATION
    prevention patients with uncorrected
    and treatment of pernicious, aplastic, or
    megaloblastic and normocytic anemias
    macrocytic anemias; (neurologic damage will
    folic acid deficiency; progress despite correction of
    given during hematologic abnormalities);
    pregnancy to promote preparations containing benzyl
    normal fetal alcohol should not be used in
    development newborns; undiagnosed
    anemias (use cautiously)
    NURSING RESPONSIBILITIES
    Observe client’s 10 rights to administration of drugs:
    1. Right patient
    2. Right medication
    3. Right dosage
    4. Right route
    5. Right time
    6. Right documentation
    7. Right client education
    8. Right to refuse
    9. Right assessment
    10. Right evaluation
    NURSING RESPONSIBILITIES
    Observe for signs of adverse reactions;       
    Assess for patient’s allergic history to folic acid preparations;   
    Prepare equipment and emergency drugs readily available in case of
    serious allergic/adverse response;       
    Obtain patient history for pernicious, aplastic, normocytic anemias;  
    Conduct physical assessment for skin lesions, color; R, adventitious
    sounds; Schilling test;       
    Monitor plasma folic acid levels, hemoglobin, hematocrit, and
    reticulocyte count before and periodically during therapy;   
    NURSING RESPONSIBILITIES
    Administer orally if at all possible. With severe GI malabsorption or
    very severe disease, give IM, SC, or IV;    
    Educate patient of the contraindications of the drugs and its side
    effects;     
    Explain that folic acid may make urine more intensely yellow;
    Instruct patient to notify health care professional if rash occurs,
    which may indicate hypersensitivity;      
    Educate patient to take the right amount of dosage per doctor’s
    order;
    NURSING RESPONSIBILITIES
    Educate patient about the drug-drug interactions for them to avoid
    these drugs;
    Educate patients who are self-medicating folic acid as vitamin
    supplements to be careful not to exceed RDA.
    ADDITIONAL
    INFORMATION
    DRUG-DRUG INTERACTION
    Pyrimethamine, methotrexate, trimethoprim, and triamterene - prevent the activation of
    folic acid (leucovorin should be used instead to treat overdoses of these drugs)
    Sulfonamides (including sulfasalazine), antacids, and cholestyramine – decrease absorption
    of folic acid
    Estrogens, phenytoin, phenobarbital, primidone, carbamazepine, or corticosteroids – folic
    acid requirements will increase   
    Phenytoin - decreases serum folate levels
    ADDITIONAL
    INFORMATION
    RECOMMENDED DAILY ALLOWANCE
    (Adults and Children 15 yr): 0.2 mg/day.
    (Adults): Females of childbearing potential – 0.4 – 0.8 mg/day.
    (Children 11– 14 yr): 0.15 mg/day.
    (Children 7– 10 yr): 0.1 mg/day.
    (Children 4– 6 yr): 0.075 mg/day.
    (Infants 6 mo– 3 yr): 0.05 mg/day
    REFERENCES:
    F.A. Davis Company. (2015). folic acid [Ebook] (pp. 1-2). Retrieved from
    https://davisplus.fadavis.com/3976/meddeck/pdf/folicacid.pdf

    Folic acid. (2005). Retrieved 21 September 2020, from


    https://go.drugbank.com/drugs/DB00158

    Folic Acid. (2008). Retrieved 21 September 2020, from


    https://www.scribd.com/document/6982597/Folic-Acid

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