Medication Information

for Parents and Teachers

Amphetamine—Dexedrine, ProCentra,
Zenzedi, Adderall, Vyvanse
General Information About Medication

Each child and adolescent is different. No one has exactly the same combination of medical and psychological
problems. It is a good idea to talk with the doctor or nurse about the reasons a medicine is being used. It is
very important to keep all appointments and to be in touch by telephone if you have concerns. It is important
to communicate with the doctor, nurse, or therapist. An advanced practice nurse (APN) has additional education
and training after becoming a registered nurse (RN). Your child’s medication may be prescribed by a medical
doctor (MD or DO) or an APN. In addition, a physician assistant (PA) working with a physician may prescribe
certain medications. In this information sheet, “doctor” includes medical doctors as well as APNs and PAs who
prescribe medication. Often a nurse (RN) will be part of the team and answer questions and give information.
It is very important that the medicine be taken exactly as the doctor instructs. However, once in a while,
everyone forgets to give a medicine on time. It is a good idea to ask the doctor or nurse what to do if this
happens. Do not stop or change a medicine without asking the doctor or nurse first.
If the medicine seems to stop working, it may be because it is not being taken regularly. The youth may
be “cheeking” or hiding the medicine or forgetting to take it (especially at school). The doses may be too far
apart or a different dose or medicine may be needed. Something at school, at home, or in the neighborhood
may be upsetting the youth, or he or she may need special help for learning disabilities or tutoring. Please
discuss your concerns with the doctor. Do not just increase the dose. It is also very important not to de-
crease the dose or stop the medicine without talking to the doctor first. The problem being treated may come
back, or there could be uncomfortable or even dangerous results.
All medicines should be kept in a safe place, out of the reach of children, and should be supervised by an
adult. If someone takes too much of a medicine, call the doctor, the poison control center, or a hospital emer-
gency room.
Each medicine has a “generic” or chemical name. Just like laundry detergents or paper towels, some med-
icines are sold by more than one company under different brand names. The same medicine may be available
under a generic name and several brand names. The generic medications are usually less expensive than the
brand name ones. The generic medications have the same chemical formula, but they may or may not be ex-
actly the same strength as the brand-name medications. Also, some brands of pills contain dye or other things
that can cause allergic reactions. It is a good idea to talk to the doctor and the pharmacist about whether it is
important to use a specific brand of medicine.
Any medicine can cause an allergic reaction. Examples are hives, itching, rashes, swelling, and trouble
breathing. Even a tiny amount of a medicine can cause a reaction in patients who are allergic to that medicine.
Be sure to talk to the doctor before restarting a medicine that has caused an allergic reaction and tell the doctor
about any reactions to medicine that your child has had before.
Taking more than one medicine at the same time may cause more side effects or cause one of the
medicines to not work as well. Always ask the doctor, nurse, or pharmacist before adding another
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medicine, either prescription or bought without a prescription in a store or on the Internet. Be sure
that each doctor knows about all of the medicines your child is taking. Also tell the doctor about any
vitamins, herbal medicines, or supplements your child may be taking. Some of these may have side ef-
fects alone or when taken with this medication. It is a very good idea to keep a list with you of the names and
doses of all medicines that your child is taking.
Everyone taking medicine should have a physical examination at least once a year.
If you think that your child may be using drugs or alcohol, please tell the doctor right away.
Pregnancy requires special care in the use of medicine. Some medicines can cause birth defects if taken by
a pregnant mother. Please tell the doctor immediately if you suspect the teenager is at risk of becoming
pregnant. The doctor may wish to discuss sexual behavior and/or birth control with your daughter.
Printed information like this applies to children and adolescents in general. If you have questions about
the medicine, or if you notice changes or anything unusual, please ask the doctor or nurse. As scientific re-
search advances, knowledge increases and advice changes. Even experts do not always agree. Many medicines
have not been “approved” by the U.S. Food and Drug Administration (FDA) for use in children or use for
particular problems. For this reason, use of the medicine for a problem or age group often is not listed in the
Physicians’ Desk Reference. This does not necessarily mean that the medicine is dangerous or does not work,
only that the company that makes the medicine has not received permission to advertise the medicine for use
in children. Companies often do not apply for this permission because it is expensive to do the tests needed
to apply for approval for use in children. Once a medication is approved by the FDA for any purpose, a doctor
is allowed to prescribe it according to research and clinical experience.

Note to Teachers

It is a good idea to talk with the parent(s) about the reason(s) that a medication is being used. If the parent(s)
sign consent to release information, it is often helpful for you to talk with the doctor. If the parent(s) give per-
mission, the doctor may ask you to fill out rating forms about your experience with the student’s behavior,
feelings, academic performance, and medication side effects. This information is very useful in selecting and
monitoring medication treatment. If you have observations that you think are important, do not hesitate to
share these with the student’s parent(s) and treating clinicians (with parental consent).
It is very important that the medicine be taken exactly as the doctor instructs. However, everyone forgets
to give a medicine on time once in a while. It is a good idea to ask the parent(s) in advance what to do if this
happens. Do not stop or change the time you are giving a medicine at school without parental permission. If
a medication is to be taken with food, but lunchtime or snack time changes, be sure to notify the parent(s) so
appropriate adjustments can be made.
All medicines should be kept in a secure place and should be supervised by an adult. If someone takes too
much of a medicine, follow your school procedure for an urgent medical problem.
Taking medicine is a private matter and is best managed discreetly and confidentially. It is important to be
sensitive to the student’s feelings about taking medicine.
If you suspect that the student is using drugs or alcohol, please tell the parent(s) or a school counselor right
away.
Please tell the parent(s) or school nurse if you suspect medication side effects.
Modifications of the classroom environment or assignments may be useful in addition to medication. The
student may need to be evaluated for additional help or a 504 plan or an Individualized Education Plan for
learning problems or emotional or behavioral issues.
Any expression of suicidal thoughts or feelings or self-harm by a child or adolescent is a signal of distress
and should be taken seriously. These behaviors should not be dismissed as “attention seeking.” School proce-
dures for safety issues should be followed.

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Amphetamine—Dexedrine, ProCentra, Zenzedi, Adderall, Vyvanse Page 3 of 9

What Is Amphetamine (Dexedrine, ProCentra, Zenzedi, Adderall,

Vyvanse)?

Amphetamine is called a stimulant. It is used to treat attention-deficit/hyperactivity disorder (ADHD),

whether the person has hyperactivity (increased moving around) or not. It comes in a generic form and several
brand name formulations (see table below). Although all of these medicines have amphetamine as the active
ingredient, they are made differently, so that there are many different ways to take amphetamine. This helps
the doctor to find just the right form of the medicine for each person.

Generic and brand name formulations

Short-acting, or immediate-release dextroamphetamine (3–5 hours)
Generic dextroamphetamine
Dexedrine
Zenzedi
ProCentra (liquid)
Long-acting dextroamphetamine (6–8 hours)
Dexedrine Spansule (capsule with particles)
Dextroamphetamine ER (extended release)
Very long-acting lisdexamfetamine dimesylate: dextroamphetamine prodrug (turns into dextroamphet-
amine when digested) (12–14 hours)
Vyvanse (capsule may be opened and dissolved in water or mixed with yogurt or orange juice and taken
right away)
Mixed amphetamine salts
Generic mixed amphetamine salts (immediate release) (3–5 hours)
Adderall (immediate release, short acting) (3–5 hours)
Adderall XR (extended release, very long acting; capsule with beads—may be sprinkled on food)
(10–12 hours)
Generic mixed amphetamine salts extended release (10–12 hours)

How Can This Medicine Help?

Amphetamine can increase attention and the ability to follow instructions. It can improve attention span,
decrease distractibility, increase the ability to finish things, decrease hyperactivity, and improve the ability to
think before acting (decrease impulsivity). Handwriting and completion of schoolwork and homework can
improve. Amphetamine can improve willingness to follow directions and decrease stubbornness in youngsters
with both ADHD and oppositional defiant disorder (ODD).
Many people with Tourette’s disorder (chronic motor and vocal tics) also have symptoms of ADHD. Am-
phetamine may be used cautiously to reduce these symptoms of hyperactivity, impulsivity, and trouble paying
attention and usually does not make the tics worse. If the tics get worse, talk with your child’s doctor. Lower-
ing the dose or stopping the amphetamine will usually lead to the tics decreasing again. Tics also increase and
decrease for a lot of reasons that are not related to medicine.
Medicine may not resolve all symptoms in children with ADHD. These children may also need special
help in school and behavior modification at home and at school. Some youngsters and families are helped by
family therapy or group social skills therapy.

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Stimulant medicines last for different amounts of time. ADHD symptoms may come back when the med-
icine wears off. This does not mean the medicine is not working but means that longer coverage may be
needed.
Amphetamine is also used to help people with narcolepsy (sudden and uncontrollable episodes of deep
sleep) to stay awake.

How Does This Medicine Work?

In people who have ADHD, parts of the brain are not working as well as they should. An example would be
the part that controls impulsive actions (“the brakes”). Amphetamine helps these parts of the brain work better
by acting as a stimulant, increasing the activity of neurotransmitters—mostly dopamine but also norepinephrine.
Neurotransmitters are the chemicals that the brain makes for the nerve cells to communicate with each other.
Amphetamine is not a tranquilizer or sedative. It works in the same way in children and adults and in peo-
ple with or without ADHD.
Methylphenidate and amphetamine are both stimulant medicines, but they work in different ways on the
neurotransmitters. A person with ADHD might be helped by one stimulant but not the other, so if one is not
working, the doctor may try the other one.

How Long Does This Medicine Last?

All types of amphetamine start working in 30–60 minutes after taking them. Different forms last for different
lengths of time. The immediate-release or short-acting forms last for 3–5 hours. The long-acting forms of
dextroamphetamine last for 6–8 hours. Adderall XR lasts for 10–12 hours. Vyvanse can take up to an hour to
start working, but it lasts for 12–14 hours. The length of time is different for different people, and the medi-
cine may work longer for some symptoms than for others. An advantage of the longer-acting forms is that
they do not have to be given during the school day.

How Will the Doctor Monitor This Medicine?

The doctor will review your child’s medical history and physical examination before starting amphetamine.
The doctor may order some blood or urine tests to be sure your child does not have a hidden medical condi-
tion. Be sure to tell the doctor if your child or anyone in the family was born with or has had heart problems,
seizures, irregular heartbeat (pulse), high blood pressure (hypertension), dizziness, fainting, shortness of
breath, glaucoma, hyperthyroidism, or severe tiredness. Tell the doctor if anyone in the family has died sud-
denly. People who have a history of heart problems generally should not take amphetamine. Talk to your doc-
tor if your child has a history of seizures, as amphetamines may lower the seizure threshold in some children
with a history of seizure disorders. Also tell the doctor if your child or anyone in the family has had motor or
vocal tics (hard-to-control repeated movements or sounds) or Tourette’s disorder (also called Tourette’s syn-
drome). The doctor or nurse will measure your child’s height, weight, pulse, and blood pressure before start-
ing the medicine. The doctor will usually ask parents and teachers to fill out behavior rating scales (checklists).
After the medicine is started, the doctor will want to have regular appointments with you and your child
to see how the medicine is working, to see if a dose change is needed, to watch for side effects, to see if am-
phetamine is still needed, and to see if any other treatment is needed. The doctor or nurse may check your
child’s height, weight, pulse, and blood pressure. With parental permission, the doctor will usually ask for re-

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ports (rating scale, checklist, testing results, comments) from the teacher(s) to keep track of progress in learn-
ing and behavior. Some young people take the medicine three or four times a day, every day. Others need to
take it only once or twice a day or only on school days. You and your child’s doctor will work out the doses
and timing and type of medicine that is best for your child and his or her symptoms and schedule.

What Side Effects Can This Medicine Have?

Any medicine can have side effects, including an allergy to the medicine. Because each patient is different, the
doctor will monitor the youth closely, especially when the medicine is started. The doctor will work with you
to increase the positive effects and decrease the negative effects of the medicine. Please tell the doctor if any
of the listed side effects appear or if you think that the medicine is causing any other problems. Not all of the
rare or unusual side effects are listed.
Side effects are most common after starting the medicine or after a dose increase. Many side effects can
be avoided or lessened by starting with a very low dose and increasing it slowly—ask the doctor.

Allergic Reaction

Tell the doctor in a day or two (if possible, before the next dose of medicine):

• Hives
• Itching
• Rash

Stop the medicine and get immediate medical care:

• Trouble breathing or chest tightness

• Swelling of lips, tongue, or throat

Common Side Effects

If the following side effects do not go away after about 2 weeks, ask the doctor about lowering your child’s
dose:

• Lack of appetite and weight loss—Encourage your child to eat a good breakfast and afternoon and evening
snacks; give medicine during or after meals.
• Insomnia (trouble falling asleep)—This may be the ADHD coming back and not a side effect. Talk with
your child’s doctor. Changing the time or dose of medicine, starting a bedtime routine, or adding another
medicine may help.
• Headaches
• Stomachaches
• Irritability, crankiness, crying, emotional sensitivity
• Loss of interest in friends
• Staring into space
• Rapid pulse rate (heartbeat) or increased blood pressure

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Less Common Side Effects

Tell the doctor within a week or two if you notice

• Rebound—As the medicine wears off, hyperactivity or bad mood may get worse than before the medicine
was taken. The doctor can make adjustments to help this problem.
• Slowing of growth—This is why your child’s height and weight are checked regularly; if this is a problem,
growth usually catches up if the medicine is stopped or the dose is decreased.
• Nervous habits—Examples are picking at skin or biting nails (although these habits are also common in
children with ADHD who do not take medicine).
• Stuttering

Rare, but Serious, Side Effects

If any of the following occur, call the doctor or go to an emergency room right away:

• Chest pain that does not go away after a few minutes

• Very fast or irregular heartbeat not related to exercise or exertion
• Shortness of breath not related to exercise or exertion
• Fainting
• Seizures (fits, convulsions)

Call the doctor within a day or two:

• Motor or vocal tics (fast, repeated movements or sounds) or muscle twitches (jerking movements) of parts
of the body
• Pain, numbness, or changes in skin color or temperature sensitivity in fingers and/or toes
• Sadness that lasts more than a few days
• Auditory, visual, or tactile hallucinations (hearing, seeing, or feeling things that are not there)
• Any behavior that is very unusual for your child

Some Interactions With Other Medicines or Food

Please note that the following are only the most likely interactions with other medicines or food.
Caffeine may increase side effects.
Amphetamine may be taken with or without food. Very acid juices (like grapefruit or tomato) or vitamin
C may decrease levels of amphetamine so that it does not work as well.
It is not a good idea to combine stimulants with nasal decongestants or cough and cold medicines that con-
tain ingredients such as pseudoephedrine or phenylpropanolamine, because rapid pulse rate (heartbeat) or
high blood pressure may develop. If a stuffy nose is really troublesome, it is better to use a nasal spray. Check
with the pharmacist before giving an over-the-counter medicine. Also, many children with ADHD become
cranky or more hyperactive while taking antihistamines (such as Benadryl). If medicine for allergies is needed,
ask your child’s doctor.
Using amphetamine together with imipramine (Tofranil), nortriptyline (Pamelor), or amitriptyline
(Elavil) may be dangerous because these combinations can increase the risk of serious heart problems.

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Amphetamine—Dexedrine, ProCentra, Zenzedi, Adderall, Vyvanse Page 7 of 9

Amphetamine should not be taken at the same time as or even within a month of taking another
type of medicine called a monoamine oxidase inhibitor (MAOI), such as selegiline (Eldepryl), phenel-
zine (Nardil), tranylcypromine (Parnate), or isocarboxazid (Marplan). The combination could cause
dangerous high blood pressure.

What Could Happen if This Medicine Is Stopped Suddenly?

No medical withdrawal effects occur if prescribed amphetamine is stopped suddenly. The ADHD symptoms
will come back as soon as the medicine wears off. Some people may have irritability, trouble sleeping, or
increased hyperactivity for a day or two if they have been taking the medicine every day for a long time, espe-
cially at high doses. It may be better to decrease the medicine slowly (taper) over a week or so.

How Long Will This Medicine Be Needed?

There is no way to know how long a person will need to take amphetamine. The parent(s), the doctor, and
the school will work together to determine what is right for each patient. Sometimes the medicine is needed
for a few years, but many people need to take medicine for ADHD even as adults.

What Else Should I Know About This Medicine?

Many people have incorrect information about stimulants. If you hear anything that worries you, please check
with your doctor.
Unlike methylphenidate, amphetamines are FDA approved for children younger than 6 years old. This is
a historical accident that happened as rules changed for approval of medicines. There is actually less research
on using amphetamines for ADHD in young children than there is for methylphenidate.
Stimulants do not cause drug use or addiction. However, because the patient or other people (especially if
they have a history of drug abuse) may abuse these medicines, adult supervision is especially important. Some
teenagers may try to sell or share their medicine, so it should be kept in a secure place and given by an adult.
Amphetamine will not help people who do not have ADHD to get better grades or do better on tests, but
some people think that it will, so they try to take someone else’s medicine. It is important to talk to your teen-
ager about why he or she should never give away or sell medication. This is called diversion and can be con-
sidered a federal crime.
The government considers amphetamine to be a controlled substance. There are special rules for how much
of this medicine may be prescribed at one time and how soon prescriptions must be filled after they are writ-
ten. Prescriptions may not have refills and may not be telephoned to the pharmacy. The doctor must write a
new prescription for stimulants each time. Prescriptions may be mailed or picked up at the doctor’s office.
It is important for the child not to chew the long-acting tablets because doing so releases too much med-
icine all at once.
For children who cannot swallow pills, the capsule forms may be opened and the tiny beads inside sprin-
kled onto a spoonful of applesauce. The mixture of applesauce and medicine should be swallowed right away
without chewing. The beads should not be mixed in liquid. The medicine should not be mixed into food and
then stored. Do not divide the dose.

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Page 8 of 9 Medication Information for Parents and Teachers

Some of these medicines have similar names but have different strengths or last different amounts of time
(for example, Adderall and Adderall XR). Be sure to check your prescription to be sure you have the correct
medicine from the pharmacy.
Questions have been raised after a very small number of people died suddenly while taking amphetamine.
Clearly, amphetamine in very high doses can be dangerous. However, the chance of sudden death when taking
amphetamine as prescribed by a doctor is not higher than without medication. In most of the deaths, problems
in the shape, size, or rhythm of the heart were found that were not related to the amphetamine use. Be sure to
tell the doctor if your child or anyone in the family has had heart problems or if a family member died suddenly.

Notes

Use this space to take notes or to write down questions you want to ask the doctor.

Copyright © 2015 American Psychiatric Publishing, Inc. The purchaser of this book is licensed to dis-
tribute copies of this form in limited numbers for personal practice use. Permission must be requested for
commercial use and any electronic use. The authors have worked to ensure that all information in this book
concerning drug dosages, schedules, routes of administration, and side effects is accurate as of the time of pub-
lication and consistent with standards set by the U.S. Food and Drug Administration and the general medical
community and accepted child psychiatric practice. The information on this medication sheet does not cover

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Amphetamine—Dexedrine, ProCentra, Zenzedi, Adderall, Vyvanse Page 9 of 9

all the possible uses, precautions, side effects, or interactions of this drug. For a complete listing of side effects,
see the manufacturer’s package insert, which can be obtained from your physician or pharmacist. As medical
research and practice advance, therapeutic standards may change. For this reason and because human and me-
chanical errors sometimes occur, we recommend that readers follow the advice of a physician who is directly
involved in their care or the care of a member of their family.
From Dulcan MK, Ballard R (editors): Helping Parents and Teachers Understand Medications for Behavioral
and Emotional Problems: A Resource Book of Medication Information Handouts, Fourth Edition. Washington, DC,
American Psychiatric Publishing, 2015

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