Scribd Logo
Upload

Welcome to Scribd!

  • 16 views

    Intracellular Signal Transduction

    Uploaded by

    grace meunier

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Intracellular Signal Transduction

    Uploaded by

    grace meunier
    16 views11 pages

    Original Title

    Intracellular signal transduction

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    16 views11 pages

    Intracellular Signal Transduction

    Uploaded by

    grace meunier

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    You are on page 1of 11

    Intracellular signal transduction

    The process in which a signal is passed on to downstream


    components within the cell, which become activated themselves to
    further propagate the signal and finally trigger a change in the
    function or state of the cell.

    MAPK is exploited by:


    Bacterial toxins.
    Effector proteins.
    One of the key causes of anthrax virulence is the production of
    three specific toxins, derived from three genes lethal factor LF,
    protective antigen PA and edema factor EF. PA which is a
    cellular receptor recognizes toxins. LF and EF protein binds to
    the PA pre pore.In the endosomal compartment the acidic pH
    causes conformation change that insert PA fragment and
    releases LF and EF into the cytoplasm. LF acts as a protease
    that cleaves MAP kinase (MAPK1 & MAPK2)
    Type III secreted protein YOPJ of Yersinia pestis

    Inhibits the activation of MAPK signaling pathway by


    covalently modify key serine and threonine residues of MAP
    kinase.

    Functions as acetyl transferase (addition of acetyl CoA).


    Inability of upstream kinases to transphosphorylase the
    downstream kinase.

    Prevent MAPK-mediated cytokine transcriptional response to


    Yersinia infection
    ii) Salmonella, AvrA

    Harbor acetyl transferase activity


    Inhibit MAPK4& MAPK7(c-Jun NH2-terminal kinase)
    signaling pathway.
    Prevent the transcription of prosurvival genes

    New era of anti-innate immune signaling research


    Mass spectrometry analysis
     OspF catalyzes a b elimination reaction of
    phosphothreonine
     Produces b-methyldehydroalanine
     Permanent inactivity of MAPK cascade
     Inhibit inflammatory activation.

    You might also like

    pFad - Phonifier reborn

    Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

    Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


    Alternative Proxies:

    Alternative Proxy

    pFad Proxy

    pFad v3 Proxy

    pFad v4 Proxy