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Phenothiazine From Diphenylamine

Heating diphenylamine and sulfur with anhydrous aluminum chloride as a catalyst results in the crystallization of 2-substituted diphenyl sulfides, which is the classic synthesis of phenothiazine. Specifically, the procedure involves melting diphenylamine, sulfur, and aluminum chloride, then controlling the temperature during reaction and extraction to produce almost pure phenothiazine, which can be recrystallized from alcohol.

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Mehreen Patel
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2K views

Phenothiazine From Diphenylamine

Heating diphenylamine and sulfur with anhydrous aluminum chloride as a catalyst results in the crystallization of 2-substituted diphenyl sulfides, which is the classic synthesis of phenothiazine. Specifically, the procedure involves melting diphenylamine, sulfur, and aluminum chloride, then controlling the temperature during reaction and extraction to produce almost pure phenothiazine, which can be recrystallized from alcohol.

Uploaded by

Mehreen Patel
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Phenothiazine from

Diphenylamine
 Aim: To prepare and submit Phenothiazine from
Diphenylamine
 Chemicals: Diphenylamine, sulphur, iodine
 Principle: Heating Diphenylamine and sulphur with
anhydrous aluminium chloride catalyst and result in
crystalization of 2-substituted diphenyl sulphides in
classic synthesis of Phenothiazine.
 Procedure:
1. Melt 22g of Diphenylamine,8.2g of sulphur,3.2g of
anhydrous aluminium chloride together.
2. The reaction sets 140-150⁰C with the rapid evaluation
of hydrogen sulfide; by lowering the temperature, a
few degrees the reaction can be slackened.
3. When reaction has moderated, the temperature is
raised to 160⁰C for a time.
4. The melt, after cooling is ground up and extracted
first with water and then with dilute alcohol.
5. The residue consists of almost pure Phenothiazine.
6. It can be recrystallized from alcohol.
7. Report yield and melting point

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