THE MEETING IS DEDICATED TO THE 75TH ANNIVERSARY OF FAZLY ATAULLAKHANOV

SYSTEMS BIOLOGY AND

SYSTEMS PHYSIOLOGY:
REGULATION OF
BIOLOGICAL NETWORKS
HYBRID CONFERENCE
AUG 25-27, 2021
SCIENTIFIC PROGRAM
 Illuminating the nature of complex
systems

SBPReports is the Open-Access Journal,

devoted to studies of complex biological
systems

SBPReports is a forum for in-depth

discussions between physicians,
biophysicists, biologists, mathematicians and
professionals
from related fields
SBPReports publishes articles, brief reports
and reviews both in English and in Russian

sbpreports.com
 Our Scope
Self-organization at the level of molecules
and macromolecular complexes, molecular
mechanisms of biochemical reactions

Сell signal transduction and metabolic

networks, regulation of cell cycle, gene
expression and epigenetic regulation

Mechanisms of physiological and

pathophysiological processes at the levels
of cells, tissues, organs and organisms
Pharmacological research and diagnostics

sbpreports.com
 SCIENTIFIC PROGRAM
AUGUST 25th, 2021
GMT+3

9:00-10:00 MAIN REGISTRATION

10:00-11:30 GRAND OPENING

11:30-12:30 L U N C H B R E A K

SECTIONS

12:30-16:30 BIOLOGICAL SYSTEMS OF THE

SUPRACELLULAR LEVEL:
HEMOSTASIS, IMMUNITY,
NEUROBIOLOGY (PART 1)

Chairs: Vitaly Volpert, France

Vladimir Kolyadko, USA

12:30-13:05 Simulation of the coagulation system,

Tool or Toy?
Coenraad Hemker
Maastricht University
the Netherlands
13:05-13:35 Construction of self-adaptive
biomaterials surface with high blood
compatibility
Qiang Shi
Changchun Institute of Applied
Chemistry, Chinese Academy of Sciences
China

13:35-14:05 Synergism between anticoagulation and

phototherapy to prevent the thrombotic
complications
Zhifang Ma
Changchun Institute of Applied
Chemistry, Chinese Academy of Sciences
China

14:05-14:35 Modelling of blood clotting in aneurysm

Vitaly Volpert
Institut Camille Jordan, University Lyon 1
France

14:35-14:50 C O F F E E B R E A K

14:50-15:20 Numerical and qualitative investigation

of the mathematical model of blood
coagulation with membrane reactions
Alexey Lobanov
Moscow Institute of Physics and
Technology
Russia
15:20-15:40 Inhibition of blood coagulation:
biochemistry, structural biology, and
translational applications
Vladimir Kolyadko
The Children's Hospital of Philadelphia
Philadelphia, USA

15:40-16:00 A mechanistic model for

thromboelastography
Anand Mohan

IIT Hyderabad
Sangareddy, India

16:00-16:30 In silico modelling of hemostatic

response: challenges and perspectives
Dmitry Nechipurenko

Center for Theoretical Problems of

Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia

16:30-17:50 FUNDAMENTALS OF LIFE:

PRINCIPLES OF FUNCTIONING OF
BIOLOGICAL SYSTEMS
(ANNIVERSARY SECTION)

Chair: Mikhail Panteleev, Russia

16:30-16:50 The end of hemostasis
Mikhail Panteleev
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia

16:50-17:10 Fazli – scientist, friend, Boss

Victor Vitvitsky
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia

17:10-17:30 Fazly’s scientific life in the Wild West

Richard McIntosh
University of Colorado Boulder
Colorado, USA

17:30-17:50 50 years in science: The Outcome

Fazly Ataullakhanov
Center for Theoretical Problems of
Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia

17:50-18:05 C O F F E E B R E A K
18:05-21:40 CELL DIVISION AND MOLECULAR
MOTORS

Chairs: Nikita Gudimchuk, Russia

Vladimir Volkov, the Neterlands

18:05-18:40 The tip of a growing microtubule and its

implications for polymer dynamics
Richard McIntosh

University of Colorado Boulder

Colorado, USA

18:40-19:10 Electron cryo-tomography provides

insight into the regulation of
microtubule dynamics by end-binding
protein assemblies
Vladimir Volkov

Delft University of Technology

the Netherlands

19:10-19:40 Mechanisms of microtubule dynamic

instability examined with Monte-Carlo
simulations and in vitro reconstitution
experiments
Nikita Gudimchuk

Center for Theoretical Problems of

Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia
19:40-20:10 Harnessing Dynamic Microtubule Ends:
lessons from reconstruction studies in
vitro
Ekaterina Grischuk

University of Pennsylvania,
Philadelphia, USA

20:10-20:20 C O F F E E B R E A K

20:20-20:50 Role of tropomyosin dynamics in

regulation of cardiac muscle in health
and disease
Andrey Tsaturyan

Lomonosov Moscow State University

Russia

20:50-21:20 Structure of super-relaxed myosin heads

in relaxed muscle
Natalia Koubasova

Lomonosov Moscow State University

Russia

21:20-21:40 The ratio of Tpm α- and β-chains in the

thin filament affects the actin-myosin
interaction
Salavat Nabiev

Institute of Immunology and Physiology,

Ural Branch of the Russian Academy of
Sciences
Russia
 AUGUST 26th, 2021
GMT+3
9:30-13:00 METHODOLOGICAL ISSUES OF
BIOPHYSICS

Chairs: Vladik Avetisov, Russia

Anatoly Vanin, Russia

9:30-10:00 Oxidative modification of fibrinogen

molecules: structural and functional
aspects
Lyubov Yurina

N.M. Emanuel Institute of Biochemical

Physics Russian Academy of Sciences
Russia

10:00-10:30 Physical chemistry of dinitrosyl iron

complexes as a determinant of their
biological activity
Anatoly Vanin

Semenov Federal Research Center for

Chemical Physics, Russian Academy of
Sciences
Russia

10:30-11:00 Reversible aggregation and

deformation of RBC as determining
factors of blood fluidity control
Alexander Priezhev

Lomonosov Moscow State University

Russia
11:00-11:30 Biophysics in tissue engineering
Yury Rochev

Centre for Research in Medical Devices

(CURAM), National University of
Ireland
Ireland

11:30-12:00 Euler arches and Duffing oscillators a

few nanometers in size
Vladik Avetisov

Semenov Institute of Chemical Physics

of the Russian Academy of Sciences
Russia

12:00-12:30 How does viscosity help (!) the dynamics

of spatial self-organization of molecular
and supramolecular structures?
Konstantin Shaitan

Lomonosov Moscow State University

Russia

12:30-13:00 Computer Simulation of the Heart and

Machine Learning for Basic Research in
Physiology and Clinical Applications
Olga Solovieva

Institute of Immunology and Physiology,

Ural Branch of the Russian Academy of
Sciences
Russia

13:00-13:15 C O F F E E B R E A K
13:15-18:20 METHODOLOGICAL ISSUES OF
SYSTEMS BIOLOGY AND SYSTEMS
PHYSIOLOGY
Chairs: Svetlana Komarova, Canada
Vladimir Sulimov, Russia

13:15-13:45 Biophysical and biochemical properties

of biocrystal hemozoin produced by
malaria parasite
Oleksii Skorohod

University of Torino
Italy

13:45-14:15 Reimagining the interaction between

stress-induced glucocorticoids and
gastric ulceration: the importance of a
methodological approach
Lyudmila Filaretova

Pavlov Institute of Physiology, Russian

Academy of Sciences
Russia

14:15-14:45 Quantum docking

Vladimir Sulimov

Research Computing Center

Russia
14:45-15:00 PI3 kinase ligands LY294002, LY303511
and PI828 block coupling of the 5-HT2C
receptor with Ca2 + mobilization in a
PI3 kinase-independent manner
Ekaterina Dymova

Institute of Cell Biophysics, Russian

Academy of Sciences
Russia

15:00-15:45 Overcoming kinase inhibitor resistance

and oncogenic RAS signaling
Boris Kholodenko

University College Dublin

Ireland

15:45-16:00 C O F F E E B R E A K

16:00-16:35 Using Microwave radiometry for

measuring kinetic constants or New
metagenomic methods for drug targets
identification
Igor Goryanin

Cluster of Biological and Medical

Technologies of the Skolkovo Innovation
Center
Russia
16:35-17:05 Processes in the photosynthetic
membrane as an object of systems
biology
Galina Riznichenko

Lomonosov Moscow State University

Russia

17:05-17:35 Microgravity-induced bone loss: lessons

learned from systematic reviews and
meta-analysis
Svetlana Komarova

McGill Univeristy
Canada

17:35-18:05 A possible mechanism of ligand-

receptor binding of short peptides to
NaV1.8 channels: a novel approach to
development of safe and effective
analgesics
Ilya Rogachevskiy

Pavlov Institute of Physiology, Russian

Academy of Sciences
Russia

18:05-18:20 Application of machine learning

technologies in a non-invasive sensor
system for diagnostics of a human
functional state
Anna Zaytseva

Institute of Analytical Instrumentation,

Russian Academy of Sciences
Russia
18:20-18:35 C O F F E E B R E A K

18:35-21:15 BIOLOGICAL SYSTEMS OF THE

SUPRACELLULAR LEVEL:
HEMOSTASIS, IMMUNITY,
NEUROBIOLOGY (PART 2)

Chairs: Dmitry Nechipurenko, Russia

Grigorii Panasenko, France

18:35-19:10 A new look at the retraction

(contraction) of blood clots and thrombi
Rustem Litvinov

University of Pennsylvania
Philadelphia, USA

19:10-19:45 Multiscale studies of blood clot

mechanics
John Weisel

University of Pennsylvania
Philadelphia, USA
19:45-20:15 Mathematical modeling of
hemodynamics in the left atrium during
atrial fibrillation
Grigorii Panasenko

Jean Monnet University of Saint-Etienne

France

20:15-20:45 Couple morphogen-mechanical models

for tissue growth and organogenesis
Sergey Nuzhdin

University of Southern California

California, USA

20:45-21:15 Corticotropin-releasing factor (CRF) as

a mediator of pain response to stressor:
involvement of CRF receptors of
subtype 2, opioid receptors and
glucocorticoid receptors in CRF-induced
analgesic effect in rats
Natalya Yarushkina

Pavlov Institute of Physiology, Russian

Academy of Sciences
Russia
 AUGUST 27th, 2021
GMT+3

10:00-11:50 PRACTICAL APPLICATIONS OF CELL

BIOPHYSICS: ERYTHROCYTES AS
CARRIERS OF DRUGS

Chair: Victor Vitvitsky, Russia

10:00-10:35 Red blood cells-based drug delivery:

new applications and current clinical
developments
Mauro Magnani

University of Urbino
Italy

10:35-11:10 Erythrocyte mediated therapy for rare

diseases: a complicated affair
Bridget Bax

St. George's University of London

United Kingdom

11:10-11:30 Development of an automatic device for

creating drug-loaded erythrocytes
Larisa Koleva

Dmitry Rogachev National Medical

Research Center Of Pediatric
Hematology, Oncology and Immunology
Russia
11:30-11:50 Mathematical modelling of erythrocytes-
bioreactors
Eugeny Protasov

Dmitry Rogachev National Medical

Research Center Of Pediatric
Hematology, Oncology and Immunology
Russia

11:50-12:05 C O F F E E B R E A K

12:05-15:10 GENOMICS AND BIOINFORMATICS

Chairs: Fazly Ataullakhanov, Russia

Artem Efremov, China

12:05-12:40 mRNA editing in soft-bodied

cephalopods as evolutionary adaptive
functional diversification
Mikhail Gelfand

Skolkovo Institute of Science and

Technology
Russia

12:40-13:15 Reverse genetics and biomedical models

Sergey Nedospasov

Engelhardt Institute of Molecular

Biology
Russia
13:15-13:45 Mechanical equilibrium of the cell
nucleus and its potential role in
regulation of chromatin structure

Artem Efremov

Institute of Systems ond Physical

Biology
China

13:45-14:00 C O F F E E B R E A K

14:00-14:30 Molecular aspects of screening

technologies in biodiversity

Alexander Gabibov

M. M. Shemyakin and Yu. A.

Ovchinnikov Institute of Bioorganic
Chemistry of the Russian Academy of
Sciences
Russia

14:30-14:50 Single-cell-resolution transcriptome map

of human, chimpanzee, bonobo, and
macaque brains

Ekaterina Khrameeva

Skolkovo Institute of Science and

Technology
Russia
14:50-15:10 Dynamics of chromatin folding: lessons
learned from single-cell and time-
resolved bulk Hi-C data

Alexandra Galitsyna

Skolkovo Institute of Science and

Technology
Russia

15:10-19:05 CELLULAR METABOLISM AND

ENERGETICS

Chairs: Victor Vitvitsky, Russia

Alexander Tikhonov, Russia

15:10-15:40 Virtual cell and theory of metabolic

control

Victor Vitvitsky

Center for Theoretical Problems of

Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia

15:40-16:05 Mapping Mitochondrial Activity in

Postmortem Human Brain

Eugene Mosharov

Columbia University
New York, USA
16:05-16:20 Experimental anticancer compound
TIC10 induces transformation of BT474
human breast cancer cells to stable
stress-state

Artem Mishukov

Institute of Theoretical and

Experimental Biophysics, Russian
Academy of Sciences
Russia

16:20-16:30 C O F F E E B R E A K

16:30-17:00 Calcium oscillations and autowaves in

cells

Valery Zinchenko

Institute of Cell Biophysics of Russian

Academy of Sciences
Russia

17:00-17:30 Structural and functional mechanisms of

regulation of light stages in
photosynthesis

Alexander Tikhonov

Lomonosov Moscow State University

Russia
17:30-18:05 Signaling through Sulfide

Ruma Banerjee

University of Michigan
Michigan, USA

18:05-18:35 Novel genetically encoded tools for

compartment-specific manipulation of
NADH/NAD+ and NADPH/NADP+
ratios in living cells

Valentin Cracan

Scintillon Institute
California, USA

18:35-18:50 The effect of antioxidants on the

dynamics of oxidative stress in human
sperm

Eugene Bochkov

Lomonosov Moscow State University

Russia

18:50-19:05 Dynamics of structural changes in

cryoprotective media for
cryopreservation of cells

Anna Ivanova

Lomonosov Moscow State University

Russia
19:05-19:20 C O F F E E B R E A K

19:20-21:20 BIOLOGICAL SYSTEMS OF THE

SUPRACELLULAR LEVEL:
HEMOSTASIS, IMMUNITY,
NEUROBIOLOGY (PART 3)

Chairs: Dmitry Nechipurenko, Russia

Irina Grigorova, USA

19:20-19:50 Design of potential anti-aggregatory

agents and their influence on human
platelets activation
Olga Demina
N.M. Emanuel Institute of Biochemical
Physics Russian Academy of Sciences
Russia

19:50-20:20 Wandering cells: dissecting spatio-

temporal regulation of B cell immune
response
Irina Grigorova
University of Michigan Medical School
Michigan, USA
20:20-20:40 The influence of blood clotting on
pulmonary circulation
Anastasia Mozokhina

Peoples Friendship University of Russia

Russia

20:40-21:00 Elevated shear rate is not specific to

arterial thrombosis, but also relevant to
hemostasis
Alexandra Yakusheva

Center for Theoretical Problems of

Physico-Chemical Pharmacology,
Russian Academy of Sciences
Russia

21:00-21:20 Effect of heparin on the formation and

healing of stomach ulcers in rats
Denis Sakhno

Pavlov Institute of Physiology, Russian

Academy of Sciences
Russia
NOTES