Scribd
Upload
63 views1 page

Anticoagulant Drugs (HEPARIN)

Heparin is used to treat venous thromboembolism, disseminated intravascular coagulation, and acute myocardial infarction. It works by inhibiting thrombin and fibrin formation through activation of antithrombin III. Adverse effects include bleeding, bruising, and hematoma formation. Warfarin is used to treat thromboembolism and works by altering the liver's ability to synthesize vitamin K-dependent clotting factors. Antiplatelet drugs have several indications and inhibit clot formation by blocking prostaglandin synthesis or platelet aggregation. Heparin requires careful monitoring of PTT levels and has drug interactions with oral anticoagulants, NSAIDs, and other drugs.

Uploaded by

KyrrielJimenoCelada
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
63 views1 page

Anticoagulant Drugs (HEPARIN)

Heparin is used to treat venous thromboembolism, disseminated intravascular coagulation, and acute myocardial infarction. It works by inhibiting thrombin and fibrin formation through activation of antithrombin III. Adverse effects include bleeding, bruising, and hematoma formation. Warfarin is used to treat thromboembolism and works by altering the liver's ability to synthesize vitamin K-dependent clotting factors. Antiplatelet drugs have several indications and inhibit clot formation by blocking prostaglandin synthesis or platelet aggregation. Heparin requires careful monitoring of PTT levels and has drug interactions with oral anticoagulants, NSAIDs, and other drugs.

Uploaded by

KyrrielJimenoCelada
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

ANTICOAGULANT DRUGS: PHARMACOLOGY

HEPARIN
November 02, 2020
Transcribers: Celada, Kyrriel J.
__________________________________________________________________________________________________
PHARMACOTHERAPEUTICS ADVERSE REACTIONS
⎯ Heparin: Venous thromboembolism, ⎯ Bleeding
Disseminated intravascular coagulation and ⎯ Bruising
Acute myocardial infarction ⎯ Hematoma formation
⎯ Warfarin: thromboembolism ⎯ Necrosis of the skin
⎯ Antiplatelet: Several indications ⎯ Thrombocytopenia

PHARMACOKINETIC IMPLEMENTATION
⎯ Heparin: Continuous IV infusion ⎯ Carefully and regularly monitor PTT.
⎯ Warfarin: Oral anticoagulants Anticoagulation is present when PTT values
⎯ Antiplatelet: Oral- 1-2 hours and IV – 15-20 are 11 /2 to 2 times the control values.
minutes ⎯ Don’t administer heparin IM; avoid IM
injections of any anticoagulant, if possible.
⎯ Keep protamine sulfate available to treat
PHARMACODYNAMICS severe bleeding caused by the drug.
⎯ Notify the prescriber about serious or
⎯ Heparin: Inhibits the formation of thrombin
persistent adverse reactions.
and fibrin by activating antithrombin III
⎯ Maintain bleeding precautions throughout
⎯ Warfarin: Alters the ability of the liver to
therapy.
synthesize vitamin and K–dependent
⎯ Administer IV solutions using an infusion
clotting factors
pump, as appropriate.
⎯ Antiplatelet: Aspirin inhibits clot formation
⎯ Avoid excessive IM injection of other drugs,
by blocking the synthesis of prostaglandin
to minimize the risk of hematoma.
and Clopidogrel inhibits platelet aggregation
by inhibiting platelet fibrinogen binding

DRUG INTERACTIONS
⎯ Oral anticoagulants
⎯ NSAIDs Iron dextran
⎯ Antihistamines
⎯ Digoxin
⎯ Nicotine
⎯ Nitroglycerin
⎯ Protamine sulfate

Page 1|1

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy