LiPiD METABOLISM

dadun of datluaud
Bnng,, Hodryo
Saiuy auds ant Amolard s0um. o1chlidpod-Jt hin
enayme
atdy aud u dmi Bq, rrodusinn k a n
atu y cmen han totu aca
m o u hiduiol nd"
hus uson Lot olrvm
aty e n l (orrrure
toon guycopm
9ulee mou eniny
by oud ouso
ards anny
ydstuo, Jofy
a a aapts, ule o
() ltain han, au non Mas.Snuw0
Knssy lewru alnng
uks Sauurashau and
u Hack Mau klerlyl un stotad bad as
eniay.Jhx au
k kuo naadno p fatiy
wmk Homonnay
loru
qucert ond qygen
on o hot TiNm neay ntuds
A k dalun
tzo {momhs) ntng d od Stoage
A aks aw o g
ard Mou) deltan
H-C-i-E
H C-R'
D--R
--
H--0
-C0H
HO-C- R
-0H
iRyole
CEius yauo)
he
JrioyundTagtgu.u mayos ovmo dulagepel
a u amd ou, uhchu dswol parts amwmal
 Ad

urhene tmen
Xhe s e s aund
Ordalo0 ti
deqnadatzw r t y acds
Kad alsmo
a
Then anSuAal yfa lly ocnd

poudoluno o atly aco

acd
oxudabin of ftly
) co
aty acud
BOdako o
uhuh ply o d a im
oocudalum to Ahe scens q
* Buta mikdh-
onot uulesl a $oken doum in
CoA
hfovm to gmenake Aceky
nenale oGA-
o LNorA&omes
Ordna amd/o
t u s TA Cycle
u ,kudmey amd
A many, usues mcludung
bCans

head
bordalrcn dounl oCCn m osao, as 4hatty accd
a i y aad
Cam e tokuo ythoai oiqam
Comr

S Co A
Palmttnf GA

datty d
Stoges o Bodnun
accd m he Cykoso
Aclwaluo a t l y
anto melchondna
atualad faKky acd
2- TAonapot of
CARNIT INE
SHUTTLE)
un mdochondna) mmalmr
3 Beda Orudatuoo phopes
Acusto8 Jtly Acvd aA Syhe-
Thunknae (aral
euds Hatl ac
Jhie
Cv16sOL
Iho prducd
Att ohSH, Mg1.
hskUnaR hlaun
(oM ujaln
aul
hia Aeocusm &o

Cunsol CoA+ AMPA

hMPt
Coh+
CoA t ATP- Fadlnaud
Fatt,aud
faty attd 2.

l6:0 ho o dnubl bords

Now almlui acud:

-0H
C- C-
3
Gaty Ac 6A
Readuso
s-oA +t+
)-CH- -S-CoA
C14)-cH-
GA ATP
Cy -0 Cy- -O
C-C
AMP+2 2AT
2Jsamoposto aly ocyl CoA %om Gtd unto2apsi
Mlcchendnd (Rocte.rmng Kap)
m milchondma,
*Lsng chau a CoA uses As
a shcuaA amaost
mcharram Calld
moelo sam w
w h 8mall thauo au toA Can
Casnadunt Bhuttl.
Arto hu michondal
malwa
mbur u
 Casntlum
Shrttle
Camilunt
tNCCH) mot vaund bas zust
Ros Aumdrotandunä)
H--0d#*
Ch
The utoso.R-s-oA
FAoACawndunt Acul thormohtna T
HS-CoA
Co ASA Cagniu
FACanttunt.
Dmenmutocherdvd
hamokacase memkame
PACaunslasmtume
HSCo A Jkomonan N
Caxnalunt Acy
FA CoA
the matne
Casntiune to (o
Ayl 9heups {so au oA Komohened To
J Casnulint acytranaetaxI,
auy tambarit Cotalyyd by
h o o t u miinchondnal memlosame
hoo khudtled ao1s he vmen milochonolua
Autantem
membsant eya amdocas poyms mabu bu
Krack Ko G A m
3J auantb w ianahon
Casmdun a mafuai
 .

bananc, m nehonge 1 Am onang ay tanohho

Jati ard
a t actd 0uuds Co

Jakty acel

Goy a u GACAT71
Cavrua

JAmdscase

datty ac CAT Caertun Connnlung

BOalum
Acz CA Cmlachndnal Matun)
TCA ytl
ATP
NADH FADE
Eleerm Amaco1 Chauo

3 hpes "B Orudatiuo o t mmtochandual matua

Jhew an 4 ap pC 6dalus
Se T Oxodatuno by FAD nkid dihydrngemat

Hoptare
U
Sh Oxdakum NAD Kmkud dehyAAg ono
Stuy Thulyi cduasc haan
Theotant
 SttrT Oxualton o Aylto
ovdaluan ofatry Son
'Jhe hat Atotuno As the

FAD
0Palmtloi loh
auR A
FaDIl,
dhyoanqpmok

R-Ca-C= -C-S-CoA
O

rama- AA

Enstyl-GA

Ster T Hydralzon doulh krord to p hyeeaey aA

R-CH S-CoA

lnoyl-oA
hdnala.
R-CH C4-CS-6A
F-Hydrg-ayl G
Ste DrudatunioBhoruprfCoA to
PAthac 6A. a MADdonAsnt RiacSuin

R-CH S-CoA
1 T
NAD
-hdnKqar-leA Ht
SNA DH 4

R- C c -g-CeA

B kotean-oA

R-CA- CH
2
BReiace Co
acu GA
oASH
atr Danafesat
Ihland
C12 t - G S A* C S-Co A

aueta &A
OunRlRIatten o p O0udalu
-S-Co A
RC
FAD
aLul tondo hydrngnan
FADH,
ams- enoul CoA
CS-CoA

enoyl- A huydnatane

R-C C - g-CoA

NAD
hudnpoetoA NAD+)
Aoaena/C

-HT -Ca S-A

pkadnauR-CaA

R-Ctl, S-CoA +
CH-saA
acy oA 2. (asbona hnstenid
+acet GA
 7T

N
 Canlm akom- Acue GA
Souscta ef NAPPH
Souncea oheducm. lauuaonts

o "2ntAgy ATT
Sowne

Ss e {ay ac anlheoto
0
NADPA
A&NADPH)
PAurlon( bamabosf)Pacelih Co
b malony oA
ih Cmuev tn e acl
Reastins aty acd ymthan Complenc
ni) ét.
Acety Con & NADPH
PAvduim (tanopoD o4

GA do phadund n mtlchondna y
Ac
Oudaton of puu le,
auds
Odoctno o{ atty Kone bodues
&ome omuno ards &
asodako oh

o lmaalle koy aula G4

Hewe , mlochomdaroi
So,an attnali amgement
u made fos amofe
ctlnet
ulal A ts culaotnbe fovm oh
vò milchordnua o. fesm
CaA Cmdues Auth 0A
Aut o fao
Cdd. Cihak ekn tramobod
bucirat lyase ta acety GA &DAA
H U-i cleaund
OAA Cyrie torunked Ao malale
dkhydoayeran cmuts matat ysuunl
To
Mala
& Co
wlh ddtud of NADPH
e aul aA Som toehondua to Cylssof
Iomafbnt
(ot blorwth adu in o NADPH and cO, both
*iA 4ynho
u m a ultlonpd
 TRamofet Atf toa & NADn

TShum qlutn

qswake MUchrrdual analnwn

NAD H

NA DP
Satiy ad
Malate
PDH PCorlgyon
NAD
Acolge CoA
NADH H
OAA
OAA
LAut &A Cilhaea
CoASH
cuAal utsa

b 2: Jmaum otmoko Co Raulo)

Ac CA A Casbozalatae s malonul CoA Byacetil A
Canbnsa

Rt Agcukalerjemamt nu
Acikal GA Casberan
palnu a

CH
Acu lg oA
AcLe »A ATP,00
Caktorylane ADP +P
Coc-CH-C-SoA
Malonu CA
 A om
Nate htacluno AUa Came
Camed
Amo w uhyhe bheuwows
o 4oee acd melet
hos ntheata of t y nce
a9. Ntt kmour a t ham as
ao a
CA hao lo
le oonecl logcCher
e Aity
thus erallung {ht Kow
tae Aearfno
IAl hen ou
uould Inot at
-S-Co A
-S(oA
Scen C
trC Comfo umd
C-acetyl
20 Auty GA 2 mamen apua
hts
Camot habboo
Atauion
3.900d alaiuaphale
SA alout

aekycaun tasbnyl Canbon

nuilbphue atiiacko jon h
and Camnot Aendes a
and fhu
huo
aleus Ata cdum ko appm
r d . n c a s b o o of Atctf& A K
the
Jhus Ao maks aun
Lasna
goooB un
a uhuky ss'
a -toogoup
OTtachunq
ttacung all J
Ahu oaunmq R Cam gur
ghe (adco,) to e f-casbon h u s
pa
*Ai C", geupGneas
makima a goodhuohuka

Faty ac &gntbare Ceimle

s a ypeptelt cont
JAe ctiy acud brthar tomex tam,
adualusrIn vactena amd tlas,
ununga
Ueun emmyme
4heeuuduod emmumea o aty acad 8qithant 6gsemo
asl scbanaie
ackhaducls ant.(ound ) Combmatuoo uuth a proleg
The
Calad Acy tamu photuoCAcP)
m a m a l s Amd u d o Khe Srthac system ta
nn
I ycaot
ioposale
a mutUingyme poybepeds compect
ACP, uhch ttes bukhi
Aole oh Ca
 AA semlly e lora, Chaumay oud tarlcnfA ohouno
toslcoFh Chouo
lm sqrihisd
Once malony lo Aas
api
be aoseni ed uo a heheakua, to fob
mau
s wdh Lach tamage heus y l tha totiy o r
Atordid Vy uo asvons
cham o
chaun Aatha 16C,- pdutt holm1lakt 0G:0)
Nhun h
aneshi uydu
JAmoeae sACP
s CoA
O=O
o Mai ACP

alsnyl G A

JhamoRAR -sACP
C-S
-

CoA
CH

Autnl 6A
Acu y Ar

p kib acf
AutL kay, SYN
Nsw the omy THÅSE Joemumg a ree us to
SkeT CoNDENgATION a uo marula)
CO

C
ACP
bond bknk

Malm AcP
Ax Atp
4C

Bketo ayl ACP

bt REDUCTIOA}

Raduitan
-C4 C-S. AcP C- -SACP
OH
NADPH NAD +H
B RelaACP P hudboyau
acloasl AlP
 Adutks Rttoaty 9e hydio.
Kelmyl AtÁuekaat

*Ohe Atdu:nq Laurualens

ast scppluid, by AAD P

t t DEHYDRATIDN

C S ACP
chdra uo C-C-c -S Acr

n.cul ACr

Stn TyRTDUCTIDN-

C
RAtat
-SACP C-H ACF
NADPH NADPT acyt- Acr
aC) aoma breyn
euasomad.
3he aeu hsun stps ant
Acpcatid Gtans tach tume
atty acd u
lenaatrd oy Ac unt
At e tid o
yeku, a lEcnotly ad
AtACp tiatzunathd) i fovmd
Jh imgme theglunaot
seharrtu halmtkatr kiom ftt, a..
rhi Comfutt
keity acid Aunlhat
ACPSH

is-ACr ACF
hcaeNRne CH--C-oH
 Rrqutalion aily an mdabn e)

CAT CRate Aimttima Ammme vm ais ov golhina

Malrn (oA Au hnh

atk a0 am anhuAAo1 of (AT

a Acutul CGA Canbylant (Ace)

-1 Aoporae d qm
Al amd he phoduiiso oh dnaulsm omd ogom

ACC a be putt body n oth phoplrofsi

amd otphaofhanfatud e
A e k u . e hipn
muun high qluto )
ACC-0 H Ackuaa phoaphakast

Lego uagonklooguar
ACC-0 P -vhadue
Ac e t u a t e k i m a k

3. B-hduru aylco Adohydogemao

unhlrts
gh AtutCoA AMPK
Kat ATP,>hrah AMMP
aUwat

AMPk on ACC Rs
5 hoophaylat
Ac¢

malual t
Fatty Aud Oxudaurn lghtky kigulattd
Otidatm af atty uds nmacumta aphicosl,nd
he moec ho1Ah

I n thi kuuws , fatty acul- Co femd n dhe cfanol hasun

maes thuny
F datim dbq znnmt mtchordna
seneeai h inacylatytunots amd rhophoiuhd
tmyma uo khe opieso

+Sht pathuas takeo dekovo oothu

of hatt
Lemg chau datiy ach-toA unto mlochondnmabomoher of

0c qups ant Cauud im ctosoue aty acul- lo

Amto ohmdnisl malwt haiu lentg fos foklyaud
oLdaturo and s mran t oaulaiuo) .

ercL atiy aay aheup a u tuntd tht

mlacho
huy aN Commut1d o bridrimdo attu Cod
Malm{ Cod,dbe Ai ntmdsat ai lb cosole rosty-
rhre Ama
chouo
y acd bim aiy oa, aestx do
Cmcunirtumo Uuhintu e
mmal s Aull oupud dh
Canboyd RMCLd unat Thak Camot e oxndngd os

Sorag as hiala

h e tnhltuooh Caniunt y a n a I by mulenylGa

Rmaunnsa t *he 6acudatusoof t y acds i hhdtd
Cuhunue lunu atly Sutlud autth qluuo
a huel anmd u acbmuly mkeng iac/algund n e
 lghtka, Kgulatud
.

Aud Oxcdalun
Fatty
Omd
taudakd de dto u n bnluy Auhun Ahl mird ko1Ans

I n thi uen , fatty acyl- Con fomd tn e oymof thni n

mayosrthunays bfen
mt mdthtmdva
B oudatuo ky
9 Conevamo aUb uaylalytnats and phnaphubrd
Ky enymts uo he cylosot

he pahwaus tokn depund onthu kak1 ofbomahn. of

leng chau day oc- toA unto mtlnchondnna

he Ku Kb photend CCamnzlurt Austtle by uuhudh

tay
Oc oups ont Caud in otooue atty acf-a
mko nrchndnial wdue a had
lndao, fen akyacd
ocudatuin ond i kmrilamt bount of AgusauoD
6r aty aaxohoup Nau tutd Bhe
milbcherdin.
h an Commu1d ts bridalmrfo Q CoA

*MMalmul CoA,ihe Ro tumudiaa m e cforole rory-

nthoao ora, chovòay aods
Kvm auty A, antan o
Cncambatso Uuhimunhe omimmad ss Nuil ouppud udh
Canbonadrd RatuadL That Camot kr ondined 0
Bud a oyugenu Corusd unthaoyfo
0 of
tnko
Klyaus e

Jhe unhdtduoo laniunt auamaheare T by mulenylGa

emauuslat he coudatnofatty acda o nhibtd
utth olur
Cuhnne Lunu ampy Bubtld
 1
nd
Lppio md tatso ysf
6Ufoun n q im hal, trakytomd1s munt t A
doum hayd lys0 Amt, i n isn unof
osekon
Lomberents, oi Odds hrd ouyos

bty B d o l t
o
Dudsd
Wtm kati OA an
by
und Karb Oycl
Arde Occtul oAu hu
im 7iauyannd, ohn
Ailiantd
J h r aujano that M 7ohuioua D HAP

Toa
sgnalrd h àciuuty o
hu
diniiy ents
bont tra aueuld
hamoe 4ytuo
Usays o makL A7P. AP
comuulid Undy D+
uyery0 o f élma
.
Gycene 3 phethat

s kura
L0--H
C-1 He 0vp NAD
AADH H
ATP
D0-C- ADP + P DHAP
yonol 3 phephatt
CH, Dhydnu
acetene f h t

4C-0H

HAcOx ph oskatt
CH-OP UeminAK

D-ycaJánbyde

phupha
 00C- C--S-Con

Kte
Atgcalakid le
Oxtdalenoant aluo
mmyma B
Y Jurnhe

luona
am aditoo hugh o ntentra
g a n s o r a ' Amhi6ctdy

musele Connaclio9 ®Å duwmg arlumo

U y hlgevdts

AMP -ActTualtd pAettuo kumad

Ancluolumg
*AMPK heophesfakes Aeusnal Tonoct emaymes
a c T GA Canboxulan ,Auihach Cakalynpo
Makmil oA &eynliera.
hz phophonglatuo ad hus mheleiuto ok acskyla A
kanlorylat lsuu ConcinNakuorumalm{ A, Aelw
Amykhr mhinln oatty acu-CaTunt kramobstantn
mdchartna and alloiung B Oxdaiun lo Keplonerhlh

Suphyo AT CAtC AetA Casboytaat)

Duia -hbloed Lacete Fariya CoAsH
Casbohuka A
Cahrtun
9utae Camutng
at
Acc
Inatu
mmtw Caviulont
PKA
C AMPE Co
Ace JFAD
ay
Camilune Ordatuy NA DH
qlucok -3A:t{GA Malmy
qtue, Atby &A
ahaonad datyard (TA Mutbanda
UCemtc (A Sthenta) Foxisu
 Y
d ot A R/VIDA

erds em ,Om

KRogMatd
T tAAR ru
olu ouds od (nA
c eatdhnh
ho the
i, ho orital Karin rycle houn)
A00i rrddrmrd od nridirnen
fah Ond
ond raneot
Adshnd
IMon9d olo, Chval,
hool,
faeot
kotora
katrg bri
hrrdiin

iuhsmoton Suko hem

tlm moaf o mninoll o da)ii Omd
tho
Cahnlalim umn tomo
thAuh o
Kls cycl amd
uhunkbo mch auki
CoA
Auadlqnal kifons Acdsin
Tn tAs ktone aramulalu
Auihams Aaduom, s s
Amohydemgtutan Gn
XHMG CoAsa phUso o CHMG Co)
aciiu oA Cm.ed
ChpoAl omo a on dilmudol
ha phamon klme tbly am lon d
o. mD imos4u dsmomduna, gom, gma /a o all sugan
1sedy
Auntnmt oo But uhun
yruNod
"D JAO Adilmd gyugn
amo unt o
Ao Aum&loan Aong
ttubd odafipo whuh
encillt
o m a l o d a m auly
6A a m
u l s n e Arodis
y u
 Kiloont

CH-CS-lo A) tH- -S -(oA

Autal oAX2

Thulaot tACH

A uto actil aA

S-CoA

HMG CoA
C--s-CoA yibae
(Acutat eA)

ulam di chan
B-Hdnaty-B- mthdalukank oA C#MG %A)
C-C-SeA HMG Co A anc

Autoautatikulme Body
--C
0
Acuoautae
hdrsxbugkalh dehydho nae
c dtanbotylat NADH NAD

D--CH -CH
Awbong
Bhudu,butynate
..w f h
heul kelönn bodans tm
ALactte Comd f to0 a guro <0m
d o
ltoot udher Aut eaon rid,)no nt
acd .Keadincto wghun Aumnsalino oaritnl
Co
CoA Auhch ut Aonulr Ao kolmi od
Kton uhea d oAt6cLalid i l h i a , i l i ant

to smdum , loodushuh com orl a d nn

f of ble and t Keads k a cordlio daliod ondaun
aulors Keads ts Come dsoth
o1 ka
CHOLESTEROL

PRint am tu amd um Hama Plhu os choladare

aAgraal kom Comibund ulh o org thaun o a d

I ama, ooth an Rnomatola) as potnotum

-Mthe uehucii o
uto ol
C LDL- lou demdyOp Kn un eny
lasloxst ond bvotosfau
ublocki o{ cho
-ihamopovied to
Kaposkotum
) HDL-hoh
dimady hu bdy
tihu

l AA ted om
LAmuna
J , uea

un
tnocols a dinotrd ly
ha n d uras umas
ABCond D) Jhan atla
hod to
ydno tasbo)
P wd omd baamchid
dunelumo of halentenol
AA a
mm f'
Moatudad Ate sef ln hetman and
bre nn

ttutnt opla mem sant. and o paoma

8t sed hesmo nea Xhat Ameludt ndunnta1aral

Phecus o
Sc hamene Platenlal havmones Uc

DKesa0s oVUamen D, (aiduac qyco elas SUnsterolo

he lamt kumelm, Scr Me monoe, placond al homanta
Reqntd o mesue Eransa s(onCholealonol tu Aleolele
otciecetid td all celks ohe beoly bat faati cealarl.

CHOLESTE ROL BlOSyNTHE SIS

Choustan&toy ntherta hano Am Ruen amd Aea ckim

ChcCae als8 duriued m Aovdinanlem

aetl G
Y Cholislinol Ateqilhass the e ht Aell
0maleeo of
HmG o s dame ae m kilant Kady kmfhesto

2 Auta 6A 1M (, A

-So A

CeA s
betana. S 2NADPH
deusl Aedu 2NADP HM CoA heduckac
hapheno oa 0

CC O
Meualmlu

Ntwald Tsop2,.tl bood ol adtno tJots

hr Aq)
alenc Cl30)
asetuti
ChoCetAo Ca1cC)
 Kiqulatuno (ostest fovmntunn Palamoa Bynfhvsto
miliMe
Phdsoy Pmilh
lir fane (A
kumua)
Kotom
Amrdbendint p quioycn
ATTAM Aeduk aae
HMG C A, Miulonate
AlosutAIul
multxa
Cholsinal
CUinaululan
hrlaatva
2s Recupe midualzd
èrdotylor
LOL-chrestna
eclnaululan)
lalamcco sgnthea u th a t
K2guiotaro d thot1oku omatio
debhhaylotum Cactuaku) )
oHAMoA
Lvauln - phomnoto
fudueto
uhun atiwad y Aow [ATp
AMP eondmk Photun RymaM,
phbhe4latus and
ottuake HuC CeA
ArSataus tolAMP]
*0y e milalolutu o chotusUny Cho1 e, 4)-
hydnoxy chls
aan) 2imulsf AIDstn O HMG CoA
31Auttane
h i mayos Alqulokonq mhme o
.HMG GA Raduta o
holoksd bwrynttuu
 23
Rootuburral Reaudatuno

chetaled lyrhhan by SPtEP. t»d Yizulolru

Krqulaturo o
itmerhordung pion
rd dj
K: tupiirry3lmurl urdurg tir'nSPEEP

Il ud AD Uord Tra, SPEPP 1, lro mi

Dmd SCAP D d, eklA riaaj p'a

Crtfsn Dnd PEp Joond 7 n d urs a uaulatrderou
-Iho. omaudrm

Rasulalry
Ubiakn lonapls dryaun n t

Ir
CPEBP Golat

Sig JArOelu
bd
ER chhore
EP ER
) Hrah v m

diaun ot CREB
P E B p /lor1d o "5lalp
EPbourd tt 1ry