Siklus Sel
Siklus Sel
Siklus Sel
Direfensiasi Sel
Nisha D R., S. Kep., Ns., M. Si.
http://www.free-powerpoint-templates-design.com
Kontinuitas kehidupan
Didasarkan atas reproduksi sel atau pembelahan sel
Figure 12.1
100 µm
200 µm 20 µm
prophase
Telophase
Cytokinesis
1X
Figure 12.1
• A cell’s endowment of DNA (its genetic
information) is called its genome
• Molekul DNA dalam sel ter-pack menjadi
kromosom
0.5 µm
A eukaryotic cell has multiple
chromosomes, one of which is
represented here. Before
duplication, each chromosome
has a single DNA molecule. Chromosome
duplication
(including DNA
synthesis)
Once duplicated, a chromosome
consists of two sister chromatids Centromere
connected at the centromere. Each
chromatid contains a copy of the
DNA molecule.
Sister
Separation chromatids
of sister
Mechanical processes separate chromatids
the sister chromatids into two
chromosomes and distribute
them to two daughter cells.
Mitosis
PEMBELAHAN (tidak terjadi reduksi
SEL jumlah kromosom)
Meiosis
(terjadi reduksi
jumlah kromosom)
AMITOSIS PEMBELAHAN BINER /LANGSUNG
(pada Bakteri)
Kromosom bakteri
menempel pada
membran plasma
Bagian DNA
kromosom yang
menempel mengalami
replikasi
Origin Origin
Replication continues. One
copy of the origin is now at
each end of the cell.
Cell wall
Origin of
replication
Plasma
membrane
E. coli cell Bacterial
Chromosome chromosome
Two copies
replication begins. of origin
Soon thereafter,
one copy of the origin
moves rapidly toward
the other end of the
cell.
Origin Origin
Replication continues.
One copy of the origin
is now at each end of
the cell.
Replication finishes.
The plasma membrane
grows inward, and
new cell wall is
deposited.
Two daughter
cells result.
Phases of the Cell Cycle
• Siklus sel terdiri dari
• Mitotic (M) phase (mitosis and cytokinesis)
• Interphase (cell growth and copying of chromosomes in
preparation for cell division)
• Interphase (terdiri dari sekitar 90% dari siklus sel)
yang dapat dibagi dalam sub fase:
• G1 phase (“first gap”)
• S phase (“synthesis”)
• G2 phase (“second gap”)
SIKLUS SEL
Fase-fase dalam Siklus Sel
• Siklus sel terdiri dari
INTERPHASE
• Fase mitosis
• Interphase
S
G1 (DNA synthesis)
• Interphase
– G1 phase G2
– S phase
– G2 phase
Figure 12.5
Anafase
Anafase
Telofase awal
Telofase
Telofase akhir
2 sel anakan
interfase Profase Prometafase Metafase
Profase 1I Metafase1 I
Metafase
Telofase
Telofase 1 I Anafase
Anafase 1 I
Metafase I
Profase I Prometafase I
Profase II
Telofase I
Anafase II Metafase II
Telofase II
Mitosis Meiosis
Kromosom homolog tidak bersinapsis Kromosom homolog bersinapsis
Dihasilkan 2 sel anakan per siklus Dihasilkan 4 sel anakan per siklus
Jumlah kromosom sel anakan sama Jumlah kromosom sel anakan setengah
dengan jumlah kromosom sel induk jumlah kromosom sel induk