Scribd Logo
Upload

Welcome to Scribd!

  • 371 views

    p53 Worksheet Overview Final

    Uploaded by

    smol ukelele
    The document is a student handout about the p53 gene and its role in cancer. It explains that p53 is both a gene and a protein, with the gene providing instructions to make the p53 protein. As a tumor suppressor gene, p53 helps repair DNA damage and stop uncontrolled cell growth. However, when the p53 gene is mutated in about half of cancers, it can no longer regulate the cell cycle and DNA replication properly, allowing damaged cells to multiply unchecked and potentially form tumors. The handout guides students through learning about p53's structure and function, how it is activated by cellular stress, and how it works to control gene expression to inhibit cancer development.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    p53 Worksheet Overview Final

    Uploaded by

    smol ukelele
    371 views2 pages
    The document is a student handout about the p53 gene and its role in cancer. It explains that p53 is both a gene and a protein, with the gene providing instructions to make the p53 protein. As a tumor suppressor gene, p53 helps repair DNA damage and stop uncontrolled cell growth. However, when the p53 gene is mutated in about half of cancers, it can no longer regulate the cell cycle and DNA replication properly, allowing damaged cells to multiply unchecked and potentially form tumors. The handout guides students through learning about p53's structure and function, how it is activated by cellular stress, and how it works to control gene expression to inhibit cancer development.

    Original Title

    p53_Worksheet_Overview_Final

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document is a student handout about the p53 gene and its role in cancer. It explains that p53 is both a gene and a protein, with the gene providing instructions to make the p53 protein. As a tumor suppressor gene, p53 helps repair DNA damage and stop uncontrolled cell growth. However, when the p53 gene is mutated in about half of cancers, it can no longer regulate the cell cycle and DNA replication properly, allowing damaged cells to multiply unchecked and potentially form tumors. The handout guides students through learning about p53's structure and function, how it is activated by cellular stress, and how it works to control gene expression to inhibit cancer development.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    371 views2 pages

    p53 Worksheet Overview Final

    Uploaded by

    smol ukelele
    The document is a student handout about the p53 gene and its role in cancer. It explains that p53 is both a gene and a protein, with the gene providing instructions to make the p53 protein. As a tumor suppressor gene, p53 helps repair DNA damage and stop uncontrolled cell growth. However, when the p53 gene is mutated in about half of cancers, it can no longer regulate the cell cycle and DNA replication properly, allowing damaged cells to multiply unchecked and potentially form tumors. The handout guides students through learning about p53's structure and function, how it is activated by cellular stress, and how it works to control gene expression to inhibit cancer development.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    Click and Learn Student Handout

    The p53 Gene and Cancer Overview


    INTRODUCTION
    This handout should be used with the Click and Learn “The p53 Gene and Cancer”
    (http://www.hhmi.org/biointeractive/p53-gene-and-cancer). It is intended as a basic introduction to
    the p53 gene and its role in cancer.

    PROCEDURE
    Follow the instructions as you proceed through the Click and Learn and answer the questions in the
    spaces below.

    1. On slide 1, “p53” is referred to as a molecule, a protein, and a gene. In your own words, and based
    on your knowledge of molecular genetics, how are these terms related?
    genes are molecules with information that are neeeded to make up proteins

    2. After reading the text on slide 2 and watching the video, describe the three types of cancer genes:

    Normal function What happens if they’re mutated?

    Oncogenes accelerate cell division and growth they no longer properly function in
    amplifying cell division and growth
    (broken gas pedal)

    Tumor act like brakes (inhibitors or supressors of the brakes fail (genes can no longer
    Suppressor Genes tumor growth) supres tumor growth)

    DNA Repair fix minor damage to DNA when it is DNA damage can accumulate and lead
    Genes replicated to cancer

    Published August 2014


    Revised May 2016
    www.BioInteractive.org
    Page 1 of 2
    Click and Learn Student Handout
    The p53 Gene and Cancer Overview

    3. If a cell is stressed, p53 normally functions to shut down cell division. What activates p53 and what,
    in turn, does p53 do (slide 3)?

    Low oxygen concentration, DNA damage, Chemotherapeutic agents, as well as other stress can activate
    p53. In turn, p53 activates genes that stop cell growth or even trigger the cell to die.
    Low oxygen concentration, DNA damage, Chemotherapeutic agents, as well as other stress can activate
    4. To understand how the p53 protein works, you need to understand its structure. In your own
    words, describe the function of each of p53’s domains (slide 4).
    a. Transactivation domain:
    The transactivation domain (red) lets p53 activate other genes after binding to their regulatory
    regions. This domain engages other RNA polymerase and other enzymes that transcribe RNA.
    b. DNA binding domain:
    The DNA binding domain (green) helps p53 bind to regulatory sequences of genes. Most
    mutations in the p53 protein found in cancers, are in this domain.
    c. Complexing domain:
    The complexing domain (yellow) is responsible for bringing four individual p53 molecules
    together.
    5. Slide 5 describes transcription factors. In your own words what is a transcription factor? Does p53
    act as a transcription factor?
    he transcription factor is a protein that binds to DNA and regulates gene expression by promoting or
    suppressing transcription for example p53.

    6. Why is the complexing domain of p53 so important to its function (slide 5)?
    A single p53 molecule isn't fully functional since it has to form a complex before it can bind to DNA and
    activate other genes.

    7. Describe how the p53 protein works once it has been activated (slide 7).
    Once the p53 protein is activated by Low oxygen concentration, DNA damage, Chemotherapeutic agents,
    as well as other stress, it can bind to a specific sequence of DNA to activate a particular gene. The genes
    that p53 activates in turn control many functions, including the cell cycle and programmed cell death.

    Summarize what you’ve learned:

    On slide 1 you learned that the p53 gene is mutated in about half of all cancers. Explain how and why a
    mutated p53 gene can lead to cancers.
    Without functioning p53 genes, cell proliferation is not regulated effectively and DNA damage can

    accumulate in cells. Those cells may continue to divide in an uncontrolled way, leading to tumor growth
    and/or cancer.

    Published August 2014


    Revised May 2016
    www.BioInteractive.org
    Page 2 of 2

    You might also like

    pFad - Phonifier reborn

    Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

    Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


    Alternative Proxies:

    Alternative Proxy

    pFad Proxy

    pFad v3 Proxy

    pFad v4 Proxy