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    Tugas Biofar

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    Dan Archa
    1) The document presents data on drug levels in the blood over time following administration of a drug. 2) The data is fitted to two-compartment pharmacokinetic models to determine elimination rate (β), distribution rate (α), and absorption rate (Ka). 3) The elimination half-life is determined to be 21 hours, distribution half-life is 4.91 hours, and absorption half-life is 1.73 hours.

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    Tugas Biofar

    Uploaded by

    Dan Archa
    13 views3 pages
    1) The document presents data on drug levels in the blood over time following administration of a drug. 2) The data is fitted to two-compartment pharmacokinetic models to determine elimination rate (β), distribution rate (α), and absorption rate (Ka). 3) The elimination half-life is determined to be 21 hours, distribution half-life is 4.91 hours, and absorption half-life is 1.73 hours.

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    1) The document presents data on drug levels in the blood over time following administration of a drug. 2) The data is fitted to two-compartment pharmacokinetic models to determine elimination rate (β), distribution rate (α), and absorption rate (Ka). 3) The elimination half-life is determined to be 21 hours, distribution half-life is 4.91 hours, and absorption half-life is 1.73 hours.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    13 views3 pages

    Tugas Biofar

    Uploaded by

    Dan Archa
    1) The document presents data on drug levels in the blood over time following administration of a drug. 2) The data is fitted to two-compartment pharmacokinetic models to determine elimination rate (β), distribution rate (α), and absorption rate (Ka). 3) The elimination half-life is determined to be 21 hours, distribution half-life is 4.91 hours, and absorption half-life is 1.73 hours.

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    © All Rights Reserved
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    of 3

    Waktu (Jam) Kadar obat (mg/L) B.𝒆−β.𝒕 (mg/L) Cres 1 A.

    𝒆
    −α.𝒕
    (mg/L) Cres2
    0.10 4.70 41.2 -36.50 104.00 140.50
    0.30 13.20 40.9 -27.70 101.00 128.70
    0.50 20.80 40.6 -19.80 97.85 118.00
    1.00 36.30 40 -3.70 91.19 95.00
    2.50 61.40 38 23.40 74.00 50.60
    5.00 68.10 35 33.10 51.90
    7.50 61.10 32.2 28.90 36.50
    10.00 52.10 29.7 22.40 25.63
    15.00 37.30 25.2 12.10
    20.00 27.50 21.3 6.20
    25.00 21.10 18.1 3.00
    30.00 16.90 15.4 1.50
    40.00 11.40
    50.00 8.20
    60.00 5.90 B.𝒆−β.𝒕 (mg/L)
    Cs= 41,3.𝒆−𝟎,𝟎𝟑𝟑.𝒕 T1/2 Eliminasi = 0,693/0,033 = 21jam
    Cs= 41,3.e−0,033.0,10=41,16 mg/L
    Cs= 41,3.e−0,033.0,30=40,89 mg/L
    Cs= 41,3.e−0,033.0,50=40,62 mg/L
    Cs= 41,3.e−0,033.1,00=39.95 mg/L
    Cs= 41,3.e−0,033.2,50=38,02 mg/L
    Cs= 41,3.e−0,033.5,00=35,01 mg/L
    Cs= 41,3.e−0,033.7,50= 32,2 mg/L
    Cs= 41,3.e−0,033.10,00=29,69 mg/L
    Cs= 41,3.e−0,033.15,00=25,17 mg/L
    Cs= 41,3.e−0,033.20,00=21,34 mg/L
    Cs= 41,3.e−0,033.25,00=18,09 mg/L
    Cs= 41,3.e−0,033.30,00=15,34 mg/L
    A.𝒆−α.𝒕 (mg/L)
    Waktu (Jam) Ln Cres-1 (mg/L) Cs=105.e−0,141.𝑡 T1/2 distribusi = 0.693/0,141=4,91 jam
    15 12.1 Cs=105.e−0,141.0,10 = 103,52 mg /L
    20 6.2 Cs=105.e−0,141.0,30 = 100,66 mg /L
    25 3 Cs=105.e−0,141.0,50 = 97,85 mg/ L
    30 1.5 Cs=105.e−0,141.1,00 = 91,19 mg/L
    Cs=105.e−0,141.2,50 = 73,80 mg/L
    Cs=105.e−0,141.5,00 = 51,88 mg/L
    Cs=105.e−0,141.7,50 = 36,46 mg/L
    Cs=105.e−0,141.10,00 = 25,63 mg/ L

    Waktu (jam) Ln Cres 2 (mg/L)


    0.1 140.5 Ka=0,40 jam
    0.3 128.7 Intersep C = 146,3 mg/L
    0.5 118 kadar obat pada t=0,1 jam adalah 41,2 mg/L
    1 95.2 T1/2 absorbsi = 0,693/0,40 = 1,73 jam
    2.5 50.6
    Persamaan model 2 kompartemen
    Cs=105,0.e−0,141.𝑡 + 41,3. e−0,033.𝑡 − 146,3.e−0,40.𝑡
    dari data diatas : Ka>α>β

    Nilai AUC (t=0 sampai t=∞)


    41,3 146,3
    AUC=105,0 + − =1630,45 mg.jam/L
    0,141 0,033 0,4

    Waktu (Jam) Kadar Obat (mg/L) AUC (mg.jam/L)


    0 0 0
    0.1 4.7 0.235
    0.3 13.2 1.79
    0.5 20.8 3.4
    1 36.3 14.275
    2.5 61.4 73.275
    5 68.1 161.875
    7.5 61.1 161.5
    10 52.1 141.5
    15 37.3 223.5
    20 27.5 162
    25 21.1 121.5
    30 16.9 95
    40 11.4 141.5
    50 8.2 98
    60 5.9 70.5
    ∞ 178.79
    AUC total 1648.64

    Kadar obat C70 = 4,10 mg/L Vd area = 7.58 L


    A𝑏70 = V𝑑𝑎𝑟𝑒𝑎.𝐶70= 7,58.4,10 = 31,08 mg
    31,08
    % Obat yang tersisa dalam tubuh = x 100% = 7,8%
    (0,8)(500)
    Nama : Rts. Reni
    Kadar obat (mg/L) Nurhidayanti NIM :
    80.00 2048201084
    60.00 Kelas : Farmasi 5B
    40.00

    Kadar obat (mg/L)


    20.00
    0.00
    0.0020.0040.0060.0080.00

    Eliminasi
    15.00
    y = 42.559e-0.033x
    R² = 1
    10.00
    Axis

    5.00 60.00, 5.90 Series1


    Expon. (Series1)
    0.00
    0.0020.00 40.00 60.00 80.00
    Axis Title

    Ln Cres-1 (mg/L)
    y = 99.542e-0.14x
    15 R² = 0.9998
    Ln Cres-1 (mg/L)
    10

    -1 5 Expon. (Ln Cres-1


    (mg/L))
    0
    0 10 20 30 40

    Ln Cres 2 (mg/L)
    150 y = 146.14e-0.425x R² = 1

    100 Ln Cres 2 (mg/L)

    50 Expon. (Ln Cres 2


    (mg/L))
    0
    0 1 2 3

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