Cell-Cycle Reviewer

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The Cell Cycle and Mitosis • The main stages of the cell cycle are gap 1,

synthesis, gap 2, and mitosis.


What is Cell Cycle?
The cell cycle was discovered by Prevost and Dumas Gap 1 (G1): cell growth and normal functions
(1824) while studying the cleavage of zygote of DNA synthesis (S): copies DNA
Frog. It is a series of stages a cell passes through, to Gap 2 (G2): additional growth (chromatids become
divide and produce new cells. replicated chromosomes)
This entire process where with the help of one single Mitosis (M): includes division of the cell nucleus
parent cell a new cell population grows and develops (mitosis) and division of the cell cytoplasm
is known as the cell cycle.  (cytokinesis)
Mitosis occurs only if the cell is large enough and the
Phases of Cell Cycle DNA undamaged.
• Cell cycle or cell division refers to the series of
events that take place in a cell leading to its Interphase
maturity and subsequent division. These Also known as the resting phase of the cell cycle;
events include duplication of its genome and interphase is the time during which the cell prepares
synthesis of the cell organelles followed by for division by undergoing both cell growth and DNA
division of the cytoplasm. replication. It occupies around 95% time of the
• A typical eukaryotic cell cycle is divided into overall cycle. The interphase is divided into three
two main phases: INTERPHASE AND M PHASE phases:

G1 phase (Gap 1)
G1 phase is the phase of the cell between mitosis
and initiation of replication of the genetic material of
the cell. During this phase, the cell is metabolically
active and continues to grow without replicating its
DNA.

S phase (Synthesis)
DNA replication takes place during this phase. If the
initial quantity of DNA in the cell is denoted as 2N,
then after replication it becomes 4N. However, the
number of chromosomes does not vary, viz., if the
number of chromosomes during G1 phase was 2n, it
will remain 2n at the end of S phase. The centriole
also divides into two centriole pairs in the cells which
The cell cycle has four main stages.
contain centriole.
• The cell cycle is a regular pattern of growth,
DNA replication, and cell division.
G2 phase (Gap 2)
During this phase, the RNA, proteins, other
macromolecules required for multiplication of cell
organelles, spindle formation, and cell growth are
produced as the cell prepares to go into the mitotic
phase.

Some cells like cardiac cells in the adult animals do


not exhibit division and some others only divide to
replace those cells which have been either damaged
or lost due to cell death. Such cells which do not
divide further attain an inactive G0 phase also known
as quiescent phase after they exit the G1 phase.
These cells remain metabolically active but do not
divide unless called upon to do so.
Chromosomes condense at the start of mitosis.
• DNA wraps around proteins (histones) that
condense it.
• Ina typical human cell, there is about 6.5 feet
of DNA!

Mitosis
 The purpose of mitosis is cell division: making
two cells out of one.
 Each cell has to have its own cytoplasm and
DNA.
 The DNA is replicated in interphase when two
chromosome strands became four strands
(two strands per chromatid).
 In mitosis the four strands (two sister
chromatid) have to break apart so that each
new cell only has one double-stranded
chromosome.
 Two sister chromatids together make a
chromosome
The process of mitosis generates new cells that are genetically identical to each other. Mitosis helps
organisms grow in size and repair damaged tissue.
Some species of algae are capable of growing very quickly.

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