DR Asif Ali Nle Imp Topics

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NLE EXTREMELY IMPORTANT TOPICS BY DR ASIF ALI

1. Nerves injuries and its deformities


2. Fractures and its nerve injuries
3. Embryological defects (Developmental anatomy PDF available in telegram group)
4. Necrosis it’s types: Coagulative necrosis, Liquefactive necrosis, Caseous necrosis, Fat
necrosis, Fibrinoid necrosis and Gummatous necrosis
5. TYPES OF GANGRENE: Dry gangrene, Wet gangrene and Gas gangrene
6. Cell injury
7. Apoptosis
8. Shock its classification
9. Hypersensitivity reaction it’s example
10. Oxygen hemoglobin curve it’s example
11. Lung surfactant
12. Hb dissociation curve its example
13. Endocrine hormone its functions
14. GI hormone its function
15. Diuretics site of action
16. Electrolyte disturbances its ECG finding and treatment.
17. Renin-angiotensin-aldosterone system
18. Kidney hormone functions
19. Hormones acting on kidney
20. Tumor markers
21. ABGs interpretations
22. Sleep stages
23. Heart sounds, Murmur
24. Cardiac enzymes, it’s features
25. ECG finding of various common conditions
26. ABO classification and blood transfusion, its reaction
27. Anemia it’s types
28. Types of graft and Transplantation
29. Types of Hepatitis it’s common features, markers of hepatitis
30. Immunoglobulins its types and their biomedical significance: IgG, IgA, IgM, and IgE
31. Hypersensitivity types
 Type I hypersensitivity
 Type II hypersensitivity
 Type III hypersensitivity
 Type IV hypersensitivity
1. BIOCHEMISTRY
1. Rate-determining enzymes of metabolic processes
2. Marasmus
3. Kwashiorkor
4. Glucose-6-phosphate dehydrogenase deficiency
5. Essential fructosuria
6. Hereditary fructose intolerance
7. Galactokinase deficiency
8. Classic Galactosemia
9. Lactase deficiency
10. Amino acids (essential and non-essential)
11. Hyperammonemia
12. Phenylketonuria
13. Albinism
14. Maple syrup urine Disease
15. Alkaptonuria
16. Homocystinuria
17. Cystinuria

18. Glycogen storage diseases


 Von Gierke Disease (Type I)
 Pompe Disease (Type II)
 Cori Disease (Type III)
 Andersen Disease (Type IV)
 McArdle Disease (Type V)
 Hers disease (Type VI)

19. Lysosomal storage diseases


 Tay-Sachs disease
 Fabry disease
 Niemann-Pick disease
 Krabbe disease
 Gaucher disease
 Metachromatic leukodystrophy
 Hurler syndrome (MPSI)
 Hunter syndrome (MPSII)

20. Familial dyslipidemias


 Hyperchylomicronemia Type-I
 Hypercholesterolemia Type-II
 Dysbetalipoproteinemia Type-III
 Hypertriglyceridemia Type-IV
 Mixed hyperlipidemia Type-V
2. Microbiology
1. Pneumonia
2. Meningitis
3. Dengue
4. COVID-19
5. Tuberculosis
6. Typhoid
7. Malaria
8. Chlamydia
9. Syphilis
10. Gonorrhoea
11. Infectious Mononucleosis
12. Lyme disease
13. Anthrax
14. Polio
15. Giardiasis
16. V.cholerae
17. Clostridium difficile
18. C.perfringens
19. Diphtheria
20. Tetanus
21. Ascariasis
22. Amebiasis
23. Cryptosporidium
24. Enterobius vermicularis (pinworm)
25. Ascaris lumbricoides (giant roundworm)
26. Ancylostoma spp, Necator americanus (hookworms)
27. Trichuris trichiura (whipworm)
28. Onchocerca volvulus
29. Loa loa
30. Wuchereria bancrofti
31. Cysticercosis
32. Diphyllobothrium latum
33. Echinococcus granulosus
34. Schistosoma
35. Clonorchis sinensis
36. Sarcoptes scabiei
37. Rabies
38. Herpes zoster (Shingles)
39. HIV
40. CMV
41. EBV
3. Paediatrics:
 Developmental milestones
 Congenital Heart defects
 Rheumatic fever
 Kawasaki disease
 Cystic Fibrosis
 Pyloric stenosis
 Intussusception
 Meckel’s Diverticulum
 Hirschsprung’s disease
 Volvulus malrotation
 Acute epiglottitis
 Croup
 Acute Otitis media
 ARDS
 Neonatal Jaundice
 Cerebral palsy
 Febrile seizures
 Chickenpox
 Measles
 Mumps
 Rubella

4. Surgery:
 ATLS
 Fluid management
 Mammary Duct Ectasia
 Fibroadenoma
 Phyllodes Tumor
 Intraductal Papilloma
 Galactocele (Breast Cyst)
 Carcinoma of Male Breast
 Carcinoma of Breast
 Ductal Carcinoma in Situ (DCIS)
 Lobular Carcinoma in Situ (LCIS)
 Breast Reconstruction
 Acute cholecystitis
 Acute cholangitis
 Acute pancreatitis
 Acute appendicitis
 Cholelithiasis
 Choledocholithiasis
 Liver abscess
 Hydatid liver cyst
 Intestinal obstruction
 Mesenteric ischemia
 Rectal polyps
 Pilonidal sinus disease
 Perianal Abscess
 Anal Fissure
 Perianal Fistula
 Fistula in ano
 Hemorrhoids
 Colorectal carcinoma
 Testicular Torsion
 Varicocele
 Spermatocele
 Hydrocele
 Acute Epididymoorchitis
 Fournier’s Gangrene (Idiopathic Scrotal Gangrene)
 Testicular Cancer

5. Medicine:
 ACLS and BLS protocol
 Rheumatic fever
 Infective endocarditis
 Myocarditis
 Pericarditis
 Arteriosclerosis
 Atherosclerosis
 Aortic dissection
 Subclavian steal syndrome
 Coronary steal syndrome
 Sudden cardiac death
 Myocardial infarction
 Atrial fibrillation
 Atrial flutter
 Heart Block (AV Block)
 Dilated cardiomyopathy
 Hypertrophic cardiomyopathy
 Cardiac tamponade
 Congestive cardiac failure
 Gastro-esophageal reflux disease (GERD)
 Peptic ulcer
 Carcinoma stomach
 Barret’s esophagus
 Achalasia
 Carcinoma esophagus
 Irritable bowel syndrome
 Celiac disease
 Tropical sprue
 Whipple disease
 Ulcerative colitis
 Crohn’s disease
 Carcinoma colon
 Pseudo-membrane colitis
 Physiologic neonatal jaundice
 Intra hepatic and extra hepatic cholestasis
 Gilbert syndrome
 Crigler-Najjar syndrome, type I
 Dubin-Johnson syndrome
 Rotor syndrome
 Liver cirrhosis
 Hemochromatosis
 Wilson’s disease
 Primary sclerosing cholangitis
 Primary biliary cholangitis
 Liver tumor (hepatocellular carcinoma)
 Iron Deficiency Anemia
 Megaloblastic anemia
 Thalassemia Syndrome
 Sickle Cell Anemia
 Glucose-6-Phosphate Dehydrogenase Deficiency Anemias
 Hereditary Spherocytosis
 Paroxysmal Nocturnal Hemoglobinuria
 Autoimmune Hemolytic Anemia
 Erythroblastosis Fetalis (EBF)
 Aplastic anemia
 Acute lymphoblastic leukemia
 Acute myeloid leukemia
 Chronic lymphoblastic leukemia
 Chronic myeloid leukemia
 Myelofibrosis
 Polycythemia
 Hodgkin lymphoma
 Non-hodkin lymphoma
 Multiple myeloma
 ITP
 TTP
 DIC
 Von willebrand disease
 Hemophilia A, B and C
 Hyperthyroidism (Graves’ disease, Thyroid storm)
 Hypothyroidism (Hashimoto thyroiditis, Subacute granulomatous thyroiditis, Congenital
hypothyroidism)
 Hypoparathyroidism
 Hyperparathyroidism
 Nelson syndrome
 Adrenal insufficiency
 Hyperaldosteronism
 Pheochromocytoma
 Acromegaly
 Cushing syndrome
 Gigantism
 Diabetes mellitus type 1 and 2
 Diabetic ketoacidosis (DKA)
 Hyperosmolar hyperglycemic state (HHS)
 Nephritic syndrome
 Nephrotic syndrome
 Pyelonephritis
 Acute tubular necrosis
 Autosomal dominant polycystic kidney disease
 Autosomal recessive polycystic kidney disease
 COPD
 Bronchial Asthma
 Sarcoidosis
 Coal workers’ Pneumoconiosis
 Silicosis
 Berylliosis
 Acute respiratory distress syndrome
 Obstructive sleep apnea
 Atelectasis
 Pneumothorax
 Pneumonia

6. ENT

7. Eye

8. Gynaecology and obstritics


BOOKS/NOTES

1. First-Aid (Special focus on General, pathology, immunology, Biochemistry and

Pharmacology) + First CK2 or MTB or DIMS notes

2. Plebian 1700 MCQS with Keys

3. 1200 Mock test by TEPS/NLE (All mock test are same, just MCQ sequence are

changed so don’t be confused)

4. NLE Past-Papers from NLE Essence with Errata

5. Surgery topics (Manipal surgery book Or Dims notes (available in telegram group)

6. ENT topics (Dhingra ENT – available in telegram group)

7. Eye topics (Dims notes enough, Or AK Khurana PDF available in telegram group)

8. Gynaecology and obstritics (Hackers and Moore’s +/- Dims notes)

9. High-yield points mention in the end of First-Aid CK2

10. 1000 points from NLE essence, if possible do Pharma, surgery, micro, general patho,

physio and first-Aid systemic points as well

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