11 I January 2023

https://doi.org/10.22214/ijraset.2023.48692
 International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue I Jan 2023- Available at www.ijraset.com

Role of Nutraceuticals in Health and Disease

Prevention
Jeeshan Alam Kajmi1, Richa Singh2, Dr. Tarkeshwar P. Shukla3
1, 2, 3
SCPM College of Pharmacy Lucknow Road Haripur Gonda

Abstract: Nutraceuticals are the pharmaceutically blended products that possess both nutritional as well as the medicinal value.
Such aproduct is designed to improve the physicalhealth, fight against day-to-day challenges such as stress, increase longevity,
etc. The food products used as nutraceuticals can be categorized as dietary fiber, prebiotics, probiotics, polyunsaturated Fatty
acids, antioxidants and other different types of herbal natural foods. These nutraceuticals used in various diseases such as
Obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc.. In recent years there Is a growing
interest in nutraceuticals which provide health benefits and are alternative to Modern medicine. By using nutraceuticals, it may
be possible to reduce or eliminate the need for conventional medications, reducing the chances of any adverse effect. The
Nutraceuticals are the best way to boost immunity. The nutraceuticals also plays an important role in economic growth of some
developing countries including India.
Keywords: Disease, Nutrition, Adverse effect, Health, Medicine

I. INTRODUCTION
Nutraceutical defined as a “food, or parts of a food, that provide medical or health benefits, including the prevention and of disease’’
.The term “nutraceutical” combines the word “nutrient” (a nourishing food or food component) with “pharmaceutical” (a medical
drug).The term nutraceutical was coined from nutrition and pharmaceutical in 1989 by Stephen De felice, founder and chairman of
foundation for innovation in medicine, an American organization which encourages medical health. Nutraceuticals contain a lot of
vitamins, minerals, and nutritional supplements, which makes them Unique. Crucial in sustaining health, acting as an antidote to a
variety of diseases, and so promoting Most of the drug molecules Available in the formulations were anciently used in crude form.
Nutraceuticals may be used to improve health, delay the aging process, prevent chronic diseases, increase life Expectancy, or
support the structure or function of the body. Nowadays, nutraceuticals have received considerable interest due to potential
nutritional, safety and therapeutic effects. Some popular nutraceuticals include ginseng, Echinacea, green tea, glucosamine, omega-
3, lutein, folic acid, and cod liver oil. Majority of the nutraceuticals possess multiple therapeutic properties.

Nutraceuticals mainly consists of...

1) Nutrients: Substances which have established Nutritional functions e.g. Vitamins, Minerals, Amino Acids, Fatty acids, etc.
2) Herbals/ Phytochemicals: Herbs or Botanical products.
3) Dietary Supplements: Probiotics, Prebiotics, Antioxidants, Enzymes, etc [1].

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 International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue I Jan 2023- Available at www.ijraset.com

II. NUTRACEUTICALS AND DISEASES

Nutraceuticals have been claimed to have a physiological benefit or provide protection against the following diseases such as:
Cardiovascular, Diabetes, Obesity, Parkinson’s Alzheimer’s, Cancer, Allergy, Osteoarthritis, Eye disorders, Immune system and
Inflammations

A. Cardiovascular Disease
Cardiovascular diseases (CVD) is a chronic disease by means of disorders of the heart and blood vessels which generally include
hypertension (high blood pressure), coronary heart disease (heart attack), cerebro-vascular disease (stroke), heart failure, peripheral
vascular disease, etc. In cardiac heart disease, atherosclerotic plaques form on the inner surface of arteries, which narrow the lumen
and reduced the blood flow. Further it would be the leading cause of death in developing countries. Majority of these diseases would
be preventable and controllable. Nutraceuticals used in cardiovascular diseases are Anti-oxidants, Dietary fibers, Omega-3 poly
unsaturated fatty acids, Vitamins, minerals for prevention and treatment of CVD. Milk and eggs having gamma linolenic acid
(GLA) which has many benefits, including prevention and management of cardiovascular diseases. Polyphenols (in grape) prevent
and control arterial diseases. Flavonoids (in onion, vegetables, grapes, red wine, apples, and cherries) Block the ACE and strengthen
the tiny capillaries that carry oxygen and Essential nutrients to all cells [2-9].

B. Diabetes
Diabetes mellitus is characterized by abnormally high levels of blood glucose, either Due to insufficient insulin production, or due
to its ineffectiveness. The most common forms of Diabetes are type 1diabetes (5%), an Autoimmune disorder, and type 2 diabetes
(95%), which is associated with obesity. Gestational diabetes occurs in pregnancy. Globally the total number of people with
Diabetes is projected to raise from 171 million In 2000 to 366 million in2003.Docosahexaenoic acid modulates insulin Resistance
and is also vital for neurovascular Development. This is especially important in Women with gestational diabetes mellitus which
foster the recommendation for essential Fatty acids during pregnancy. Lipoic acid is a universal antioxidant, now used in Germany
for the treatment of diabetic Neuropathy. It is possible that lipoic acid may be more effective as a long-term dietary Supplement
aimed at the prophylactic Protection of diabetics from complications. Dietary fibers from psyllium have been used Extensively both
as pharmacological Supplements, food ingredients, in processed Food to aid weight reduction, for glucose Control in diabetic
patients and to reduce lipid Levels in hyperlipidemia.Good magnesium status reduces diabetes risk And improves insulin sensitivity;
chromium. Picolinate, calcium and vitamin D appear to Promote insulin sensitivity and improve Glycemic control in some diabetics;
extracts of Bitter melon and of cinnamon have the Potential to treat and possibly prevent Diabetes. However it has been suggested
thatNutraceuticals with meaningful doses of Combinations may substantially prevent and presumably could be marketed legally
[10-15].

C. Cancer
Cancer has emerged as a major public health problem in developing countries. A high risk of cancer is associated with chronic
inflammation risk. Chronic inflammation is also linked with immune suppression, which is a risk factor for Cancer. At the
molecular level, free radicals and aldehydes, produced during chronic inflammation, can induce deleterious gene mutation and
posttranslational Modifications of key cancer-related proteins. In year 2000, malignant tumors were responsible for 12 per cent of
the Nearly 56 million deaths worldwide from all causes. According to the World Cancer Report the cancer rates there would be 15
million new cases in the year 2020 i.e. a Rise in 50%. Nutraceuticals used in cancer are lycopene concentrates in the skin, testes,
adrenal and prostate where It protects against cancer. Lycopene is one of the majorCarotenoids in western diets and is found almost
exclusively In tomatoes, water melon, guava, pink grapefruit and Papaya. Phytochemicals derived from herbs and spices also have
potential ant carcinogenic and anti-mutagenic Activities, A broad range of “phytoestrogens” with a claimed Hormonal activity, is
recommended for prevention of Prostate/breast cancer. Flavonoids found in citrus fruit Appear to protect against cancer by acting as
antioxidants Soy foods source of isoflavones, curcumin from curry and Soya isoflavones possess cancer chemo preventive
Properties. Ellagic acid is a proven anti-carcinogen present In strawberries, cranberries and walnuts. Top of form Beet Roots,
cucumber fruits, spinach leaves, and turmericRhizomes, were reported to possess anti-tumour activity Tannins present in
blackberries, blueberries, cranberries, Grapes, lentils, tea and wine with advantage to detoxify Carcinogens and scavenge harmful
free radicals. Curcumin (diferuloylmethane) which is a polyphenol of turmeric Possesses anticarcinogenic, antioxidative and
antiinflammatory properties. Pectin (apples) prevents prostate Cancer by inhibiting cancer cells from adhering to other body cells
[16-22].

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 International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue I Jan 2023- Available at www.ijraset.com

D. Arthritis
Osteoarthritis is degenerative damage and loss of the articular cartilage of the joint due to loss of protein Substance between the
bones of joints. Osteoarthritis (OA), a debilitating joint disorder, is the most common form of Arthritis in the United States, where it
affects an estimated 21 million people. Joint disorders may reduce physical Activity in individuals resulting in energy imbalance and
weight gain. Nutraceuticals used in osteoarthritis are Glucosamine (GLN) and chondroitin sulphate (CS) are widely used to improve
symptoms of osteoarthritis. Methyl Sulfonyl Methane (MSM) used in combination with Glucosamine and chondroitin for helping to
treat or prevent Osteoarthritis or joint disorder [23].

E. Obesity
Obesity is now a global public health problem, defined as an Unhealthy amount of body fat, which is responsible for Many disorders
like angina pectoris, congestive heart Failure, hypertension, hyperlipidaemia, respiratory Disorders, renal vein thrombosis,
osteoarthritis, cancer, Reduced fertility etc. The principal causes this rapid rise in Obesity rates is the increased accessibility of high-
fat, Energy dense foods such as energy-rich foods (snacks, Drinks, burger, pizzas etc) can encourage weight gain, which Calls for a
limit in the consumption of saturated and trans Fats apart from sugars and salt in the diet about 315 million People are estimated to
fall into the WHO-defined obesity Categories. Nutraceutical interventions are currently being investigated on a large-scale basis as
potential treatments for obesity and weight management. Nutraceuticals used in Obesities are Buckwheat is a crop has special
biological Activities of cholesterol lowering effect, anti-hypertension Effects and improving the constipation and obesity condition
by acting similar as to dietary fiber present in Food. 5-hydroxytryptophan and green tea extract may promote weight loss, while the
former decreases appetite, the later increases the energy expenditure. Herbal stimulants, such as ephedrine, caffeine, ma huang-
guarana, and green tea help in body weight loss. A blend of glucomannan, chitosan, fenugreek, G Silvestre, and vitamin C in the
dietary supplement significantly reduced body weight. Conjugated linoleic acid (CLA), capsaicin, Momordica Charantia (MC)
possesses potential anti obese properties [24-26].

F. Constipation
A fibre rich diet can relieve constipation. Herbal medicines and certain phytochemicals are very useful to treat constipation.
Botanical laxatives such as senna, frangula, aloe, rhubarb and cascara are used in the treatment of constipation. Some natural fibers
present in skin of vegetables and fruits, leafy vegetables, buckwheat seed proteins have beneficial role in constipation [27].

G. Diarrhoea
The discomfort caused from diarrhea is due to excessive fluid loss followed by dehydration. Affected individuals are advised to take
herbal drinks like peppermint tea, rosemary, lemon, orange, and catnip to get relief. They can be beneficial in stopping diarrhea due
to the presence of tannin which plays an important role in contracting the human tissue which results in fluid retention in the body
[28].

H. Gastritis
Certain flavonoids show anti-ulcer activity and help in prevention of gastric mucosal lesions. The bioactive component of aloe vera
is reported to help in prevention of stress-induced gastric ulceration in the rats [108]. Similarly, curcumin has proven to be effective
in improving endoscopic healing of pepticulcers. [29].

I. Nutraceutical Scenario in India

There is growing acceptance of the potential role of nutraceuticals and functional foods to minimize health risks, lifestyle diseases
and improve health quality among the Indian population. People are becoming more aware of their nutritional needs and taking
progressive steps to prevent chronic lifestyle diseases for well-being. The youngsters are now actively pursuing fitness practices to
prevent obesity, cardiovascular diseases, diabetes and other secondary complications derived from that. The Indian nutraceuticals
industry is rapidly growing despite the economic down turn and rising inflation rates. Literature suggests that there is a huge scope
of growth of nutraceuticals market in India and is concentrated in the southern part followed by the eastern part of the country. This
market is majorly dominated by some pharmaceutical companies like Dabur, Himalaya Drugs etc. Previously, production of
functional foods or nutraceuticals was limited to food companies only, but pharmaceutical companies are now diversifying their
product line due to earn revenue on this. Simultaneously, extensive research is going onto utilize the large pool of natural resources
having minimal side effects and to move into less expensive drugs.

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 International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue I Jan 2023- Available at www.ijraset.com

The dietary supplements, such as vitamins, antioxidants, purified extracts and spot medicines have been captured by pharmaceutical
giants and nutraceuticals along with beverage are now majorly produced by Fast Moving Consumer Goods (FMCG) companies like
Amway, Sami Labs, Zandu Pharmaceuticals etc. It is predicted by extensive market research by www.bccresearch.com that global
nutraceutical market should touch $336.1 billion by 2023 from $230.9 billion in 2018 at a Compound Annual Growth Rate (CAGR)
of 7.8%, from 2018 to 2023. According to the Assocham Report, the nutraceuticals market in India is estimated at around $ 4 billion
in 2017 and is expected to grow at a significant 21% CAGR to $ 10 billion in 2022. For accelerated growth, production companies
along with researchers and scientists must educate common people for their better understanding and to adopt effective
communication strategies without harming the interest of chemists and druggists for the target consumers [30 -34].

III. CONCLUSION
Nutraceuticals are widely used in the food and Pharmaceutical industries. Most of the nutraceuticals are From either mineral origin,
animal origin or vegetable origin Like gamma terpenes, beta carotene, curcumins, limonene, Eugenol, pinene, safranal, geraniol,
aloine, caryophyllene, Lycopene and silymarin. These constituents are prepared into dosage forms as topical, oral, etc. viz. creams,
lotions, Ointments, emulsions, unani formulations, aromatic oils, Microemulsions, SMEDDS, beads, tablets, emulgels, herbal
Formulations etc. used in various categories as antidiabetic, Antibiotic, antimicrobial, anti-inflammatory, anti-cancer, Protective,
etc. Nutraceuticals are quickly replacing Pharmaceuticals in prevention and management of acute And chronic health problems.
Nutraceuticals show an ample Scope to flourish in future as therapeutic agents with Preventive and curative properties.
Althoughnutraceuticals Show a promising approach for the promotion of health and Prevention of various diseases, yet health
professionals, Nutritionists, toxicologists should strategically work in Collaboration to explore them for their full potential. A ray of
cure preference in the mind of common patients revolves Around nutraceuticals because of their false perception “All Natural
medicines are good”. Also, a high cost of Prescription pharmaceuticals and reluctance of some Insurance companies to cover the
cost of drugs help the Nutraceuticals to solidify their presence in the global market of therapies and therapeutic agents. Use of
nutraceuticals As an attempt to explore their therapeutic potential with Minimum side effects as compared to conventional
Pharmaceuticals has observed a great success and met with Huge monetary benefits. The preference for exploration and production
of nutraceuticals over pharmaceuticals is evident in various pharmaceutical and biotechnology Companies. Nutraceuticals still need
extensive scientific Research to prove their preference over pharmaceuticals. It can be achieved by enactment of FIM Proposed
Nutraceutical Research and Education Act (NREA). It includes creation of a Nutraceutical Commission (NUCOM) Specifically for
the review and approval of nutraceuticals as Well as clinical research. As per FIM, NREA should look into Exclusive rights over the
research and development. Cost Wise of nutraceuticals should be kept within the Accessibility of common man. There is an
imperative need to focus on the establishments of new horizons in Nutraceutical development.
Nutraceuticals might be defined as substances that have physiological benefits or provide protection against chronic diseases.
Nutraceuticals may be used to improve health, delay the aging process, prevent chronic diseases, increase life expectancy, or
support the structure or function of the body. Nowadays, nutraceuticals have received considerable interest due to potential
nutritional, safety and therapeutic effects. Recent studies have shown promising results for these compounds in various
complications. In the present review much effort has been devoted to provide their diseases modifying indications related to
oxidative stress including allergy, Alzheimer, cardiovascular, cancer, diabetes, eye, immune, inflammatory and Parkinson’s diseases
as well as obesity.

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 International Journal for Research in Applied Science & Engineering Technology (IJRASET)
ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.538
Volume 11 Issue I Jan 2023- Available at www.ijraset.com

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