(/)

   
Home Academy Blog About
(../) (https://clincalc.com/academy)
(../blog) (../About.aspx)
(/Default.aspx)

(/Default.aspx)

 Menu

The Top 300 of 2020

Provided by the ClinCalc DrugStats Database
 ClinCalc.com (/) » Pharmacy (/Pharmacy) » ClinCalc DrugStats (/DrugStats) » Top 300 Drugs

The Top 300 Drugs of 2020 2020

Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

1 Atorvastatin (Drugs/Atorvastatin) 114,509,814 26,640,141 0

2 Levothyroxine (Drugs/Levothyroxine) 98,970,640 20,225,373 0

3 Metformin (Drugs/Metformin) 92,591,486 20,122,987  1

4 Lisinopril (Drugs/Lisinopril) 88,597,017 19,816,361  1

5 Amlodipine (Drugs/Amlodipine) 69,786,684 16,799,810  1

6 Metoprolol (Drugs/Metoprolol) 66,413,692 15,007,908  1

7 Albuterol (Drugs/Albuterol) 61,948,347 17,902,020 0

8 Omeprazole (Drugs/Omeprazole) 56,300,064 13,879,629 0

9 Losartan (Drugs/Losartan) 54,815,411 12,690,563 0

10 Gabapentin (Drugs/Gabapentin) 49,961,066 10,571,700 0

11 Hydrochlorothiazide (Drugs/Hydrochlorothiazide) 41,476,098 10,031,904 0

12 Sertraline (Drugs/Sertraline) 38,219,814 7,768,366 0

13 Simvastatin (Drugs/Simvastatin) 36,600,871 8,557,525 0

14 Montelukast (Drugs/Montelukast) 31,984,479 7,227,021 0

15 Escitalopram (Drugs/Escitalopram) 30,605,646 6,342,599  4

16 Acetaminophen; Hydrocodone (Drugs/AcetaminophenHydrocodone) 30,100,356 8,587,152  1

17 Rosuvastatin (Drugs/Rosuvastatin) 29,750,488 7,393,686  4

18 Bupropion (Drugs/Bupropion) 28,889,368 5,801,282  4

19 Furosemide (Drugs/Furosemide) 26,786,296 6,405,654  2

20 Pantoprazole (Drugs/Pantoprazole) 26,604,040 6,814,036  4

21 Trazodone (Drugs/Trazodone) 26,210,731 5,294,364  4

Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate

22 26,080,151 3,633,541  2
(Drugs/DextroamphetamineDextroamphetamineSaccharateAmphetamineAmphetamineAspartate)

23 Fluticasone (Drugs/Fluticasone) 24,777,490 7,805,740  5

24 Tamsulosin (Drugs/Tamsulosin) 24,692,402 5,856,108  4

25 Fluoxetine (Drugs/Fluoxetine) 23,403,050 4,717,183  5

26 Carvedilol (Drugs/Carvedilol) 23,159,628 4,948,170  7

27 Duloxetine (Drugs/Duloxetine) 22,546,920 4,461,604  1

28 Meloxicam (Drugs/Meloxicam) 19,808,581 6,057,630  3

 Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

29 Clopidogrel (Drugs/Clopidogrel) 19,377,527 4,340,688  7

30 Prednisone (Drugs/Prednisone) 19,044,926 9,203,354  3

31 Citalopram (Drugs/Citalopram) 18,549,176 3,683,842  1

32 Insulin Glargine (Drugs/InsulinGlargine) 17,973,209 3,662,505  5

33 Potassium Chloride (Drugs/PotassiumChloride) 17,811,732 4,637,643  1

34 Pravastatin (Drugs/Pravastatin) 17,549,151 4,132,511  2

35 Tramadol (Drugs/Tramadol) 17,475,419 4,878,951 0

36 Aspirin (Drugs/Aspirin) 17,287,372 4,741,732  2

37 Alprazolam (Drugs/Alprazolam) 16,780,805 3,632,458  4

38 Ibuprofen (Drugs/Ibuprofen) 16,533,209 8,896,328  9

39 Cyclobenzaprine (Drugs/Cyclobenzaprine) 16,151,696 5,129,829  6

40 Amoxicillin (Drugs/Amoxicillin) 15,922,907 12,780,652  17

41 Methylphenidate (Drugs/Methylphenidate) 15,449,350 2,441,634  10

42 Allopurinol (Drugs/Allopurinol) 15,303,283 3,606,249  1

43 Venlafaxine (Drugs/Venlafaxine) 15,022,423 2,863,619  3

44 Clonazepam (Drugs/Clonazepam) 14,758,212 2,498,126  2

45 Ethinyl Estradiol; Norethindrone (Drugs/EthinylEstradiolNorethindrone) 14,716,809 2,955,082  3

46 Ergocalciferol (Drugs/Ergocalciferol) 14,670,983 4,448,964  9

47 Zolpidem (Drugs/Zolpidem) 14,272,253 2,592,750 0

48 Apixaban (Drugs/Apixaban) 13,918,650 3,305,979  4

49 Glipizide (Drugs/Glipizide) 13,674,142 3,383,057  5

50 Hydrochlorothiazide; Lisinopril (Drugs/HydrochlorothiazideLisinopril) 13,559,563 2,899,536  6

51 Spironolactone (Drugs/Spironolactone) 13,354,566 3,131,156  12

52 Cetirizine (Drugs/Cetirizine) 13,125,543 3,357,330  15

53 Atenolol (Drugs/Atenolol) 12,860,512 3,143,500  14

54 Oxycodone (Drugs/Oxycodone) 12,289,518 4,092,089  5

55 Buspirone (Drugs/Buspirone) 11,820,023 2,562,053  21

56 Fluticasone; Salmeterol (Drugs/FluticasoneSalmeterol) 11,577,409 2,562,481  24

57 Topiramate (Drugs/Topiramate) 11,482,269 2,124,766  11

58 Warfarin (Drugs/Warfarin) 11,467,999 2,424,821  8

59 Estradiol (Drugs/Estradiol) 11,307,655 3,131,982  1

60 Cholecalciferol (Drugs/Cholecalciferol) 11,115,876 2,977,877  22

61 Budesonide; Formoterol (Drugs/BudesonideFormoterol) 11,114,689 2,348,352  4

62 Lamotrigine (Drugs/Lamotrigine) 10,801,628 1,713,712  9

63 Ethinyl Estradiol; Norgestimate (Drugs/EthinylEstradiolNorgestimate) 10,686,537 2,556,898  7

64 Quetiapine (Drugs/Quetiapine) 10,574,791 1,784,327  8

65 Lorazepam (Drugs/Lorazepam) 10,559,374 2,492,279  4

66 Famotidine (Drugs/Famotidine) 10,441,964 3,383,683  38

67 Folic Acid (Drugs/FolicAcid) 10,334,172 2,557,764  22

68 Azithromycin (Drugs/Azithromycin) 10,155,807 7,405,927  20

69 Acetaminophen; Oxycodone (Drugs/AcetaminophenOxycodone) 10,086,467 2,702,463  10

70 Hydroxyzine (Drugs/Hydroxyzine) 10,058,837 2,967,009  5

 Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

71 Insulin Lispro (Drugs/InsulinLispro) 10,013,738 2,272,153  6

72 Diclofenac (Drugs/Diclofenac) 9,926,749 3,647,127  2

73 Loratadine (Drugs/Loratadine) 9,914,365 2,695,131  7

74 Sitagliptin (Drugs/Sitagliptin) 9,885,657 1,937,355  14

75 Clonidine (Drugs/Clonidine) 9,867,546 1,956,023  11

76 Diltiazem (Drugs/Diltiazem) 9,787,088 2,114,110  4

77 Latanoprost (Drugs/Latanoprost) 9,722,630 2,650,387 0

78 Pregabalin (Drugs/Pregabalin) 9,227,867 1,711,184  3

79 Doxycycline (Drugs/Doxycycline) 9,152,604 5,132,350  11

80 Insulin Aspart (Drugs/InsulinAspart) 9,124,642 1,929,132  5

81 Amitriptyline (Drugs/Amitriptyline) 9,083,401 1,850,495  13

82 Paroxetine (Drugs/Paroxetine) 9,029,667 1,813,642  4

83 Ondansetron (Drugs/Ondansetron) 8,773,584 4,247,796  23

84 Tizanidine (Drugs/Tizanidine) 8,705,644 2,269,444  8

85 Lisdexamfetamine (Drugs/Lisdexamfetamine) 8,647,783 1,326,189  6

86 Rivaroxaban (Drugs/Rivaroxaban) 8,644,837 2,090,497  5

87 Glimepiride (Drugs/Glimepiride) 8,566,883 1,899,338  25

88 Propranolol (Drugs/Propranolol) 8,470,628 1,906,375  5

89 Aripiprazole (Drugs/Aripiprazole) 8,267,949 1,330,788  12

90 Finasteride (Drugs/Finasteride) 8,185,106 2,156,558  4

91 Naproxen (Drugs/Naproxen) 8,184,638 3,381,034  30

92 Levetiracetam (Drugs/Levetiracetam) 7,967,535 1,469,443  5

93 Hydrochlorothiazide; Losartan (Drugs/HydrochlorothiazideLosartan) 7,948,927 2,055,422  20

94 Alendronate (Drugs/Alendronate) 7,923,120 2,010,411  2

95 Fenofibrate (Drugs/Fenofibrate) 7,668,856 1,672,430  8

96 Dulaglutide (Drugs/Dulaglutide) 7,657,320 1,506,236  38

97 Oxybutynin (Drugs/Oxybutynin) 7,098,461 1,782,229  15

98 Celecoxib (Drugs/Celecoxib) 7,089,211 1,800,049  4

99 Lovastatin (Drugs/Lovastatin) 7,033,634 1,609,729  4

100 Ezetimibe (Drugs/Ezetimibe) 7,029,302 1,822,350  8

101 Cephalexin (Drugs/Cephalexin) 7,011,968 4,975,921  17

102 Empagliflozin (Drugs/Empagliflozin) 6,724,608 1,607,647  44

103 Hydralazine (Drugs/Hydralazine) 6,663,220 1,649,246  4

104 Mirtazapine (Drugs/Mirtazapine) 6,601,131 1,160,871  2

105 Cyanocobalamin (Drugs/Cyanocobalamin) 6,596,311 1,696,951  50

106 Triamcinolone (Drugs/Triamcinolone) 6,422,561 3,926,352  1

107 Amoxicillin; Clavulanate (Drugs/AmoxicillinClavulanate) 6,086,124 4,558,138  14

108 Baclofen (Drugs/Baclofen) 6,009,146 1,519,109  17

109 Valproate (Drugs/Valproate) 6,000,123 909,451  5

110 Tiotropium (Drugs/Tiotropium) 5,933,058 1,191,833  22

111 Sumatriptan (Drugs/Sumatriptan) 5,915,272 1,658,061  13

112 Donepezil (Drugs/Donepezil) 5,899,553 1,436,971  8

 Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

113 Methotrexate (Drugs/Methotrexate) 5,824,013 1,130,078  2

114 Isosorbide (Drugs/Isosorbide) 5,795,198 1,395,825  9

115 Fluticasone; Vilanterol (Drugs/FluticasoneVilanterol) 5,678,546 1,087,587  6

116 Ferrous Sulfate (Drugs/FerrousSulfate) 5,652,902 1,828,969  13

117 Thyroid (Drugs/Thyroid) 5,625,456 1,197,128  1

118 Acetaminophen (Drugs/Acetaminophen) 5,610,163 2,717,148  27

119 Valacyclovir (Drugs/Valacyclovir) 5,466,726 2,410,470  9

120 Desogestrel; Ethinyl Estradiol (Drugs/DesogestrelEthinylEstradiol) 5,444,043 1,185,053  8

121 Sulfamethoxazole; Trimethoprim (Drugs/SulfamethoxazoleTrimethoprim) 5,425,466 3,404,743  21

122 Esomeprazole (Drugs/Esomeprazole) 5,204,950 1,257,544  5

123 Valsartan (Drugs/Valsartan) 5,173,072 1,328,940  31

124 Insulin Detemir (Drugs/InsulinDetemir) 5,164,647 1,111,229  3

125 Clindamycin (Drugs/Clindamycin) 5,130,999 2,709,249  6

126 Hydroxychloroquine (Drugs/Hydroxychloroquine) 4,992,835 1,224,515  4

127 Methocarbamol (Drugs/Methocarbamol) 4,981,836 1,822,996  9

128 Diazepam (Drugs/Diazepam) 4,972,397 1,184,256  11

129 Semaglutide (Drugs/Semaglutide) 4,827,483 1,126,514  107

130 Dexmethylphenidate (Drugs/Dexmethylphenidate) 4,802,551 681,537  1

131 Hydrochlorothiazide; Triamterene (Drugs/HydrochlorothiazideTriamterene) 4,783,812 1,167,750  16

132 Ciprofloxacin (Drugs/Ciprofloxacin) 4,759,043 3,141,345  19

133 Chlorthalidone (Drugs/Chlorthalidone) 4,707,841 1,269,577  2

134 Rizatriptan (Drugs/Rizatriptan) 4,667,144 955,189  38

135 Nifedipine (Drugs/Nifedipine) 4,657,308 1,032,862  17

136 Insulin Degludec (Drugs/InsulinDegludec) 4,600,262 932,573  32

137 Norethindrone (Drugs/Norethindrone) 4,501,968 1,191,825  6

138 Risperidone (Drugs/Risperidone) 4,462,991 698,895  11

139 Olmesartan (Drugs/Olmesartan) 4,458,453 1,163,607  25

140 Morphine (Drugs/Morphine) 4,384,336 667,722  23

141 Benazepril (Drugs/Benazepril) 4,374,519 1,026,815  11

142 Meclizine (Drugs/Meclizine) 4,349,444 1,742,409  8

143 Timolol (Drugs/Timolol) 4,295,412 949,166  17

144 Oxcarbazepine (Drugs/Oxcarbazepine) 4,276,699 567,473  18

145 Drospirenone; Ethinyl Estradiol (Drugs/DrospirenoneEthinylEstradiol) 4,124,207 996,093  3

146 Liraglutide (Drugs/Liraglutide) 4,063,184 957,309  4

147 Dicyclomine (Drugs/Dicyclomine) 4,060,734 1,125,571  18

148 Irbesartan (Drugs/Irbesartan) 4,028,832 933,587  34

149 Hydrocortisone (Drugs/Hydrocortisone) 3,998,412 2,172,726  2

150 Albuterol; Ipratropium (Drugs/AlbuterolIpratropium) 3,967,936 902,034  1

151 Verapamil (Drugs/Verapamil) 3,936,378 874,295  10

152 Memantine (Drugs/Memantine) 3,928,015 815,190  17

153 Prednisolone (Drugs/Prednisolone) 3,894,468 2,082,074  14

154 Metformin; Sitagliptin (Drugs/MetforminSitagliptin) 3,847,462 726,067  22

 Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

155 Nortriptyline (Drugs/Nortriptyline) 3,815,024 695,323  2

156 Ropinirole (Drugs/Ropinirole) 3,776,826 765,133  12

157 Benzonatate (Drugs/Benzonatate) 3,689,272 2,686,915  52

158 Progesterone (Drugs/Progesterone) 3,617,743 983,405  31

159 Ethinyl Estradiol; Levonorgestrel (Drugs/EthinylEstradiolLevonorgestrel) 3,588,502 1,157,623  35

160 Mirabegron (Drugs/Mirabegron) 3,570,676 838,764  30

161 Methylprednisolone (Drugs/Methylprednisolone) 3,535,987 2,456,989 0

162 Acyclovir (Drugs/Acyclovir) 3,517,810 1,100,883  5

163 Docusate (Drugs/Docusate) 3,511,398 1,662,829  25

164 Olanzapine (Drugs/Olanzapine) 3,498,182 638,470  22

165 Nitroglycerin (Drugs/Nitroglycerin) 3,483,186 1,228,296  20

166 Bimatoprost (Drugs/Bimatoprost) 3,483,064 720,422  93

167 Nitrofurantoin (Drugs/Nitrofurantoin) 3,456,512 2,390,228  26

168 Pioglitazone (Drugs/Pioglitazone) 3,443,215 872,309  12

169 Amlodipine; Benazepril (Drugs/AmlodipineBenazepril) 3,434,363 711,394  45

170 Ketoconazole (Drugs/Ketoconazole) 3,417,349 1,674,690  1

171 Clobetasol (Drugs/Clobetasol) 3,395,469 1,640,838  10

172 Testosterone (Drugs/Testosterone) 3,359,583 946,138  46

173 Azelastine (Drugs/Azelastine) 3,334,304 1,210,421  6

174 Fluconazole (Drugs/Fluconazole) 3,308,929 2,031,951  41

175 Brimonidine (Drugs/Brimonidine) 3,271,308 860,260  44

176 Desvenlafaxine (Drugs/Desvenlafaxine) 3,267,575 624,316  2

177 Ranitidine (Drugs/Ranitidine) 3,260,051 1,094,672  124

178 Oseltamivir (Drugs/Oseltamivir) 3,185,814 2,838,901  49

179 Levocetirizine (Drugs/Levocetirizine) 3,108,431 803,646  15

180 Anastrozole (Drugs/Anastrozole) 3,090,061 727,779  3

181 Phentermine (Drugs/Phentermine) 3,071,041 824,329  23

182 Sucralfate (Drugs/Sucralfate) 2,971,604 836,122  5

183 Sildenafil (Drugs/Sildenafil) 2,963,291 1,080,675  14

184 Mesalamine (Drugs/Mesalamine) 2,949,823 601,145  46

185 Carbamazepine (Drugs/Carbamazepine) 2,858,880 440,198  13

186 Buprenorphine (Drugs/Buprenorphine) 2,850,298 331,721  46

187 Acetaminophen; Codeine (Drugs/AcetaminophenCodeine) 2,791,617 1,314,846  14

188 Flecainide (Drugs/Flecainide) 2,707,962 558,077  29

189 Gemfibrozil (Drugs/Gemfibrozil) 2,679,954 585,900  24

190 Prazosin (Drugs/Prazosin) 2,675,264 460,446  20

191 Lansoprazole (Drugs/Lansoprazole) 2,623,738 617,945  10

192 Diphenhydramine (Drugs/Diphenhydramine) 2,614,773 564,389  87

193 Pramipexole (Drugs/Pramipexole) 2,589,438 580,226  27

194 Ethinyl Estradiol; Etonogestrel (Drugs/EthinylEstradiolEtonogestrel) 2,540,913 693,822  38

195 Dorzolamide; Timolol (Drugs/DorzolamideTimolol) 2,482,440 604,169  13

196 Ramipril (Drugs/Ramipril) 2,466,660 772,772  17

 Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

197 Lithium (Drugs/Lithium) 2,460,054 396,292  9

198 Amiodarone (Drugs/Amiodarone) 2,445,496 677,240  14

199 Omega-3-acid Ethyl Esters (Drugs/Omega3AcidEthylEsters) 2,418,806 674,805  88

200 Glyburide (Drugs/Glyburide) 2,417,882 506,025  55

201 Acetaminophen; Butalbital; Caffeine (Drugs/AcetaminophenButalbitalCaffeine) 2,396,592 588,117  28

202 Magnesium Salts (Drugs/MagnesiumSalts) 2,384,021 721,760  13

203 Mupirocin (Drugs/Mupirocin) 2,373,039 1,750,780  12

204 Calcium (Drugs/Calcium) 2,362,576 566,984  29

205 Adalimumab (Drugs/Adalimumab) 2,356,920 311,947  53

206 Methimazole (Drugs/Methimazole) 2,344,339 557,324  11

207 Budesonide (Drugs/Budesonide) 2,337,016 791,502  5

208 Promethazine (Drugs/Promethazine) 2,309,125 848,455  34

209 Doxazosin (Drugs/Doxazosin) 2,303,044 559,689  2

210 Labetalol (Drugs/Labetalol) 2,301,338 586,272  11

211 Terazosin (Drugs/Terazosin) 2,285,079 612,834  7

212 Cyclosporine (Drugs/Cyclosporine) 2,267,430 934,638  16

213 Torsemide (Drugs/Torsemide) 2,257,787 543,956  15

214 Medroxyprogesterone (Drugs/Medroxyprogesterone) 2,240,857 732,915  47

215 Calcium; Vitamin D (Drugs/CalciumVitaminD) 2,238,411 624,329 0

216 Dorzolamide (Drugs/Dorzolamide) 2,237,619 604,302  49

217 Dapagliflozin (Drugs/Dapagliflozin) 2,233,919 457,195  93

218 Liothyronine (Drugs/Liothyronine) 2,220,213 453,030  13

219 Sacubitril; Valsartan (Drugs/SacubitrilValsartan) 2,212,116 449,592  7

220 Beclomethasone (Drugs/Beclomethasone) 2,184,209 552,670  20

221 Insulin Isophane (Drugs/InsulinIsophane) 2,171,841 553,015  39

222 Metronidazole (Drugs/Metronidazole) 2,163,820 1,500,573  84

223 Temazepam (Drugs/Temazepam) 2,143,561 551,311  7

224 Fluticasone; Umeclidinium; Vilanterol (Drugs/FluticasoneUmeclidiniumVilanterol) 2,125,887 463,445  111

225 Erythromycin (Drugs/Erythromycin) 2,091,152 1,575,509  9

226 Polyethylene Glycol 3350 (Drugs/PolyethyleneGlycol3350) 2,069,530 841,133  22

227 Nystatin (Drugs/Nystatin) 2,068,647 1,148,064  3

228 Cefdinir (Drugs/Cefdinir) 2,061,206 1,703,206  69

229 Benztropine (Drugs/Benztropine) 2,060,460 315,849  6

230 Tretinoin (Drugs/Tretinoin) 2,045,304 995,322  15

231 Mometasone (Drugs/Mometasone) 1,954,898 746,981  32

232 Eszopiclone (Drugs/Eszopiclone) 1,937,204 414,225  7

233 Betamethasone (Drugs/Betamethasone) 1,934,650 911,314  63

234 Erenumab (Drugs/Erenumab) 1,929,984 307,965  50

235 Hydrochlorothiazide; Valsartan (Drugs/HydrochlorothiazideValsartan) 1,914,068 481,490  4

236 Minocycline (Drugs/Minocycline) 1,913,971 708,553  10

237 Digoxin (Drugs/Digoxin) 1,905,633 384,729  30

238 Empagliflozin; Metformin (Drugs/EmpagliflozinMetformin) 1,891,719 286,222 0

 Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

239 Nebivolol (Drugs/Nebivolol) 1,889,275 492,665  47

240 Levofloxacin (Drugs/Levofloxacin) 1,883,619 1,324,984  57

241 Colchicine (Drugs/Colchicine) 1,876,591 640,055  38

242 Ofloxacin (Drugs/Ofloxacin) 1,844,982 1,245,552  9

243 Vortioxetine (Drugs/Vortioxetine) 1,826,351 341,417  65

244 Linaclotide (Drugs/Linaclotide) 1,796,463 469,222  41

245 Umeclidinium (Drugs/Umeclidinium) 1,763,097 278,808  4

246 Insulin Human; Insulin Isophane Human (Drugs/InsulinHumanInsulinIsophaneHuman) 1,755,906 349,026  36

247 Ticagrelor (Drugs/Ticagrelor) 1,752,727 343,966  29

248 Telmisartan (Drugs/Telmisartan) 1,750,581 405,735  22

249 Ketorolac (Drugs/Ketorolac) 1,750,298 1,052,950  17

250 Hydromorphone (Drugs/Hydromorphone) 1,747,151 468,579  13

251 Epinephrine (Drugs/Epinephrine) 1,730,366 1,221,585  2

252 Doxepin (Drugs/Doxepin) 1,721,843 420,159  17

253 Quinapril (Drugs/Quinapril) 1,671,490 395,353  41

254 Umeclidinium; Vilanterol (Drugs/UmeclidiniumVilanterol) 1,668,008 380,037  49

255 Fexofenadine (Drugs/Fexofenadine) 1,665,749 431,871  28

256 Brimonidine; Timolol (Drugs/BrimonidineTimolol) 1,661,947 344,927  15

257 Letrozole (Drugs/Letrozole) 1,654,579 303,224  14

258 Ranolazine (Drugs/Ranolazine) 1,651,335 385,469  46

259 Lurasidone (Drugs/Lurasidone) 1,646,183 278,202  37

260 Phenytoin (Drugs/Phenytoin) 1,616,629 270,818  11

261 Tadalafil (Drugs/Tadalafil) 1,615,968 439,516  28

Pancrelipase Amylase; Pancrelipase Lipase; Pancrelipase Protease

262 1,607,847 282,382  19
(Drugs/PancrelipaseAmylasePancrelipaseLipasePancrelipaseProtease)

263 Dexlansoprazole (Drugs/Dexlansoprazole) 1,576,633 404,472  43

264 Isotretinoin (Drugs/Isotretinoin) 1,572,313 419,799  51

265 Sodium Fluoride (Drugs/SodiumFluoride) 1,559,305 634,087  54

266 Solifenacin (Drugs/Solifenacin) 1,479,169 433,288  31

267 Bisoprolol (Drugs/Bisoprolol) 1,467,218 351,588  17

268 Olopatadine (Drugs/Olopatadine) 1,459,567 627,443  1

269 Primidone (Drugs/Primidone) 1,404,364 237,352  64

270 Bumetanide (Drugs/Bumetanide) 1,383,116 310,253  28

271 Tolterodine (Drugs/Tolterodine) 1,366,267 374,201  21

272 Dexamethasone (Drugs/Dexamethasone) 1,353,239 663,451  87

273 Chlorhexidine (Drugs/Chlorhexidine) 1,344,170 898,529  26

274 Sodium Salts (Drugs/SodiumSalts) 1,336,355 575,454  47

275 Varenicline (Drugs/Varenicline) 1,333,643 511,076  23

276 Zonisamide (Drugs/Zonisamide) 1,316,716 250,639  6

277 Calcitriol (Drugs/Calcitriol) 1,300,156 411,529  26

278 Emtricitabine; Tenofovir Disoproxil (Drugs/EmtricitabineTenofovirDisoproxil) 1,299,708 307,641  13

279 Terbinafine (Drugs/Terbinafine) 1,286,843 579,309  2

280 Fluocinonide (Drugs/Fluocinonide) 1,282,149 734,410  20

 Total Total
Annual
Rank Drug Name Prescriptions Patients
Change
(2020) (2020)

281 Hydrochlorothiazide; Olmesartan (Drugs/HydrochlorothiazideOlmesartan) 1,263,816 334,397  57

282 Ziprasidone (Drugs/Ziprasidone) 1,262,673 189,620 0

283 Estrogens, Conjugated (Drugs/EstrogensConjugated) 1,248,465 353,694  29

284 Sulfasalazine (Drugs/Sulfasalazine) 1,239,553 324,195  20

285 Icosapent Ethyl (Drugs/IcosapentEthyl) 1,238,694 261,585  33

286 Dexamethasone; Moxifloxacin (Drugs/DexamethasoneMoxifloxacin) 1,237,556 604,051 0

287 Atomoxetine (Drugs/Atomoxetine) 1,225,655 195,834  19

288 Formoterol; Mometasone (Drugs/FormoterolMometasone) 1,218,644 277,290  64

289 Ketotifen (Drugs/Ketotifen) 1,207,445 668,966  102

290 Bisoprolol; Hydrochlorothiazide (Drugs/BisoprololHydrochlorothiazide) 1,205,616 299,975  10

291 Sennosides (Drugs/Sennosides) 1,199,554 336,980  53

292 Raloxifene (Drugs/Raloxifene) 1,193,739 326,288  19

293 Linagliptin (Drugs/Linagliptin) 1,168,073 270,576  49

294 Canagliflozin (Drugs/Canagliflozin) 1,143,266 273,305  4

295 Alogliptin (Drugs/Alogliptin) 1,141,082 227,950 0

296 Sotalol (Drugs/Sotalol) 1,121,291 216,534  38

297 Potassium Citrate (Drugs/PotassiumCitrate) 1,107,473 228,853  51

298 Melatonin (Drugs/Melatonin) 1,090,897 289,956  89

299 Isosorbide Dinitrate (Drugs/IsosorbideDinitrate) 1,084,169 218,671  5

300 Guanfacine (Drugs/Guanfacine) 1,082,830 271,573  160

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from
two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS
release. There is an inherent delay in collecting the survey data (eg, in the 2021 calendar year), MEPS releasing the data from patients (August 2023),
and the ClinCalc DrugStats release (a few months later, classified as the 2021 drug list). Click here to read more about the process of creating the
DrugStats database from the MEPS prescribed medicines file (About.aspx).

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2020. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version
2022.08. Read more about the ClinCalc DrugStats database (/DrugStats/About.aspx).

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) (https://creativecommons.org/licenses/by-
sa/4.0/).

 Search
Enter search term ... 

 Related Links
The Top 200 Drug List (Top200Drugs.aspx)

The Top 300 Drug List (Top300Drugs.aspx)

 Follow Us!

 (http://www.facebook.com/clincalc)  (http://twitter.com/clincalc)  (http://feeds.feedburner.com/ClinCalc)

 Get Email Updates (http://eepurl.com/mXpuL)

 New and Popular

Vancomycin Calculator (/Vancomycin)
 ClinCalc DrugStats 2021 Update – The Most Commonly Prescribed Drugs in the United States
(//clincalc.com/blog/2021/09/clincalc-drugstats-2021-update-the-most-commonly-prescribed-drugs-in-the-united-states/)

DrugStats Database (/DrugStats)

ASCVD Risk Calculator (/Cardiology/ASCVD/PooledCohort.aspx)

Acute Physiology and Chronic Health Evaluation (APACHE II) Calculator (/IcuMortality/APACHEII.aspx)

RapidASCVD: Calculate ASCVD scores seriously fast (//clincalc.com/blog/2020/08/rapidascvd-calculate-ascvd-scores-seriously-

fast/)

Opioid Equianalgesic Calculator (/Opioids)

RxHero for iOS: Educational Gaming of the Top 250 Drugs (//clincalc.com/blog/2019/04/rxhero-for-ios-educational-gaming-of-
the-top-250-drugs/)

 Open Menu

 Cite This Page

Show AMA citation

(//clincalc.com/academy)

©2023 - ClinCalc LLC. All rights reserved.

 Home (../)  Academy (https://clincalc.com/academy)  Blog (../blog)

 About (../About.aspx)
Disclaimer (../Disclaimer.aspx) - Privacy Policy (../Privacy.aspx) - Contact Us (../About.aspx)
Updated Sep 12, 2021