Scribd Logo
Upload

Welcome to Scribd!

  • 96 views

    Ankur Bhaumik 18895 UC206L Lab4 Pyrazole Synthesis

    Uploaded by

    Ankur Bhaumik
    The document describes the synthesis of 3,5-Dimethylpyrazole through the reaction of acetylacetone and hydrazine hydrate. The reaction yields a crystalline solid that was filtered and dried. The melting point of the synthesized compound was measured to be 106-108°C. The percent yield was calculated to be 74.99% based on the theoretical and actual masses obtained.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Ankur Bhaumik 18895 UC206L Lab4 Pyrazole Synthesis

    Uploaded by

    Ankur Bhaumik
    96 views3 pages
    The document describes the synthesis of 3,5-Dimethylpyrazole through the reaction of acetylacetone and hydrazine hydrate. The reaction yields a crystalline solid that was filtered and dried. The melting point of the synthesized compound was measured to be 106-108°C. The percent yield was calculated to be 74.99% based on the theoretical and actual masses obtained.

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document describes the synthesis of 3,5-Dimethylpyrazole through the reaction of acetylacetone and hydrazine hydrate. The reaction yields a crystalline solid that was filtered and dried. The melting point of the synthesized compound was measured to be 106-108°C. The percent yield was calculated to be 74.99% based on the theoretical and actual masses obtained.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    96 views3 pages

    Ankur Bhaumik 18895 UC206L Lab4 Pyrazole Synthesis

    Uploaded by

    Ankur Bhaumik
    The document describes the synthesis of 3,5-Dimethylpyrazole through the reaction of acetylacetone and hydrazine hydrate. The reaction yields a crystalline solid that was filtered and dried. The melting point of the synthesized compound was measured to be 106-108°C. The percent yield was calculated to be 74.99% based on the theoretical and actual masses obtained.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    You are on page 1of 3

    UC206L

    Ankur Bhaumik
    18895

    Lab -4
    Synthesis of 3,5- Dimethylpyrazole

    Aim- To synthesize 3,5- Dimethylpyrazole, a nitrogen containing heterocyclic


    compound.

    Principle-
    Heterocyclic compounds are cyclic organic compounds containing carbon and
    other heteroatoms such as oxygen, nitrogen, or sulphur. The ring may be
    aromatic or non-aromatic. They are quite commonly encountered in nature.
    They are of immense importance in medicinal chemistry and in agrochemistry
    and polymer chemistry.

    General reaction

    Acetyl Acetone Hydrazine hydrate 3,5- Dimethylpyrazole

    Mechanism
    Calculation

    Compound Mol. Wt. (g/mol) Density (g/mL) Amount (mL) Equivalent mol
    Acetylacetone 100.12 0.975 10 0.0974 0.0974
    Hydrazine hydrate 50.061 1.03 8 0.1646 0.1646
    H O 18 1 50 - -
    2

    Theoretically- Acetylacetone and hydrazine hydrate should be taken in a 1:1


    ratio but in the experiment it was taken in a 1:1.67 ratio to increase the rate of
    the reaction.

    Procedure

    1. In a 100 mL RB 10 ml of acetylacetone) and 50 ml of water was taken.


    2. The reaction mixture was heated at 40 °C
    3. 8 ml of hydrazine hydrate was slowly added into the reaction mixture and
    temperature was maintained at 40 °C to 50 °C
    4. After the addition was completed, a crystalline solid was precipitated out.
    5. Stirring was continued further for 10-15 min. After the RB was put in ice-
    bath.
    6. The solid was filtered, dried in air, and weighed.
    7. Yield was calculated.
    8. Melting point is measured.

    Melting Point

    Melting point observed- 106˚C to 108˚C

    Yield Calculation
    1 𝑚𝑜𝑙𝑒 𝑜𝑓 ℎ𝑦𝑑𝑟𝑎𝑧𝑖𝑛𝑒 𝑟𝑒𝑎𝑐𝑡𝑠 𝑤𝑖𝑡ℎ 1 𝑚𝑜𝑙𝑒 𝑜𝑓 𝑎𝑐𝑒𝑡𝑦𝑙𝑎𝑐𝑒𝑡𝑜𝑛𝑒.
    𝑁𝑜𝑤, 𝑙𝑒𝑠𝑠𝑒𝑟 𝑎𝑚𝑜𝑢𝑛𝑡 𝑜𝑓 𝑎𝑐𝑒𝑡𝑦𝑙𝑎𝑐𝑒𝑡𝑜𝑛𝑒 𝑖𝑠 𝑝𝑟𝑒𝑠𝑒𝑛𝑡 𝑠𝑜, 𝑖𝑡 𝑖𝑠 𝑡ℎ𝑒 𝑙𝑖𝑚𝑖𝑡𝑖𝑛𝑔 𝑟𝑒𝑎𝑔𝑒𝑛𝑡.

    𝐸𝑥𝑝𝑒𝑐𝑡𝑒𝑑 𝑛𝑜. 𝑜𝑓 𝑚𝑜𝑙𝑒𝑠 𝑜𝑓 3,5 − 𝐷𝑖𝑚𝑒𝑡ℎ𝑦𝑙𝑝𝑦𝑟𝑎𝑧𝑜𝑙𝑒 = 0.0974

    𝑀𝑜𝑙𝑎𝑟 𝑚𝑎𝑠𝑠 𝑜𝑓 3,5 − 𝐷𝑖𝑚𝑒𝑡ℎ𝑦𝑙𝑝𝑦𝑟𝑎𝑧𝑜𝑙𝑒 = 96 𝑔/𝑚𝑜𝑙𝑒


    𝐸𝑥𝑝𝑒𝑐𝑡𝑒𝑑 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 3,5 − 𝐷𝑖𝑚𝑒𝑡ℎ𝑦𝑙𝑝𝑦𝑟𝑎𝑧𝑜𝑙𝑒 = 0.0974 𝑚𝑜𝑙𝑒 × 96 𝑔/𝑚𝑜𝑙𝑒 = 9.35 𝑔
    𝑂𝑏𝑡𝑎𝑖𝑛𝑒𝑑 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 3,5 − 𝐷𝑖𝑚𝑒𝑡ℎ𝑦𝑙𝑝𝑦𝑟𝑎𝑧𝑜𝑙𝑒 = 7.012 𝑔

    𝑂𝑏𝑡𝑎𝑖𝑛𝑒𝑑 𝑤𝑒𝑖𝑔ℎ𝑡 7.012


    𝑆𝑜, 𝑌𝑖𝑒𝑙𝑑 = × 100% = × 100% = 74.99%
    𝐸𝑥𝑝𝑒𝑐𝑡𝑒𝑑 𝑤𝑒𝑖𝑔ℎ𝑡 9.35

    Conclusion

    • 3,5-Dimethylpyrazole was synthesized with 74.99% yield.


    • Acetylacetone is the limiting reagent.
    • Observed melting point for the synthesized compound is 106˚C to 108˚C.

    You might also like

    pFad - Phonifier reborn

    Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

    Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


    Alternative Proxies:

    Alternative Proxy

    pFad Proxy

    pFad v3 Proxy

    pFad v4 Proxy