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Running head: RESPONSES TO PEERS 1

Responses to Peers

Student’s Name:

Institution Affiliation:
RESPONSES TO PEERS 2

Responses to Peers

First Response: Nadege Zebaze

Hi Nadege.

I am really impressed by your enlightening post on factors that influence disease. Although there

are numerous factors that influence diseases, physical examination by a qualified clinician can

help in determining the underlying causes of a disease. In the patient history that you provided,

the patient complained of food poisoning, but was diagnosed with colon cancer. In most cases,

people who suffer from colon cancer complain of abdominal symptoms, which prompt clinicians

to carry out colonoscopy, owing to the suspicion of colon cancer (Vega, Valentín & Cubiella,

2015). CT scan can help in confirming the stage of colon cancer. Although surgery offer the best

option in the treatment of colon cancer in early cases, most patients are only diagnosed when the

disease is in advanced stage (De Rosa et al., 2015). The malignant cells within the adenoma can

be detected early, but it takes quite long to penetrate the submucosa, thus, making hard to detect

colon cancer early.

References

De Rosa, M., Pace, U., Rega, D., Costabile, V., Duraturo, F., Izzo, P., & Delrio, P. (2015).

Genetics, diagnosis and management of colorectal cancer. Oncology reports, 34(3), 1087-

1096.

Vega, P., Valentín, F., & Cubiella, J. (2015). Colorectal cancer diagnosis: Pitfalls and

opportunities. World Journal of Gastrointestinal Oncology, 7(12), 422.


RESPONSES TO PEERS 3

Second Response: Adaeze Nwankwo

Hi Adaeze.

Thank you for your detailed and insightful post on the pathophysiology of hemophilia. Based on

the patient history that you provided, the patient could be had developed hemophilia, and the

coagulation pathway is necessary in this case to prevent spontaneous bleeding.

The coagulation pathway helps in keeping hemostasis, which is an accumulation of platelets that

develop a plug where endothelial cells have been exposed (Chaudhry & Babiker, 2018).

Two essential patient factors that influence hemophilia are genetics and gender, which are

closely linked through an X-linked recessive pattern. While most cases of hemophilia are

inherited, the genetics of hemophilia affects disease severity, inhibitor development, as well as

preconception testing (Hoots, Shapiro & Heiman, 2019). Having more X chromosomes can help

in preventing hemophilia, as long as there is one normal X chromosome to create clotting factors

after activation.

References

Chaudhry, R., & Babiker, H. M. (2018). Physiology, coagulation pathways. In StatPearls

[Internet]. StatPearls Publishing.

Hoots, W. K., Shapiro, A. D., & Heiman, M. (2019). Genetics of hemophilia A and B.

UpToDate. Retrieved from https://www.uptodate.com/contents/genetics-of-hemophilia-a-

and-b

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