Scribd
Upload
60 views2 pages

Magnesium Gluconate

Magnesium Gluconate is a magnesium salt of D-gluconic acid with the chemical formula C12H22MgO14. It contains not less than 98% and not more than 102% of the anhydrous compound. Tests are performed to identify the compound and ensure limits of water content, chloride, sulfate, heavy metals and reducing substances are not exceeded. The amount of the magnesium salt is assayed by titration with edetate disodium.

Uploaded by

Wangu
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
60 views2 pages

Magnesium Gluconate

Magnesium Gluconate is a magnesium salt of D-gluconic acid with the chemical formula C12H22MgO14. It contains not less than 98% and not more than 102% of the anhydrous compound. Tests are performed to identify the compound and ensure limits of water content, chloride, sulfate, heavy metals and reducing substances are not exceeded. The amount of the magnesium salt is assayed by titration with edetate disodium.

Uploaded by

Wangu
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 2

Magnesium Gluconate

C12H22MgO14·xH2O (anhydrous)  414.60

D-Gluconic
acid, magnesium salt (2:1), hydrate.
Magnesium D-gluconate (1:2) hydrate.
Magnesium D-gluconate (1:2) dihydrate 450.64  [59625-89-7].

Anhydrous  [3632-91-5].
» Magnesium Gluconate contains not less than 98.0 percent and not more
than 102.0 percent of C12H22MgO14, calculated on the anhydrous basis.
Packaging and storage— Preserve in well-closed containers.

USP Reference standards  11 —


USP Potassium Gluconate RS.
Identification—
A: A solution (1 in 10) responds to the tests for Magnesium  191 .
B: It responds to Identification test B under Calcium Gluconate.

pH  791 : between 6.0 and 7.8, in a solution (1 in 20).

Water, Method Ib  921 : between 3.0% and 12.0%, 30 minutes being allowed for
solubilization of the specimen and for the reaction to reach completion, and a blank
determination being performed with the same volume of Reagent but without the
specimen. Calculate the water content of the specimen, in mg, taken by the formula:
F(X    X)R,
 b

in which X  is the volume, in mL, of standardized Water-Methanol Solution required to


b

neutralize the unconsumed Reagent in the blank determination; and the other terms are
as defined therein.

Chloride  221 — A 1.0-g portion shows no more chloride than corresponds to 0.70
mL of 0.020 N hydrochloric acid (0.05%).

Sulfate  221 — A 2.0-g portion shows no more sulfate than corresponds to 1.0 mL of
0.020 N sulfuric acid (0.05%).
Heavy metals  231 — Dissolve 1.0 g in 10 mL of water, add 6 mL of 3 N hydrochloric
acid, and dilute with water to 25 mL: the limit is 0.002%.
Reducing substances— Transfer 1.0 g to a 250-mL conical flask, dissolve in 10 mL of
water, and add 25 mL of alkaline cupric citrate TS. Cover the flask, boil gently for 5
minutes, accurately timed, and cool rapidly to room temperature. Add 25 mL of 0.6 N
acetic acid, 10.0 mL of 0.1 N iodine VS, and 10 mL of 3 N hydrochloric acid, and titrate
with 0.1 N sodium thiosulfate VS, adding 3 mL of starch TS as the endpoint is
approached. Perform a blank determination, omitting the specimen, and note the
difference in volumes required. Each mL of the difference in volume of 0.1 N sodium
thiosulfate consumed is equivalent to 2.7 mg of reducing substances (as dextrose): the
limit is 1.0%.
Assay— Weigh accurately about 800 mg of Magnesium Gluconate, dissolve in 20 mL
of water, add 5 mL of ammonia-ammonium chloride buffer TS and 0.1 mL of eriochrome
black TS, and titrate with 0.05 M edetate disodium VS to a blue endpoint. Each mL of
0.05 M edetate disodium is equivalent to 20.73 mg of C 12H22MgO14.
Auxiliary Information— Please check for your question in the FAQs before contacting
USP.
Topic/Question Contact Expert Committee
Monograph Curtis Phinney (DSN05) Dietary Supplements - Non-
Botanicals
1-301-816-8540
Reference Lili Wang, Technical Services
Standards Scientist
1-301-816-8129
RSTech@usp.org
USP32–NF27 Page 2833
Chromatographic Column—
MAGNESIUM GLUCONATE
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy