Safety Data Sheet

According to Regulation (EC) No 1907/2006

Aspartate Aminotransferase Reagent Kit (IFCC Method)
Version 1.0
Issue date: 23/09/2015
Revision date: 23/09/2015 SDS Record Number: CSSS-TCO-010-118234

Section 1 Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier:
Identification on the label/Trade name: Aspartate Aminotransferase Reagent Kit (IFCC Method)
Additional identification: Not available
Identification of the product: See section 3
Index Number: Not available
REACH registration No.: Not available
1.2 Relevant identified uses of the substance and uses advised against:
1.2.1 Identified uses:
Suitable for in vitro quantitative determination of human serum or plasma aspartate aminotransferase (AST) vitality.
1.2.2 Uses advised against:
Not available.
1.3 Details of the supplier of the safety data sheet:
Supplier(Only representative): -
Supplier(Manufacturer): DIRUI Industrial Co., Ltd
Address: 3333 Yiju Street, New &High Tech. Development Zone, Changchun, Jilin 130103,
P.R. China
Contact person(E-mail): shiyanping@dirui.com.cn
Telephone: +86-431-85835743
Fax: +86-431-85835742
1.4 Emergency telephone Number:
+86-431-85835743
Available outside office hours? YES NO X

Section 2 Hazards Identification

2.1 Classification of the substance/mixture:
2.1.1 Classification:
The mixture is classified as following according to REGULATION (EC) No 1272/2008:
REGULATION (EC) No 1272/2008
Hazard classes/Hazard categories Hazard codes
N/A N/A
For full text of H- phrases: see section 2.2.

2.2 label elements:

Hazard Pictograms: No hazard pictogram is used.
Signal Word(S): No signal word is used.
Hazard Statement: Not applicable.
Precautionary statement: Not applicable.
Product name: Aspartate Aminotransferase Reagent Kit (IFCC Method) SDS EU
Version #: 1.0 Issue date: 23-09-2015. Revision date: 23-09-2015. 1/6
2.3 Other hazards:
Not available.

Section 3 Composition/information on ingredients

Substance/Mixture: Mixture
Ingredient(s):
Registration
Chemical Name CAS No. EC No. Concentration Classification
No.
Lactate
- 9028-36-8 232-829-0 0.20% H334
dehydrogenase
L-aspartic acid - 56-84-8 200-291-6 0.20% Not Classified
Reagent 1 (R1)
Tris buffer - 77-86-1 201-064-4 1% Not Classified
EDTA - 60-00-4 200-449-4 0.20% H319
Water - 7732-18-5 231-791-2 98.40% Not Classified
Malic
- 9001-64-3 232-622-5 0.20% H334
dehydrogenase
α-ketoglutaric acid - 328-50-7 206-330-3 0.10% H318
Reagent 2 (R2) NADH - 606-68-8 210-123-3 0.10% Not Classified
Tris buffer - 77-86-1 201-064-4 1% Not Classified
EDTA - 60-00-4 200-449-4 0.20% H319
Water - 7732-18-5 231-791-2 98.40% Not Classified

Section 4 First aid measures

4.1 Description of first aid measures:
In all cases of doubt, or when symptoms persist, seek medical attention.
4.1.1 In case of inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
4.1.2 In case of skin contact:
Wash off with soap and plenty of water.
4.1.3 In case of eyes contact:
Immediately flush eyes with plenty of water, lifting upper and lower eyelids occasionally. Get medical attention if irritation
persists.
4.1.4 In case of ingestion:
If large amounts were swallowed, give water to drink and get medical advice.

4.2 Most important symptoms and effects, both acute and delayed:
The product is not classified as harmful to human health effect.
4.3 Indication of any immediate medical attention and special treatment needed:
If skin irritation or rash occurs, get medical advice/attention.

Section 5 Fire-Fighting measures

5.1 Extinguishing media:
Suitable extinguishing media: Use extinguishing measures that are appropriate to local circumstances and the

Product name: Aspartate Aminotransferase Reagent Kit (IFCC Method) SDS EU

Version #: 1.0 Issue date: 23-09-2015. Revision date: 23-09-2015. 2/6
 surrounding environment.
Unsuitable extinguishing media: Not available.
5.2 Special hazards arising from the No specific fire or explosion hazard.
substance or mixture
5.3 Special fire fighting methods and Wear self contained breathing apparatus for fire-fighting if necessary.
special protective actions for
fire-fighters:

Section 6 Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures:
6.1.1 For non-emergency personnel: Provide adequate ventilation. Avoid inhalation of vapor. Avoid skin and eye contact.
Refer to section 8 of SDS for personal protection details.
6.1.2 For emergency responders: Wear an appropriate NIOSH/MSHA approved respirator if vapor is generated.

6.2 Environmental Precautions: Do not let product enter drains.

6.3 Methods for Containment and Cleaning Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders,
up: sawdust). Ensure adequate ventilation.
6.4 Reference to other sections: See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for information on disposal.
6.5 Additional information: Not applicable.

Section 7 Handling and storage

7.1 Precautions for safe handling:
7.1.1 Protective measures: Ensure good ventilation/exhaustion at the workplace. Avoid contact with eyes. Keep
ignition sources away - Do not smoke. Protect against electrostatic charges.
7.1.2 Advice on general occupational Do not eat, drink and smoke in work areas. Wash hands after use. Remove
hygiene: contaminated clothing and protective equipment before entering eating areas.
7.2 Conditions for safe storage, including Store in a cool location. Keep away from ignition sources. Store away from
any incompatibilities: foodstuffs. Keep container tightly closed in a dry and well-ventilated place.
7.3 Specific end use(s): Not applicable.

Section 8 Exposure Controls/Personal Protection

8.1 Control parameters:
3
8.1.1 Occupational exposure limits: L-aspartic acid (CAS#56-84-8): Exposure limits(8h):10.0 mg/m (Bulgaria)
8.1.2 Additional exposure limits under the Not available.
conditions of use:
8.1.3 DNEL/DMEL and PNEC-Values: Not available.
8.2 Exposure controls:
8.2.1Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and at the end of workday.
8.2.2 Individual protection measures, such as personal protective equipment:
Eye/face protection: No special protective equipment required. If necessary, wear protective glasses.
Hand protection: No special protective equipment required. If necessary, wear protective gloves.
Body protection: No special protective equipment required. If necessary, wear protective clothing.
Respiratory protection: No special protective equipment required. If necessary, wear protective respiratory.

Product name: Aspartate Aminotransferase Reagent Kit (IFCC Method) SDS EU

Version #: 1.0 Issue date: 23-09-2015. Revision date: 23-09-2015. 3/6
 Thermal hazards: Wear suitable protective clothing to prevent heat.
8.2.3 Environmental exposure controls: Avoid discharge into the environment.
According to local regulations, Federal and official regulations.

Section 9 Physical and chemical properties

9.1 Information on basic physical and chemical properties:
Appearance: Liquid
Colour: Not available
Odour: Not available
Odour threshold: Not available
pH: Not available
Melting point/range (°C): 169 °C (CAS#77-86-1)
Boiling point/range (°C): 288 °C (CAS#77-86-1)
Flash point (°C): Not available
Evaporation rate: Not available
Flammability limit - lower (%): Not available
Flammability (solid, gas): Not available
Ignition temperature (°C): Not available
Upper/lower flammability/explosive limits: Not available
Vapour pressure (20°C): 0.000267 Pa (CAS#77-86-1)
Vapour density: Not available
Relative density: 1.32 (CAS#77-86-1)
3
Bulk density (kg/m ): Not available
Water solubility (g/l): Soluble
n-Octanol/Water (log Po/w): log Pow = -2.31 (20°C) (CAS#77-86-1)
Auto-ignition temperature: Not available
Decomposition temperature: ca. 288 °C (CAS#77-86-1)
Viscosity, dynamic (mPa.s): Not available
Explosive properties: Not available
Oxidising properties: Not available
Molecular Formula: Not available
Molecular Weight: Not available
9.2. Other information:
Fat solubility(solvent– oil to be specified) Not available
etc:
Surface tension: Not available
Dissociation constant in water( pKa): 8.22 (25°C) (CAS#77-86-1)
Oxidation-reduction Potential: Not available
Specific gravity: Not available

Section 10 Stability and reactivity

10.1 Reactivity: The substance is stable under normal storage and handling conditions.
10.2 Chemical stability: Stable at room temperature in closed containers under normal storage and handling
Product name: Aspartate Aminotransferase Reagent Kit (IFCC Method) SDS EU
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 conditions.
10.3 Possibility of hazardous reactions: No dangerous reactions known.
10.4 Conditions to avoid: Incompatible materials.
10.5 Incompatible materials: Strong oxidizing agents.
10.6 Hazardous decomposition products: No hazardous decomposition products.

Section 11 Toxicological information

11.1 Toxicokinetics, metabolism and distribution:
Non-human toxikological data: Not available
11.2 Information on toxicological effects:
Tris buffer (CAS#77-86-1)
Acute toxicity:
LD50(Oral, Rat): > 5000 mg/kg bw
LD50(Dermal, Rat): > 5000 mg/kg bw
LC50(Inhalation, Rat): Not available
Skin corrosion/Irritation: Not classified
Serious eye damage/irritation: Not classified
Respiratory or skin sensitization: Not classified
Germ cell mutagenicity: Not classified
Carcinogenicity: Not classified
Reproductive toxicity: Not classified
STOT- single exposure: Not classified
STOT-repeated exposure: Not classified

Section 12 Ecological information

Toxicity:
Tris buffer (CAS#77-86-1)
Acute toxicity Time Species Method Evaluation Remarks
LC50 N/A 48h Fish OECD 203 N/A N/A
LC50 > 980 mg/L 24h Daphnia OECD 202 N/A N/A
EC50 397 mg/L 72h Algae OECD 201 N/A N/A
Persistence and degradability: Tris buffer (CAS#77-86-1): Readily biodegradable.
Bioaccumulative potential: Not available.
Mobility in soil: Not available.
Results of PBT&vPvB assessment: Not available.
Other adverse effects: Not available.

Section 13 Disposal considerations

13.1 Waste treatment methods: The material should be disposed of by incineration in a chemical incinerator in
compliance with national and regional requirements.
13.2 Product / Packaging disposal: If empty container retains product residues, all label precautions must be observed.
Return for reuse or dispose according to national or local regulations.

Product name: Aspartate Aminotransferase Reagent Kit (IFCC Method) SDS EU

Version #: 1.0 Issue date: 23-09-2015. Revision date: 23-09-2015. 5/6
Section 14 Transport information

Land transport(ADR/RID) Sea transport (IMDG) Air transport (ICAO/IATA)

UN-Number Not regulated Not regulated Not regulated

UN Proper shipping name Not regulated Not regulated Not regulated

Transport hazard Class Not regulated Not regulated Not regulated

Packaging group Not regulated Not regulated Not regulated

Environmental hazards No No No

Special precautions for user See section 2.2 See section 2.2 See section 2.2

Transport in bulk according to

Annex II of MARPOL 73/78 and Not regulated Not regulated Not regulated
the IBC Code

Section 15 Regulation information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture:
Relevant information regarding authorization: Not applicable.
Relevant information regarding restriction: Not applicable.
Other EU regulations: Employment restrictions concerning young person must be observed. For
use only by technically qualified individuals.
Other National regulations: Not applicable
Chemical Safety Assessment has been carried out? YES NO X

Section 16 Other information

16.1 Indication of changes:
Version 1.0 Amended by EU No 453/2010
16.2 Training instructions:
Not applicable.
16.3 Further information:
This information is based upon the present state of our knowledge. This SDS has been compiled and is solely intended for this
product.
16.4 Notice to reader:
Employers should use this information only as a supplement to other information gathered by them, and should make independent
judgment of suitability of this information to ensure proper use and protect the health and safety of employees. This information is
furnished without warranty, and any use of the product not in conformance with this Safety Data Sheet, or in combination with any
other product or process, is the responsibility of the user.
Author: Hangzhou CIRS Co., Limited Website:www.cirs-group.com Tel:0571-87206555 Email:info@cirs-group.com

Product name: Aspartate Aminotransferase Reagent Kit (IFCC Method) SDS EU

Version #: 1.0 Issue date: 23-09-2015. Revision date: 23-09-2015. 6/6