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    Phy Pharm - Kinetics Workshop 2

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    koojunwei3624
    This document summarizes a physical pharmacy workshop on chemical kinetics. It includes 4 problems involving calculations of: 1) Rate constants, activation energies, and half-lives for first-order drug decomposition and N2O5 gas phase decomposition. 2) Rate constant, half-life, and pre-exponential factor for first-order atropine base hydrolysis. 3) Determining the rate law and rate constant from experimental initial rate data for the decomposition of nitrosyl chloride.

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    Phy Pharm - Kinetics Workshop 2

    Uploaded by

    koojunwei3624
    17 views2 pages
    This document summarizes a physical pharmacy workshop on chemical kinetics. It includes 4 problems involving calculations of: 1) Rate constants, activation energies, and half-lives for first-order drug decomposition and N2O5 gas phase decomposition. 2) Rate constant, half-life, and pre-exponential factor for first-order atropine base hydrolysis. 3) Determining the rate law and rate constant from experimental initial rate data for the decomposition of nitrosyl chloride.

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    This document summarizes a physical pharmacy workshop on chemical kinetics. It includes 4 problems involving calculations of: 1) Rate constants, activation energies, and half-lives for first-order drug decomposition and N2O5 gas phase decomposition. 2) Rate constant, half-life, and pre-exponential factor for first-order atropine base hydrolysis. 3) Determining the rate law and rate constant from experimental initial rate data for the decomposition of nitrosyl chloride.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views2 pages

    Phy Pharm - Kinetics Workshop 2

    Uploaded by

    koojunwei3624
    This document summarizes a physical pharmacy workshop on chemical kinetics. It includes 4 problems involving calculations of: 1) Rate constants, activation energies, and half-lives for first-order drug decomposition and N2O5 gas phase decomposition. 2) Rate constant, half-life, and pre-exponential factor for first-order atropine base hydrolysis. 3) Determining the rate law and rate constant from experimental initial rate data for the decomposition of nitrosyl chloride.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    International Medical University

    Semester 2
    Physical Pharmacy – Chemical Kinetics Workshop

    1. At 373°C, the half-life period for the first order decomposition of a drug is
    363 min, and the activation energy (Ea) of the reaction is 218 kJ mol-1. Calculate:
    a. the value of rate constant, k, at 450°C. (5 marks)
    b. the time required for the drug to be 75% decomposed at 373°C.
    (3 marks)
    2. The gas-phase decomposition of N2O5(g) follows first-order kinetics according to
    the following equation:
    2N2O5(g) 4NO2(g) + O2(g)
    The plot of ln k versus 1/T for the reaction gives a straight line that has a slope
    of -5500 K and an intercept of 13.5.
    a. Determine the values of a, b and c in the following equation:
    a (d[N2O5]/dt) = b (d[NO2]/dt) = c (d[O2]/dt)
    (3 marks)
    b. Determine the Arrhenius activation energy, E a, for the reaction. (2 marks)
    c. Determine the rate constant (in s-1) for the reaction at 25C. (2 marks)
    d. Calculate the half-life (t0.5) for the reaction at 25C. Express your answer
    in seconds. (2 marks)
    e. What is the effect on the half-life for the reaction at 25C if the volume of
    the reaction vessel is doubled? (1 mark)
    f. If rate law for the reaction is: Rate = k[N2O5(g)]. What is the effect on the
    rate of production of O2(g) if the number of moles of N2O5(g) in the reaction
    vessel is doubled? (1 mark)
    International Medical University
    Semester 2
    Physical Pharmacy – Chemical Kinetics Workshop
    3. Atropine base undergoes a first-order hydrolysis with a rate constant of
    1.6  10-2 s-1 at 40C. The activation energy is 32.2 kJ mol-1.
    a. Determine the half-life (t0.5) for the hydrolysis at 40C. (2 marks)
    b. Determine the pre-exponential factor, A, for the hydrolysis at 40C.
    (2 marks)
    c. Determine the rate constant for the hydrolysis at 25C. (4 marks)
    d. What is the percentage of unhydrolysed atropine base after 2 minutes at
    25C. (2 marks)

    4. The decomposition of nitrosyl chloride was studied:


    2NOCl(g) ↔ 2NO(g) + Cl2(g)
    The following data were obtained:
    [NOCl]0 Initial rate
    (molecules/cm3) (molecules/cm3.s)
    3.0 x 1016 5.98 x 104
    2.0 x 1016 2.66 x 104
    1.0 x 1016 6.64 x 103
    4.0 x 1016 1.06 x 105

    a) What is the rate law?


    b) Calculate the rate constant.
    c) What is the effect on the rate when the volume of the reaction container is
    halved?

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