The image below depicts longitudinally cut surface of a kindly from a 40 yr old male patient who developed renal failure. Cut surface of a liver. 1, What is the diagnosis? 2. What is this appearance called? 3. Describe the gross and microscopic morphology. 4. Give the pathogenesis of this condition.‘A 44 yr old woman reported to a gynecologist with complaints of irregular bleeding and low backache. She was diagnosed as a case of fibroid uterus. A large tumor was surgically removed. On sectioning the tumor revealed white chalky areas which felt gritty and hard to cut. Gross and H & E sections shown below. moe 1. Identify the lesion. 2. Write identification points for this lesion. 3. Name two organs where,this type of lesion commonly occurs. 4, What is the cofnmon cause of metastatic calcification? 5. What is the special stain used for calcium.= a a a | On a routine visit to the physician an otherwise healthy 51 yr old male has BP 150/95. If the patient's HT remains untreated for years, what are the gross changes that are likely to occur in Heart? Observe the gross photograph of the specimen and answer the following questions. . Isthe heart enlarged? . Name the process of cellular adaptation that has occurred and fine it. . Name two other types of cellular adaptations. . Give two physiological examples for this type of adaptation. Qe wn ep . Is the condition physiological /pathological.47-year-old female present with lump in left breast upper outer quadrant. Excision of the lump done which shows features of Infiltrating ductal carcinoma. Immunohistochemical stain done and pictures are given below. ER PR HER2 Write the detailed names of the IHC markers given above? Which part of the cell is stained by ER and PR? Which part of the cell is stained by HER2? How will be the HER2 positivity is graded?Identify the picture Write it usesIdentify the picture ee Write it uses HARRIS HEMATOXYLIN Ri muae San Caeiog aXIdentify the picture and write the types Write the usesIdentify the picture Write about the usesIdentify the picture Write about the usesIdentify the picture Name the material used for this? Write the usesSPECIAL STAIN. 40 year old immune compromised male came with complaints of cough with expectoration, low grade fever, loss of weight and appetite for the past 2 months. On examination, cervical lymph nodes are enlarged and matted from which biopsy taken. Histopathology shows a necrotizing granulomatous inflammation. Special stain performed and the pictures given below. Identify the special stain? Write the principle of the stain? Name the diagnostic uses of this stain and its modified form?SPECIAL STAIN: 8-year-old boy with history of anemia and repeated blood transfusion on and off during exacerbation. Bone marrow aspiration and biopsy taken and special stain done Identify the special stain? Which structure is stained in this procedure? Name the uses of this stain in various other diseases?TAL IN 40-year-old diabetic male with high HBAic is presenting with complaints of blackish discharge from nasal cavity. Sinonasal endoscopy shows a necrotic friable tissue in sinuses and biopsy taken. Histopathology and special stain images given. Identify the special stain used in this case and correlate with histopathology picture? Identify the structure stained by the special stain? Name the other structures stained by the special stain?IMMUNOHISTOCHEMISTRY 50-year-old female with abdominal pain, vomiting, loss of weight and loss of appetite. Endoscopy shows a ulcer proliferative mass in the body of stomach. Gastrectomy done and microscopic picture shows clusters and glandular arrangement of pleomorphic tumor cells infiltrating the muscle layer of the stomach, Immunohistochemistry done and the picture is given below Cytokeratin (CK) What is the interpretation of the given IHC marker? Which part of the cell is stained by CK? Which tumor cells will be negative for Cytokeratin?IMMUNOHSTOCHEMISTRY 55-Year-old female present with history of slow growing mass in right side of neck for the past 6 months. Excision biopsy of node done and reported as Non-Hodgkin lymphoma. Immunohistochemical study done for further categorization. Histopathology and IHC markers pictures are given below H&E BCL2 What is the interpretation of each IHC marker given above? Which cells are stained by CD20? Which Cells are stained by CD10 and BCL2?