UNIVERSITY OF CAMBRIDGE INTERNATIONAL EXAMINATIONS

General Certificate of Education

Advanced Subsidiary Level and Advanced Level
* 9 6 2 2 9 4 9 8 9 5 *

BIOLOGY 9700/21
Paper 2 Structured Questions AS October/November 2011
1 hour 15 minutes
Candidates answer on the Question Paper.
No Additional Materials are required.

READ THESE INSTRUCTIONS FIRST

Write your Centre number, candidate number and name in the spaces provided at the top of this page.
Write in dark blue or black ink.
You may use a soft pencil for any diagrams, graphs or rough working.
Do not use staples, paper clips, highlighters, glue or correction fluid.
DO NOT WRITE IN ANY BARCODES.

Answer all questions.

At the end of the examination, fasten all your work securely together.
The number of marks is given in brackets [ ] at the end of each question or part question.

For Examiner’s Use

Total

This document consists of 15 printed pages and 1 blank page.

DC (KN/DJ) 34115/5
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Answer all the questions. For

Examiner’s
Use
1 Fig. 1.1 is a diagram of a cell surface membrane.

Fig. 1.1

(a) Use a label line and the appropriate letter to label each of the following on Fig. 1.1.

P protein for active uptake of potassium ions

Q protein for facilitated diffusion of polar molecules

R receptor site for a hormone

S hydrophilic heads of phospholipids on the internal surface of the membrane

T molecule that modifies the fluidity of the membrane [5]

(b) Some cells take in bacteria by endocytosis.

Explain how endocytosis occurs at a cell surface membrane.

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[Total: 8]

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2 A student investigated the initial rate of reaction of catalase in breaking down hydrogen For
peroxide into oxygen and water: Examiner’s
Use

catalase
2H2O2 O2 + 2H2O

The volume of oxygen collected was recorded over a period of 140 seconds. The results are
shown in Fig. 2.1.

10

6
volume
of
5
oxygen
/ cm3
4

0
0 20 40 60 80 100 120 140
time / s

Fig. 2.1

(a) (i) Use the information in Fig. 2.1 to calculate the initial rate of reaction in cm3 s–1.

Show your working.

answer ..................................... cm3 s–1 [2]

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(ii) Explain the change in volume of oxygen collected as shown in Fig. 2.1. For
Examiner’s
.................................................................................................................................. Use

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The student continued the investigation by determining the initial rates of reaction for five
different concentrations of hydrogen peroxide. The line marked W in Fig. 2.2 shows the
results.

The whole procedure was repeated after adding copper ions to the different concentrations
of hydrogen peroxide. The line marked V on Fig. 2.2 shows the results.

3.5

3.0

2.5

2.0
W
initial rate of
reaction / cm3 s–1 1.5

1.0
V
0.5

0.0
0 2 4 6 8 10 12 14 16 18 20
concentration of hydrogen peroxide / arbitrary units

Fig. 2.2

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(b) Use the information in Fig. 2.2 to explain the effect of copper ions on the action of an For
enzyme, such as catalase. Examiner’s
Use

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(c) Enzyme molecules in cells eventually stop working and are broken down.

Outline how cells replace the enzymes that are broken down.

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[Total: 12]

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3 Fig. 3.1 shows a molecule of haemoglobin. For

Examiner’s
Use

α globin

β globin

Fig. 3.1

(a) Explain how a molecule of haemoglobin shows the four levels of organisation of protein
molecules.

primary structure ..............................................................................................................

..........................................................................................................................................
arrangement of amino acis
..........................................................................................................................................
alpha helix
secondary structure .........................................................................................................

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folding of polypeptide chain

tertiary structure ..............................................................................................................

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quaternary structure ........................................................................................................

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There are many different variants of haemoglobin. The sequence of bases in DNA that For
code for the first seven amino acids in two variants of the β-globin polypeptide are shown in Examiner’s
Fig. 3.2. Use

The genetic dictionary for some of the amino acids is in Table 3.1.

Variant 1

1 2 3 4 5 6 7

CAC GTG GAC TGA GGA CTC CTC

Variant 2

1 2 3 4 5 6 7

CAC GTG GAC TGA GGA CAC CTC

Fig. 3.2

Table 3.1

amino acid abbreviation DNA triplets on the coding polynucleotide

valine val CAA, CAC, CAG, CAT

proline pro GGA, GGC, GGG, GGT

threonine thr TGA, TGC, TGG, TGT

histidine his GTA, GTG

glutamic acid glu CTC, CTT

leucine leu AAC, AAT, GAA, GAC, GAG, GAT

(b) Use the genetic dictionary to describe the similarities and differences between the two
variants of haemoglobin.

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(c) Collagen is a fibrous protein found in many tissues in animals. For

Examiner’s
(i) State the function of collagen in the walls of arteries. Use

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.............................................................................................................................. [1]

(ii) State one way in which the structure of collagen differs from the structure of
haemoglobin.

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[Total: 9]

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4 (a) (i) Name two factors that increase the chances that cancer will develop. For
Examiner’s
1. ............................................................................................................................... Use

2. ........................................................................................................................... [2]

(ii) State why lung cancer is categorised as a non-infectious disease.

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.............................................................................................................................. [1]

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The effectiveness of anti-cancer drugs may be determined by growing different tumours in For
culture. Examiner’s
Use
The effectiveness of two drugs on two human tumours (A and B) from different tissues was
assessed. The two drugs, T138067 and vinblastine, were added to the tumours in culture on
days 5, 12 and 19. The volumes of the tumours were compared with the volumes of tumours
that were not treated with any drugs.

The results are shown in Fig. 4.1.

700
Key
600 no drug
vinblastine
500 T138067

volume of 400
tumour A
/ mm3 300

200

100

0
0 5 10 15 20 25
time / days

700

600

500

volume of 400
tumour B
/ mm3 300

200

100

0
0 5 10 15 20 25
time / days

Fig. 4.1

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(b) Use the data in Fig. 4.1 to compare the effectiveness of the two drugs used to treat the For
tumours. Examiner’s
Use

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(c) Vinblastine disrupts the formation of the spindle apparatus during mitosis.

Explain how vinblastine has its effect as an anti-cancer drug.

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[Total: 10]

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5 Phloem transfer cells are modified companion cells that move sucrose and other assimilates For
from mesophyll tissue into phloem sieve tube elements. Examiner’s
Use
Fig. 5.1 is an electron micrograph of a phloem transfer cell.

cell wall

mitochondrion

magnification = × 10 000

Fig. 5.1

(a) Calculate the actual distance across the transfer cell from X to Y.

Show your working and express your answer to the nearest micrometre.

answer ........................................... µm [2]

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(b) With reference to Fig. 5.1, explain how phloem transfer cells help in the movement of For
sucrose from the mesophyll of a leaf into a phloem sieve tube element. Examiner’s
Use
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(c) Explain how sucrose in the phloem sap is moved from sieve tube elements in leaves to
cells in a sink, such as a root.

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[Total: 11]

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6 Phagocytes and lymphocytes are part of the body’s cellular response to infection by For
pathogens. Examiner’s
Use
Fig. 6.1 shows the origin and maturation of phagocytes and lymphocytes.

mature
cells

C
A B
Not to scale

Fig. 6.1

(a) Name the site of origin of phagocytes and lymphocytes.

...................................................................................................................................... [1]

(b) Name:

(i) cells A, B and C

A ...............................................................................................................................

B ...............................................................................................................................

C ........................................................................................................................... [3]

(ii) organ D.

.............................................................................................................................. [1]

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(c) Explain the roles of the cells, A, B and C in an immune response. For
Examiner’s
In your answer use the terms antigen and non-self. Use

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[Total: 10]

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Copyright Acknowledgements:

Question 5, Fig. 5.1 © “Plant Cell Biology on DVD”; 2007; by B E S Gunning; www.plantcellbiologdvdyon.com.

Permission to reproduce items where third-party owned material protected by copyright is included has been sought and cleared where possible. Every
reasonable effort has been made by the publisher (UCLES) to trace copyright holders, but if any items requiring clearance have unwittingly been included, the
publisher will be pleased to make amends at the earliest possible opportunity.

University of Cambridge International Examinations is part of the Cambridge Assessment Group. Cambridge Assessment is the brand name of University of
Cambridge Local Examinations Syndicate (UCLES), which is itself a department of the University of Cambridge.

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