SAFETY DATA SHEET Version 6.

4
Revision Date 02.02.2021
according to Regulation (EC) No. 1907/2006 Print Date 04.02.2021
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Ethyl methyl ketone for analysis EMSURE®
ACS,Reag. Ph Eur
Product Number : 1.09708
Catalogue No. : 109708
Brand : Millipore
Index-No. : 606-002-00-3
REACH No. : 01-2119457290-43-XXXX
CAS-No. : 78-93-3
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Reagent for analysis
1.3 Details of the supplier of the safety data sheet
Company : Merck KGaA
Frankfurter Str. 250
D-64271 DARMSTADT
Telephone : +49 (0)6151 72-0
Fax : +49 6151 727780
E-mail address : TechnicalService@merckgroup.com
1.4 Emergency telephone
Emergency Phone # : +(44)-870-8200418 (CHEMTREC (GB))
+(353)-19014670 (CHEMTREC Ireland)
001-803-017-9114 (CHEMTREC India)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Eye irritation (Category 2), H319
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008

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 Pictogram

Signal word Danger

Hazard statement(s)
H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 Use non-sparking tools.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
Supplemental Hazard information (EU)
EUH066 Repeated exposure may cause skin dryness or cracking.
Reduced Labeling (<= 125 ml)
Pictogram

Signal word Danger

Hazard statement(s) none
Precautionary none
statement(s)
Supplemental Hazard information (EU)
EUH066 Repeated exposure may cause skin dryness or cracking.
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : C4H8O
Molecular weight : 72,11 g/mol
CAS-No. : 78-93-3
EC-No. : 201-159-0
Index-No. : 606-002-00-3
Component Classification Concentration
Ethyl Methyl Ketone
CAS-No. 78-93-3 Flam. Liq. 2; Eye Irrit. 2; <= 100 %
EC-No. 201-159-0 STOT SE 3; H225, H319,
Index-No. 606-002-00-3 H336
Concentration limits:
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 20 %: STOT SE 3, H336;
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact
lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
5.4 Further information
Remove container from danger zone and cool with water. Prevent fire extinguishing water
from contaminating surface water or the ground water system.

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SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Advice on safe handling
Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary
measures against static discharge.
Hygiene measures
Change contaminated clothing. Preventive skin protection recommended. Wash hands after
working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Protected from light.Keep container tightly closed in a dry and well-ventilated place. Keep
away from heat and sources of ignition.
Store at +5°C to +30°C.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Ingredients with workplace control parameters
Predicted No Effect Concentration (PNEC)
Compartment Value
Fresh water 55,8 mg/l
Sea water 55,8 mg/l
Fresh water sediment 284,74 mg/kg
Sea sediment 287,7 mg/kg
Soil 22,5 mg/kg

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8.2 Exposure controls

Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 240 min
Material tested:Butoject® (KCL 898)
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic
compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Color: colorless
b) Odor No data available
c) Odor Threshold No data available
d) pH No data available
e) Melting Melting point: -87 °C
point/freezing point
f) Initial boiling point 79,6 °C at 1.013 hPa
and boiling range
g) Flash point -3 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)

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 j) Upper/lower Upper explosion limit: 10,1 %(V)
flammability or Lower explosion limit: 1,8 %(V)
explosive limits
k) Vapor pressure 95 hPa at 20 °C
l) Vapor density 2,49 - (Air = 1.0)
m) Relative density 0,805 g/cm³ at 20 °C
n) Water solubility soluble
o) Partition coefficient: log Pow: 0,3 at 40 °C - Bioaccumulation is not expected.
n-octanol/water
p) Autoignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: 0,41 mPa.s at 20 °C
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Surface tension 24,6 mN/m at 20 °C

Relative vapor 2,49 - (Air = 1.0)

density

SECTION 10: Stability and reactivity

10.1 Reactivity
Vapors may form explosive mixture with air.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Warming.
10.5 Incompatible materials
Oxidizing agents, Strong reducing agents
10.6 Hazardous decomposition products
Peroxides
In the event of fire: see section 5

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SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - 2.193 mg/kg
(OECD Test Guideline 423)
LC50 Inhalation - Mouse - 4 h - 32.000 mg/m³
Remarks:
(RTECS)
LD50 Dermal - Rabbit - 6.480 mg/kg
Remarks:
(RTECS)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Severe irritations
(OECD Test Guideline 405)
Remarks:
(Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative
(OECD Test Guideline 406)
Germ cell mutagenicity
Ames test
S. typhimurium
Result: negative
Mutagenicity (mammal cell test): chromosome aberration.
rat hepatocytes
Result: negative
In vitro mammalian cell gene mutation test
mouse lymphoma cells
Result: negative
OECD Test Guideline 474
Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
No data available

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 Aspiration hazard
No data available

11.2 Additional Information

Not available

Central nervous system depression, Gastrointestinal disturbance, narcosis

To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Liver - Irregularities - Based on Human Evidence

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish static test LC50 - Pimephales promelas (fathead minnow) - 2.993
mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 308 mg/l - 48 h
and other aquatic (OECD Test Guideline 202)
invertebrates
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata - 1.972 mg/l - 72
h
(OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 98 % - Readily biodegradable.
(OECD Test Guideline 301D)
Theoretical oxygen 2.440 mg/g
demand Remarks: (Lit.)
Ratio BOD/ThBOD 76 %
Remarks: (IUCLID)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
No data available

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SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1193 IMDG: 1193 IATA: 1193
14.2 UN proper shipping name
ADR/RID: ETHYL METHYL KETONE
IMDG: ETHYL METHYL KETONE
IATA: Ethyl methyl ketone
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
REACH - Restrictions on the manufacture, :
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)
REACH - Restrictions on the manufacture, :
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)

National legislation
Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the
control of major-accident hazards involving dangerous substances.
P5c FLAMMABLE LIQUIDS

Other regulations
Take note of Dir 94/33/EC on the protection of young people at work.

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15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
EUH066 Repeated exposure may cause skin dryness or cracking.
H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
Further information
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
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