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This document is a written assignment submitted by Nishith Amit Suratwala to George Brown College professor Kavitha Siva on March 29, 2023. It discusses modern DNA analysis technologies such as cloning, PCR, DNA fingerprinting, and DNA profiling. It analyzes challenges with analyzing DNA samples containing multiple contributors and novel techniques being developed using specific markers and massively parallel sequencing. These techniques aim to provide more accurate, reliable, and transparent DNA evidence while still being compatible with existing DNA databases and STR markers. DNA technology is expected to continue transforming medical diagnostics, treatments, forensics and profiling.

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14 views

Bodyworkswritten Assignment

This document is a written assignment submitted by Nishith Amit Suratwala to George Brown College professor Kavitha Siva on March 29, 2023. It discusses modern DNA analysis technologies such as cloning, PCR, DNA fingerprinting, and DNA profiling. It analyzes challenges with analyzing DNA samples containing multiple contributors and novel techniques being developed using specific markers and massively parallel sequencing. These techniques aim to provide more accurate, reliable, and transparent DNA evidence while still being compatible with existing DNA databases and STR markers. DNA technology is expected to continue transforming medical diagnostics, treatments, forensics and profiling.

Uploaded by

suratwalanishith22
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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WRITTEN ASSIGNMENT

NAME: Nishith Amit Suratwala (101398242)

ACAEDEMIC INSTITUTION: George Brown College

PROFESSOR NAME: Kavitha Siva

DATE: 29th March 2023


MODERN TECHNOLOGY OF DNA ANALYSIS

INTRODUCTION: -
Modern science has been revolutionised by DNA technology. Deoxyribonucleic acid (DNA), or
genetic material passed down from one generation to the next, contains many hints that have
helped to solve some of the mysteries surrounding ageing, disease, and human behaviour. New
DNA-based technologies will appear as a result of technical advancements that improve our
understanding of DNA. Cloning, polymerase chain reaction (PCR), recombinant DNA technology,
DNA fingerprinting, gene therapy, DNA microarray technology, and DNA profiling are just a few
of the recent advances in DNA technology that are already having an impact on medicine,
forensic science, environmental science, and national security.

ANALYSIS: -
By developing novel techniques for analysing samples with numerous contributors, we are
addressing some of the major challenges of DNA analysis in forensic research. When samples
are taken at a crime scene and sent for analysis, a complicated mixture of DNA sequences can
be found. For instance, if the sample was taken from a bag, it's possible that several people
touched the bag and their DNA is present in the sample. The procedures used by the present
data analysis tools for DNA profiling may not always produce consistent results. In order to
produce more accurate and reliable DNA evidence for the criminal justice system, we are
looking at novel approaches to analyse these complicated samples. Legal challenges are being
brought on the grounds that the analysis is a black box with a commercial foundation and lacks
openness to permit process validation. Short Tandem Repeat Markers (STRs), which enable us
to compare certain portions of a DNA sequence, are used in the majority of forensic DNA
analyses. In order to give data that can be analysed in consistent, transparent ways to allow
examination of samples including DNA from many contributors, we are developing novel
techniques for DNA analysis employing specific markers and massively parallel sequencing. To
continue using the present DNA databases, these techniques will also work with the existing
STR markers. One of the most exciting developments in structural DNA nanotechnology is the
DNA origami technology developed by Paul Rothemund. As reviewed by Yan, Gothelf and
colleagues. DNA origami has been used to assemble complex 2D and 3D nanostructures in the
past five years. As generic polymeric materials, DNA can assemble in large quantities. Luo and
colleagues review some real-world applications of DNA nanomaterials. In view of using DNA as
construction material, Sleiman and colleagues discuss supramolecular DNA assemblies. They
highlight how the powerful self-assembly of DNA can be used as a unique template to finely
organise and control matter on the nanometre scale.
CONCLUSION: -
DNA technology is a very new field of study that is highly contentious. It's expected to stay a
major topic of discussion in the public and affect every facet of medical diagnostics, treatments,
forensics, and genetic profiling.

REFERENCES: -
https://science.jrank.org/pages/2134/DNA-Technology.html#:~:text=DNA%20microarray
%20technology%2C%20also%20known,being%20up%20or%20down%2Dregulated.

https://www.dundee.ac.uk/projects/new-technologies-dna-analysis

https://pubs.rsc.org/en/content/articlehtml/2011/cs/c1cs90048j

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