SAFETY DATA SHEET Version 6.

3
Revision Date 29.10.2021
according to Regulation (EC) No. 1907/2006 Print Date 25.09.2022
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Sodium hydroxide solution for 1000 ml,
c(NaOH) = 0.25 mol/l (0.25 N) Titrisol®
Product Number : 1.09958
Catalogue No. : 109958
Brand : Millipore
REACH No. : This product is a mixture. REACH Registration Number see
section 3.

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Reagent for analysis
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemie GmbH
Eschenstrasse 5
D-82024 TAUFKIRCHEN
Telephone : +49 (0)89 6513-1130
Fax : +49 (0)89 6513-1161
E-mail address : technischerservice@merckgroup.com
1.4 Emergency telephone
Emergency Phone # : 0800 181 7059 (CHEMTREC Deutschland)
+49 (0)696 43508409 (CHEMTREC
weltweit)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Corrosive to Metals (Category 1), H290
Skin corrosion (Sub-category 1A), H314
Serious eye damage (Category 1), H318
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008

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 Pictogram

Signal word Danger

Hazard statement(s)
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P234 Keep only in original packaging.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection/ hearing protection.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P363 Wash contaminated clothing before reuse.
Supplemental Hazard none
Statements
Reduced Labeling (<= 125 ml)
Pictogram

Signal word Danger

Hazard statement(s)
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection/ hearing protection.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/ doctor.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P363 Wash contaminated clothing before reuse.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.2 Mixtures

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 Component Classification Concentration
sodium hydroxide
CAS-No. 1310-73-2 Met. Corr. 1; Skin Corr. >= 10 - < 20
EC-No. 215-185-5 1A; Eye Dam. 1; H290, %
Index-No. 011-002-00-6 H314, H318
Registration 01-2119457892-27- Concentration limits:
number XXXX >= 5 %: Skin Corr. 1A,
H314; 2 - < 5 %: Skin
Corr. 1B, H314; 0,5 - < 2
%: Skin Irrit. 2, H315; 0,5
- < 2 %: Eye Irrit. 2,
H319; >= 0,4 %: Met.
Corr. 1, H290;
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
First aiders need to protect themselves.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of
perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

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5.2 Special hazards arising from the substance or mixture
Sodium oxides
Not combustible.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Suppress (knock down) gases/vapors/mists with a water spray jet.Prevent fire
extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid substance contact. Do not breathe vapors,
aerosols. Ensure adequate ventilation. Evacuate the danger area, observe emergency
procedures, consult an expert.Advice for emergency responders:
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g.
Chemizorb® OH⁻, Merck Art. No. 101596). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Advice on safe handling
Observe label precautions.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
No aluminium, tin, or zinc containers.
Tightly closed.No metal containers.
Recommended storage temperature see product label.
Storage class
Storage class (TRGS 510): 8B: Non-combustible, corrosive hazardous materials
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls

Personal protective equipment

Eye/face protection
Tightly fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
Body Protection
protective clothing
Respiratory protection
Recommended Filter type: Filter type P2
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Color: colorless
b) Odor odorless

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 c) Odor Threshold Not applicable
d) pH ca.14 at 20 °C

e) Melting No data available

point/freezing point
f) Initial boiling point No data available
and boiling range
g) Flash point Not applicable
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower No data available
flammability or
explosive limits
k) Vapor pressure No data available
l) Vapor density No data available
m) Density ca.1,185 g/cm3 at 20 °C
Relative density No data available
n) Water solubility at 20 °C soluble
o) Partition coefficient: No data available
n-octanol/water
p) Autoignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
s) Explosive properties Not classified as explosive.
t) Oxidizing properties none

9.2 Other safety information

No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
No data available
10.3 Possibility of hazardous reactions
Risk of ignition or formation of inflammable gases or vapours with:
Metals
Light metals
Possible formation of:

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 Hydrogen
Violent reactions possible with:
ammonium compounds
Cyanides
organic nitro compounds
organic combustible substances
phenols
powdered alkaline earth metals
Acids
Nitriles
Magnesium

10.4 Conditions to avoid

no information available
10.5 Incompatible materials
Aluminum, various plastics, Brass, Metals, metal alloys, Zinc, Tin, Light metals, glass,
quartzes/silicate ceramics, animal/vegetable tissues
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Mixture
Acute toxicity
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of
perforation of the esophagus and the stomach.
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of
respiratory tract
Dermal: No data available
Skin corrosion/irritation
Necrosis Mixture causes severe burns.
Serious eye damage/eye irritation
Mixture causes serious eye damage. Risk of blindness! Necrosis
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available

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 Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
Irritation and corrosion, Risk of blindness!, Cough, Shortness of breath
Irritation and corrosion
Cough
Shortness of breath
collapse
death
Risk of blindness!

Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

Components
sodium hydroxide
Acute toxicity
Oral: No data available
Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger
of perforation of the esophagus and the stomach.
Symptoms: burns of mucous membranes, Cough, Shortness of breath, Possible
damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns.
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye damage.
(OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Causes serious eye damage.
Respiratory or skin sensitization
Patch test: - In vitro study
Result: negative
Remarks: (ECHA)
Germ cell mutagenicity
No data available

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 Carcinogenicity
IARC: No ingredient of this product present at levels greater
than or equal to 0.1% is identified as probable, possible
or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
Acute oral toxicity - If ingested, severe burns of the mouth and throat, as well as a
danger of perforation of the esophagus and the stomach.
Acute inhalation toxicity - burns of mucous membranes, Cough, Shortness of
breath, Possible damages:, damage of respiratory tract
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available

SECTION 12: Ecological information

12.1 Toxicity
Mixture
No data available
12.2 Persistence and degradability
The methods for determining the biological degradability are not applicable to inorganic
substances.
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

Harmful effect due to pH shift.
Death of fish possible.
Does not cause biological oxygen deficit.
Neutralisation possible in waste water treatment plants.

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 Discharge into the environment must be avoided.
No data available
Components
sodium hydroxide
Toxicity to fish LC50 - Gambusia affinis (Mosquito fish) - 125 mg/l - 96 h
Remarks: (ECOTOX Database)

Toxicity to daphnia EC50 - Ceriodaphnia (water flea) - 40,4 mg/l - 48 h

and other aquatic Remarks: (ECHA)
invertebrates

Toxicity to bacteria EC50 - Photobacterium phosphoreum - 22 mg/l - 15 min

Remarks: (External MSDS)

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1824 IMDG: 1824 IATA: 1824
14.2 UN proper shipping name
ADR/RID: SODIUM HYDROXIDE SOLUTION
IMDG: SODIUM HYDROXIDE SOLUTION
IATA: Sodium hydroxide solution
14.3 Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.

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15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H290 May be corrosive to metals.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H319 Causes serious eye irritation.
Further information

The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
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